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Volumn 28, Issue 1, 2014, Pages 395-407

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1

Author keywords

Angiogenesis; Endothelial cells; Mitophagy

Indexed keywords

EXPORTIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MATRIGEL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; PROTEIN KINASE B3; REGULATOR PROTEIN; UNCLASSIFIED DRUG; AKT3 PROTEIN, MOUSE; CELL RECEPTOR; EXPORTIN 1 PROTEIN; KARYOPHERIN;

EID: 84894599226     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-235382     Document Type: Article
Times cited : (38)

References (58)
  • 1
    • 61949107700 scopus 로고    scopus 로고
    • Guidance of vascular development: Lessons from the nervous system
    • Larrivee, B., Freitas, C., Suchting, S., Brunet, I., and Eichmann, A. (2009) Guidance of vascular development: lessons from the nervous system. Circ. Res. 104, 428-441
    • (2009) Circ. Res. , vol.104 , pp. 428-441
    • Larrivee, B.1    Freitas, C.2    Suchting, S.3    Brunet, I.4    Eichmann, A.5
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P., and Jain, R. K. (2000) Angiogenesis in cancer and other diseases. Nature 407, 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1alpha: A key regulator of energy metabolism
    • Liang, H., and Ward, W. F. (2006) PGC-1alpha: a key regulator of energy metabolism. Adv. Physiol. Educ. 30, 145-151
    • (2006) Adv. Physiol. Educ. , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 7
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., and Kelly, D. P. (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106, 847-856
    • (2000) J. Clin. Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 10
    • 34247172582 scopus 로고    scopus 로고
    • Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival
    • Tal, R., Winter, G., Ecker, N., Klionsky, D. J., and Abeliovich, H. (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J. Biol. Chem. 282, 5617-5624
    • (2007) J. Biol. Chem. , vol.282 , pp. 5617-5624
    • Tal, R.1    Winter, G.2    Ecker, N.3    Klionsky, D.J.4    Abeliovich, H.5
  • 11
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers, I., Vincent, E. E., and Tavare, J. M. (2011) Akt signalling in health and disease. Cell. Signal. 23, 1515-1527
    • (2011) Cell. Signal. , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 12
    • 84858079914 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR pathway in angiogenesis
    • Karar, J., and Maity, A. (2011) PI3K/AKT/mTOR pathway in angiogenesis. Front. Mol. Neurosci. 4, 51
    • (2011) Front. Mol. Neurosci. , vol.4 , pp. 51
    • Karar, J.1    Maity, A.2
  • 13
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • Chen, J., Somanath, P. R., Razorenova, O., Chen, W. S., Hay, N., Bornstein, P., and Byzova, T. V. (2005) Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat. Med. 11, 1188-1196
    • (2005) Nat. Med. , vol.11 , pp. 1188-1196
    • Chen, J.1    Somanath, P.R.2    Razorenova, O.3    Chen, W.S.4    Hay, N.5    Bornstein, P.6    Byzova, T.V.7
  • 18
    • 69249208791 scopus 로고    scopus 로고
    • The Akt kinases: Isoform specificity in metabolism and cancer
    • Gonzalez, E., and McGraw, T. E. (2009) The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 8, 2502-2508
    • (2009) Cell Cycle , vol.8 , pp. 2502-2508
    • Gonzalez, E.1    McGraw, T.E.2
  • 19
    • 39049172652 scopus 로고    scopus 로고
    • Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
    • Cozzone, D., Frojdo, S., Disse, E., Debard, C., Laville, M., Pirola, L., and Vidal, H. (2008) Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Diabetologia 51, 512-521
    • (2008) Diabetologia , vol.51 , pp. 512-521
    • Cozzone, D.1    Frojdo, S.2    Disse, E.3    Debard, C.4    Laville, M.5    Pirola, L.6    Vidal, H.7
  • 21
    • 34247116441 scopus 로고    scopus 로고
    • Physiological roles of PKB/Akt isoforms in development and disease
    • Dummler, B., and Hemmings, B. A. (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem. Soc. Trans. 35, 231-235
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 231-235
    • Dummler, B.1    Hemmings, B.A.2
  • 22
    • 79958831578 scopus 로고    scopus 로고
    • Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model
    • Endersby, R., Zhu, X., Hay, N., Ellison, D. W., and Baker, S. J. (2011) Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res. 71, 4106-4116
    • (2011) Cancer Res. , vol.71 , pp. 4106-4116
    • Endersby, R.1    Zhu, X.2    Hay, N.3    Ellison, D.W.4    Baker, S.J.5
  • 23
    • 80053239972 scopus 로고    scopus 로고
    • Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells
    • Grabinski, N., Bartkowiak, K., Grupp, K., Brandt, B., Pantel, K., and Jucker, M. (2011) Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells. Cell. Signal. 23, 1952-1960
    • (2011) Cell. Signal. , vol.23 , pp. 1952-1960
    • Grabinski, N.1    Bartkowiak, K.2    Grupp, K.3    Brandt, B.4    Pantel, K.5    Jucker, M.6
  • 24
    • 34548266099 scopus 로고    scopus 로고
    • AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
    • Koseoglu, S., Lu, Z., Kumar, C., Kirschmeier, P., and Zou, J. (2007) AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biol. Ther. 6, 755-762
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 755-762
    • Koseoglu, S.1    Lu, Z.2    Kumar, C.3    Kirschmeier, P.4    Zou, J.5
  • 30
    • 33645211015 scopus 로고    scopus 로고
    • Modulation of total Akt kinase by increased expression of a single isoform: Requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGFdependent expression of Akt3 in primary endothelial cells
    • Fieber, C. B., Eldridge, J., Taha, T. A., Obeid, L. M., and Muise-Helmericks, R. C. (2006) Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGFdependent expression of Akt3 in primary endothelial cells. Exp. Cell. Res. 312, 1164-1173
    • (2006) Exp. Cell. Res. , vol.312 , pp. 1164-1173
    • Fieber, C.B.1    Eldridge, J.2    Taha, T.A.3    Obeid, L.M.4    Muise-Helmericks, R.C.5
  • 31
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • Ferrara, N., and Alitalo, K. (1999) Clinical applications of angiogenic growth factors and their inhibitors. Nat. Med. 5, 1359-1364
    • (1999) Nat. Med. , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 32
    • 0033134604 scopus 로고    scopus 로고
    • Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization
    • Isner, J. M., and Asahara, T. (1999) Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Invest. 103, 1231-1236
    • (1999) J. Clin. Invest. , vol.103 , pp. 1231-1236
    • Isner, J.M.1    Asahara, T.2
  • 34
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegelman, B. M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 35
    • 23144449790 scopus 로고    scopus 로고
    • Temporal and spatial control of nucleophosmin by the Ran- Crm1 complex in centrosome duplication
    • Wang, W., Budhu, A., Forgues, M., and Wang, X. W. (2005) Temporal and spatial control of nucleophosmin by the Ran- Crm1 complex in centrosome duplication. Nat. Cell Biol. 7, 823-830
    • (2005) Nat. Cell Biol. , vol.7 , pp. 823-830
    • Wang, W.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 36
    • 84901041125 scopus 로고
    • An easily controlled method for staining mitochondria
    • Cain, A. J. (1948) An easily controlled method for staining mitochondria. Q. J. Microsc. Sci. 89, 229-231
    • (1948) Q. J. Microsc. Sci. , vol.89 , pp. 229-231
    • Cain, A.J.1
  • 37
    • 84870056476 scopus 로고    scopus 로고
    • VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation
    • Gentile, C., Muise-Helmericks, R. C., and Drake, C. J. (2013) VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Dev. Biol. 373, 163-175
    • (2013) Dev. Biol. , vol.373 , pp. 163-175
    • Gentile, C.1    Muise-Helmericks, R.C.2    Drake, C.J.3
  • 38
    • 84875582776 scopus 로고    scopus 로고
    • PKB/Akt-dependent regulation of cell motility
    • Xue, G., and Hemmings, B. A. (2013) PKB/Akt-dependent regulation of cell motility. J. Natl. Cancer Inst. 105, 393-404
    • (2013) J. Natl. Cancer Inst. , vol.105 , pp. 393-404
    • Xue, G.1    Hemmings, B.A.2
  • 40
    • 33947726050 scopus 로고    scopus 로고
    • CRM1-mediated nuclear export: To the pore and beyond
    • Hutten, S., and Kehlenbach, R. H. (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol. 17, 193-201
    • (2007) Trends Cell Biol. , vol.17 , pp. 193-201
    • Hutten, S.1    Kehlenbach, R.H.2
  • 41
    • 33744534726 scopus 로고    scopus 로고
    • GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
    • Lerin, C., Rodgers, J. T., Kalume, D. E., Kim, S. H., Pandey, A., and Puigserver, P. (2006) GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell. Metab. 3, 429-438
    • (2006) Cell. Metab. , vol.3 , pp. 429-438
    • Lerin, C.1    Rodgers, J.T.2    Kalume, D.E.3    Kim, S.H.4    Pandey, A.5    Puigserver, P.6
  • 42
    • 79958041601 scopus 로고    scopus 로고
    • The SirT3 divining rod points to oxidative stress
    • Bell, E. L., and Guarente, L. (2011) The SirT3 divining rod points to oxidative stress. Mol. Cell 42, 561-568
    • (2011) Mol. Cell , vol.42 , pp. 561-568
    • Bell, E.L.1    Guarente, L.2
  • 43
    • 0031053791 scopus 로고    scopus 로고
    • The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
    • Fornerod, M., van Deursen, J., van Baal, S., Reynolds, A., Davis, D., Murti, K. G., Fransen, J., and Grosveld, G. (1997) The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 16, 807-816
    • (1997) EMBO J. , vol.16 , pp. 807-816
    • Fornerod, M.1    Van Deursen, J.2    Van Baal, S.3    Reynolds, A.4    Davis, D.5    Murti, K.G.6    Fransen, J.7    Grosveld, G.8
  • 44
    • 77952931582 scopus 로고    scopus 로고
    • Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1
    • Chang, J. S., Huypens, P., Zhang, Y., Black, C., Kralli, A., and Gettys, T. W. (2010) Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J. Biol. Chem. 285, 18039-18050
    • (2010) J. Biol. Chem. , vol.285 , pp. 18039-18050
    • Chang, J.S.1    Huypens, P.2    Zhang, Y.3    Black, C.4    Kralli, A.5    Gettys, T.W.6
  • 45
    • 77952766891 scopus 로고    scopus 로고
    • Autophagy: Assays and artifacts
    • Barth, S., Glick, D., and Macleod, K. F. (2010) Autophagy: assays and artifacts. J. Pathol. 221, 117-124
    • (2010) J. Pathol. , vol.221 , pp. 117-124
    • Barth, S.1    Glick, D.2    Macleod, K.F.3
  • 47
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • Scarpulla, R. C. (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim. Biophys. Acta 1813, 1269-1278
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 49
    • 14744301997 scopus 로고    scopus 로고
    • Leucine-rich nuclear-export signals: Born to be weak
    • Kutay, U., and Guttinger, S. (2005) Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol. 15, 121-124
    • (2005) Trends Cell Biol. , vol.15 , pp. 121-124
    • Kutay, U.1    Guttinger, S.2
  • 50
    • 80052230265 scopus 로고    scopus 로고
    • Ran-dependent nuclear export mediators: A structural perspective
    • Guttler, T., and Gorlich, D. (2011) Ran-dependent nuclear export mediators: a structural perspective. EMBO J. 30, 3457-3474
    • (2011) EMBO J. , vol.30 , pp. 3457-3474
    • Guttler, T.1    Gorlich, D.2
  • 51
    • 0242266953 scopus 로고    scopus 로고
    • RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development
    • Adini, I., Rabinovitz, I., Sun, J. F., Prendergast, G. C., and Benjamin, L. E. (2003) RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 17, 2721-2732
    • (2003) Genes Dev. , vol.17 , pp. 2721-2732
    • Adini, I.1    Rabinovitz, I.2    Sun, J.F.3    Prendergast, G.C.4    Benjamin, L.E.5
  • 54
    • 84861161546 scopus 로고    scopus 로고
    • SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis
    • Haigis, M. C., Deng, C. X., Finley, L. W., Kim, H. S., and Gius, D. (2012) SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res. 72, 2468-2472
    • (2012) Cancer Res. , vol.72 , pp. 2468-2472
    • Haigis, M.C.1    Deng, C.X.2    Finley, L.W.3    Kim, H.S.4    Gius, D.5
  • 57
    • 79251544549 scopus 로고    scopus 로고
    • Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy
    • Marchesi, V. T. (2011) Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy. FASEB J. 25, 5-13
    • (2011) FASEB J. , vol.25 , pp. 5-13
    • Marchesi, V.T.1


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