Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apopt

Autophagy

Volumn 8, Issue 4, 2012, Pages 559-576

  Zhang, Tiejun ^a   Li, Yuwen ^a   Park, Kyeong Ah ^a   Byun, Hee Sun ^a   Won, Minho ^a   Jeon, Juhee ^a   Lee, Yoonjung ^a   Seok, Jeong Ho ^a   Choi, Seung Won ^a   Lee, Sang Hee ^b   Kim, Jin Man ^b   Lee, Ji Hoon ^c   Son, Chang Gue ^d   Lee, Zee Won ^e   Shen, Han Ming ^f   Hur, Gang Min ^a  

^a Infection Signaling Network Research Center   (South Korea)

^b Chungnam National University   (South Korea)

^c Oxford Academy   (United States)

^d Daejeon University   (South Korea)

^e Korea Basic Science Institute (KBSI)   (South Korea)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Autophagy; Cell death; Cell signaling; Cucurbitacin; STAT3

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CASPASE 9; CUCURBITACIN; CUCURBITACIN B; CUCURBITACIN I; MITOGEN ACTIVATED PROTEIN KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRION;

EID: 84862292239     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.18867     Document Type: Article

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