Inflammation in children and adolescents with neuropsychiatric disorders: A systematic review

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 53, Issue 3, 2014, Pages 274-296

  Mitchell, Rachel H B ^a   Goldstein, Benjamin I ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

cytokines; inflammation; psychiatric disorders

Indexed keywords

ADOLESCENT; CHILD; HUMAN; IMMUNOLOGY; INFLAMMATION; MENTAL DISEASE;

ADOLESCENT; CHILD; HUMANS; INFLAMMATION; MENTAL DISORDERS;

EID: 84894535084     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2013.11.013     Document Type: Review

References (148)

1. V. Kumar, A.K. Abbas, N. Fausto, S.L. Robbins, and R.S. Cotran Robbins and Cotran Pathologic Basis of Disease 7th ed. 2005 Elsevier Saunders Philadelphia
2. E. Szigethy, L. McLafferty, and A. Goyal Inflammatory bowel disease Pediatr Clin North Am 58 2011 903 920 x-xi
3. A.N. Ortega, S.E. Huertas, G. Canino, R. Ramirez, and M. Rubio-Stipec Childhood asthma, chronic illness, and psychiatric disorders J Nerv Ment Dis 190 2002 275 281
4. B.I. Goldstein, S.M. Liu, N. Zivkovic, A. Schaffer, L.C. Chien, and C. Blanco The burden of obesity among adults with bipolar disorder in the United States Bipolar Disord 13 2011 387 395
5. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol Psychiatry 65 2009 732 741
6. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol 27 2006 24 31
7. A.H. Miller, and H.K. Manji On redefining the role of the immune system in psychiatric disease Biol Psychiatry 60 2006 796 798
8. R.S. Smith The immune system is a key factor in the etiology of psychosocial disease Med Hypotheses 34 1991 49 57
9. J. Mendlewicz, P. Kriwin, P. Oswald, D. Souery, S. Alboni, and N. Brunello Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study Int Clin Psychopharmacol 21 2006 227 231
10. J. Savitz, S. Preskorn, T.K. Teague, D. Drevets, W. Yates, and W. Drevets Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial BMJ Open 2 2012 e000643
11. S. Akhondzadeh, S. Jafari, and F. Raisi et al. Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial Depress Anxiety 26 2009 607 611
12. N. Müller, M.J. Schwarz, and S. Dehning et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine Mol Psychiatry 11 2006 680 684
13. F.G. Nery, E.S. Monkul, and J.P. Hatch et al. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study Hum Psychopharmacol 23 2008 87 94
14. C.L. Raison, R.E. Rutherford, and B.J. Woolwine et al. A randomized controlled trial of the tumor necrosis factor antagonist Infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers JAMA Psychiatry 70 2013 31 41
15. M.P. Freeman, J.R. Hibbeln, and K.L. Wisner et al. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry J Clin Psychiatry 67 2006 1954 1967
16. F.E. Lotrich, M. Rabinovitz, P. Gironda, and B.G. Pollock Depression following pegylated interferon-alpha: characteristics and vulnerability J Psychosom Res 63 2007 131 135
17. F.E. Lotrich Major depression during interferon-alpha treatment: vulnerability and prevention Dialogues Clin Neurosci 11 2009 417 425
18. F.E. Lotrich, R.E. Ferrell, M. Rabinovitz, and B.G. Pollock Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism Biol Psychiatry 65 2009 344 348
19. Y. Dowlati, N. Herrmann, and W. Swardfager et al. A meta-analysis of cytokines in major depression Biol Psychiatry 67 2010 446 457
20. B.I. Goldstein, D.E. Kemp, J.K. Soczynska, and R.S. McIntyre Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature J Clin Psychiatry 70 2009 1078 1090
21. S. Potvin, E. Stip, A.A. Sepehry, A. Gendron, R. Bah, and E. Kouassi Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review Biol Psychiatry 63 2008 801 808
22. T.W. Pace, and A.H. Miller Cytokines and glucocorticoid receptor signaling. Relevance to major depression Ann N Y Acad Sci 1179 2009 86 105
23. N. Müller, and M. Ackenheil Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders Prog Neuropsychopharmacol Biol Psychiatry 22 1998 1 33
24. Z. Kronfol, and D.G. Remick Cytokines and the brain: implications for clinical psychiatry Am J Psychiatry 157 2000 683 694
25. D.M. Christmas, J. Potokar, and S.J. Davies A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase Neuropsychiatr Dis Treat 7 2011 431 439
26. N.A. Harrison, L. Brydon, C. Walker, M.A. Gray, A. Steptoe, and H.D. Critchley Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity Biol Psychiatry 66 2009 407 414
27. O.M. Wolkowitz, S.H. Mellon, and E.S. Epel et al. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress-preliminary findings PLoS One 6 2011 e17837
28. J. Hannestad, J.D. Gallezot, and T. Schafbauer et al. Endotoxin-induced systemic inflammation activates microglia: [(11)C]PBR28 positron emission tomography in nonhuman primates Neuroimage 63 2012 232 239
29. S.M. Allan, and N.J. Rothwell Cytokines and acute neurodegeneration Nat Rev Neurosci 2 2001 734 744
30. C. Raison, and A. Miller Brain-immune system interaction: Relevance to the pathophysiology and treatment of neuropsychiatric disorders A. Schatzberg, C. Nemeroff, American Psychiatric Publishing Textbook of Psychopharmacology 3rd ed. 2004 American Psychiatric Press Washington DC 147 162
31. S. Sen, R. Duman, and G. Sanacora Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications Biol Psychiatry 64 2008 527 532
32. R.M. Post Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications J Psychiatr Res 41 2007 979 990
33. D. Lilic, A.J. Cant, M. Abinun, J.E. Calvert, and G.P. Spickett Cytokine production differs in children and adults Pediatr Res 42 1997 237 240
34. F. Kapczinski, E. Vieta, and A.C. Andreazza et al. Allostatic load in bipolar disorder: implications for pathophysiology and treatment Neurosci Biobehav Rev 32 2008 675 692
35. B.S. McEwen Protective and damaging effects of stress mediators N Engl J Med 338 1998 171 179
36. D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman, and P. Group Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement PLoS Med 6 2009 e1000097
37. E. Henje Blom, M. Lekander, M. Ingvar, M. Åsberg, F. Mobarrez, and E. Serlachius Proinflammatory cytokines are elevated in adolescent females with emotional disorders not treated with SSRIs J Affect Disord 136 2012 716 723
38. G.N. Pandey, H.S. Rizavi, and X. Ren et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims J Psychiatr Res 46 2012 57 63
39. G.E. Miller, and S.W. Cole Clustering of depression and inflammation in adolescents previously exposed to childhood adversity Biol Psychiatry 72 2012 34 40
40. T. Falcone, V. Fazio, and C. Lee et al. Serum S100B: a potential biomarker for suicidality in adolescents? PLoS One 5 2010 e11089
41. V. Gabbay, R.G. Klein, and L.E. Guttman et al. A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression J Child Adolesc Psychopharmacol 19 2009 423 430
42. V. Gabbay, R.G. Klein, and C.M. Alonso et al. Immune system dysregulation in adolescent major depressive disorder J Affect Disord 115 2009 177 182
43. F. Brambilla, P. Monteleone, and M. Maj Interleukin-1beta and tumor necrosis factor-alpha in children with major depressive disorder or dysthymia J Affect Disord 78 2004 273 277
44. B.I. Goldstein, K.A. Collinger, and F. Lotrich et al. Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders J Child Adolesc Psychopharmacol 21 2011 479 484
45. R.C. Padmos, M.H. Hillegers, and E.M. Knijff et al. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes Arch Gen Psychiatry 65 2008 395 407
46. P. Pervanidou, G. Kolaitis, and S. Charitaki et al. Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident Psychoneuroendocrinology 32 2007 991 999
47. Y.H. Cheng, Y. Zheng, and F. He et al. Detection of autoantibodies and increased concentrations of interleukins in plasma from patients with Tourette's syndrome J Mol Neurosci 48 2012 219 224
48. J. Matz, D.L. Krause, and S. Dehning et al. Altered monocyte activation markers in Tourette's syndrome: a case-control study BMC Psychiatry 12 2012 29
49. S. Liu, M. Yi, M. Wang, Y. Sun, F. Che, and X. Ma Association of IL8 -251A/T, IL12B -1188A/C and TNF-α -238A/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population Neurosci Lett 495 2011 155 158
50. S. Liu, M. Yi, F. Qi, F. Che, and X. Ma Lack of association between polymorphism -592A/C in the promoter region of the IL10 gene and Tourette's syndrome in a family-based association study in the Chinese Han population Genet Test Mol Biomarkers 15 2011 733 735
51. N.G. Bos-Veneman, J. Bijzet, P.C. Limburg, R.B. Minderaa, C.G. Kallenberg, and P.J. Hoekstra Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder Prog Neuropsychopharmacol Biol Psychiatry 34 2010 1390 1395
52. I.C. Chou, H.C. Lin, and C.H. Wang et al. Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome Pediatr Neurol 42 2010 320 324
53. V. Gabbay, B.J. Coffey, and L.E. Guttman et al. A cytokine study in children and adolescents with Tourette's disorder Prog Neuropsychopharmacol Biol Psychiatry 33 2009 967 971
54. J.F. Leckman, L. Katsovich, and I. Kawikova et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome Biol Psychiatry 57 2005 667 673
55. F. Luo, J.F. Leckman, and L. Katsovich et al. Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections Pediatrics 113 2004 e578 e585
56. B.B. Mittleman, F.X. Castellanos, L.K. Jacobsen, J.L. Rapoport, S.E. Swedo, and G.M. Shearer Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease J Immunol 159 1997 2994 2999
57. R.D. Oades An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD) Atten Defic Hyperact Disord 3 2011 301 318
58. R.D. Oades, A.M. Myint, M.R. Dauvermann, B.G. Schimmelmann, and M.J. Schwarz Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention Behav Brain Funct 6 2010 32
59. R.D. Oades, M.R. Dauvermann, B.G. Schimmelmann, M.J. Schwarz, and A.M. Myint Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism - effects of medication Behav Brain Funct 6 2010 29
60. J. Lasky-Su, B.M. Neale, and B. Franke et al. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations Am J Med Genet B Neuropsychiatr Genet 147B 2008 1345 1354
61. V.L. Misener, R. Schachar, and A. Ickowicz et al. Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder Neuropsychobiology 50 2004 231 234
62. J. Lasky-Su, R.J. Anney, and B.M. Neale et al. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder Am J Med Genet B Neuropsychiatr Genet 147B 2008 1355 1358
63. R.H. Segman, A. Meltzer, and V. Gross-Tsur et al. Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder Mol Psychiatry 7 2002 72 74
64. A.L. Sporn, A.J. Bobb, and N. Gogtay et al. Hormonal correlates of clozapine-induced weight gain in psychotic children: an exploratory study J Am Acad Child Adolesc Psychiatry 44 2005 925 933
65. L.Y. Al-Ayadhi, and G.A. Mostafa Elevated serum levels of interleukin-17A in children with autism J Neuroinflammation 9 2012 158
66. S. Bent, K. Bertoglio, P. Ashwood, E. Nemeth, and R.L. Hendren Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial J Autism Dev Disord 42 2012 1127 1132
67. A. El-Ansary, and L. Al-Ayadhi Neuroinflammation in autism spectrum disorders J Neuroinflammation 9 2012 265
68. A.M. Manzardo, R. Henkhaus, S. Dhillon, and M.G. Butler Plasma cytokine levels in children with autistic disorder and unrelated siblings Int J Dev Neurosci 30 2012 121 127
69. H. Jyonouchi, L. Geng, D.L. Streck, and G.A. Toruner Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study J Neuroinflammation 9 2012 4
70. M.H. Tostes, H.C. Teixeira, W.F. Gattaz, M.A. Brandão, and N.R. Raposo Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism Pharmacopsychiatry 45 2012 241 243
71. P. Ashwood, P. Krakowiak, I. Hertz-Picciotto, R. Hansen, I.N. Pessah, and J. Van de Water Altered T cell responses in children with autism Brain Behav Immun 25 2011 840 849
72. P. Ashwood, P. Krakowiak, I. Hertz-Picciotto, R. Hansen, I. Pessah, and J. Van de Water Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome Brain Behav Immun 25 2011 40 45
73. A.K. El-Ansary, A.G. Ben Bacha, and L.Y. Al-Ayadhi Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia J Neuroinflammation 8 2011 142
74. M. Malik, A.M. Sheikh, G. Wen, W. Spivack, W.T. Brown, and X. Li Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects Immunobiology 216 2011 80 85
75. H. Jyonouchi, L. Geng, D.L. Streck, and G.A. Toruner Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes J Neuroimmunol 238 2011 73 80
76. K. Suzuki, H. Matsuzaki, and K. Iwata et al. Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders PLoS One 6 2011 e20470
77. Z. Tobiasova, K.H. van der Lingen, and L. Scahill et al. Risperidone-related improvement of irritability in children with autism is not associated with changes in serum of epidermal growth factor and interleukin-13 J Child Adolesc Psychopharmacol 21 2011 555 564
78. H. Wei, H. Zou, and A.M. Sheikh et al. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation J Neuroinflammation 8 2011 52
79. P. Ashwood, D.V. Nguyen, D. Hessl, R.J. Hagerman, and F. Tassone Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis? Brain Behav Immun 24 2010 898 902
80. A.M. Enstrom, C.E. Onore, J.A. Van de Water, and P. Ashwood Differential monocyte responses to TLR ligands in children with autism spectrum disorders Brain Behav Immun 24 2010 64 71
81. P. Ashwood, J. Schauer, I.N. Pessah, and J. Van de Water Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders J Neuroimmunol 208 2009 130 135
82. X. Li, A. Chauhan, and A.M. Sheikh et al. Elevated immune response in the brain of autistic patients J Neuroimmunol 207 2009 111 116
83. C. Onore, A. Enstrom, and P. Krakowiak et al. Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders J Neuroimmunol 216 2009 126 129
84. H. Jyonouchi, L. Geng, A. Cushing-Ruby, and H. Quraishi Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study J Neuroinflammation 5 2008 52
85. A. Enstrom, C. Onore, I.H. Picciotto, L. Croen, J. Van De Water, and P. Ashwood Detection of IL-17 and IL-23 in plasma samples of children with autism Am J Biochem Biotechnol 4 2008 114 120
86. M.G. Chez, T. Dowling, P.B. Patel, P. Khanna, and M. Kominsky Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children Pediatr Neurol 36 2007 361 365
87. D.A. Rossignol, L.W. Rossignol, S.J. James, S. Melnyk, and E. Mumper The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study BMC Pediatr 7 2007 36
88. C.A. Molloy, A.L. Morrow, and J. Meinzen-Derr et al. Elevated cytokine levels in children with autism spectrum disorder J Neuroimmunol 172 2006 198 205
89. H. Jyonouchi, L. Geng, A. Ruby, C. Reddy, and B. Zimmerman-Bier Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders J Pediatr 146 2005 605 610
90. H. Jyonouchi, L. Geng, A. Ruby, and B. Zimmerman-Bier Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention Neuropsychobiology 51 2005 77 85
91. D.L. Vargas, C. Nascimbene, C. Krishnan, A.W. Zimmerman, and C.A. Pardo Neuroglial activation and neuroinflammation in the brain of patients with autism Ann Neurol 57 2005 67 81
92. A.W. Zimmerman, H. Jyonouchi, and A.M. Comi et al. Cerebrospinal fluid and serum markers of inflammation in autism Pediatr Neurol 33 2005 195 201
93. P. Ashwood, A. Anthony, F. Torrente, and A.J. Wakefield Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10 J Clin Immunol 24 2004 664 673
94. T.L. Sweeten, and R.S. Fujinami A potential link between measles virus and autism: age-matched control groups are essential Pediatr Neurol 30 2004 78 author reply 78
95. J. Croonenberghs, E. Bosmans, D. Deboutte, G. Kenis, and M. Maes Activation of the inflammatory response system in autism Neuropsychobiology 45 2002 1 6
96. M.L. DeFelice, E.D. Ruchelli, and J.E. Markowitz et al. Intestinal cytokines in children with pervasive developmental disorders Am J Gastroenterol 98 2003 1777 1782
97. H. Jyonouchi, S. Sun, and N. Itokazu Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder Neuropsychobiology 46 2002 76 84
98. H. Jyonouchi, S. Sun, and H. Le Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression J Neuroimmunol 120 2001 170 179
99. S. Gupta, S. Aggarwal, B. Rashanravan, and T. Lee Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism J Neuroimmunol 85 1998 106 109
100. D.R. Denney, B.W. Frei, and G.R. Gaffney Lymphocyte subsets and interleukin-2 receptors in autistic children J Autism Dev Disord 26 1996 87 97
101. V.K. Singh Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism J Neuroimmunol 66 1996 143 145
102. G. Stubbs Interferonemia and autism J Autism Dev Disord 25 1995 71 73
103. V.K. Singh, R.P. Warren, J.D. Odell, and P. Cole Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children Clin Immunol Immunopathol 61 1991 448 455
104. B. Birmaher, D. Axelson, and B. Goldstein et al. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study Am J Psychiatry 166 2009 795 804
105. P.M. Ridker, C.H. Hennekens, J.E. Buring, and N. Rifai C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 2000 836 843
106. P.M. Ridker, N. Rifai, L. Rose, J.E. Buring, and N.R. Cook Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events N Engl J Med 347 2002 1557 1565
107. P.M. Ridker, E. Danielson, and F.A. Fonseca et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N Engl J Med 359 2008 2195 2207
108. I. Drtilkova, O. Sery, and P. Theiner et al. Clinical and molecular-genetic markers of ADHD in children Neuro Endocrinol Lett 29 2008 320 327
109. T.L. Sweeten, D.J. Posey, S. Shankar, and C.J. McDougle High nitric oxide production in autistic disorder: a possible role for interferon-gamma Biol Psychiatry 55 2004 434 437
110. S. Janelidze, D. Mattei, Å. Westrin, L. Träskman-Bendz, and L. Brundin Cytokine levels in the blood may distinguish suicide attempters from depressed patients Brain Behav Immun 25 2011 335 339
111. D. Lindqvist, S. Janelidze, S. Erhardt, L. Träskman-Bendz, G. Engström, and L. Brundin CSF biomarkers in suicide attempters - a principal component analysis Acta Psychiatr Scand 124 2011 52 61
112. L.H. Tonelli, J. Stiller, and D. Rujescu et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide Acta Psychiatr Scand 117 2008 198 206
113. F. Dickerson, C. Stallings, A. Origoni, J. Boronow, and R. Yolken Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder Prog Neuropsychopharmacol Biol Psychiatry 31 2007 952 955
114. P. Pervanidou Biology of post-traumatic stress disorder in childhood and adolescence J Neuroendocrinol 20 2008 632 638
115. M. Maes, A.H. Lin, and L. Delmeire et al. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events Biol Psychiatry 45 1999 833 839
116. D.G. Baker, N.N. Ekhator, and J.W. Kasckow et al. Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder Neuroimmunomodulation 9 2001 209 217
117. J. Gill, M. Vythilingam, and G.G. Page Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD J Trauma Stress 21 2008 530 539
118. J. Gill, D. Luckenbaugh, D. Charney, and M. Vythilingam Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression Biol Psychiatry 68 2010 999 1006
119. D.A. Papanicolaou, R.L. Wilder, S.C. Manolagas, and G.P. Chrousos The pathophysiologic roles of interleukin-6 in human disease Ann Intern Med 128 1998 127 137
120. A. Danese, C.M. Pariante, A. Caspi, A. Taylor, and R. Poulton Childhood maltreatment predicts adult inflammation in a life-course study Proc Natl Acad Sci U S A 104 2007 1319 1324
121. S.M. Lehto, A.P. Elomaa, and L. Niskanen et al. Serum adipokine levels in adults with a history of childhood maltreatment Prog Neuropsychopharmacol Biol Psychiatry 37 2012 217 221
122. T.W. Pace, K. Wingenfeld, I. Schmidt, G. Meinlschmidt, D.H. Hellhammer, and C.M. Heim Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder Brain Behav Immun 26 2012 13 17
123. T.W. Pace, T.C. Mletzko, and O. Alagbe et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress Am J Psychiatry 163 2006 1630 1633
124. A. Danese, T.E. Moffitt, C.M. Pariante, A. Ambler, R. Poulton, and A. Caspi Elevated inflammation levels in depressed adults with a history of childhood maltreatment Arch Gen Psychiatry 65 2008 409 415
125. F.F. da Rocha, H. Correa, and A.L. Teixeira Obsessive-compulsive disorder and immunology: a review Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1139 1146
126. D.L. Krause, J.K. Wagner, and A. Wildenauer et al. Intracellular monocytic cytokine levels in schizophrenia show an alteration of IL-6 Eur Arch Psychiatry Clin Neurosci 262 2012 393 401
127. D. Martino, A.J. Church, and G. Defazio et al. Soluble adhesion molecules in Gilles de la Tourette's syndrome J Neurol Sci 234 2005 79 85
128. A.G. Hounie, C. Cappi, and Q. Cordeiro et al. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder Neurosci Lett 442 2008 86 90
129. T.K. Murphy, R. Kurlan, and J. Leckman The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward J Child Adolesc Psychopharmacol 20 2010 317 331
130. V.A. Russell, R.D. Oades, and R. Tannock et al. Response variability in attention-deficit/hyperactivity disorder: a neuronal and glial energetics hypothesis Behav Brain Funct 2 2006 30
131. F. Boin, R. Zanardini, R. Pioli, C.A. Altamura, M. Maes, and M. Gennarelli Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia Mol Psychiatry 6 2001 79 82
132. K. Hänninen, H. Katila, and M. Saarela et al. Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia Eur Arch Psychiatry Clin Neurosci 258 2008 10 15
133. R.C. Drexhage, L. van der Heul-Nieuwenhuijsen, and R.C. Padmos et al. Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients Int J Neuropsychopharmacol 13 2010 1369 1381
134. D.A. Rossignol, and R.E. Frye A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures Mol Psychiatry 17 2012 389 401
135. M.R. Buehler A proposed mechanism for autism: an aberrant neuroimmune response manifested as a psychiatric disorder Med Hypotheses 76 2011 863 870
136. S.L. Buka, M.T. Tsuang, E.F. Torrey, M.A. Klebanoff, R.L. Wagner, and R.H. Yolken Maternal cytokine levels during pregnancy and adult psychosis Brain Behav Immun 15 2001 411 420
137. A.S. Brown Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism Dev Neurobiol 72 2012 1272 1276
138. O. Dammann, and A. Leviton Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn Pediatr Res 42 1997 1 8
139. H.O. Atladóttir, P. Thorsen, and L. ∅stergaard et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders J Autism Dev Disord 40 2010 1423 1430
140. M.W. Abdallah, N. Larsen, and J. Grove et al. Amniotic fluid chemokines and autism spectrum disorders: an exploratory study utilizing a Danish Historic Birth Cohort Brain Behav Immun 26 2012 170 176
141. M.W. Abdallah, N. Larsen, and J. Grove et al. Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders World J Biol Psychiatry 14 2013 528 538
142. M.W. Abdallah, N. Larsen, and E.L. Mortensen et al. Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank J Neuroimmunol 252 2012 75 82
143. M.N. Ziats, and O.M. Rennert Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways PLoS One 6 2011 e24691
144. D. Friberg, J. Bryant, W. Shannon, and T.L. Whiteside In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation Clin Diagn Lab Immunol 1 1994 261 268
145. R.K. Katial, D. Sachanandani, C. Pinney, and M.M. Lieberman Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hosts Clin Diagn Lab Immunol 5 1998 78 81
146. J. Licinio, and M.L. Wong The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection Mol Psychiatry 4 1999 317 327
147. E.C. Breen, M. McDonald, J. Fan, J. Boscardin, and J.L. Fahey Cytokine gene expression occurs more rapidly in stimulated peripheral blood mononuclear cells from human immunodeficiency virus-infected persons Clin Diagn Lab Immunol 7 2000 769 773
148. T.R. Insel, and P.S. Wang Rethinking mental illness JAMA 303 2010 1970 1971