Metabolic engineering from a cybernetic perspective. 2. Qualitative investigation of nodal architechtures and their response to genetic perturbation

Biotechnology Progress

Volumn 15, Issue 3, 1999, Pages 426-438

  Varner, J ^a,b   Ramkrishna, D ^b  

^a ETH ZURICH   (Switzerland)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYBERNETICS; GENETIC MANIPULATION; MATHEMATICAL MODEL; METABOLIC ENGINEERING;

CONTROL SYSTEM ANALYSIS; CONTROL SYSTEMS; CYBERNETICS; ENZYMES; MICROORGANISMS; NETWORKS (CIRCUITS); PERTURBATION TECHNIQUES; SYSTEM STABILITY;

CYBERNETIC CONTROL VARIABLES; CYBERNETIC METABOLIC NETWORK; ENZYMATIC AMPLIFICATION; FLEXIBLE NODE; GENETIC PERTURBATION; METABOLIC ENGINEERING; NODAL CONTROL ARCHITECTURES;

GENETIC ENGINEERING;

EID: 0033011204     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990018h     Document Type: Article

References (16)

1. Bailey, J. E. Toward a science of metabolic engineering, Science 1991, 252, 1668-1675.
2. Baloo, S.; Ramkrishna, D. Metabolic regulation in bacterial continuous cultures- I. Biotechnol. Bioeng. 1991, 20, 1337-1352.
3. Hatzimanikatis, V.; Floudas, C.; Bailey, J. E. Optimization of Regulatory Architectures in Metabolic Reaction Engineering. Biotechnol. Bioeng. 1996a, 52, 485-500.
4. Hatzimanikatis, V.; Floudas, C.; Bailey, J. E. Analysis and design of metabolic reaction networks via mixed-integer linear optimization. AIChE J. 1996b, 42, 1277-1292.
5. Hatzimanikatis, V.; Emmerling, M.; Sauer, U.; Bailey J. E. Application of mathematical tools for metabolic design of microbial ethanol production. Biotechnol. Bioeng. 1998, 58, 154-161.
6. Kascer, H.; Burns, J. A. The control of flux. Symp. Soc. Exp. Biol. 1973, 27, 65-104.
7. Kompala, D.; Jansen, N.; Tsao, G.; Ramkrishna, D. Investigation of Bacterial Growth on Mixed Substrates: Experimental Evaluation of Cybernetic Models. Biotechnol. Bioeng. 1986, 28, 1044-1055.
8. Ramakrishna, R.; Ramkrishna, D.; Konopka, A. Cybernetic modeling of Mixed Substitutable Substrate Environments: Simultaneous and Sequential Utilization. Biotechnol. Bioeng. 1996, 52, 144-154.
9. Reder, C. Metabolic Control Theory: A Structural Approach. J. Theor. Biol. 1988, 135, 175-201.
10. Savageau, M. Biochemical Systems Analysis; Addison-Wesley: Reading, MA, 1976.
11. Stephanopoulos, G.; Vallino, J. Network rigidity and metabolic engineering in metabolite overproduction. Science 1991, 252, 1675-1681.
12. Straight, J.; Ramkrishna, D. Cybernetic modeling and regulation of metabolic pathways. Growth on Complementary Nutrients. Biotechnol. Prog. 1994, 10, 574-587.
13. Varner, J. Metabolic Engineering from a Cybernetic Perspective. A Conceptual Framework. Ph.D. Thesis, School of Chemical Engineering, Purdue University, 1997.
14. Varner, J.; Ramkrishna, D. Metabolic Engineering from A Cybernetic Perspective. The Aspartate Family of Amino Acids. Met. Eng. 1999a, 1, 88-116.
15. Varner, J.; Ramkrishna; D. The Nonlinear Analysis of Cybernetic Models. Guidelines for Model Formulation. J. Biotechnol. 1999b, in press.
16. Varner, J.; Ramkrishna, D.; Bailey, J. E. A Self-optimizing Adaptive Cybernetic Model of Glucose Catabolism in Escherichia coli. Prediction of Network Response to Amplification of Key Glycolytic Enzymes. Biotechnol. Prog. 1999, in Press.