-
1
-
-
0037025173
-
Cancer: Addiction to oncogenes - The Achilles heal of cancer
-
I.B. Weinstein, Cancer: Addiction to oncogenes - The Achilles heal of cancer, Science 297 (2002) pp. 63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
2
-
-
84866552319
-
Addiction to c-MYC in multiple myeloma
-
T. Holien, T.K. Vatsveen, H. Hella, A. Waage, A. Sundan, Addiction to c-MYC in multiple myeloma, Blood 120 (2012) pp. 2450-2453.
-
(2012)
Blood
, vol.120
, pp. 2450-2453
-
-
Holien, T.1
Vatsveen, T.K.2
Hella, H.3
Waage, A.4
Sundan, A.5
-
3
-
-
7744220635
-
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
-
C.M. Shachaf, A.M. Kopelman, C. Arvanitis, A. Karlsson, S. Beer, S. Mandl, M.H. Bachmann, A.D. Borowsky, B. Ruebner, R.D. Cardiff, Q.W. Yang, J.M. Bishop, C.H. Contag, D.W. Felsher, MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer, Nature 431 (2004) pp. 1112-1117.
-
(2004)
Nature
, vol.431
, pp. 1112-1117
-
-
Shachaf, C.M.1
Kopelman, A.M.2
Arvanitis, C.3
Karlsson, A.4
Beer, S.5
Mandl, S.6
Bachmann, M.H.7
Borowsky, A.D.8
Ruebner, B.9
Cardiff, R.D.10
Yang, Q.W.11
Bishop, J.M.12
Contag, C.H.13
Felsher, D.W.14
-
4
-
-
0037025201
-
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
-
M. Jain, C. Arvanitis, K. Chu, W. Dewey, E. Leonhardt, M. Trinh, C.D. Sundberg, J.M. Bishop, D.W. Felsher, Sustained loss of a neoplastic phenotype by brief inactivation of MYC, Science 297 (2002) pp. 102-104.
-
(2002)
Science
, vol.297
, pp. 102-104
-
-
Jain, M.1
Arvanitis, C.2
Chu, K.3
Dewey, W.4
Leonhardt, E.5
Trinh, M.6
Sundberg, C.D.7
Bishop, J.M.8
Felsher, D.W.9
-
5
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
D.W. Felsher and J.M. Bishop, Reversible tumorigenesis by MYC in hematopoietic lineages, Mol. Cell 4 (1999) pp. 199-207.
-
(1999)
Mol. Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
6
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
L. Chin, A. Tam, J. Pomerantz, M. Wong, J. Holash, N. Bardeesy, Q. Shen, R. O'Hagan, J. Pantginis, H. Zhou, J.W. Horner, C. Cordon-Cardo, G.D. Yancopoulos, R.A. DePinho, Essential role for oncogenic Ras in tumour maintenance, Nature 400 (1999) pp. 468-472.
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, Q.7
O'Hagan, R.8
Pantginis, J.9
Zhou, H.10
Horner, J.W.11
Cordon-Cardo, C.12
Yancopoulos, G.D.13
DePinho, R.A.14
-
7
-
-
0033987718
-
Reversibility of acute B-cell leukaemia induced by BCRABL1
-
C.S. Huettner, P. Zhang, R.A. Van Etten, D.G. Tenen, Reversibility of acute B-cell leukaemia induced by BCRABL1, Nat. Genet. 24 (2000) pp. 57-60.
-
(2000)
Nat. Genet.
, vol.24
, pp. 57-60
-
-
Huettner, C.S.1
Zhang, P.2
Van Etten, R.A.3
Tenen, D.G.4
-
8
-
-
68749112705
-
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
-
(vol 136, pg 823, 2009)
-
J. Luo, N.L. Solimini, S.J. Elledge, Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (vol 136, pg 823, 2009), Cell 138 (2009) p.807.
-
(2009)
Cell
, vol.138
, pp. 807
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
9
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
L.F. Chang and M. Karin, Mammalian MAP kinase signalling cascades, Nature 410 (2001) pp. 37-40.
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.F.1
Karin, M.2
-
10
-
-
0037264633
-
Targeting ras signalling pathways in cancer therapy
-
J. Downward, Targeting ras signalling pathways in cancer therapy, Nat. Rev. Cancer 3 (2003) pp. 11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
11
-
-
38949131824
-
BRAF(E600) in benign and malignant human tumours
-
C. Michaloglou, L.C. Vredeveld, W.J. Mooi, D.S. Peeper, BRAF(E600) in benign and malignant human tumours, Oncogene 27 (2008) pp. 877-895.
-
(2008)
Oncogene
, vol.27
, pp. 877-895
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Mooi, W.J.3
Peeper, D.S.4
-
12
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies, G.R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M.J. Garnett, W. Bottomley, N. Davis, N. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, et al., Mutations of the BRAF gene in human cancer, Nature 417 (2002) pp. 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, N.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
-
13
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
P.T. Wan, M.J. Garnett, S.M. Roe, S. Lee, D. Niculescu-Duvaz, V.M. Good, C.M. Jones, C.J. Marshall, C.J. Springer, D. Barford, R. Marais, Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF, Cell 116 (2004) pp. 855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
-
14
-
-
1942506706
-
B-V599E-RAF is an oncogene in melanocytes
-
C. Wellbrock, L. Ogilvie, D. Hedley, M. Karasarides, J. Martin, D. Niculescu-Duvaz, C.J. Springer, R. Marais, B-V599E-RAF is an oncogene in melanocytes, Cancer Res. 64 (2004) pp. 2338-2342.
-
(2004)
Cancer Res
, vol.64
, pp. 2338-2342
-
-
Wellbrock, C.1
Ogilvie, L.2
Hedley, D.3
Karasarides, M.4
Martin, J.5
Niculescu-Duvaz, D.6
Springer, C.J.7
Marais, R.8
-
15
-
-
4344584872
-
B-RAF is a therapeutic target in melanoma
-
M. Karasarides, A. Chiloeches, R. Hayward, D. Niculescu-Duvaz, I. Scanlon, F. Friedlos, L. Ogilvie, D. Hedley, J. Martin, C.J. Marshall, C.J. Springer, R. Marais, B-RAF is a therapeutic target in melanoma, Oncogene 23 (2004) pp. 6292-6298.
-
(2004)
Oncogene
, vol.23
, pp. 6292-6298
-
-
Karasarides, M.1
Chiloeches, A.2
Hayward, R.3
Niculescu-Duvaz, D.4
Scanlon, I.5
Friedlos, F.6
Ogilvie, L.7
Hedley, D.8
Martin, J.9
Marshall, C.J.10
Springer, C.J.11
Marais, R.12
-
16
-
-
4444240325
-
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
-
H. Sumimoto, M. Miyagishi, H. Miyoshi, S. Yamagata, A. Shimizu, K. Taira, Y. Kawakami, Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference, Oncogene 23 (2004) pp. 6031-6039.
-
(2004)
Oncogene
, vol.23
, pp. 6031-6039
-
-
Sumimoto, H.1
Miyagishi, M.2
Miyoshi, H.3
Yamagata, S.4
Shimizu, A.5
Taira, K.6
Kawakami, Y.7
-
17
-
-
30544434479
-
Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF
-
C. Christensen and P. Guldberg, Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF, Oncogene 24 (2005) pp. 6292-6302.
-
(2005)
Oncogene
, vol.24
, pp. 6292-6302
-
-
Christensen, C.1
Guldberg, P.2
-
18
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity, Proc
-
U. S. A
-
J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, N.K. Haass, K. Sproesser, L. Li, K.S.M. Smalley, D. Fong, Y.L. Zhu, A. Marimuthu, et al., Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity, Proc. Natl. Acad. Sci. U. S. A. 105 (2008) pp. 3041-3046.
-
(2008)
Natl. Acad. Sci.
, vol.105
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Cho, H.5
Mamo, S.6
Bremer, R.7
Gillette, S.8
Kong, J.9
Haass, N.K.10
Sproesser, K.11
Li, L.12
Smalley, K.S.M.13
Fong, D.14
Zhu, Y.L.15
Marimuthu, A.16
-
19
-
-
47249097988
-
BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells, Mol
-
E. Sala, L. Mologni, S. Truffa, C. Gaetano, G.E. Bollag, C. Gambacorti-Passerini, BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells, Mol. Cancer Res. 6 (2008) pp. 751-759.
-
(2008)
Cancer Res
, vol.6
, pp. 751-759
-
-
Sala, E.1
Mologni, L.2
Truffa, S.3
Gaetano, C.4
Bollag, G.E.5
Gambacorti-Passerini, C.6
-
20
-
-
77954376912
-
RG7204 (PLX4032), a Selective BRAF(V600E) Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
-
(vol 70, pg 5518, 2010)
-
H. Yang, RG7204 (PLX4032), a Selective BRAF(V600E) Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models (vol 70, pg 5518, 2010), Cancer Res. 70 (2010) p.9527.
-
(2010)
Cancer Res
, vol.70
, pp. 9527
-
-
Yang, H.1
-
21
-
-
79959795786
-
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation, N
-
P.B. Chapman, A. Hauschild, C. Robert, J.B. Haanen, P. Ascierto, J. Larkin, R. Dummer, C. Garbe, A. Testori, M. Maio, D. Hogg, P. Lorigan, C. Lebbe, T. Jouary, D. Schadendorf, A. Ribas, et al., Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation, N. Engl. J. Med. 364 (2011) pp. 2507-2516.
-
(2011)
Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
Dummer, R.7
Garbe, C.8
Testori, A.9
Maio, M.10
Hogg, D.11
Lorigan, P.12
Lebbe, C.13
Jouary, T.14
Schadendorf, D.15
Ribas, A.16
-
22
-
-
0141508024
-
Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade
-
E.A. Collisson, A. De, H. Suzuki, S.S. Gambhir, M.S. Kolodney, Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade, Cancer Res. 63 (2003) pp. 5669-5673.
-
(2003)
Cancer Res
, vol.63
, pp. 5669-5673
-
-
Collisson, E.A.1
De, A.2
Suzuki, H.3
Gambhir, S.S.4
Kolodney, M.S.5
-
23
-
-
0038439258
-
Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/ DIABLO release from mitochondria
-
X.D. Zhang, J.M. Borrow, X.Y. Zhang, T. Nguyen, P. Hersey, Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/ DIABLO release from mitochondria, Oncogene 22 (2003) pp. 2869-2881.
-
(2003)
Oncogene
, vol.22
, pp. 2869-2881
-
-
Zhang, X.D.1
Borrow, J.M.2
Zhang, X.Y.3
Nguyen, T.4
Hersey, P.5
-
24
-
-
34548097240
-
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/ pharmacodynamic relationship, and potential for combination in preclinical models
-
B.R. Davies, A. Logie, J.S. Mckay, P. Martin, S. Steele, R. Jenkins, M. Cockerill, S. Cartlidge, P.D. Smith, AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/ pharmacodynamic relationship, and potential for combination in preclinical models, Mol. Cancer Ther. 6 (2007) pp. 2209-2219.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2209-2219
-
-
Davies, B.R.1
Logie, A.2
Mckay, J.S.3
Martin, P.4
Steele, S.5
Jenkins, R.6
Cockerill, M.7
Cartlidge, S.8
Smith, P.D.9
-
25
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
D.B. Solit, L.A. Garraway, C.A. Pratilas, A. Sawai, G. Getz, A. Basso, Q. Ye, J.M. Lobo, Y.H. She, I. Osman, T.R. Golub, J. Sebolt-Leopold, W.R. Sellers, N. Rosen, BRAF mutation predicts sensitivity to MEK inhibition, Nature 439 (2006) pp. 358-362.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.H.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
26
-
-
84863673204
-
Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
-
K.T. Flaherty, C. Robert, P. Hersey, P. Nathan, C. Garbe, M. Milhem, L.V. Demidov, J.C. Hassel, P. Rutkowski, P. Mohr, R. Dummer, U. Trefzer, J.M.G. Larkin, J. Utikal, B. Dreno, M. Nyakas, et al., Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma, N. Engl. J. Med. 367 (2012) pp. 107-114.
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
Nathan, P.4
Garbe, C.5
Milhem, M.6
Demidov, L.V.7
Hassel, J.C.8
Rutkowski, P.9
Mohr, P.10
Dummer, R.11
Trefzer, U.12
Larkin, J.M.G.13
Utikal, J.14
Dreno, B.15
Nyakas, M.16
-
27
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
U118
-
R. Straussman, T. Morikawa, K. Shee, M. Barzily-Rokni, Z.R. Qian, J.Y. Du, A. Davis, M.M. Mongare, J. Gould, D.T. Frederick, Z.A. Cooper, P.B. Chapman, D.B. Solit, A. Ribas, R.S. Lo, K.T. Flaherty, S. Ogino, J.A. Wargo, T.R. Golub, Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature 487 (2012) p.500-U118.
-
(2012)
Nature
, vol.487
, pp. 500
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
Barzily-Rokni, M.4
Qian, Z.R.5
Du, J.Y.6
Davis, A.7
Mongare, M.M.8
Gould, J.9
Frederick, D.T.10
Cooper, Z.A.11
Chapman, P.B.12
Solit, D.B.13
Ribas, A.14
Lo, R.S.15
Flaherty, K.T.16
Ogino, S.17
Wargo, J.A.18
Golub, T.R.19
-
28
-
-
84864286442
-
Widespread potential for growthfactor-driven resistance to anticancer kinase inhibitors
-
T.R. Wilson, J. Fridlyand, Y.B. Yan, E. Penuel, L. Burton, E. Chan, J. Peng, E. Lin, Y.L. Wang, J. Sosman, A. Ribas, J. Li, J. Moffat, D.P. Sutherlin, H. Koeppen, M. Merchant, R. Neve, J. Settleman, Widespread potential for growthfactor-driven resistance to anticancer kinase inhibitors, Nature 487 (2012) p.505-U1652.
-
(2012)
Nature
, vol.487
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.B.3
Penuel, E.4
Burton, L.5
Chan, E.6
Peng, J.7
Lin, E.8
Wang, Y.L.9
Sosman, J.10
Ribas, A.11
Li, J.12
Moffat, J.13
Sutherlin, D.P.14
Koeppen, H.15
Merchant, M.16
Neve, R.17
Settleman, J.18
-
29
-
-
66249108601
-
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
-
M.G.V. Heiden, L.C. Cantley, C.B. Thompson, Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation, Science 324 (2009) pp. 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Heiden, M.G.V.1
Cantley, L.C.2
Thompson, C.B.3
-
30
-
-
79952280229
-
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
U278
-
P. Jiang, W.J. Du, X.W. Wang, A. Mancuso, X.A. Gao, M.A. Wu, X.L. Yang, p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase, Nat. Cell Biol. 13 (2011) p.310-U278.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 310
-
-
Jiang, P.1
Du, W.J.2
Wang, X.W.3
Mancuso, A.4
Gao, X.A.5
Wu, M.A.6
Yang, X.L.7
-
31
-
-
84858604270
-
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
-
P.S. Ward and C.B. Thompson, Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate, Cancer Cell 21 (2012) pp. 297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
33
-
-
12444279265
-
Origin of Cancer Cells
-
O. Warburg, Origin of Cancer Cells, Science 123 (1956) pp. 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
34
-
-
84860321700
-
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
-
H.Q. Ying, A.C. Kimmelman, C.A. Lyssiotis, S.J. Hua, G.C. Chu, E. Fletcher-Sananikone, J.W. Locasale, J. Son, H.L. Zhang, J.L. Coloff, H.Y. Yan, W. Wang, S.J. Chen, A. Viale, H.W. Zheng, J.H. Paik, et al., Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism, Cell 149 (2012) pp. 656-670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.Q.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.J.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.L.9
Coloff, J.L.10
Yan, H.Y.11
Wang, W.12
Chen, S.J.13
Viale, A.14
Zheng, H.W.15
Paik, J.H.16
-
35
-
-
70349331678
-
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
-
J.Y. Yun, C. Rago, I. Cheong, R. Pagliarini, P. Angenendt, H. Rajagopalan, K. Schmidt, J.K.V. Willson, S. Markowitz, S.B. Zhou, L.A. Diaz, V.E. Velculescu, C. Lengauer, K.W. Kinzler, B. Vogelstein, N. Papadopoulos, Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells, Science 325 (2009) pp. 1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.Y.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.V.8
Markowitz, S.9
Zhou, S.B.10
Diaz, L.A.11
Velculescu, V.E.12
Lengauer, C.13
Kinzler, K.W.14
Vogelstein, B.15
Papadopoulos, N.16
-
36
-
-
2342526543
-
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
-
E. Yeh, M. Cunningham, H. Arnold, D. Chasse, T. Monteith, G. Ivaldi, W.C. Hahn, P.T. Stukenberg, S. Shenolikar, T. Uchida, C.M. Counter, J.R. Nevins, A.R. Means, R. Sears, A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells, Nat. Cell Biol. 6 (2004) pp. 308-318.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 308-318
-
-
Yeh, E.1
Cunningham, M.2
Arnold, H.3
Chasse, D.4
Monteith, T.5
Ivaldi, G.6
Hahn, W.C.7
Stukenberg, P.T.8
Shenolikar, S.9
Uchida, T.10
Counter, C.M.11
Nevins, J.R.12
Means, A.R.13
Sears, R.14
-
37
-
-
34248193424
-
Mutant V600E BRAF increases hypoxia inducible factor-1 alpha expression in melanoma
-
S.M. Kumar, H. Yu, R. Edwards, L.J. Chen, S. Kazianis, P. Brafford, G. Acs, M. Herlyn, X.W. Xu, Mutant V600E BRAF increases hypoxia inducible factor-1 alpha expression in melanoma, Cancer Res. 67 (2007) pp. 3177-3184.
-
(2007)
Cancer Res
, vol.67
, pp. 3177-3184
-
-
Kumar, S.M.1
Yu, H.2
Edwards, R.3
Chen, L.J.4
Kazianis, S.5
Brafford, P.6
Acs, G.7
Herlyn, M.8
Xu, X.W.9
-
38
-
-
79955758726
-
A beta-Camera Integrated with a Microfluidic Chip for Radioassays Based on Real-Time Imaging of Glycolysis in Small Cell Populations
-
N.T. Vu, Z.T.F. Yu, B. Comin-Anduix, J.N. Sondergaard, R.W. Silverman, C.Y.N. Chang, A. Ribas, H.R. Tseng, A.F. Chatziioannou, A beta-Camera Integrated with a Microfluidic Chip for Radioassays Based on Real-Time Imaging of Glycolysis in Small Cell Populations, J Nucl Med 52 (2011) pp. 815-821.
-
(2011)
J Nucl Med
, vol.52
, pp. 815-821
-
-
Vu, N.T.1
Yu, Z.T.F.2
Comin-Anduix, B.3
Sondergaard, J.N.4
Silverman, R.W.5
Chang, C.Y.N.6
Ribas, A.7
Tseng, H.R.8
Chatziioannou, A.F.9
-
39
-
-
78650895914
-
Mitochondrial Localization and Regulation of BRAF(V600E) in Thyroid Cancer: A Clinically Used RAF Inhibitor Is Unable to Block the Mitochondrial Activities of BRAF(V600E)
-
M.H. Lee, S.E. Lee, D.W. Kim, M.J. Ryu, S.J. Kim, S.J. Kim, Y.K. Kim, J.H. Park, G.R. Kweon, J.M. Kim, J.U. Lee, V. De Falco, Y.S. Jo, M. Shong, Mitochondrial Localization and Regulation of BRAF(V600E) in Thyroid Cancer: A Clinically Used RAF Inhibitor Is Unable to Block the Mitochondrial Activities of BRAF(V600E), J. Clin. Endocrinol. Metab. 96 (2011) p.E19-E30.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Lee, M.H.1
Lee, S.E.2
Kim, D.W.3
Ryu, M.J.4
Kim, S.J.5
Kim, S.J.6
Kim, Y.K.7
Park, J.H.8
Kweon, G.R.9
Kim, J.M.10
Lee, J.U.11
De Falco, V.12
Jo, Y.S.13
Shong, M.14
-
40
-
-
79953180902
-
Assessing mitochondrial dysfunction in cells
-
M.D. Brand and D.G. Nicholls, Assessing mitochondrial dysfunction in cells, Biochem. J. 435 (2011) pp. 297-312.
-
(2011)
Biochem. J.
, vol.435
, pp. 297-312
-
-
Brand, M.D.1
Nicholls, D.G.2
-
41
-
-
82355161907
-
High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
-
D. Pesta and E. Gnaiger, High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle, Methods Mol. Biol. 810 (2012) pp. 25-58.
-
(2012)
Methods Mol. Biol.
, vol.810
, pp. 25-58
-
-
Pesta, D.1
Gnaiger, E.2
-
42
-
-
58649110598
-
Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation
-
B. Zheng, J.H. Jeong, J.M. Asara, Y.Y. Yuan, S.R. Granters, L. Chin, L.C. Cantley, Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation, Mol. Cell 33 (2009) pp. 237-247.
-
(2009)
Mol. Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granters, S.R.5
Chin, L.6
Cantley, L.C.7
-
43
-
-
0030467624
-
The p16-cyclin D Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
-
J. Bartkova, J. Lukas, P. Guldberg, J. Alsner, A.F. Kirkin, J. Zeuthen, J. Bartek, The p16-cyclin D Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis, Cancer Res. 56 (1996) pp. 5475-5483.
-
(1996)
Cancer Res
, vol.56
, pp. 5475-5483
-
-
Bartkova, J.1
Lukas, J.2
Guldberg, P.3
Alsner, J.4
Kirkin, A.F.5
Zeuthen, J.6
Bartek, J.7
-
44
-
-
0031963952
-
Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene
-
H. Tsao, E. Benoit, A.J. Sober, C. Thiele, F.G. Haluska, Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene, Cancer Res. 58 (1998) pp. 109-113.
-
(1998)
Cancer Res
, vol.58
, pp. 109-113
-
-
Tsao, H.1
Benoit, E.2
Sober, A.J.3
Thiele, C.4
Haluska, F.G.5
-
45
-
-
34447515273
-
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH
-
G. Jonsson, C. Dahl, J. Staaf, T. Sandberg, P.O. Bendahl, M. Ringner, P. Guldberg, A. Borg, Genomic profiling of malignant melanoma using tiling-resolution arrayCGH, Oncogene 26 (2007) pp. 4738-4748.
-
(2007)
Oncogene
, vol.26
, pp. 4738-4748
-
-
Jonsson, G.1
Dahl, C.2
Staaf, J.3
Sandberg, T.4
Bendahl, P.O.5
Ringner, M.6
Guldberg, P.7
Borg, A.8
-
46
-
-
34547100530
-
Positron emission tomography in oncology
-
J.D. Berry and G.J.R. Cook, Positron emission tomography in oncology, British Medical Bulletin 79-80 (2006) pp. 171-186.
-
(2006)
British Medical Bulletin
, vol.79-80
, pp. 171-186
-
-
Berry, J.D.1
Cook, G.J.R.2
-
47
-
-
82755183511
-
Comparative Metabolic Flux Profiling of Melanoma Cell Lines BEYOND THE WARBURG EFFECT
-
D.A. Scott, A.D. Richardson, F.V. Filipp, C.A. Knutzen, G.G. Chiang, Z.A. Ronai, A.L. Osterman, J.W. Smith, Comparative Metabolic Flux Profiling of Melanoma Cell Lines BEYOND THE WARBURG EFFECT, J. Biol. Chem. 286 (2011) pp. 42626-42634.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 42626-42634
-
-
Scott, D.A.1
Richardson, A.D.2
Filipp, F.V.3
Knutzen, C.A.4
Chiang, G.G.5
Ronai, Z.A.6
Osterman, A.L.7
Smith, J.W.8
-
48
-
-
84859171807
-
MYC on the Path to Cancer
-
C.V. Dang, MYC on the Path to Cancer, Cell 149 (2012) pp. 22-35.
-
(2012)
Cell
, vol.149
, pp. 22-35
-
-
Dang, C.V.1
-
50
-
-
84869080815
-
Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer
-
C.J. Ricketts, B. Shuch, C.D. Vocke, A.R. Metwalli, G. Bratslavsky, L. Middelton, Y.F. Yang, M.H. Wei, S.E. Pautler, J. Peterson, C.A. Stolle, B. Zbar, M.J. Merino, L.S. Schmidt, P.A. Pinto, R. Srinivasan, et al., Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer, Journal of Urology 188 (2012) pp. 2063-2071.
-
(2012)
Journal of Urology
, vol.188
, pp. 2063-2071
-
-
Ricketts, C.J.1
Shuch, B.2
Vocke, C.D.3
Metwalli, A.R.4
Bratslavsky, G.5
Middelton, L.6
Yang, Y.F.7
Wei, M.H.8
Pautler, S.E.9
Peterson, J.10
Stolle, C.A.11
Zbar, B.12
Merino, M.J.13
Schmidt, L.S.14
Pinto, P.A.15
Srinivasan, R.16
-
51
-
-
84863708919
-
Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia
-
A.J. Gill, Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia, Pathology 44 (2012) pp. 285-292.
-
(2012)
Pathology
, vol.44
, pp. 285-292
-
-
Gill, A.J.1
-
52
-
-
78649990315
-
Cancerassociated IDH mutations: biomarker and therapeutic opportunities
-
K.E. Yen, M.A. Bittinger, S.M. Su, V.R. Fantin, Cancerassociated IDH mutations: biomarker and therapeutic opportunities, Oncogene 29 (2010) pp. 6409-6417.
-
(2010)
Oncogene
, vol.29
, pp. 6409-6417
-
-
Yen, K.E.1
Bittinger, M.A.2
Su, S.M.3
Fantin, V.R.4
-
53
-
-
84862774556
-
Availability, not respiratory capacity governs oxygen consumption of solid tumors
-
P. Vaupel and A. Mayer, Availability, not respiratory capacity governs oxygen consumption of solid tumors, Int. J. Biochem. Cell Biol. 44 (2012) pp. 1477-1481.
-
(2012)
Int. J. Biochem. Cell Biol.
, vol.44
, pp. 1477-1481
-
-
Vaupel, P.1
Mayer, A.2
-
54
-
-
0842325793
-
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
-
R. Rossignol, R. Gilkerson, R. Aggeler, K. Yamagata, S.J. Remington, R.A. Capaldi, Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells, Cancer Res. 64 (2004) pp. 985-993.
-
(2004)
Cancer Res
, vol.64
, pp. 985-993
-
-
Rossignol, R.1
Gilkerson, R.2
Aggeler, R.3
Yamagata, K.4
Remington, S.J.5
Capaldi, R.A.6
-
55
-
-
60249085118
-
Mitochondria in cancer: Not just innocent bystanders, Seminars in Cancer
-
C. Frezza and E. Gottlieb, Mitochondria in cancer: Not just innocent bystanders, Seminars in Cancer Biology 19 (2009) pp. 4-11.
-
(2009)
Biology
, vol.19
, pp. 4-11
-
-
Frezza, C.1
Gottlieb, E.2
-
56
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
M. Wu, A. Neilson, A.L. Swift, R. Moran, J. Tamagnine, D. Parslow, S. Armistead, K. Lemire, J. Orrell, J. Teich, S. Chomicz, D.A. Ferrick, Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells, Am. J. Physiol. - Cell Physiol. 292 (2007) p.C125-C136.
-
(2007)
Am. J. Physiol. - Cell Physiol.
, vol.292
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
Parslow, D.6
Armistead, S.7
Lemire, K.8
Orrell, J.9
Teich, J.10
Chomicz, S.11
Ferrick, D.A.12
-
57
-
-
79958173253
-
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
-
K. Smolkova, L. Plecita-Hlavata, N. Bellance, G. Benard, R. Rossignol, P. Jezek, Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells, Int. J. Biochem. Cell Biol. 43 (2011) pp. 950-968.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 950-968
-
-
Smolkova, K.1
Plecita-Hlavata, L.2
Bellance, N.3
Benard, G.4
Rossignol, R.5
Jezek, P.6
-
58
-
-
84855453655
-
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
-
A. Le, A.N. Lane, M. Hamaker, S. Bose, A. Gouw, J. Barbi, T. Tsukamoto, C.J. Rojas, B.S. Slusher, H.X. Zhang, L.J. Zimmerman, D.C. Liebler, R.J.C. Slebos, P.K. Lorkiewicz, R.M. Higashi, T.W.M. Fan, C.V. Dang, Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells, Cell Metab. 15 (2012) pp. 110-121.
-
(2012)
Cell Metab
, vol.15
, pp. 110-121
-
-
Le, A.1
Lane, A.N.2
Hamaker, M.3
Bose, S.4
Gouw, A.5
Barbi, J.6
Tsukamoto, T.7
Rojas, C.J.8
Slusher, B.S.9
Zhang, H.X.10
Zimmerman, L.J.11
Liebler, D.C.12
Slebos, R.J.C.13
Lorkiewicz, P.K.14
Higashi, R.M.15
Fan, T.W.M.16
Dang, C.V.17
-
59
-
-
84869089878
-
BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma
-
Y. Shao and A.E. Aplin, BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma, Cell Death Differ. 19 (2012) pp. 2029-2039.
-
(2012)
Cell Death Differ
, vol.19
, pp. 2029-2039
-
-
Shao, Y.1
Aplin, A.E.2
-
60
-
-
0037631325
-
Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing
-
C. Munoz-Pinedo, C. Ruiz-Ruiz, C.R. De Almodovar, C. Palacios, A. Lopez-Rivas, Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing, J. Biol. Chem. 278 (2003) pp. 12759-12768.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12759-12768
-
-
Munoz-Pinedo, C.1
Ruiz-Ruiz, C.2
De Almodovar, C.R.3
Palacios, C.4
Lopez-Rivas, A.5
-
61
-
-
70449712602
-
Novel roles for GAPDH in cell death and carcinogenesis
-
A. Colell, D.R. Green, J.E. Ricci, Novel roles for GAPDH in cell death and carcinogenesis, Cell Death Differ. 16 (2009) pp. 1573-1581.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1573-1581
-
-
Colell, A.1
Green, D.R.2
Ricci, J.E.3
|