Constraint-based strain design using continuous modifications (CosMos) of flux bounds finds new strategies for metabolic engineering

Biotechnology Journal

Volumn 8, Issue 5, 2013, Pages 595-604

  Cotten, Cameron ^a,b   Reed, Jennifer L ^a,b  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Constraint based modeling; Enzyme expression; Flux balance analysis; OptKnock; Strain design

Indexed keywords

CHEMICAL MODIFICATION; ESCHERICHIA COLI; METABOLISM; PRODUCT DESIGN; YEAST;

CHEMICAL PRODUCTION; CONSTRAINT-BASED MODELING; CONSTRAINTS-BASED MODELING; CONTINUOUS MODIFICATION; DOWN-REGULATION; ENZYME EXPRESSION; FLUX BALANCE ANALYSIS; OPTKNOCK; STRAIN DESIGN; UP-REGULATION;

METABOLIC ENGINEERING;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DOWN REGULATION; ESCHERICHIA COLI; GENE DELETION; METABOLIC ENGINEERING; METABOLISM; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; UPREGULATION;

EID: 84877118199     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200316     Document Type: Article

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