Glutamine prevents DMBA-induced squamous cell cancer

Oral Oncology

Volumn 45, Issue 2, 2009, Pages 148-155

  Lim, V ^a   Korourian, S ^b   Todorova, V K ^a   Kaufmann, Y ^c   Klimberg, V S ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

DMBA; Glutamine; Glutathione; Oral squamous cell cancer

Indexed keywords

ANTIOXIDANT; DIMETHYLBENZ[A]ANTHRACENE; DNA; ENZYME; GLUTAMINE; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD LEVEL; BUCCAL POUCH SQUAMOUS CELL CARCINOMA; CARCINOGENESIS; CHEEK MUCOSA; CHEEK POUCH; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFECT; ENZYME ASSAY; GENE; GENE MUTATION; HAMSTER; HISTOPATHOLOGY; MALE; MICROSCOPY; MOUTH CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING; WILD TYPE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, TOPICAL; ANIMALS; ANTICARCINOGENIC AGENTS; BLOTTING, WESTERN; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CRICETINAE; GENES, RAS; GLUTAMINE; GLUTATHIONE; MALE; MOUTH MUCOSA; MOUTH NEOPLASMS; PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58549097263     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2008.04.008     Document Type: Article

References (68)

1. Wingo P.A., Tong T., and Bolden S. Cancer statistics. CA Cancer J Clin 45 (1995) 8-30
2. Jemal A., Murray T., Ward E., Samuels A., Tiwari R.C., Ghafoor A., et al. Cancer statistics. CA Cancer J Clin 55 (2005) 10-30
3. Burch J.D., Howe G.R., Miller A.B., and Semenciw R. Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: a case-control study. Cancer 61 (1988) 203-208
4. Preston-Martin S. Evaluation of the evidence that tobacco-specific nitrosamines cause cancer in humans. Crit Rev Toxicol 21 (1991) 295-297
5. Terry M.B., Neugut A.I., Bostick R.M., Sandler R.S., Haile R.W., Jacobson J.S., et al. Risk factors for advanced colorectal adenomas: a pooled analysis. Cancer Epidemiol Biomark Prev 11 (2002) 622-629
6. Lacey J., and Wilmore D. Is glutamine a conditionally essential amino acid?. Nutr Rev 48 (1990) 297-309
7. Labow B.I., and Souba W.W. Glutamine. World J Surg 24 (2000) 1503-1513
8. Kosower N.S., and Kosower E.M. The glutathione status of cells. Int Rev Cytol 54 (1978) 109-156
9. Kehrer J.P., and Lund L.G. Cellular reducing equivalents and oxidative stress. Free Radical Biol Med 17 (1994) 65-75
10. Savarese D.M., Savy G., Vahdat L., Wischmeyer P.E., and Corey B. Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev 29 (2003) 501-513
11. Welbourne T. Ammonia production and glutamine incorporation into glutathione in the functioning rat kidney. Can J Biochem 57 (1979) 233-237
12. Klimberg V.S. Glutamine, cancer and its therapy. Am J Surg 172 (1996) 418-424
13. Todorova V.K., Harms S.A., Kaufmann Y., Luo S., Luo K.Q., Babb K.B., et al. Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors. Breast Cancer Res Treat 88 (2004) 247-256
14. Jensen JC, Nwokedi E, Baker ML, Klimberg VS. Glutamine supports host while decreasing tumor glutathione after radiation injury. Abstr. AAS, Quebec, Canada: Nov. 11; 1992.
15. Rouse K., Nwokedi E., Woodliff J., Epstein J., and Klimberg V.S. Glutamine enhances sensitivity of chemotherapy through changes in glutathione metabolism. Ann Surg 221 4 (1995) 420
16. Schafer F.Q., and Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radical Biol Med 30 (2001) 1191-1212
17. Friezen C., Kiess Y., and Debatin K.M. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death Differ 11 Suppl. 1 (2004) S73-S85
18. Tormos C., Javier Chaves F., Garcia M.J., Garrido F., Jover R., O'Connor J.E., et al. Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells. Cancer Lett 208 1 (2004) 103-113
19. Schroder C.P., Godwin A.K., O'Dwyer P.J., Tew K.D., Hamilton T.C., and Ozols R.F. Glutathione and drug resistance. Cancer Invest 14 (1996) 158-168
20. Roth E., Oehler R., Manhart N., Exner R., Wessner B., Strasser E., et al. Regulative potential of glutamine-relation to glutathione metabolism. Nutrition 18 (2002) 217-221
21. Oehler R., and Roth E. Regulative capacity of glutamine. Curr Opin Clin Nutr Metab Care 6 (2003) 277-282
22. Voehringer D.W. Bcl-2 and glutathione alterations in cellular redox state that regulate apoptotic sensitivity. Free Radical Biol Med 27 (1999) 945-950
23. Hall A.G. The role of glutathione in the regulation of apoptosis. Eur J Clin Invest 29 (1999) 238-245
24. Reed J.C. Bcl-2 and the regulation of involuntary cell death. J Cell Biol 124 (1994) 1-6
25. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74 (1993) 609-619
26. Finucane D.M., Bossy-Wetzel E., Waterhouse N.J., Cotter T.G., and Green D.R. Bax-induced caspase activation and apoptosis via cytochrome release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 274 (1999) 2225-2233
27. Jiang C., Wang Z., Ganther H., and Lu J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res 61 7 (2001) 3062-3070
28. Green D.R., Bissonnette R.P., and Cutter T.G. Apoptosis and cancer. In: De Vita V.T., Hellman S.H., and Rosenberg S.A. (Eds). Important advances in cancer (1994), Lippincott, Philadelphia, PA 37-52
29. Schreiber V., Dantzer F., Ame J.C., and de Murcia G. Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 7 (2006) 517-528
30. Green D.R., and Martin S.J. The killer and the executioner: how apoptosis controls malignancy. Curr Opin Immunol 7 (1995) 694-703
31. Bernt E, Bergmeyer HU. l-Glutamate UV-assay with glutamate dehydrogenase and NAD. In: Bergmeyer HU, editor. Methods of enzymatic analysis, vol. 4. 2nd English ed. Deerfield Beach, FL: Verlag Chemie International; 1974. 1704-8.
32. Nahorski S.R. Fluorometric measurement of glutamine and asparagine using enzymic methods. Anal Biochem 42 (1971) 136-142
33. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Ann Biochem 27 (1969) 502-522
34. Anderson M.E. Enzymatic and chemical methods for the determination of glutathione. In: Dolphin D. (Ed). Glutathione vol. 1 (1983), John Wiley & Sons, New York 340-365
35. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106 (1980) 207-212
36. Rich T., and Allen R.L.W.A.H. Defying death after DNA damage. Nat Insight 407 (2000) 777-783
37. Chang K.W., Lin S.C., Koos S., Pather K., and Solt D. p53 and Ha-ras mutations in chemically induced hamster buccal pouch carcinomas. Carcinogenesis 17 (1996) 595-600
38. Gimenez-Conti I.B., LaBate M., Liu F., and Osterndorff E. p53 Alteration in chemically induced hamster cheek-pouch lesions. Mol Carcinogen 16 (1996) 197-202
39. Spandidos D.A., Sourvinos G., Tsatsanis C., and Zafiropoulus A. Normal ras genes: their onco-suppressor and pro-apoptotic functions [Review]. Int J Oncol 21 (2002) 237-241
40. Boyle J.O., Hakim J., Koch W., van der Riet P., Hruban R.H., Roa R.A., et al. The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53 (1993) 4477-4480
41. Ostwald C., Gogacz P., Hillmann T., Schweder J., Gundlach K., Kundt G., and Barten M. p53 Mutational spectra are different between squamous-cell carcinomas of the lip and oral cavity. Int J Cancer 88 (2000) 82-86
42. Andrejevic S., Savari J.-F., Fontolliet C., Monnier Ph., and Van Den Bergh H. 7,12-Dimethylbenz[a]anthracene-induced 'early' squamous-cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with 'early' forms of human squamous-cell carcinoma in the upper aero-digestive tract. Int J Exp Pathol 77 1 (1996) 7-14
43. Gimenez-Conti I., and Slaga T.J. The hamster cheek-pouch carcinogenesis model. J Cell Biochem Suppl. 17F (1993) 83-90
44. Boffetta P., Jourenkova N., and Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 8 (1997) 444-472
45. Gelboin H.V. Benzo[a]pyrene metabolism, activation, and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol Rev 60 (1980) 1107-1166
46. Pelkonen O., and Nebert D.W. Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev 34 (1982) 189-222
47. Guerin M.R. Energy sources of polycyclic aromatic hydrocarbons. In: Gelboin H.V., and Ts'o P.O.P. (Eds). Polycyclic hydrocarbons and cancer: chemistry, molecular biology and environment (1978), Academic Press, New York 1-42
48. Lopez-Torres M., Thiele J.J., Shindo Y., Han D., and Packer L. Topical application of alpha-tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. Brit J Dermatol 138 2 (1998) 207-215
49. Schwartz J.L., Shklar G., Flynn E., and Trickler D. The administration of beta carotene to prevent and regress oral carcinoma in the hamster cheek-pouch and the associated enhancement of the immune response. Adv Exp Med Biol 262 (1990) 77-93
50. Lambert J.D., Hong J., Yang G.Y., Liao J., and Yang C.S. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr 81 Suppl. 1 (2005) 284S-291S
51. Reliene R., and Schiestl R.H. Antioxidants suppress lymphoma and increase longevity in atm-deficient mice. J Nutr 137 1 (2007) 229S-232S
52. Letchoumy P.V., Mohan K.V., Kumaraguruparan R., Hara Y., and Nagini S. Black tea polyphenols protect against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Oncol Res 16 (2006) 167-178
53. Trickler D., Shklar G., and Schwartz J. Inhibition of oral carcinogenesis by glutathione. Nutr Cancer 20 2 (1993) 139-144
54. Labow B.I., and Souba W.W. Glutamine. World J Surg 24 (2000) 1503-1513
55. Rouse K., Nwokedi E., Woodliff J.E., Epstein J., and Klimberg V.S. Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg 221 4 (1995) 420-426
56. Klimberg V., Nwokedi B., Hutchins L., Pappas A.A., Lang N.P., Broadwater J.R., et al. Does glutamine facilitate chemotherapy while reducing its toxicity?. Surg Forum 42 (1991) 16-18
57. Klimberg V.S., Pappas A.A., Nwokedi E., Jensen J.C., Broadwater J.R., Lang N.P., et al. Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. Arch Surg 127 (1992) 1317-1320
58. Cao Y, Feng Z, Hoos AF, Klimberg SV. Effect of glutamine on tumor regulation of gut fractional release. In: Presented at the 52nd annual cancer symposium of the society of surgical oncology, Orlando, FL, March 4-7; 1999.
59. Farr M., Kornbluth J., Blossom S., Schaeffer R.F., and Klimberg V.S. Glutamine enhances immunoregulation of tumor growth. JPEN 18 (1994) 471-476
60. Klimberg V.S., Kornbluth J., Cao Y., Dang A., Blossom S., and Schaeffer R.F. Glutamine suppresses PGE2 synthesis and breast cancer growth. J Surg Res 63 (1996) 293-297
61. Johnson A.T., Kauffman Y.C., Luo S., Todorova V., and Klimberg V.S. Effect of glutamine on glutathione, IGF-1 and TGF-β. J Surg 111 (2002) 222-228
62. Todorova V.K., Kaufmann Y., Luo S., and Klimberg V.S. Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine. Nutr Cancer 54 2 (2006) 263-273
63. Chen M.K., Austgen T.R., Klimberg V.S., et al. Tumor glutamine use exceeds intestinal glutamine use in cachetic tumor-bearing rats. Surg Forum XLI (1990) 12-14
64. Klimberg V.S., Salloum R.M., Kasper M., Plumley D.A., Dolson D.J., Hautamaki R.D., et al. Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg 125 (1990) 1030-1045
65. Zhang L., and Mock D. Alteration in glutathione level during carcinogenesis of hamster buccal pouch mucosa. J Dent Res 70 (1991) 1061-1063
66. Rotstein J.B., and Slaga T.J. Effect of exogenous glutathione on tumor progression in the murine skin multistage carcinogenesis model. Carcinogenesis 9 (1988) 1547-1551
67. Sacks G.S. Glutamine supplementation in catabolic patients. Ann Pharmacother 33 3 (1999) 348-354
68. Rubio I.T., Cao Y., Hutchins L., Westbrook K.C., and Klimberg V.S. Effect of glutamine on methotrexate efficacy and toxicity. Ann Surg 227 5 (1998) 772-780