Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets

Cancer Letters

Volumn 332, Issue 1, 2013, Pages 35-45

  Kausar, Hina ^a   Munagala, Radha ^a   Bansal, Shyam S ^b   Aqil, Farrukh ^a   Vadhanam, Manicka V ^a   Gupta, Ramesh C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Apoptosis; Cellular thiols; Cucurbitacin B; Lung cancer

Indexed keywords

ACETYLCYSTEINE; ACTIN; BETA ACTIN; BUTHIONINE SULFOXIMINE; CASPASE 3; CASPASE 9; CUCURBITACIN; CUCURBITACIN B; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; GELSOLIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; STAT3 PROTEIN; THIOL; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; FOURIER TRANSFORM MASS SPECTROMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN INTERACTION; TUMOR VOLUME; TUMOR XENOGRAFT; ULTRAVIOLET SPECTROSCOPY;

ACETYLCYSTEINE; ACTIN CYTOSKELETON; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; GLUTATHIONE; HSP27 HEAT-SHOCK PROTEINS; HUMANS; LUNG NEOPLASMS; MASS SPECTROMETRY; MICE; MICE, NUDE; MITOCHONDRIA; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFHYDRYL COMPOUNDS; TIME FACTORS; TRITERPENES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875258085     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.01.008     Document Type: Article

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