Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1β

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6477-6488

  Okamoto, Miyako ^a   Liu, Weimin ^a   Luo, Yuchun ^a   Tanaka, Aki ^a   Cai, Xiangna ^a   Norris, David A ^a   Dinarello, Charles A ^a   Fujita, Mayumi ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; CASPASES; CONSTITUTIVELY ACTIVES; CYTOKINES; HUMAN BLOODS; HUMAN CANCER; IMMUNE RESPONSE; IN-VITRO; INTERLEUKIN-1; INTERMEDIATE STAGE; LATE STAGE; MELANOMA CELL CULTURE; MELANOMA CELLS; MOLECULAR MECHANISM; MURAMYL DIPEPTIDE; RECEPTOR SIGNALING; SMALL INTERFERING RNA; SUPERNATANTS; TISSUE REMODELING;

ANIMAL CELL CULTURE; BIOCHEMISTRY; CELL CULTURE; CELLS; ONCOLOGY; RNA;

DERMATOLOGY;

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MURAMYL DIPEPTIDE; SMALL INTERFERING RNA; CARRIER PROTEIN; CASPASE 2; NLRP3 PROTEIN, HUMAN;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MELANOMA; MONOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; CHEMOTAXIS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SECRETION; TUMOR CELL LINE;

CARRIER PROTEINS; CASPASE 2; CELL LINE, TUMOR; CHEMOTAXIS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MACROPHAGES; MELANOMA; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, INTERLEUKIN-1;

EID: 77949889567     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064907     Document Type: Article

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