-
1
-
-
0028910214
-
And their pharmacological effects
-
Miró M. Cucurbitacins and their pharmacological effects. Phytother Res 1995; 9:159-168.
-
(1995)
Phytother Res
, vol.9
, pp. 159-168
-
-
Cucurbitacins, M.M.1
-
2
-
-
21244470815
-
Cucurbitacins and cucurbitane glycosides: Structures and biological activities
-
Chen JC, Chiu MH, Nie RL, Cordell GA, Qiu SX. Cucurbitacins and cucurbitane glycosides: structures and biological activities. Nat Prod Rep 2005; 22:386-399.
-
(2005)
Nat Prod Rep
, vol.22
, pp. 386-399
-
-
Chen, J.C.1
Chiu, M.H.2
Nie, R.L.3
Cordell, G.A.4
Qiu, S.X.5
-
3
-
-
79251511306
-
General research situation of cucurbitacins
-
Yao HK, Liu L, Wang J, Yin JT, Zhong Y. General research situation of cucurbitacins. Shangdong Pharma Industry 2005; 24:737-739.
-
(2005)
Shangdong Pharma Industry
, vol.24
, pp. 737-739
-
-
Yao, H.K.1
Liu, L.2
Wang, J.3
Yin, J.T.4
Zhong, Y.5
-
4
-
-
79251477871
-
Ecological function and prospects for utilization of cucurbitacins
-
Ling B, Zhang MX, Wang YZ. Ecological function and prospects for utilization of cucurbitacins. Acta Ecol Sin 2010; 30:780-793.
-
(2010)
Acta Ecol Sin
, vol.30
, pp. 780-793
-
-
Ling, B.1
Zhang, M.X.2
Wang, Y.Z.3
-
6
-
-
0003184535
-
Further studies on the antitumor effect of cucurbitacins
-
Gallily R, Shohat B, Kalish J, Gitter S, Lavie D. Further studies on the antitumor effect of cucurbitacins. Cancer Res 1962; 22:1038-1045.
-
(1962)
Cancer Res
, vol.22
, pp. 1038-1045
-
-
Gallily, R.1
Shohat, B.2
Kalish, J.3
Gitter, S.4
Lavie, D.5
-
7
-
-
0011975154
-
Antitumor activity of cucurbitacins: Metabolic aspects
-
Shohat B, Gitter S, Lavie D. Antitumor activity of cucurbitacins: metabolic aspects. Cancer Chemother Rep 1962; 23:19-24.
-
(1962)
Cancer Chemother Rep
, vol.23
, pp. 19-24
-
-
Shohat, B.1
Gitter, S.2
Lavie, D.3
-
8
-
-
0013813823
-
The combined effect of cucurbitacins and X-ray treatment on transplanted tumors in mice
-
Shohat B, Gitter S, Levie B, Lavie D. The combined effect of cucurbitacins and X-ray treatment on transplanted tumors in mice. Cancer Res 1965; 25:1828-1835.
-
(1965)
Cancer Res
, vol.25
, pp. 1828-1835
-
-
Shohat, B.1
Gitter, S.2
Levie, B.3
Lavie, D.4
-
9
-
-
0014529805
-
Cucurbitacin B the cytotoxic principle of begonia tuberhybrida var. alba
-
Doskotch RW, Malik MY, Beal JL. Cucurbitacin B the cytotoxic principle of Begonia tuberhybrida var. alba. Lloydia 1969; 32:115-122.
-
(1969)
Lloydia
, vol.32
, pp. 115-122
-
-
Doskotch, R.W.1
Malik, M.Y.2
Beal, J.L.3
-
10
-
-
0014852723
-
Tumor inhibitors. LVI. Cucurbitacins O, P, and Q, the cytotoxic principles of brandegea bigelovii
-
Kupchan SM, Smith RM, Aynehchi Y, Maruyama M. Tumor inhibitors. LVI. Cucurbitacins O, P, and Q, the cytotoxic principles of Brandegea bigelovii. J Org Chem 1970; 35:2891-2894.
-
(1970)
J Org Chem
, vol.35
, pp. 2891-2894
-
-
Kupchan, S.M.1
Smith, R.M.2
Aynehchi, Y.3
Maruyama, M.4
-
11
-
-
0016290461
-
Cucurbitacins, cytotoxic and antitumor substances from Bryonia alba L. I: Isolation and identification
-
Konopa J, Zielinski J, Matuszkiewicz A. Cucurbitacins, cytotoxic and antitumor substances from Bryonia alba L. I: isolation and identification. Arzneimittelforschung 1974; 24:1554-1557.
-
(1974)
Arzneimittelforschung
, Issue.24
, pp. 1554-1557
-
-
Konopa, J.1
Zielinski, J.2
Matuszkiewicz, A.3
-
12
-
-
0018045105
-
Study of some african toxic euphobiacees containing cucurbitacins (author's transl)
-
Tessier AM, Paris RR. Study of some African toxic euphobiacees containing cucurbitacins (author's transl). Toxicol Eur Res 1978; 1:329-336.
-
(1978)
Toxicol Eur Res
, vol.1
, pp. 329-336
-
-
Tessier, A.M.1
Paris, R.R.2
-
13
-
-
0021353311
-
Plant anticancer agents XXX: Cucurbitacins from Ipomopsis aggregata (Polemoniaceae)
-
DOI 10.1002/jps.2600730335
-
Arisawa M, Pezzuto JM, Kinghorn AD, Cordell GA, Farnsworth NR. Plant anticancer agents. XXX: cucurbitacins from Ipomopsis aggregata (Polemoniaceae). J Pharm Sci 1984; 73:411-413. (Pubitemid 14156600)
-
(1984)
Journal of Pharmaceutical Sciences
, vol.73
, Issue.3
, pp. 411-413
-
-
Arisawa, M.1
Pezzuto, J.M.2
Kinghorn, A.D.3
-
14
-
-
77951723076
-
Cucurbitacin: Ancient compound shedding new light on cancer treatment
-
Lee DH, Iwanski GB, Thoennissen NH. Cucurbitacin: ancient compound shedding new light on cancer treatment. Scientific World Journal 2010; 10:413-418.
-
(2010)
Scientific World Journal
, vol.10
, pp. 413-418
-
-
Lee, D.H.1
Iwanski, G.B.2
Thoennissen, N.H.3
-
15
-
-
50149105711
-
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo
-
Wakimoto N, Yin D, O'Kelly J, Haritunians T, Karlan B, Said J, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Sci 2008; 99:1793-1797.
-
(2008)
Cancer Sci
, vol.99
, pp. 1793-1797
-
-
Wakimoto, N.1
Yin, D.2
O'Kelly, J.3
Haritunians, T.4
Karlan, B.5
Said, J.6
-
16
-
-
69049120250
-
Cytotoxic properties of root extract and fruit juice of trichosanthes cucumerina
-
Kongtun S, Jiratchariyakul W, Kummalue T, Tan-ariya P, Kunnachak S, Frahm AW. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta Med 2009; 75:839-842.
-
(2009)
Planta Med
, vol.75
, pp. 839-842
-
-
Kongtun, S.1
Jiratchariyakul, W.2
Kummalue, T.3
Tan-Ariya, P.4
Kunnachak, S.5
Frahm, A.W.6
-
17
-
-
0037427563
-
Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
-
DOI 10.1016/S0304-3835(02)00497-4, PII S0304383502004974
-
Jayaprakasam B, Seeram NP, Nair MG. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 2003; 189:11-16. (Pubitemid 35351514)
-
(2003)
Cancer Letters
, vol.189
, Issue.1
, pp. 11-16
-
-
Jayaprakasam, B.1
Seeram, N.P.2
Nair, M.G.3
-
18
-
-
77953021503
-
Cucurbitacin B induces apoptosis and S phase cell cycle arrest in bel-7402 human hepatocellular carcinoma cells and is effective via oral administration
-
Chan KT, Meng FY, Li Q, Ho CY, Lam TS, To Y, et al. Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration. Cancer Lett 2010; 294:118-124.
-
(2010)
Cancer Lett
, vol.294
, pp. 118-124
-
-
Chan, K.T.1
Meng, F.Y.2
Li, Q.3
Ho, C.Y.4
Lam, T.S.5
To, Y.6
-
19
-
-
58849166215
-
Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B
-
Zhang M, Zhang H, Sun C, Shan X, Yang X, Li-Ling J, Deng Y. Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. Cancer Chemother Pharmacol 2009; 63:635-642.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 635-642
-
-
Zhang, M.1
Zhang, H.2
Sun, C.3
Shan, X.4
Yang, X.5
Li-Ling, J.6
Deng, Y.7
-
20
-
-
67650995911
-
Cucurbitacin B induces apoptosis by inhibition of the jak/stat pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
-
Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, et al. Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res 2009; 69:5876-5884.
-
(2009)
Cancer Res
, vol.69
, pp. 5876-5884
-
-
Thoennissen, N.H.1
Iwanski, G.B.2
Doan, N.B.3
Okamoto, R.4
Lin, P.5
Abbassi, S.6
-
21
-
-
77955199094
-
Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling
-
Zhang M, Sun C, Shan X, Yang X, Li-Ling J, Deng Y. Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. Pancreas 2010; 39:923-929.
-
(2010)
Pancreas
, vol.39
, pp. 923-929
-
-
Zhang, M.1
Sun, C.2
Shan, X.3
Yang, X.4
Li-Ling, J.5
Deng, Y.6
-
22
-
-
77951721052
-
Cucurbitane-type triterpenes with anti-proliferative effects on u937 cells from an egyptian natural medicine, bryonia cretica: Structures of new triterpene glycosides, bryoniaosides A and B
-
Matsuda H, Nakashima S, Abdel-Halim OB, Morikawa T, Yoshikawa M. Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an Egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B. Chem Pharm Bull (Tokyo) 2010; 58:747-751.
-
(2010)
Chem Pharm Bull (Tokyo)
, vol.58
, pp. 747-751
-
-
Matsuda, H.1
Nakashima, S.2
Abdel-Halim, O.B.3
Morikawa, T.4
Yoshikawa, M.5
-
23
-
-
43049175018
-
Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells
-
Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, et al. Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk Res 2008; 32:1366-1373.
-
(2008)
Leuk Res
, vol.32
, pp. 1366-1373
-
-
Haritunians, T.1
Gueller, S.2
Zhang, L.3
Badr, R.4
Yin, D.5
Xing, H.6
-
24
-
-
77951038935
-
Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma sw480 cells
-
Yasuda S, Yogosawa S, Izutani Y, Nakamura Y, Watanabe H, Sakai T. Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. Mol Nutr Food Res 2010; 54:559-565.
-
(2010)
Mol Nutr Food Res
, vol.54
, pp. 559-565
-
-
Yasuda, S.1
Yogosawa, S.2
Izutani, Y.3
Nakamura, Y.4
Watanabe, H.5
Sakai, T.6
-
25
-
-
75949101396
-
Cucurbitacin B inhibits stat3 and the raf/mek/erk pathway in leukemia cell line k562
-
Chan KT, Li K, Liu SL, Chu KH, Toh M, Xie WD. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett 2010; 289:46-52.
-
(2010)
Cancer Lett
, vol.289
, pp. 46-52
-
-
Chan, K.T.1
Li, K.2
Liu, S.L.3
Chu, K.H.4
Toh, M.5
Xie, W.D.6
-
26
-
-
49749119221
-
Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme
-
Yin D, Wakimoto N, Xing H, Lu D, Huynh T, Wang X, et al. Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. Int J Cancer 2008; 123:1364-1375.
-
(2008)
Int J Cancer
, vol.123
, pp. 1364-1375
-
-
Yin, D.1
Wakimoto, N.2
Xing, H.3
Lu, D.4
Huynh, T.5
Wang, X.6
-
27
-
-
50649125816
-
Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma
-
Liu T, Zhang M, Zhang H, Sun C, Deng Y. Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol 2008; 265:1225-1232.
-
(2008)
Eur Arch Otorhinolaryngol
, vol.265
, pp. 1225-1232
-
-
Liu, T.1
Zhang, M.2
Zhang, H.3
Sun, C.4
Deng, Y.5
-
28
-
-
75949107266
-
Effects of cucurbitacin B on cell proliferation and apoptosis in hep-2 cells
-
Liu T, Zhang M, Deng Y, Zhang H, Sun C, Yang X, Ji W. Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008; 22:403-407.
-
(2008)
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
, vol.22
, pp. 403-407
-
-
Liu, T.1
Zhang, M.2
Deng, Y.3
Zhang, H.4
Sun, C.5
Yang, X.6
Ji, W.7
-
29
-
-
0016198022
-
Cucurbitacines, cytotoxic and antitumor substances from bryonia alba L. Part II: Biological studies
-
Konopa J, Matuszkiewicz A, Hrabowska M, Onoszka K. Cucurbitacines, cytotoxic and antitumor substances from Bryonia alba L. Part II: biological studies. Arzneimittelforschung 1974; 24:1741-1743.
-
(1974)
Arzneimittelforschung
, vol.24
, pp. 1741-1743
-
-
Konopa, J.1
Matuszkiewicz, A.2
Hrabowska, M.3
Onoszka, K.4
-
30
-
-
79958786749
-
Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human t-cell leukemia
-
Ding N, Yamashita U, Matsuoka H, Sugiura T, Tsukada J, Noguchi J, Yoshida Y. Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia. Cancer 2011; 117:2735-2746.
-
(2011)
Cancer
, vol.117
, pp. 2735-2746
-
-
Ding, N.1
Yamashita, U.2
Matsuoka, H.3
Sugiura, T.4
Tsukada, J.5
Noguchi, J.6
Yoshida, Y.7
-
31
-
-
78649450333
-
Cucurbitacin D induces fetal hemoglobin synthesis in k562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the gamma-globin mrna
-
Liu K, Xing H, Zhang S, Liu S, Fung M. Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the gamma-globin mRNA. Blood Cells Mol Dis 2010; 45:269-275.
-
(2010)
Blood Cells Mol Dis
, vol.45
, pp. 269-275
-
-
Liu, K.1
Xing, H.2
Zhang, S.3
Liu, S.4
Fung, M.5
-
32
-
-
61649114173
-
Cucurbitacin D isolated from trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro
-
Takahashi N, Yoshida Y, Sugiura T, Matsuno K, Fujino A, Yamashita U. Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro. Int Immunopharmacol 2009; 9:508-513.
-
(2009)
Int Immunopharmacol
, vol.9
, pp. 508-513
-
-
Takahashi, N.1
Yoshida, Y.2
Sugiura, T.3
Matsuno, K.4
Fujino, A.5
Yamashita, U.6
-
33
-
-
21544440157
-
Immunomodulatory activity of cucurbitacin E isolated from Ecballium elaterium
-
DOI 10.1016/j.fitote.2005.02.007, PII S0367326X05000651
-
Attard E, Brincat MP, Cuschieri A. Immunomodulatory activity of cucurbitacin E isolated from Ecballium elaterium. Fitoterapia 2005; 76:439-441. (Pubitemid 40922604)
-
(2005)
Fitoterapia
, vol.76
, Issue.5
, pp. 439-441
-
-
Attard, E.1
Brincat, M.P.2
Cuschieri, A.3
-
34
-
-
77950864226
-
Cucurbitacin e as a new inhibitor of cofilin phosphorylation in human leukemia u937 cells
-
Nakashima S, Matsuda H, Kurume A, Oda Y, Nakamura S, Yamashita M, Yoshikawa M. Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells. Bioorg Med Chem Lett 2010; 20:2994-2997.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2994-2997
-
-
Nakashima, S.1
Matsuda, H.2
Kurume, A.3
Oda, Y.4
Nakamura, S.5
Yamashita, M.6
Yoshikawa, M.7
-
35
-
-
77949356144
-
The induction of g2/m cell-cycle arrest and apoptosis by cucurbitacin e is associated with increased phosphorylation of eif2alpha in leukemia cells
-
Li Y, Wang R, Ma E, Deng Y, Wang X, Xiao J, Jing Y. The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells. Anticancer Drugs 2010; 21:389-400.
-
(2010)
Anticancer Drugs
, vol.21
, pp. 389-400
-
-
Li, Y.1
Wang, R.2
Ma, E.3
Deng, Y.4
Wang, X.5
Xiao, J.6
Jing, Y.7
-
36
-
-
78649763564
-
Cucurbitacin E, a tetracyclic triterpenes compound from chinese medicine, inhibits tumor angiogenesis through vegfr2-mediated jak2-stat3 signaling pathway
-
Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, et al. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. Carcinogenesis 2010; 31:2097-2104.
-
(2010)
Carcinogenesis
, vol.31
, pp. 2097-2104
-
-
Dong, Y.1
Lu, B.2
Zhang, X.3
Zhang, J.4
Lai, L.5
Li, D.6
-
37
-
-
0030598398
-
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
-
DOI 10.1016/S0006-2952(96)00557-6, PII S0006295296005576
-
Duncan KL, Duncan MD, Alley MC, Sausville EA. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 1996; 52:1553-1560. (Pubitemid 26375461)
-
(1996)
Biochemical Pharmacology
, vol.52
, Issue.10
, pp. 1553-1560
-
-
Duncan, K.L.K.1
Duncan, M.D.2
Alley, M.C.3
Sausville, E.A.4
-
38
-
-
77949272182
-
Inhibitory effect of cucurbitacin e on pancreatic cancer cells growth via stat3 signaling
-
Sun C, Zhang M, Shan X, Zhou X, Yang J, Wang Y, et al. Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J Cancer Res Clin Oncol 2010; 136:603-610.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 603-610
-
-
Sun, C.1
Zhang, M.2
Shan, X.3
Zhou, X.4
Yang, J.5
Wang, Y.6
-
39
-
-
78649787912
-
Inhibitory effect of cucurbitacin e on the proliferation of ovarian cancer cells and its mechanism
-
Shan XL, Zhou XY, Yang J, Wang YL, Deng YH, Zhang MX. Inhibitory effect of cucurbitacin E on the proliferation of ovarian cancer cells and its mechanism. Chin J Cancer 2010; 29:20-24.
-
(2010)
Chin J Cancer
, vol.29
, pp. 20-24
-
-
Shan, X.L.1
Zhou, X.Y.2
Yang, J.3
Wang, Y.L.4
Deng, Y.H.5
Zhang, M.X.6
-
40
-
-
84863057259
-
Induces G(2)/M phase arrest through stat3/p53/p21 signaling and provokes apoptosis via fas/cd95 and mitochondria-dependent pathways in human bladder cancer t24 cells
-
Huang WW, Yang JS, Lin MW, Chen PY, Chiou SM, Chueh FS, et al. Induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 Cells. Evid Based Complement Alternat Med 2012; 2012:952762.
-
(2012)
Evid Based Complement Alternat Med
, vol.2012
, pp. 952762
-
-
Huang, W.W.1
Yang, J.S.2
Lin, M.W.3
Chen, P.Y.4
Chiou, S.M.5
Chueh, F.S.6
-
41
-
-
84864403628
-
Inhibitory effect of cucurbitacin e on the prolifferation of hepatoma cells through induction of g2/m phase arrest
-
Yang Y, Zhang P, Luo Q, Deng Y, Ma E, Jing Y. Inhibitory effect of cucurbitacin E on the prolifferation of hepatoma cells through induction of G2/M phase arrest. J Shenyang Pharma Univ 2010; 27:388-391.
-
(2010)
J Shenyang Pharma Univ
, vol.27
, pp. 388-391
-
-
Yang, Y.1
Zhang, P.2
Luo, Q.3
Deng, Y.4
Ma, E.5
Jing, Y.6
-
42
-
-
73949160835
-
Cucurbitacin i elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells
-
Lui VW, Yau DM, Wong EY, Ng YK, Lau CP, Ho Y, et al. Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells. Carcinogenesis 2009; 30:2085-2094.
-
(2009)
Carcinogenesis
, vol.30
, pp. 2085-2094
-
-
Lui, V.W.1
Yau, D.M.2
Wong, E.Y.3
Ng, Y.K.4
Lau, C.P.5
Ho, Y.6
-
43
-
-
33748341084
-
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
-
DOI 10.1111/j.1365-2141.2006.06259.x
-
Shi X, Franko B, Frantz C, Amin HM, Lai R. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Br J Haematol 2006; 135:26-32. (Pubitemid 44337660)
-
(2006)
British Journal of Haematology
, vol.135
, Issue.1
, pp. 26-32
-
-
Shi, X.1
Franko, B.2
Frantz, C.3
Amin, H.M.4
Lai, R.5
-
44
-
-
49749129612
-
Jsi-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
-
Su Y, Li G, Zhang X, Gu J, Zhang C, Tian Z, Zhang J. JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment. Cancer Biol Ther 2008; 7:1243-1249.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1243-1249
-
-
Su, Y.1
Li, G.2
Zhang, X.3
Gu, J.4
Zhang, C.5
Tian, Z.6
Zhang, J.7
-
45
-
-
45649084397
-
Activated kras protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21
-
Escandell JM, Kaler P, Recio MC, Sasazuki T, Shirasawa S, Augenlicht L, et al. Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21. Biochem Pharmacol 2008; 76:198-207.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 198-207
-
-
Escandell, J.M.1
Kaler, P.2
Recio, M.C.3
Sasazuki, T.4
Shirasawa, S.5
Augenlicht, L.6
-
46
-
-
33845225917
-
Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells
-
DOI 10.1016/j.bcp.2006.09.012, PII S0006295206005818
-
Tannin-Spitz T, Grossman S, Dovrat S, Gottlieb HE, Bergman M. Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochem Pharmacol 2007; 73:56-67. (Pubitemid 44853933)
-
(2007)
Biochemical Pharmacology
, vol.73
, Issue.1
, pp. 56-67
-
-
Tannin-Spitz, T.1
Grossman, S.2
Dovrat, S.3
Gottlieb, H.E.4
Bergman, M.5
-
47
-
-
34548672367
-
2/M cell-cycle arrest and mitochondria-dependent apoptosis in human breast cancer cells (Bcap37)
-
DOI 10.1016/j.canlet.2007.06.018, PII S0304383507002959
-
Yang L, Wu S, Zhang Q, Liu F, Wu P. 23, 24-Dihydrocucurbitacin B induces G2/M cell-cycle arrest and mitochondria-dependent apoptosis in human breast cancer cells (Bcap37). Cancer Lett 2007; 256:267-278. (Pubitemid 47418353)
-
(2007)
Cancer Letters
, vol.256
, Issue.2
, pp. 267-278
-
-
Yang, L.1
Wu, S.2
Zhang, Q.3
Liu, F.4
Wu, P.5
-
48
-
-
57149119928
-
Cytotoxic cucurbitane-type triterpenoids from elaeocarpus hainanensis
-
Meng D, Qiang S, Lou L, Zhao W. Cytotoxic cucurbitane-type triterpenoids from Elaeocarpus hainanensis. Planta Med 2008; 74:1741-1744.
-
(2008)
Planta Med
, vol.74
, pp. 1741-1744
-
-
Meng, D.1
Qiang, S.2
Lou, L.3
Zhao, W.4
-
49
-
-
78650488834
-
Inhibition of constitutive activation of stat3 by curcurbitacin-i (JSI-124) sensitized human b-leukemia cells to apoptosis
-
Ishdorj G, Johnston JB, Gibson SB. Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis. Mol Cancer Ther 2010; 9:3302-3314.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 3302-3314
-
-
Ishdorj, G.1
Johnston, J.B.2
Gibson, S.B.3
-
50
-
-
18844370367
-
Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
-
DOI 10.1038/sj.onc.1208470
-
Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005; 24:3236-3245. (Pubitemid 40695105)
-
(2005)
Oncogene
, vol.24
, Issue.20
, pp. 3236-3245
-
-
Sun, J.1
Blaskovich, M.A.2
Jove, R.3
Livingston, S.K.4
Coppola, D.5
Sebti, S.M.6
-
51
-
-
77950391697
-
Stat3 orchestrates tumor development and progression: The achilles' heel of head and neck cancers?
-
Masuda M, Wakasaki T, Suzui M, Toh S, Joe AK, Weinstein IB. Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers? Curr Cancer Drug Targets 2010; 10:117-126.
-
(2010)
Curr Cancer Drug Targets
, vol.10
, pp. 117-126
-
-
Masuda, M.1
Wakasaki, T.2
Suzui, M.3
Toh, S.4
Joe, A.K.5
Weinstein, I.B.6
-
52
-
-
44949105638
-
Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells
-
DOI 10.1038/sj.jid.5701246, PII 5701246
-
Van Kester MS, Out-Luiting JJ, von dem Borne PA, Willemze R, Tensen CP, Vermeer MH. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sezary cells. J Invest Dermatol 2008; 128:1691-1695. (Pubitemid 351847375)
-
(2008)
Journal of Investigative Dermatology
, vol.128
, Issue.7
, pp. 1691-1695
-
-
Van Kester, M.S.1
Out-Luiting, J.J.2
Von Dem Borne, P.A.3
Willemze, R.4
Tensen, C.P.5
Vermeer, M.H.6
-
53
-
-
84862292239
-
Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis
-
Zhang T, Li Y, Park KA, Byun HS, Won M, Jeon J, et al. Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis. Autophagy 2012; 8:1-18.
-
(2012)
Autophagy
, vol.8
, pp. 1-18
-
-
Zhang, T.1
Li, Y.2
Park, K.A.3
Byun, H.S.4
Won, M.5
Jeon, J.6
-
54
-
-
27144538568
-
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the Janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
-
DOI 10.1158/0008-5472.CAN-05-0529
-
Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the Janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 2005; 65:9525-9535. (Pubitemid 41508023)
-
(2005)
Cancer Research
, vol.65
, Issue.20
, pp. 9525-9535
-
-
Nefedova, Y.1
Nagaraj, S.2
Rosenbauer, A.3
Muro-Cacho, C.4
Sebti, S.M.5
Gabrilovich, D.I.6
-
55
-
-
59149096563
-
Dysregulation of the c/ebpalpha differentiation pathway in human cancer
-
Koschmieder S, Halmos B, Levantini E, Tenen DG. Dysregulation of the C/EBPalpha differentiation pathway in human cancer. J Clin Oncol 2009; 27:619-628.
-
(2009)
J Clin Oncol
, vol.27
, pp. 619-628
-
-
Koschmieder, S.1
Halmos, B.2
Levantini, E.3
Tenen, D.G.4
-
56
-
-
67649203124
-
Il-6-induced activation of MYC is responsible for the down-regulation of cd33 expression in cd33+ myeloma cells
-
Shamsasenjan K, Otsuyama K, Abroun S, Iqbal MS, Mahmoud MS, Asaoku H, Kawano MM. IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells. Int J Hematol 2009; 89:310-318.
-
(2009)
Int J Hematol
, vol.89
, pp. 310-318
-
-
Shamsasenjan, K.1
Otsuyama, K.2
Abroun, S.3
Iqbal, M.S.4
Mahmoud, M.S.5
Asaoku, H.6
Kawano, M.M.7
-
57
-
-
79959622792
-
Cucurbitacin i inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived cd133-positive cells
-
Hsu HS, Huang PI, Chang YL, Tzao C, Chen YW, Shih HC, et al. Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells. Cancer 2011; 117:2970-2985.
-
(2011)
Cancer
, vol.117
, pp. 2970-2985
-
-
Hsu, H.S.1
Huang, P.I.2
Chang, Y.L.3
Tzao, C.4
Chen, Y.W.5
Shih, H.C.6
-
58
-
-
78649648154
-
Cucurbitacin i suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma-derived CD44(+)ALDH1(+) cells
-
Chen YW, Chen KH, Huang PI, Chen YC, Chiou GY, Lo WL, et al. Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma-derived CD44(+)ALDH1(+) cells. Mol Cancer Ther 2010; 9:2879-2892.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2879-2892
-
-
Chen, Y.W.1
Chen, K.H.2
Huang, P.I.3
Chen, Y.C.4
Chiou, G.Y.5
Lo, W.L.6
-
59
-
-
39549102220
-
STAT3: A critical transcription activator in angiogenesis
-
DOI 10.1002/med.20101
-
Chen Z, Han ZC. STAT3: a critical transcription activator in angiogenesis. Med Res Rev 2008; 28:185-200. (Pubitemid 351281185)
-
(2008)
Medicinal Research Reviews
, vol.28
, Issue.2
, pp. 185-200
-
-
Chen, Z.1
Zhong, C.H.2
-
60
-
-
0003364811
-
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: Mutant Tie-2 causing venous malformations signals a distinct STAT activation response
-
DOI 10.1038/sj.onc.1202288
-
Korpelainen EI, Karkkainen M, Gunji Y, Vikkula M, Alitalo K. Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. Oncogene 1999; 18:1-8. (Pubitemid 29060573)
-
(1999)
Oncogene
, vol.18
, Issue.1
, pp. 1-8
-
-
Korpelainen, E.I.1
Karkkainen, M.2
Gunji, Y.3
Vikkula, M.4
Alitalo, K.5
-
61
-
-
0242285719
-
STAT proteins: From normal control of cellular events to tumorigenesis
-
DOI 10.1002/jcp.10364
-
Calo V, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N, Russo A. STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol 2003; 197:157-168. (Pubitemid 37485244)
-
(2003)
Journal of Cellular Physiology
, vol.197
, Issue.2
, pp. 157-168
-
-
Calo, V.1
Migliavacca, M.2
Bazan, V.3
Macaluso, M.4
Buscemi, M.5
Gebbia, N.6
Russo, A.7
-
62
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003; 63:1270-1279. (Pubitemid 36348705)
-
(2003)
Cancer Research
, vol.63
, Issue.6
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
63
-
-
11244255857
-
Implication of stat3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3)-And vascular endothelial growth factor-mediated cellular invasion and tumor growth
-
Rivat C, Rodrigues S, Bruyneel E, Pietu G, Robert A, Redeuilh G, et al. Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3)-and vascular endothelial growth factor-mediated cellular invasion and tumor growth. Cancer Res 2005; 65:195-202.
-
(2005)
Cancer Res
, vol.65
, pp. 195-202
-
-
Rivat, C.1
Rodrigues, S.2
Bruyneel, E.3
Pietu, G.4
Robert, A.5
Redeuilh, G.6
-
64
-
-
77956020768
-
Stat3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone
-
Tang JZ, Kong XJ, Banerjee A, Muniraj N, Pandey V, Steiner M, et al. STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone. Endocrinology 2010; 151:4133-4145.
-
(2010)
Endocrinology
, vol.151
, pp. 4133-4145
-
-
Tang, J.Z.1
Kong, X.J.2
Banerjee, A.3
Muniraj, N.4
Pandey, V.5
Steiner, M.6
-
65
-
-
77956532375
-
Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines
-
Chen W, Leiter A, Yin D, Meiring M, Louw VJ, Koeffler HP. Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. Int J Oncol 2010; 37:737-743.
-
(2010)
Int J Oncol
, vol.37
, pp. 737-743
-
-
Chen, W.1
Leiter, A.2
Yin, D.3
Meiring, M.4
Louw, V.J.5
Koeffler, H.P.6
-
66
-
-
84863337986
-
Cucurbitacin B inhibits 12-o-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and pi3k/akt signal transduction pathways
-
Zhou X, Yang J, Wang Y, Li W, Li-Ling J, Deng Y, Zhang M. Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways. Hepatol Res 2011; 42:401-411.
-
(2011)
Hepatol Res
, vol.42
, pp. 401-411
-
-
Zhou, X.1
Yang, J.2
Wang, Y.3
Li, W.4
Li-Ling, J.5
Deng, Y.6
Zhang, M.7
-
67
-
-
77952869512
-
Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
-
Iwanski GB, Lee DH, En-Gal S, Doan NB, Castor B, Vogt M, et al. Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. Br J Pharmacol 2010; 160: 998-1007.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 998-1007
-
-
Iwanski, G.B.1
Lee, D.H.2
En-Gal, S.3
Doan, N.B.4
Castor, B.5
Vogt, M.6
-
68
-
-
44149087816
-
Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer
-
Liu T, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. Eur J Pharmacol 2008; 587:78-84.
-
(2008)
Eur J Pharmacol
, vol.587
, pp. 78-84
-
-
Liu, T.1
Zhang, M.2
Zhang, H.3
Sun, C.4
Yang, X.5
Deng, Y.6
Ji, W.7
-
69
-
-
77953807862
-
A small molecule inhibitor of the stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin
-
Liu T, Peng H, Zhang M, Deng Y, Wu Z. Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur J Pharmacol 2010; 641:15-22.
-
(2010)
Eur J Pharmacol
, vol.641
, pp. 15-22
-
-
Liu, T.1
Peng, H.2
Zhang, M.3
Deng, Y.4
Wu, Z.5
Cucurbitacin, B.6
-
70
-
-
79958260109
-
Histone deacetylase inhibitor valproic acid sensitizes b16f10 melanoma cells to cucurbitacin B treatment
-
Ouyang D, Zhang Y, Xu L, Li J, Zha Q, He X. Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. Acta Biochim Biophys Sin (Shanghai) 2011; 43:487-495.
-
(2011)
Acta Biochim Biophys Sin (Shanghai)
, vol.43
, pp. 487-495
-
-
Ouyang, D.1
Zhang, Y.2
Xu, L.3
Li, J.4
Zha, Q.5
He, X.6
-
71
-
-
49649097339
-
Synergistic antitumor effects of cpg oligodeoxynucleotide and stat3 inhibitory agent jsi-124 in a mouse melanoma tumor model
-
Molavi O, Ma Z, Hamdy S, Lai R, Lavasanifar A, Samuel J. Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model. Immunol Cell Biol 2008; 86:506-514.
-
(2008)
Immunol Cell Biol
, vol.86
, pp. 506-514
-
-
Molavi, O.1
Ma, Z.2
Hamdy, S.3
Lai, R.4
Lavasanifar, A.5
Samuel, J.6
-
72
-
-
0024797054
-
Inhibition of formaldehyde-induced arthritis by a purified fraction prepared from Wilbrandia (cf) verticillata which contains novel norcucurbitacin glucosides
-
Almeida FR, Rao VS, Matos ME. Inhibition of formaldehyde-induced arthritis by a purified fraction prepared from Wilbrandia (cf) verticillata which contains novel norcucurbitacin glucosides. Braz J Med Biol Res 1989; 22:1397-1399. (Pubitemid 20015721)
-
(1989)
Brazilian Journal of Medical and Biological Research
, vol.22
, Issue.11
, pp. 1397-1399
-
-
Almeida, F.R.C.1
Rao, V.S.N.2
Matos, M.E.O.3
-
73
-
-
0042594522
-
Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata
-
DOI 10.1016/S0024-3205(03)00602-7
-
Peters RR, Baier Krepsky P, Siqueira-Junior JM, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, et al. Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci 2003; 73:2185-2197. (Pubitemid 36966172)
-
(2003)
Life Sciences
, vol.73
, Issue.17
, pp. 2185-2197
-
-
Rebelo Peters, R.1
Krepsky, P.B.2
Siqueira-Junior, J.M.3
Da Silva Rocha, J.C.4
Bezerra, M.M.5
De Albuquerque Ribeiro, R.6
De Brum-Fernandes, A.J.7
Farias, M.R.8
Castro Da Rocha, F.A.9
Ribeiro-Do-Valle, R.M.10
-
74
-
-
2642543270
-
AnTi-Inflammatory Activity of Two Cucurbitacins Isolated from Cayaponia tayuya roots
-
DOI 10.1055/s-2004-818968
-
Recio MC, Prieto M, Bonucelli M, Orsi C, Manez S, Giner RM, et al. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med 2004; 70:414-420. (Pubitemid 38716473)
-
(2004)
Planta Medica
, vol.70
, Issue.5
, pp. 414-420
-
-
Recio, M.C.1
Prieto, M.2
Bonucelli, M.3
Orsi, C.4
Manez, S.5
Giner, R.M.6
Cerda-Nicolas, M.7
Rios, J.-L.8
-
75
-
-
33847619674
-
Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn
-
DOI 10.1016/j.lfs.2006.12.021, PII S0024320507000215
-
Siqueira JM Jr., Peters RR, Gazola AC, Krepsky PB, Farias MR, Rae GA, et al. Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn. Life Sci 2007; 80:1382-1387. (Pubitemid 46367064)
-
(2007)
Life Sciences
, vol.80
, Issue.15
, pp. 1382-1387
-
-
Siqueira Jr., J.M.1
Peters, R.R.2
Gazola, A.C.3
Krepsky, P.B.4
Farias, M.R.5
Rae, G.A.6
De Brum-Fernandes, A.J.7
Ribeiro-Do-Valle, R.M.8
-
76
-
-
33846420177
-
Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of tumor necrosis factor-α in T lymphocytes and macrophages
-
DOI 10.1124/jpet.106.107003
-
Escandell JM, Recio MC, Manez S, Giner RM, Cerda-Nicolas M, Rios JL. Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. J Pharmacol Exp Ther 2007; 320:581-590. (Pubitemid 46147937)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.2
, pp. 581-590
-
-
Escandell, J.M.1
Recio, M.C.2
Manez, S.3
Giner, R.M.4
Cerda-Nicolas, M.5
Rios, J.L.6
-
77
-
-
76749155406
-
Inhibition of delayed-type hypersensitivity by cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor at translocation to the nucleus
-
Escandell JM, Recio MC, Giner RM, Manez S, Cerda-Nicolas M, Merfort I, Rios JL. Inhibition of delayed-type hypersensitivity by cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus. J Pharmacol Exp Ther 2010; 332:352-363.
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 352-363
-
-
Escandell, J.M.1
Recio, M.C.2
Giner, R.M.3
Manez, S.4
Cerda-Nicolas, M.5
Merfort, I.6
Rios, J.L.7
-
78
-
-
84864399551
-
The effect of cucurbitacin B on acute and chronic experimental liver injury
-
Liver disease research of shanxi medical college
-
Liver disease research of Shanxi Medical College. The effect of cucurbitacin B on acute and chronic experimental liver injury. Med Health Commun 1979; 1:19-24.
-
(1979)
Med Health Commun
, vol.1
, pp. 19-24
-
-
-
81
-
-
84864398589
-
Effect of cucurbitacin B on the expression of VEGF and oxidative stress in the liver fibrosis tissue due to schistosoma japonicum infection
-
Xu B, Tong QX. Effect of cucurbitacin B on the expression of VEGF and oxidative stress in the liver fibrosis tissue due to Schistosoma japonicum infection. Pharmacol Clin Chinese Materia Medica 2009; 25:33-36.
-
(2009)
Pharmacol Clin Chinese Materia Medica
, vol.25
, pp. 33-36
-
-
Xu, B.1
Tong, Q.X.2
-
82
-
-
84864409960
-
The long-term therapeutic effect of cucurbitacins on chronic active viral hepatitis
-
Xiang JZ, Wang HF, Li XY, Hu SQ, Wu CQ. The long-term therapeutic effect of cucurbitacins on chronic active viral hepatitis. People's Mil Surg 1987; 4:18-20.
-
(1987)
People's Mil Surg
, vol.4
, pp. 18-20
-
-
Xiang, J.Z.1
Wang, H.F.2
Li, X.Y.3
Hu, S.Q.4
Wu, C.Q.5
-
83
-
-
0022788858
-
Recent pharmacological and clinical development of cucurbitacins in the treatment of hepatitis and primary liver cancer
-
Ren FB, Hong M. Recent pharmacological and clinical development of cucurbitacins in the treatment of hepatitis and primary liver cancer. Chinese J Integr Med 1986; 6:633-635.
-
(1986)
Chinese J Integr Med
, vol.6
, pp. 633-635
-
-
Ren, F.B.1
Hong, M.2
-
84
-
-
0027424755
-
Constituents of rosaceous plants. I. Structures of new triterpenoids from Cowania mexicana
-
Konoshima T, Takasaki M, Kozuka M, Haruna M, Ito K, Estes JR, Lee KH. Constituents of rosaceous plants. I. Structure of new triterpenoids from Cowania mexicana. Chem Pharm Bull (Tokyo) 1993; 41:1612-1615. (Pubitemid 23326792)
-
(1993)
Chemical and Pharmaceutical Bulletin
, vol.41
, Issue.9
, pp. 1612-1615
-
-
Konoshima, T.1
Takasaki, M.2
Kozuka, M.3
Haruna, M.4
Ito, K.5
Estes, J.R.6
Lee, K.-H.7
-
85
-
-
0028290218
-
Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors
-
Konoshima T, Takasaki M, Tatsumoto T, Kozuka M, Kasai R, Tanaka O, et al. Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Biol Pharm Bull 1994; 17:668-671. (Pubitemid 24186114)
-
(1994)
Biological and Pharmaceutical Bulletin
, vol.17
, Issue.5
, pp. 668-671
-
-
Konoshima, T.1
Takasaki, M.2
Tatsumoto, T.3
Kozuka, M.4
Kasai, R.5
Tanaka, O.6
Nie -, R.L.7
Tokuda, H.8
Nishino, H.9
Iwashima, A.10
-
86
-
-
39049091092
-
Octanorcucurbitane and cucurbitane triterpenoids from the tubers of hemsleya endecaphylla with hiv-1 inhibitory activity
-
Chen JC, Zhang GH, Zhang ZQ, Qiu MH, Zheng YT, Yang LM, Yu KB. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity. J Nat Prod 2008; 71:153-155.
-
(2008)
J Nat Prod
, vol.71
, pp. 153-155
-
-
Chen, J.C.1
Zhang, G.H.2
Zhang, Z.Q.3
Qiu, M.H.4
Zheng, Y.T.5
Yang, L.M.6
Yu, K.B.7
-
88
-
-
0030237827
-
Effect of cucurbitacin D on in vitro growth of Xenorhabdus and Photorhabdus spp., symbiotic bacteria of entomopathogenic nematodes
-
DOI 10.1006/jipa.1996.0071
-
Barbercheck ME, Wang J. Effect of cucurbitacin D on in vitro growth of Xenorhabdus and Photorhabdus spp., symbiotic bacteria of entomopathogenic nematodes. J Invertebr Pathol 1996; 68:141-145. (Pubitemid 126320537)
-
(1996)
Journal of Invertebrate Pathology
, vol.68
, Issue.2
, pp. 141-145
-
-
Barbercheck, M.E.1
Wang, J.2
-
89
-
-
0031127782
-
Cucurbitacin E targets proliferating endothelia
-
DOI 10.1006/jsre.1997.5028
-
Duncan MD, Duncan KL. Cucurbitacin E targets proliferating endothelia. J Surg Res 1997; 69:55-60. (Pubitemid 27265827)
-
(1997)
Journal of Surgical Research
, vol.69
, Issue.1
, pp. 55-60
-
-
Duncan, M.D.1
Duncan, K.L.K.2
-
90
-
-
37549072685
-
Direct interaction of cucurbitacin e isolated from alsomitra macrocarpa to actin filament
-
Momma K, Masuzawa Y, Nakai N, Chujo M, Murakami A, Kioka N, et al. Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament. Cytotechnology 2008; 56:33-39.
-
(2008)
Cytotechnology
, vol.56
, pp. 33-39
-
-
Momma, K.1
Masuzawa, Y.2
Nakai, N.3
Chujo, M.4
Murakami, A.5
Kioka, N.6
-
91
-
-
33646928625
-
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I
-
DOI 10.1016/j.bcp.2006.04.001, PII S0006295206002152
-
Graness A, Poli V, Goppelt-Struebe M. STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Biochem Pharmacol 2006; 72:32-41. (Pubitemid 43795344)
-
(2006)
Biochemical Pharmacology
, vol.72
, Issue.1
, pp. 32-41
-
-
Graness, A.1
Poli, V.2
Goppelt-Struebe, M.3
-
92
-
-
78649674867
-
Cucurbitacin i inhibits cell motility by indirectly interfering with actin dynamics
-
Knecht DA, LaFleur RA, Kahsai AW, Argueta CE, Beshir AB, Fenteany G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS One 2010; 5:e14039.
-
(2010)
PLoS One
, vol.5
-
-
Knecht, D.A.1
Lafleur, R.A.2
Kahsai, A.W.3
Argueta, C.E.4
Beshir, A.B.5
Fenteany, G.6
-
93
-
-
79952281492
-
Cucurbitacin iia: A novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of jak2/stat3 phosphorylation
-
Boykin C, Zhang G, Chen YH, Zhang RW, Fan XE, Yang WM, Lu Q. Cucurbitacin iia: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of jak2/stat3 phosphorylation. Br J Cancer 2011; 104:781-789.
-
(2011)
Br J Cancer
, vol.104
, pp. 781-789
-
-
Boykin, C.1
Zhang, G.2
Chen, Y.H.3
Zhang, R.W.4
Fan, X.E.5
Yang, W.M.6
Lu, Q.7
-
94
-
-
84863247558
-
Cucurbitacin IIa: A novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation
-
Boykin C, Zhang G, Chen YH, Zhang RW, Fan XE, Yang WM, Lu Q. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer 2012; 106:1248.
-
(2012)
Br J Cancer
, vol.106
, pp. 1248
-
-
Boykin, C.1
Zhang, G.2
Chen, Y.H.3
Zhang, R.W.4
Fan, X.E.5
Yang, W.M.6
Lu, Q.7
-
95
-
-
79960122371
-
Cucurbitacin B induces rapid depletion of the g-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells
-
Zhang Y, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin (Shanghai) 2011; 43:556-567.
-
(2011)
Acta Biochim Biophys Sin (Shanghai)
, vol.43
, pp. 556-567
-
-
Zhang, Y.1
Ouyang, D.2
Xu, L.3
Ji, Y.4
Zha, Q.5
Cai, J.6
He, X.7
-
96
-
-
70350500225
-
Stats in cancer inflammation and immunity: A leading role for stat3
-
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9:798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
97
-
-
0036747181
-
Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells
-
DOI 10.1055/s-2002-34418
-
Oh H, Mun YJ, Im SJ, Lee SY, Song HJ, Lee HS, Woo WH. Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta Med 2002; 68:832-833. (Pubitemid 35177631)
-
(2002)
Planta Medica
, vol.68
, Issue.9
, pp. 832-833
-
-
Oh, H.1
Mun, Y.-J.2
Im, S.-J.3
Lee, S.Y.4
Song, H.J.5
Lee, H.-S.6
Woo, W.-H.7
-
98
-
-
0030687560
-
Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor
-
Dinan L, Whiting P, Girault JP, Lafont R, Dhadialla TS, Cress DE, et al. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Biochem J 1997; 327:643-650. (Pubitemid 27487667)
-
(1997)
Biochemical Journal
, vol.327
, Issue.3
, pp. 643-650
-
-
Dinan, L.1
Whiting, P.2
Girault, J.-P.3
Lafont, R.4
Dhadialla, T.S.5
Cress, D.E.6
Mugat, B.7
Antoniewski, C.8
Lepesant, J.-A.9
-
99
-
-
0035108874
-
II cell bioassay for ecdysteroid agonist and antagonist activities
-
Dinan L, Bourne PC, Meng Y, Sarker SD, Tolentino RB, Whiting P. Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities. Cell Mol Life Sci 2001; 58:321-342. (Pubitemid 32217364)
-
(2001)
Cellular and Molecular Life Sciences
, vol.58
, Issue.2
, pp. 321-342
-
-
Dinan, L.1
Bourne, P.C.2
Meng, Y.3
Sarker, S.D.4
Tolentino, R.B.5
Whiting, P.6
-
100
-
-
4344718604
-
A monitoring trap for diabrotica virgifera virgifera and D. Barberi adults lured with A poisoned cucurbitacin bait
-
Shaw JT, Hummel HE. A monitoring trap for Diabrotica virgifera virgifera and D. barberi adults lured with a poisoned cucurbitacin bait. Commun Agric Appl Biol Sci 2003; 68:67-71.
-
(2003)
Commun Agric Appl Biol Sci
, vol.68
, pp. 67-71
-
-
Shaw, J.T.1
Hummel, H.E.2
|