k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design

PLoS Computational Biology

Volumn 10, Issue 2, 2014, Pages

  Chowdhury, Anupam ^a   Zomorrodi, Ali R ^a   Maranas, Costas D ^a  

^a The Pennsylvania State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOMOLECULES; CHEMICAL ANALYSIS; ENZYME INHIBITION; ESCHERICHIA COLI; METABOLISM; METABOLITES; REACTION KINETICS; SENSITIVITY ANALYSIS; STOICHIOMETRY;

CONCENTRATION BOUNDS; CONSTRAINT-BASED; DESIGN PROTOCOLS; ENZYME REGULATION; FLUX BALANCE ANALYSIS; INTERVENTION STRATEGY; KINETIC DESCRIPTION; KINETIC EXPRESSION; METABOLITE CONCENTRATIONS; STOICHIOMETRIC MODELS;

KINETICS;

LACTONE DERIVATIVE; SERINE; TRIACETIC ACID LACTONE; UNCLASSIFIED DRUG; PYRONE DERIVATIVE;

AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL STRAIN; COMPUTER AIDED DESIGN; COMPUTER MODEL; COMPUTER PREDICTION; COMPUTER PROGRAM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REGULATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE; GENE EXPRESSION; GENE REARRANGEMENT; MATHEMATICAL MODEL; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLITE; MUST GENE; NONHUMAN; PHENOTYPE; PROCESS DESIGN; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STOICHIOMETRY; STRAIN IDENTIFICATION; STRAIN IMPROVEMENT; SYSTEM ANALYSIS; ALGORITHM; BIOLOGICAL MODEL; BIOLOGY; BIOSYNTHESIS; GENETICS; KINETICS; METABOLISM;

ALGORITHMS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; KINETICS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; PYRONES; SACCHAROMYCES CEREVISIAE; SERINE;

EID: 84895756673     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003487     Document Type: Article

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