Leucine-rich nuclear-export signals: Born to be weak

Trends in Cell Biology

Volumn 15, Issue 3, 2005, Pages 121-124

  Kutay, Ulrike ^a   Güttinger, Stephan ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1; GREEN FLUORESCENT PROTEIN; ISOLEUCINE; KARYOPHERIN ALPHA; LEUCINE; PEPTIDE LIBRARY; REV PROTEIN; TRANSCRIPTION FACTOR ELF 1;

BINDING AFFINITY; BINDING SITE; CYTOPLASM; NUCLEAR EXPORT SIGNAL; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REVIEW;

EID: 14744301997     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2005.01.005     Document Type: Short Survey

References (27)

1. H. Fried, and U. Kutay Nucleocytoplasmic transport: taking an inventory Cell. Mol. Life Sci. 60 2003 1659 1688
2. N. Mosammaparast, and L.F. Pemberton Karyopherins: from nuclear-transport mediators to nuclear-function regulators Trends Cell Biol. 14 2004 547 556
3. M. Fornerod, and M. Ohno Exportin-mediated nuclear export of proteins and ribonucleoproteins Results Probl. Cell Differ. 35 2002 67 91
4. M.T. Bohnsack Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm EMBO J. 21 2002 6205 6215
5. U. Fischer The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs Cell 82 1995 475 483
6. W. Wen Identification of a signal for rapid export of proteins from the nucleus Cell 82 1995 463 473
7. M. Fornerod CRM1 is an export receptor for leucine-rich nuclear export signals Cell 90 1997 1051 1060
8. U. Kutay Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor Cell 90 1997 1061 1071
9. U. Kutay Identification of a tRNA-specific nuclear export receptor Mol. Cell 1 1998 359 369
10. G. Lipowsky Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes EMBO J. 19 2000 4362 4371
11. P. Askjaer RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase Mol. Cell. Biol. 19 1999 6276 6285
12. E. Paraskeva CRM1-mediated recycling of snurportin 1 to the cytoplasm J. Cell Biol. 145 1999 255 264
13. L. Englmeier RanBP3 influences interactions between CRM1 and its nuclear protein export substrates EMBO Rep. 2 2001 926 932
14. M.E. Lindsay Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export J. Cell Biol. 153 2001 1391 1402
15. D. Engelsma Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358 EMBO J. 23 2004 3643 3652
16. T. La Cour Analysis and prediction of leucine-rich nuclear export signals Protein Eng. Des. Sel. 17 2004 527 536
17. M. Fornerod The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88 EMBO J. 16 1997 807 816
18. R.H. Kehlenbach A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export J. Cell Biol. 145 1999 645 657
19. M.J. Matunis A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex J. Cell Biol. 135 1996 1457 1470
20. R. Mahajan A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 Cell 88 1997 97 107
21. B.B. Singh The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1 J. Biol. Chem. 274 1999 37370 37378
22. R. Bernad Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export Mol. Cell. Biol. 24 2004 2373 2384
23. S. Kuersten Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains Mol. Cell. Biol. 22 2002 5708 5720
24. J.M. Mingot Exportin 7 defines a novel general nuclear export pathway EMBO J. 23 2004 3227 3236
25. V.N. Kim MicroRNA precursors in motion: exportin-5 mediates their nuclear export Trends Cell Biol. 14 2004 156 159
26. T. Chen Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5 Mol. Cell. Biol. 24 2004 6608 6619
27. J.M. Mingot Importin 13: a novel mediator of nuclear import and export EMBO J. 20 2001 3685 3694