-
1
-
-
0027212696
-
Cucurbitacins as constituents of Wilbrandia ebracteata
-
Farias MR, Schenkel EP, Mayer R and Rucker G. Cucurbitacins as constituents of Wilbrandia ebracteata. Planta Med 1993, 59: 272-275. (Pubitemid 23168780)
-
(1993)
Planta Medica
, vol.59
, Issue.3
, pp. 272-275
-
-
Farias, M.R.1
Schenkel, E.P.2
Mayer, R.3
Rucker, G.4
-
2
-
-
0031439364
-
Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata
-
DOI 10.1055/s-2006-957755
-
Peters RR, Farias MR and Ribeiro-do-Valle RM. Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata. Planta Med 1997, 63: 525-528. (Pubitemid 28035447)
-
(1997)
Planta Medica
, vol.63
, Issue.6
, pp. 525-528
-
-
Peters, R.R.1
Farias, M.R.2
Ribeiro-do-Valle, R.Ma.3
-
3
-
-
0037427563
-
Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
-
DOI 10.1016/S0304-3835(02)00497-4, PII S0304383502004974
-
Jayaprakasam B, Seeram NP and Nair MG. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 2003, 189: 11-16. (Pubitemid 35351514)
-
(2003)
Cancer Letters
, vol.189
, Issue.1
, pp. 11-16
-
-
Jayaprakasam, B.1
Seeram, N.P.2
Nair, M.G.3
-
4
-
-
0042594522
-
Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata
-
DOI 10.1016/S0024-3205(03)00602-7
-
Peters RR, Baier Krepsky P, Siqueira-Junior JM, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R and de Brum-Fernandes AJ, et al. Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci 2003, 73: 2185-2197. (Pubitemid 36966172)
-
(2003)
Life Sciences
, vol.73
, Issue.17
, pp. 2185-2197
-
-
Rebelo Peters, R.1
Krepsky, P.B.2
Siqueira-Junior, J.M.3
Da Silva Rocha, J.C.4
Bezerra, M.M.5
De Albuquerque Ribeiro, R.6
De Brum-Fernandes, A.J.7
Farias, M.R.8
Castro Da Rocha, F.A.9
Ribeiro-Do-Valle, R.M.10
-
5
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R and Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003, 63: 1270-1279. (Pubitemid 36348705)
-
(2003)
Cancer Research
, vol.63
, Issue.6
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
6
-
-
50149105711
-
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo
-
Wakimoto N, Yin D, O'Kelly J, Haritunians T, Karlan B, Said J and Xing H, et al. Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. Cancer Sci 2008, 99: 1793-1797.
-
(2008)
Cancer Sci
, vol.99
, pp. 1793-1797
-
-
Wakimoto, N.1
Yin, D.2
O'Kelly, J.3
Haritunians, T.4
Karlan, B.5
Said, J.6
Xing, H.7
-
7
-
-
49749119221
-
Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme
-
Yin D, Wakimoto N, Xing H, Lu D, Huynh T, Wang X and Black KL, et al. Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. Int J Cancer 2008, 123: 1364-1375.
-
(2008)
Int J Cancer
, vol.123
, pp. 1364-1375
-
-
Yin, D.1
Wakimoto, N.2
Xing, H.3
Lu, D.4
Huynh, T.5
Wang, X.6
Black, K.L.7
-
8
-
-
43049175018
-
Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells
-
Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H and Fung MC, et al. Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk Res 2008, 32: 1366-1373.
-
(2008)
Leuk Res
, vol.32
, pp. 1366-1373
-
-
Haritunians, T.1
Gueller, S.2
Zhang, L.3
Badr, R.4
Yin, D.5
Xing, H.6
Fung, M.C.7
-
9
-
-
67650995911
-
Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
-
Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S and Song JH, et al. Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res 2009, 69: 5876-5884.
-
(2009)
Cancer Res
, vol.69
, pp. 5876-5884
-
-
Thoennissen, N.H.1
Iwanski, G.B.2
Doan, N.B.3
Okamoto, R.4
Lin, P.5
Abbassi, S.6
Song, J.H.7
-
10
-
-
50649125816
-
Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma
-
Liu T, Zhang M, Zhang H, Sun C and Deng Y. Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol 2008, 265: 1225-1232.
-
(2008)
Eur Arch Otorhinolaryngol
, vol.265
, pp. 1225-1232
-
-
Liu, T.1
Zhang, M.2
Zhang, H.3
Sun, C.4
Deng, Y.5
-
11
-
-
0036747181
-
Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells
-
DOI 10.1055/s-2002-34418
-
Oh H, Mun YJ, Im SJ, Lee SY, Song HJ, Lee HS and Woo WH. Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta Med 2002, 68: 832-833. (Pubitemid 35177631)
-
(2002)
Planta Medica
, vol.68
, Issue.9
, pp. 832-833
-
-
Oh, H.1
Mun, Y.-J.2
Im, S.-J.3
Lee, S.Y.4
Song, H.J.5
Lee, H.-S.6
Woo, W.-H.7
-
12
-
-
58849166215
-
Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B
-
Zhang M, Zhang H, Sun C, Shan X, Yang X, Li-Ling J and Deng Y. Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. Cancer Chemother Pharmacol 2009, 63: 635-642.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 635-642
-
-
Zhang, M.1
Zhang, H.2
Sun, C.3
Shan, X.4
Yang, X.5
Li-Ling, J.6
Deng, Y.7
-
13
-
-
75949101396
-
Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
-
Chan KT, Li K, Liu SL, Chu KH, Toh M and Xie WD. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett 2010, 289: 46-52.
-
(2010)
Cancer Lett
, vol.289
, pp. 46-52
-
-
Chan, K.T.1
Li, K.2
Liu, S.L.3
Chu, K.H.4
Toh, M.5
Xie, W.D.6
-
14
-
-
77955199094
-
Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling
-
Zhang M, Sun C, Shan X, Yang X, Li-Ling J and Deng Y. Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. Pancreas 2010, 39: 923-929.
-
(2010)
Pancreas
, vol.39
, pp. 923-929
-
-
Zhang, M.1
Sun, C.2
Shan, X.3
Yang, X.4
Li-Ling, J.5
Deng, Y.6
-
16
-
-
77950864226
-
Cucurbitacin E as a new inhibitor of cofilin phos-phorylation in human leukemia U937 cells
-
Nakashima S, Matsuda H, Kurume A, Oda Y, Nakamura S, Yamashita M and Yoshikawa M. Cucurbitacin E as a new inhibitor of cofilin phos-phorylation in human leukemia U937 cells. Bioorg Med Chem Lett 2010, 20: 2994-2997.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2994-2997
-
-
Nakashima, S.1
Matsuda, H.2
Kurume, A.3
Oda, Y.4
Nakamura, S.5
Yamashita, M.6
Yoshikawa, M.7
-
17
-
-
33646928625
-
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I
-
DOI 10.1016/j.bcp.2006.04.001, PII S0006295206002152
-
Graness A, Poli V and Goppelt-Struebe M. STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Biochem Pharmacol 2006, 72: 32-41. (Pubitemid 43795344)
-
(2006)
Biochemical Pharmacology
, vol.72
, Issue.1
, pp. 32-41
-
-
Graness, A.1
Poli, V.2
Goppelt-Struebe, M.3
-
18
-
-
44149087816
-
Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer
-
Liu T, Zhang M, Zhang H, Sun C, Yang X, Deng Y and Ji W. Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. Eur J Pharmacol 2008, 587: 78-84.
-
(2008)
Eur J Pharmacol
, vol.587
, pp. 78-84
-
-
Liu, T.1
Zhang, M.2
Zhang, H.3
Sun, C.4
Yang, X.5
Deng, Y.6
Ji, W.7
-
19
-
-
78649674867
-
Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics
-
Knecht DA, LaFleur RA, Kahsai AW, Argueta CE, Beshir AB and Fenteany G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS One 2010, 5: e14039.
-
(2010)
PLoS One
, vol.5
-
-
Knecht, D.A.1
LaFleur, R.A.2
Kahsai, A.W.3
Argueta, C.E.4
Beshir, A.B.5
Fenteany, G.6
-
20
-
-
34248637597
-
Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax
-
Mansour M, Pohajdak B, Kast WM, Fuentes-Ortega A, Korets-Smith E, Weir GM and Brown RG, et al. Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax. J Transl Med 2007, 5: 20.
-
(2007)
J Transl Med
, vol.5
, pp. 20
-
-
Mansour, M.1
Pohajdak, B.2
Kast, W.M.3
Fuentes-Ortega, A.4
Korets-Smith, E.5
Weir, G.M.6
Brown, R.G.7
-
21
-
-
66749180699
-
Antitumor activity of endogenous mFlt4 displayed on a T4 phage nanoparticle surface
-
Ren SX, Ren ZJ, Zhao MY, Wang XB, Zuo SG and Yu F. Antitumor activity of endogenous mFlt4 displayed on a T4 phage nanoparticle surface. Acta Pharmacol Sin 2009, 30: 637-645.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 637-645
-
-
Ren, S.X.1
Ren, Z.J.2
Zhao, M.Y.3
Wang, X.B.4
Zuo, S.G.5
Yu, F.6
-
22
-
-
0026584237
-
Evidence for a gelsolin-rich, labile F-actin pool in human polymorphonuclear leukocytes
-
Watts RG and Howard TH. Evidence for a gelsolin-rich, labile F-actin pool in human polymorphonuclear leukocytes. Cell Motil Cytoskeleton 1992, 21: 25-37.
-
(1992)
Cell Motil Cytoskeleton
, vol.21
, pp. 25-37
-
-
Watts, R.G.1
Howard, T.H.2
-
23
-
-
77649090592
-
Quantitative proteomics analysis of chondrogenic differentiation of C3H10T1/2 mesenchymal stem cells by iTRAQ labeling coupled with on-line two-dimensional LC/MS/MS
-
Ji YH, Ji JL, Sun FY, Zeng YY, He XH, Zhao JX and Yu Y, et al. Quantitative proteomics analysis of chondrogenic differentiation of C3H10T1/2 mesenchymal stem cells by iTRAQ labeling coupled with on-line two-dimensional LC/MS/MS. Mol Cell Proteomics 2010, 9: 550-564.
-
(2010)
Mol Cell Proteomics
, vol.9
, pp. 550-564
-
-
Ji, Y.H.1
Ji, J.L.2
Sun, F.Y.3
Zeng, Y.Y.4
He, X.H.5
Zhao, J.X.6
Yu, Y.7
-
24
-
-
18844370367
-
Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
-
DOI 10.1038/sj.onc.1208470
-
Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D and Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 2005, 24: 3236-3245. (Pubitemid 40695105)
-
(2005)
Oncogene
, vol.24
, Issue.20
, pp. 3236-3245
-
-
Sun, J.1
Blaskovich, M.A.2
Jove, R.3
Livingston, S.K.4
Coppola, D.5
Sebti, S.M.6
-
25
-
-
33748341084
-
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
-
DOI 10.1111/j.1365-2141.2006.06259.x
-
Shi X, Franko B, Frantz C, Amin HM and Lai R. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signaling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Br J Haematol 2006, 135: 26-32. (Pubitemid 44337660)
-
(2006)
British Journal of Haematology
, vol.135
, Issue.1
, pp. 26-32
-
-
Shi, X.1
Franko, B.2
Frantz, C.3
Amin, H.M.4
Lai, R.5
-
26
-
-
0030598398
-
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
-
DOI 10.1016/S0006-2952(96)00557-6, PII S0006295296005576
-
Duncan KL, Duncan MD, Alley MC and Sausville EA. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 1996, 52: 1553-1560. (Pubitemid 26375461)
-
(1996)
Biochemical Pharmacology
, vol.52
, Issue.10
, pp. 1553-1560
-
-
Duncan, K.L.K.1
Duncan, M.D.2
Alley, M.C.3
Sausville, E.A.4
-
27
-
-
0031127782
-
Cucurbitacin E targets proliferating endothelia
-
DOI 10.1006/jsre.1997.5028
-
Duncan MD and Duncan KL. Cucurbitacin E targets proliferating endothelia. J Surg Res 1997, 69: 55-60. (Pubitemid 27265827)
-
(1997)
Journal of Surgical Research
, vol.69
, Issue.1
, pp. 55-60
-
-
Duncan, M.D.1
Duncan, K.L.K.2
-
28
-
-
58149166871
-
Actin-aggregating cucurbitacins from Physocarpus capitatus
-
Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ and Clardy J. Actin-aggregating cucurbitacins from Physocarpus capitatus. J Nat Prod 2008, 71: 1927-1929.
-
(2008)
J Nat Prod
, vol.71
, pp. 1927-1929
-
-
Maloney, K.N.1
Fujita, M.2
Eggert, U.S.3
Schroeder, F.C.4
Field, C.M.5
Mitchison, T.J.6
Clardy, J.7
-
29
-
-
37549072685
-
Direct interaction of cucurbitacin E isolated from Alsomitra macrocarpa to actin filament
-
Momma K, Masuzawa Y, Nakai N, Chujo M, Murakami A, Kioka N and Kiyama Y, et al. Direct interaction of cucurbitacin E isolated from Alsomitra macrocarpa to actin filament. Cytotechnology 2008, 56: 33-39.
-
(2008)
Cytotechnology
, vol.56
, pp. 33-39
-
-
Momma, K.1
Masuzawa, Y.2
Nakai, N.3
Chujo, M.4
Murakami, A.5
Kioka, N.6
Kiyama, Y.7
-
30
-
-
70849098888
-
Actin, a central player in cell shape and movement
-
Pollard TD and Cooper JA. Actin, a central player in cell shape and movement. Science 2009, 326: 1208-1212.
-
(2009)
Science
, vol.326
, pp. 1208-1212
-
-
Pollard, T.D.1
Cooper, J.A.2
-
31
-
-
0028901095
-
The state of actin assembly regulates actin and vinculin expression by a feedback loop
-
Bershadsky AD, Gluck U, Denisenko ON, Sklyarova TV, Spector I and Ben-Ze'ev A. The state of actin assembly regulates actin and vinculin expression by a feedback loop. J Cell Sci 1995, 108: 1183-1193.
-
(1995)
J Cell Sci
, vol.108
, pp. 1183-1193
-
-
Bershadsky, A.D.1
Gluck, U.2
Denisenko, O.N.3
Sklyarova, T.V.4
Spector, I.5
Ben-Ze'ev, A.6
-
32
-
-
70249116807
-
Actin dynamics at the leading edge: From simple machinery to complex networks
-
Insall RH and Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell 2009, 17: 310-322.
-
(2009)
Dev Cell
, vol.17
, pp. 310-322
-
-
Insall, R.H.1
Machesky, L.M.2
-
33
-
-
0036900955
-
ADF/cofilin and actin dynamics in disease
-
DOI 10.1016/S0962-8924(02)02404-2, PII S0962892402024042
-
Bamburg JR and Wiggan OP. ADF/cofilin and actin dynamics in disease. Trends Cell Biol 2002, 12: 598-605. (Pubitemid 35461859)
-
(2002)
Trends in Cell Biology
, vol.12
, Issue.12
, pp. 598-605
-
-
Bamburg, J.R.1
Wiggan, O.P.2
-
34
-
-
46649105682
-
Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide
-
DOI 10.1242/jcs.017665
-
Lazaro-Dieguez F, Aguado C, Mato E, Sanchez-Ruiz Y, Esteban I, Alberch J and Knecht E, et al. Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide. J Cell Sci 2008, 121: 1415-1425. (Pubitemid 351936306)
-
(2008)
Journal of Cell Science
, vol.121
, Issue.9
, pp. 1415-1425
-
-
Lazaro-Dieguez, F.1
Aguado, C.2
Mato, E.3
Sanchez-Ruiz, Y.4
Esteban, I.5
Alberch, J.6
Knecht, E.7
Egea, G.8
-
35
-
-
0035884882
-
Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes
-
DOI 10.1016/S0891-5849(01)00650-5, PII S0891584901006505
-
Meyskens FL, Jr, McNulty SE, Buckmeier JA, Tohidian NB, Spillane TJ, Kahlon RS and Gonzalez RI. Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes. Free Radic Biol Med 2001, 31: 799-808. (Pubitemid 32835261)
-
(2001)
Free Radical Biology and Medicine
, vol.31
, Issue.6
, pp. 799-808
-
-
Meyskens Jr, F.L.1
McNulty, S.E.2
Buckmeier, J.A.3
Tohidian, N.B.4
Spillane, T.J.5
Kahlon, R.S.6
Gonzalez, R.I.7
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