A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Molecular Systems Biology

Volumn 9, Issue 1, 2013, Pages

  Vizeacoumar, Franco J ^a,b   Arnold, Roland ^a   Vizeacoumar, Frederick S ^c   Chandrashekhar, Megha ^a   Buzina, Alla ^a   Young, Jordan T F ^a,c   Kwan, Julian H M ^a   Sayad, Azin ^a   Mero, Patricia ^a   Lawo, Steffen ^a,c   Tanaka, Hiromasa ^a   Brown, Kevin R ^a   Baryshnikova, Anastasia ^a   Mak, Anthony B ^a   Fedyshyn, Yaroslav ^a   Wang, Yadong ^d   Brito, Glauber C ^a   Kasimer, Dahlia ^a   Makhnevych, Taras ^a   Ketela, Troy ^a   Datti, Alessandro ^c   Babu, Mohan ^e   Emili, Andrew ^a   Pelletier, Laurence ^a,c   Wrana, Jeff ^a,c   Wainberg, Zev ^f   Kim, Philip M ^a,g   Rottapel, Robert ^a,d,h   O'Brien, Catherine A ^d,g   Andrews, Brenda ^a   Boone, Charles ^a   Moffat, Jason ^a   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF REGINA   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

^h ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

genetic interaction; genome stability; mitotic stress; pooled shRNA screening

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SHORT HAIRPIN RNA; PTEN PROTEIN, HUMAN; SMALL INTERFERING RNA; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL CULTURE; CANCER CELL LINE; COCULTURE; COMPARATIVE GENE MAPPING; CONTROLLED STUDY; GENE INTERACTION; GENE MAPPING; GENE TARGETING; GENETIC SCREENING; GENOTYPE; HUMAN; HUMAN CELL; HUMAN GENOME; MOUSE; NONHUMAN; OVARIAN CANCER CELL LINE; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; BREAST TUMOR; DEFICIENCY; EPISTASIS; ESSENTIAL GENE; FEMALE; GENE REGULATORY NETWORK; GENETICS; METABOLISM; MUTATION; OVARY TUMOR; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; EPISTASIS, GENETIC; FEMALE; GENE REGULATORY NETWORKS; GENES, ESSENTIAL; GENOME, HUMAN; HUMANS; MUTATION; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; PANCREATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING;

EID: 84894825949     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2013.54     Document Type: Article

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