Metabolic engineering from a cybernetic perspective. 1. Theoretical preliminaries

Biotechnology Progress

Volumn 15, Issue 3, 1999, Pages 407-425

  Varner, J ^a,b   Ramkrishna, D ^b  

^a ETH ZURICH   (Switzerland)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYBERNETICS; GENETIC MANIPULATION; METABOLIC ENGINEERING;

CONTROL SYSTEM ANALYSIS; CYBERNETICS; MICROORGANISMS; PERTURBATION TECHNIQUES; SENSITIVITY ANALYSIS; SYSTEM STABILITY;

CYBERNETIC METABOLIC NETWORK; ELEMENTARY PATHWAYS; GENETIC ALTERATION; GENETIC PERTUBATION; METABOLIC DESIGN COMPONENTS; METABOLIC ENGINEERING; MODEL REALIZATION FRAMEWORK; POSTULATES;

GENETIC ENGINEERING;

EID: 0033005128     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990017p     Document Type: Article

References (17)

1. Bailey, J. E. Towards a science of metabolic engineering. Science 1991, 252, 1668-1675.
2. Baloo, S.; Ramkrishna, D. Metabolic Regulation in Bacterial Continuous Cultures- I. Biotechnol. Bioeng. 1991, 20, 1337-1352.
3. Hatzimanikatis, V.; Floudas, C. A.; Bailey, J. E. Optimization of regulatory architectures in metabolic reaction engineering. Biotechnol. Bioeng. 1996a, 52, 485-500.
4. Hatzimanikatis, V.; Floudas, C. A.; Bailey, J. E. Analysis and design of metabolic networks via mixed-integer linear optimization. AIChE J. 1996b, 42, 1277-1292.
5. Hatzimanikatis, V.; Emmerling, M.; Sauer, U.; Bailey, J. E. Application of Mathematical Tools for Metabolic Design of Microbial Ethanol Production. Biotechnol. Bioeng. 1998, 57, 154-161.
6. Kacser, H.; Burns, J. A. The control of flux. In Control of Biological Processes; Davies, D. D., Ed.; Cambridge: Cambridge University Press: Cambridge, U.K., 1973; pp 65-104.
7. Kompala, D.; Jansen, N.; Tsao, G.; Ramkrishna, D. Investigation of Bacterial Growth on Mixed Substrates: Experimental Evaluation of Cybernetic Models. Biotechnol. Bioeng. 1986, 28, 1044-1055.
8. Ramakrishna, P.; Ramkrishna, D.; Konopka, A. Cybernetic Modeling of Mixed Substitutable Substrate Environments. Simultaneous and Preferential Utilization. Biotechnol. Bioneg. 1996, 52, 144-154.
9. Reder, C. Metabolic Control Theory: A Structural Approach. J. Theor. Biol. 1988, 135, 175-201.
10. Savageau, M. Biochemical Systems Analysis; Addison-Wesley: Reading, MA, 1976.
11. Shuler, M. Bioprocess Engineering: Basic Concepts; Prentice Hall: Englewood Cliffs, NJ, 1992.
12. Straight, J.; Ramkrishna, D. Cybernetic modeling and regulation of metabolic pathways. Growth on complimentary nutrients. Biotechnol. Prog. 1994, 10, 574-587.
13. Vallino, J.; Stephanopoulos, G. Network Rigidity and Metabolic Engineering in Metabolite Overproduction. Science 1991, 252, 1675-1681.
14. Varner, J. Metabolic Engineering from A Cybernetic Perspective. Ph.D. Thesis, School of Chemical Engineering, Purdue University, 1997.
15. Varner, J.; Ramkrishna, D.; Metabolic Engineering from a Cybernetic Perspective. The Aspartate Family of Amino Acids. Met. Eng. 1998, 1, 88-116.
16. Varner, J.; Ramkrishna, D.; Nonlinear Analysis of Cybernetic Models: Guidelines for Model Formulation. J. Biotechnol. 1999, in press.
17. Varner, J.; Ramkrishna, D.; Bailey, J. E. A Self-Optimizing Adaptive Model of Glucose Catabolism in Escherichia Coli. Prediction of Network Response to Amplification of Key Glycolytic Enzymes. Biotechnol. Prog. 1999, in press.