Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn

Pediatric Research

Volumn 42, Issue 1, 1997, Pages 1-8

  Dammann, Olaf ^a   Leviton, Alan ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

BLOOD BRAIN BARRIER; BRAIN HEMORRHAGE; BRAIN INJURY; CEREBRAL PALSY; DISABILITY; DISEASE ASSOCIATION; HUMAN; INTRAUTERINE INFECTION; MATERNAL DISEASE; NEWBORN; PREMATURITY; PRIORITY JOURNAL; REVIEW; SECOND TRIMESTER PREGNANCY; WHITE MATTER;

EID: 0030924241     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199707000-00001     Document Type: Review

References (138)

1. World Health Organization 1977 International classification of diseases. Manual of the international classification of diseases, injuries, and causes of death, Vol 1. WHO, Geneva, p 764
2. Berkowitz GS, Papiernik E 1993 Epidemiology of preterm birth. Epidemiol Rev 15:414-443
3. Lee KS, Khoshnood B, Hsieh HL, Kim, BI, Schreiber MD, Mittendorf R 1995 Which birth weight groups contributed most to the overall reduction in the neonatal mortality rate in the United States from 1960 to 1986? Paediatr Perinat Epidemiol 9:420-430
4. Romero R, Lockwood C, Oyarzun E, Hobbins JC 1988 Toxemia: new concepts in an old disease. Semin Perinatol 12:302-323
5. Broughton Pipkin F 1995 The hypertensive disorders of pregnancy. BMJ 311:609-613
6. Gomez R, Hezzi F, Romero R, Muñoz H, Tolosa JE, Rojas I 1995 Premature Labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol 22:281-342
7. Guinn DA, Goldenberg RL, Hauth JC, Andrews WW, Thom E, Romero R 1995 Risk factors for the development of preterm premature rupture of the membranes after arrest of preterm labor. Am J Obstet Gynecol 173:1310-1315
8. Seo K, McGregor JA, French JI 1992 Preterm birth is associated with increased risk of maternal and neonatal infection. Obstet Gynecol 79:75-80
9. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin Dh, Cotch MF, Edelman R, Pastorek JG, Rao AV, McNellis D, Regan JA, Carey JC, Klebanoff MA, for the Vaginal Infections and Prematurity Study Group 1995 Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. N Engl J Med 333:1737-1742
10. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL 1995 Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 333:1732-1736
11. Andrews WW, Hauth JC, Goldenberg RL, Gomez R, Romero R, Cassell GH 1995 Amniotic fluid interleukin-6: correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery. Am J Obstet Gynecol 173:606-612
12. Goldenberg RL, Andrews WW 1996 Editorial: Intrauterine infection and why preterm prevention programs have failed. Am J Public Health 86:781-783
13. Paneth N, Pinto-Martin J 1990 The epidemiology of germinal matrix/intraventricular hemorrhage. In: Kiely M (ed) Reproductive and Perinatal Epidemiology. CRC Press, Boca Raton, FL, pp 371-399
14. Paneth N, Rudelli R, Kazam E, Monte W 1994 Brain Damage in the Preterm Infant. MacKeith Press, London, pp 171-185
15. Volpe JJ 1992 Brain injury in the premature neonate - current concepts of pathogenesis and prevention. Biol Neonate 62:231-242
16. Leviton A, Paneth N 1990 White matter damage in preterm newborns - an epidemiologic perspective. Early Hum Dev 24:1-22
17. Morales WJ 1987 The effect of chorioamnionitis on the developmental outcome of preterm infants at one year. Obstet Gynecol 70:183-186
18. Yoon BH, Romero R, Kim CJ, Jun JK, Gomez R, Choi JH, Syn HC 1995 Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 172:960-970
19. Salafia CM, Minior VK, Rosenkrantz TS, Pezzullo JC, Popek EJ, Cusick W, Vintzileos AM 1995 Maternal, placental, and neonatal associations with early germinal matrix/intraventricular hemorrhage in infants born before 32 wk gestation. Am J Perinatol 12:429-436
20. Mercer BM, Arheart KL 1995 Antimicrobial therapy in expectant management of preterm premature rupture of the membranes. Lancet 346:1271-1279
21. Egarter C, Leitich H, Karas H, Wieser F, Husslein P, Kaider A, Schemper M 1996 Antibiotic treatment in preterm premature rupture of membranes and neonatal morbidity: a metaanalysis. Am J Obstet Gynecol 174:589-597
22. Bejar R, Wozniak P, Allard M, Benirschke K, Vaucher Y, Coen R, Berry C, Schragg P, Villegas I, Resnik R 1988 Antenatal origin of neurologic damage in newborn infants. I. Preterm infants. Am J Obstet Gynecol 159:357-363
23. Kothadia JM, O'Shea TM, Del Paggio D, Dillard RG 1994 Prenatal risk factors for periventricular echodensity in very low birth weight neonates. Paediatr Perinat Epidemiol 8:A7
24. Zupan V, Gonzalez P, Lacaze-Masmonteil T, Boithias C, D'Allest AM, Dehan M, Gabilan JC 1996 Periventricular leukomalacia: risk factors revisited. Dev Med Child Neurol 38:1061-1067
25. Mays J, Verma U, Klein S, Tejani N 1995 Acute appendicitis in pregnancy and the occurrence of major intraventricular hemorrhage and periventricular leukomalacia. Obstet Gynecol 86:650-652
26. Perlman JM, Rollins N, Burns D, Risser R 1993 Relationship between periventricular intraparenchymal echodensities and germinal matrix-intraventricular hemorrhage in the very low birthweight neonate. Pediatrics 91:474-480
27. Trounce JQ, Rutter N, Levene MI 1986 Periventricular leucomalacia and intraventricular haemorrhage in the preterm neonate. Arch Dis Child 61:1196-1202
28. Armstrong DL, Sauls CD, Goddard-Finegold J 1987 Neuropathologic findings in short-term survivors of intraventricular hemorrhage. Am J Dis Child 141:617-621
29. Dambska M, Laure-Kamionowska M, Schmidt-Sidor B 1989 Early and late neuropathological changes in perinatal white matter damage. J Child Neurol 4:291-298
30. Yokochi K, Aiba K, Horie M, Inukai K, Fujimoto S, Kodama M, Kodama K 1991 Magnetic resonance imaging in children with spastic diplegia: correlation with the severity of their motor and mental abnormality. Dev Med Child Neurol 33:18-25
31. Krägeloh-Mann I, Petersen D, Hagberg G, Vollmer B, Hagberg B, Michaelis R 1995 Bilateral spastic cerebral palsy - MRI pathology and origin. Analysis from a representative series of 56 cases. Dev Med Child Neurol 37:379-397
32. Murphy DJ, Sellers S, MacKenzie IZ, Yudkin PL, Johnson AM 1995 Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies. Lancet 346:1449-1454
33. Grether JK, Nelson KB, Emery III ES, Cummins SK 1996 Prenatal and perinatal factors and cerebral palsy in very low birth weight infants. J Pediatr 128:407-414
34. MacDonald PC, Casey ML 1996 Preterm birth. Sci Am March/April:42-51
35. Lockwood CJ 1994 Recent advances in elucidating the pathogenesis of preterm delivery, the detection of patients at risk, and preventive therapies. Curr Opin Obstet Gynecol 6:7-18
36. Mazor M, Cohen J, Romero R, Ghezzi F, Tolosa JE, Gomez R 1995 Cytokines and preterm labor. Fetal Maternal Med Rev 7:207-233
37. Adinolfi M 1993 Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis. Dev Med Child Neurol 35:549-553
38. Leviton A 1993 Preterm birth and cerebral palsy: is tumor necrosis factor the missing link? Dev Med Child Neurol 35:553-558
39. Inglis SR, Jeremias J, Kuno K, Lescale K, Peeper Q, Chervenak FA, Witkin SS 1994 Detection of tumor necrosis factor-α, interleukin-6, and fetal fibronectin in the lower genital tract during pregnancy: relation to outcome. Am J Obstet Gynecol 171:5-10
40. Hillier SL, Witkin SS, Krohn MA, Watts DH, Kiviat NB, Eschenbach DA 1993 The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obstet Gynecol 81:941-948
41. Figueroa R, Martinez E, Sehgal P, Garry D, Patel K, Verma U, Visintainer P, Reale M, Klein S, Tejani N 1996 Elevated amniotic fluid interleukin-6 predicts neonatal periventricular leukomalacia and intraventricular hemorrhage. Am J Obstet Gynecol 174:330
42. Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC 1996 Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 174:1433-1440
43. Opsjøn SL, Wathen NC, Tingulstad S, Wiedswang G, Sundan A, Waage A, Austgulen R 1993 Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy. Am J Obstet Gynecol 169:397-404
44. Mitchell MD, Trautman MS, Dudley DJ 1993 Cytokine networking in the placenta. Placenta 14:249-275
45. Romero R, Mazor M, Sepulveda W, Avila C, Copeland D, Williams J 1992 Tumor necrosis factor in preterm and term labor. Am J Obstet Gynecol 166:1576-1587
46. Saito S, Kasahara T, Kato Y, Ishihara Y, Ichijo M 1993 Elevation of amniotic fluid interleukin-6 (IL-6), IL-8 and granulocyte colony stimulating factor (G-CSF) in term and preterm parturition. Cytokine 5:81-88
47. Stallmach T, Hebisch G, Joller-Jemelka HI, Orban P, Schwaller J, Engelmann M 1995 Cytokine production and visualized effects in the feto-maternal unit. Quantitative and topographic data on cytokines during intrauterine disease. Lab Invest 73:384-392
48. Greig PC, Ernest JM, Teot L, Erikson M, Talley R 1993 Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients in premature labor with intact membranes. Am J Obstet Gynecol 169:1035-1044
49. Singh B, Merchant P, Walker CR, Kryworuchko M, Diaz-Mitoma F 1996 Interleukin-6 expression in cord blood of patients with clinical chorioamnionitis. Pediatr Res 39:976-979
50. Miyano A, Miyamichi T, Nakayama M, Kitajima H, Shimizu A 1996 Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants. Arch Pathol Lab Med 120:245-248
51. Yachie A, Takano N, Yokoi T, Kato K, Kasahara Y, Miyawaki T, Taniguchi N 1990 The capability of neonatal leukocytes to produce IL-6 on stimulation assessed by whole blood culture. Pediatr Res 27:227-233
52. Liechty KW, Koenig JM, Mitchell MD, Romero R, Christensen RD 1991 Production of interleukin-6 by fetal and maternal cells in vivo during intraamniotic infection and in vitro after stimulation with interleukin-1. Pediatr Res 29:1-4
53. Drews K, Szczapa J, Zak J, Andrzejewska R, Zak L, Mackiewicz A 1995 Blood serum concentration of C-reactive protein and interleukin-6 in diagnosis of neonatal infection. Ann NY Acad Sci 762:398-399
54. Williams PA, Bohnsack JF, Augustine NH, Drummond WK, Rubens CE, Hill HR 1993 Production of tumor necrosis factor by human cells in vitro and in vivo, induced by group B streptococci. J Pediatr 123:292-300
55. Girardin EP, Berner ME, Grau GE, Suter S, Lacourt G, Paunier L 1990 Serum tumour necrosis factor in newborns at risk for infections. Eur J Pediatr 149:645-647
56. Messer J, Eyer D, Donato L, Gallati H, Matis J, Simeoni U 1996 Evaluation of interleukin-6 and soluble receptors of tumor necrosis factor for early diagnosis of neonatal infection. J Pediatr 129:574-580
57. Hopkins SJ, Rothwell NJ 1995 Cytokines and the nervous system. I. Expression and recognition. Trends Neurosci 18:83-88
58. Ransohoff RM, Benveniste EN (eds) 1996 Cytokines and the CNS. CRC Press, Boca Raton, FL
59. Chao CC, Hu S, Close K, Choi CS, Molitor TW, Novick WJ, Peterson PK 1992 Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis 166:847-853
60. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW 1993 Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1β. J Immunol 150:2659-2667
61. Casey ML, Cox SM, Beutler B, Milewich L, MacDonald PC 1989 Cacheclin/tumor necrosis factor-α in human decidua. Potential role of cytokines in infection-induced preterm labor. J Clin Invest 83:430-436
62. Dudley DJ, Chen CL, Branch DW, Hammond E, Mitchell MD 1993 A murine model of preterm labor: inflammatory mediators regulate the production of prostaglandin E2 and interleukin-6 by murine decidua. Biol Reprod 48:33-39
63. Kauma SW, Herman K, Wang Y, Walsh SW 1993 Differential mRNA expression and production of interleukin-6 in placental trophoblast and villous core compartments. Am J Reprod Immunol 30:131-135
64. Matsuzaki N, Taniguchi T, Shimoya K, Neki R, Okada T, Saji F, Nakayama M, Suehara N, Tanizawa O 1993 Placental interleukin-6 production is enhanced in intrauterine infection but not in labor. Am J Obstet Gynecol 168:94-97
65. Kent ASH, Sullivan MHF, Sun MY, Zosmer A, Elder MG 1993 Effects of interleukin-6 and tumor necrosis factor-α on prostaglandin production by cultured human fetal membranes. Prostaglandins 46:351-359
66. Mitchell MD, Trautman MS, Donald DJ 1993 Cytokine networking in the placenta. Placenta 14:249-275
67. Ala Y, Palluy O, Favero J, Bonne C, Modat G, Dornand J 1992 Hypoxia/ reoxygenation stimulates endothelial cells to promote interleukin-1 and interleukin-6 promotion. Effects on free radical scavengers. Agents Actions 37:134-139
68. Fortunato SJ, Menon RP, Swan KF, Menon R 1996 Inflammatory cytokine (interleukins 1, 6, and 8 and tumor necrosis factor-α) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations. Am J Obstet Gynecol 174:1855-1862
69. Adinolfi M 1985 The development of the human blood-CSF-brain barrier. Dev Med Child Neurol 27:532-537
70. Banks WA, Kastin AJ, Gutierrez EG 1993 Interleukin-1α in blood has direct access to cortical brain cells. Neurosci Lett 163:41-44
71. Banks WA, Ortiz L, Plotkin SR, Kastin AJ 1991 Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259:988-996
72. Banks WA, Kastin AJ, Gutierrez EG 1994 Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett 179:53-56
73. Gutierrez EG, Banks WA, Kastin AJ 1993 Murine tumor necrosis factor-α is transported from blood to brain in the mouse. J Neuroimmunol 47:169-176
74. Miller LC, Isa S, LoPreste G, Schaller JG, Dinarello CA 1990 Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production. J Pediatr 117:961-965
75. McCracken GH, Mustafa MM, Ramilo O, Olsen KO, Risser RC 1989 Cerebrospinal fluid interleukin 1-β and tumor necrosis factor concentrations and outcome from neonatal Gram-negative enteric bacillary meningitis. Pediatr Infect Dis J 8:155-159
76. Matsuzono Y, Narita M, Akutsu Y, Togashi T 1995 Interleukin-6 in cerebrospinal fluid of patients with central nervous system infections. Acta Paediatr 84:879-883
77. Tarlow MJ, Jenkins R, Comis SD, Osborne MP, Stephens S, Stanley P, Crocker J 1993 Ependymal cells of the choroid plexus express tumour necrosis factor-α. Neuropathol Appl Neurobiol 19:324-328
78. Merrill JE 1992 Tumor necrosis factor-α, interleukin 1 and related cytokines in brain development: normal and pathological. Dev Neurosci 14:1-10
79. Van Dam AM, Bauer J, Tilders FJ, Berkenbosch F 1995 Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: a light and electron microscopic study. Neuroscience 65:815-826
80. Bartanusz V, Jezova D 1992 The role of some circumventricular organs in hormone action and secretion. Endocr Regul 26:3-9
81. Risau W 1994 Molecular biology of blood-brain harrier ontogenesis and function. Acta Neurochir Suppl 60:109-112
82. Møllgård K, Saunders NR 1986 The development of the human blood-brain and blood-CSF barriers. Neuropathol Appl Neurobiol 12:337-358
83. Møllgård K, Balslev Y, Lauritzen B, Saunders NR 1987 Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier. J Neurocytol 16:433-444
84. Quagliarello VJ, Wispelwey B, Long Jr WJ, Scheld WM 1991 Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. J Clin Invest 87:1360-1366
85. Wright JL, Merchant RE 1994 Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-α in the rat. J Neurooncol 20:17-25
86. Saija A, Princi P, Lanza M, Scalese M, Aramnejad E, DeSarro A 1995 Systemic cytokine administration can affect blood-brain barrier permeability in the rat. Life Sci 56:775-784
87. Brett FM, Mizisin AP, Powell HC, Campbell IL 1995 Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J Neuropathol Exp Neurol 54:766-775
88. Sharief MK, Ciardi M, Thompson EJ 1992 Blood-brain barrier in patients with bacterial meningitis: association with tumor necrosis factor-α but not interleukin-1 ß. J Infect Dis 166:350-358
89. Ment LR, Oh W, Ehrenkranz RA, Philip AGS, Vohr B, Allan W, Duncan CC, Scott DT, Taylor KJW, Katz KH, Schneider KC, Makuch RW 1994 Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 93:543-550
90. Ment LR, Stewart WB, Ardito TA, Huang E, Madri JA 1992 Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. Stroke 23:1132-1137
91. Zuckerman SL, Mirro R, Armstead WM, Shibata M, Leffler CW 1992 Indomethacin reduces ischemia-induced alteration of blood-brain barrier transport in piglets. Am J Physiol 266:H2198-H2203
92. DeVries HE, Blom-Roosemalen MC, Van Oosten M, De Boer AG, Van Berkel TJ, Breimer DD, Kuiper J 1996 The influence of cytokines on the integrity of the blood-brain barrier in vitro. J Neuroimmunol 64:37-43
93. Hurwitz AA, Lyman WD, Guida MP, Calderon TM, Berman JW 1992 Tumor necrosis factor-α induces adhesion molecule expression on fetal human astrocytes. J Exp Med 176:1631-1636
94. Merrill JE, Benveniste EN 1996 Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19:331-338
95. Ransohoff RM, Hamilton TA, Tani M, Stoler MH, Shick HE, Major JA, Estes ML, Thomas DM, Tuohy VK 1993 Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J 7:592-600
96. Ohmori Y, Wyner L, Narumi S, Armstrong D, Stoler M, Hamilton TA 1993 Tumor necrosis factor-α induces cell type and tissue-specific expression of chemoattractant cytokines in vivo. Am J Pathol 142:861-870
97. Stricter RM, Kunkel SL, Arenberg DA, Burdick MD, Polverini PJ 1995 Interferon-γ-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem Biophys Res Commun 210:51-57
98. Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G 1995 Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182:155-162
99. Slungaard A, Vercellotti GM, Walker G, Nelson RD, Jacob HS 1990 Tumor necrosis factor-α/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium. J Exp Med 171:2025-2041
100. Westlin WF, Gimbrone MA Jr 1993 Neutrophil-mediated damage to human vascular endothelium. Role of cytokine activation. Am J Pathol 142:117-128
101. Carswell EA, Old LJ, Kassel FL, Green S, Fiore N, Williamson B 1975 An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72:3666-3671
102. Grau GE, Lou J 1993 TNF in vascular pathology: the importance of platelet-endothelium interactions. Res Immunol 144:355-363
103. Esmon CT 1994 Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. Baillieres Clin Haematol 7:453-468
104. Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone Jr MA 1986 Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterisation and comparison with the actions of interleukin 1. Proc Natl Acad Sci USA 83:4533-4537
105. Kawakami M, Ishibashi S, Ogawa H, Murase T, Takahu F, Shibata S 1986 Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells. Biochem Biophys Res Commun 141:482-487
106. Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone MA Jr 1988 Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 263:5797-5809
107. Dosne AM, Dubor F, Lutcher F, Parant M, Chedid L 1988 Tumor necrosis factor (TNF) stimulates plasminogen activator inhibitor (PAI) production by endothelial cells and decreases blood fibrinolytic activity in the rat. Thromb Res 51:115-122
108. Van Hinsbergh VWM, Kooistra T, Vanderberg EA, Princer HMG, Fiers W, Emeis JJ 1988 Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo. Blood 72:1467-1473
109. Wada H, Tanigawa M, Wakita Y, Nakase T, Minamikawa K, Kaneko T, Ohiwa M, Kageyama S, Kobayashi T, Noguchi T, Deguchi K, Shirakawa S 1993 Increased plasma level of interleukin-6 in disseminated intravascular coagulation. Blood Coagul Fibrinolysis 4:583-590
110. Oleksowicz L, Mrowiec Z, Zuckerman D, Isaacs R, Dutcher J, Puszkin E 1994 Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism. Thromb Haemost 72:302-308
111. Camussi G, Bussolino F, Salvidio G, Baglioni C 1987 Tumor necrosis factor/ cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet activating factor. J Exp Med 166:1390-1404
112. Armstead WM, Pourcyrous M, Mirro R, Leffler CW, Busija DW 1988 Platelet activating factor: a potent constrictor of cerebral arteriole in newborn pigs. Circ Res 62:1-7
113. Kikuchi T, Okuda Y, Kaito N, Abe T 1995 Cytokine production in cerebrospinal fluid after subarachnoid haemorrhage. Neurol Res 17:106-108
114. Rinkel GJE, VanGijn J, Wijdicks EFM 1993 Subarachnoid hemorrhage without detectable aneurysm. A review of the causes. Stroke 24:1403-1409
115. DelBigio MR, Bruni JE 1988 Changes in periventricular vasculature of rabbit brain following induction of hydrocephalus and after shunting. J Neurosurg 69:115-120
116. Sarnat HB 1992 Role of human fetal ependyma. Pediatr Neurol 8:163-178
117. Sarnat HB 1995 Ependymal reactions to injury. A review. J Neuropathol Exp Neurol 54:1-15
118. Weller RO, Mitchell J 1980 Cerebrospinal fluid edema and its sequela in hydrocephalus. Adv Neurol 28:111-123
119. Paneth N, Rudelli R, Kazam E, Monte W 1994 Brain Damage in the Preterm Infant. MacKeith Press, London, pp 119-137
120. Rypens F, Avni EF, Dussaussois L, David P, Vermeylen D, Van Bogaert P, Matos C 1994 Hyperechoic thickened ependyma: sonographic demonstration and significance in neonates. Pediatr Radiol 24:550-553
121. Kasper M, Goertchen R, Stosiek P, Perry G, Karsten U 1986 Coexistence of cytokeratin, vimentin and neurofilament protein in human choroid plexus. An immunohistochemical study of intermediate filaments in neuroepithelial tissues. Virchows Arch A Pathol Anat Histopathol 410:173-177
122. Blennow M, Rosengren L, Jonsson S, Forssberg H, Katz-Salamon M, Hagberg H, Hesser U, Lagercrantz H 1996 Glial fibrillary acidic protein is increased in the cerebrospinal fluid of preterm infants with abnormal neurological findings. Acta Paediatr 85:485-489
123. Fukumizu M, Takashima S, Becker LE 1995 Neonatal posthemorrhagic hydrocephalus: neuropathologic and immunohistochemical studies. Pediatr Neurol 13:230-234
124. Iida K, Takashima S, Takeuchi Y, Ohno T, Ueda K 1993 Neuropathologic study of newborns with prenatal-onset leukomalacia. Pediatr Neurol 9:45-48
125. Gilles FH, Leviton A, Kerr CS 1976 Endotoxin leukoencephalopathy in the telencephalon of the newborn kitten. J Neurol Sci 27:183-191
126. Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW 1994 Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856
127. Deguchi K, Mizoguchi M, Takashima S 1996 Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia. Pediatr Neurol 14:13-16
128. Chao CC, Hu S, Sheng WS, Peterson PK 1995 Tumor necrosis factor-α production by human fetal microglial cells: regulation by other cytokines. Dev Neurosci 17:97-105
129. Lee SC, Dickson DW, Liu W, Brosnan CF 1993 Induction of nitric oxide synthase activity in human astrocytcs by interleukin-1β and interferon-γ. J Neuroimmunol 46:19-24
130. Chao CC, Hu S, Ehrlich L, Peterson PK 1995 Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immun 9:355-365
131. Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA 1988 Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest 81:1162-1172
132. Peterson PK, Hu S, Anderson WR, Chao CC 1994 Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J Infect Dis 170:457-460
133. Hattori H, Wasterlain CG 1990 Excitatory amino acids in the developing brain: ontogeny, plasticity, and excitotoxicity. Pediatr Neurol 6:219-228
134. McDonald JW, Johnston MV 1990 Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Brain Res Rev 15:41-70
135. Hagberg H, Gilland E, Bona E, Hanson LÅ, Hahn-Zoric M, Blennow M, Holst M, McRae A, Söder O 1996 Enhanced expression of interleukin (IL)-1 and IL-6 messenger RNA and bioactive protein after hypoxia-ischemia in neonatal rats. Pediatr Res 40:603-609
136. Romero R, Tartakovsky B 1992 The natural interleukin-1 receptor antagonist prevents interleukin-1-induced preterm delivery in mice. Am J Obstet Gynecol 167:1041-1045
137. Shi Y, Li HQ, Chen CK, Wang JH, Pan J, Qin SW, Liu R 1993 Association between protective efficacy of antibodies to tumor necrosis factor and suppression of nitric oxide production in neonatal rats with fatal infection. Pediatr Res 34:345-348
138. Mattsby-Baltzer I, Roseanu A, Motas C, Elverfors J, Engberg I, Hanson LÅ 1996 Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells. Pediatr Res 40:257-262