Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Guo, Jiajie ^a   Wu, Guosheng ^a   Bao, Jiaolin ^a   Hao, Wenhui ^a   Lu, Jinjian ^a   Chen, Xiuping ^a  

^a China jack1987168 163com   (Macao)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 1; CUCURBITACIN; CUCURBITACIN B; CYCLIN DEPENDENT KINASE 1; DNA; PROTEIN CDC25C; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STRATIFIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DRUG TARGETING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LUNG NEOPLASMS; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES;

EID: 84894615299     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088140     Document Type: Article

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