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Volumn 216, Issue 1-2, 2011, Pages 80-85

Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects

Author keywords

Apoptosis; Autism; Bcl2; Cathepsin D; Cytokines; Inflammation

Indexed keywords

CATHEPSIN D; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 78649525669     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.03.001     Document Type: Article
Times cited : (78)

References (45)
  • 1
    • 0347355175 scopus 로고    scopus 로고
    • Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects
    • Araghi-Niknam M., Fatemi S.H. Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects. Cell. Mol. Neurobiol. 2003, 23:947-951.
    • (2003) Cell. Mol. Neurobiol. , vol.23 , pp. 947-951
    • Araghi-Niknam, M.1    Fatemi, S.H.2
  • 2
    • 33644951883 scopus 로고    scopus 로고
    • Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms
    • Ashwood P., Wakefield A.J. Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J. Neuroimmunol. 2006, 173:126-134.
    • (2006) J. Neuroimmunol. , vol.173 , pp. 126-134
    • Ashwood, P.1    Wakefield, A.J.2
  • 3
    • 33845906332 scopus 로고    scopus 로고
    • Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism
    • Baron C.A., Liu S.Y., Hicks C., Gregg J.P. Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. J. Autism Dev. Disorders 2006, 36:973-982.
    • (2006) J. Autism Dev. Disorders , vol.36 , pp. 973-982
    • Baron, C.A.1    Liu, S.Y.2    Hicks, C.3    Gregg, J.P.4
  • 5
    • 0024405827 scopus 로고
    • The biology of cachectin/TNF-a primary mediator of host response
    • Beutler B., Cerami A. The biology of cachectin/TNF-a primary mediator of host response. Annu. Rev. Immunol. 1989, 7:625-655.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 625-655
    • Beutler, B.1    Cerami, A.2
  • 6
    • 58549086951 scopus 로고    scopus 로고
    • Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
    • Benes F.M., Lim B., Matzilevich D., Subburaju S., Walsh J.P. Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(52):20935-20940.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.52 , pp. 20935-20940
    • Benes, F.M.1    Lim, B.2    Matzilevich, D.3    Subburaju, S.4    Walsh, J.P.5
  • 7
    • 34250731835 scopus 로고    scopus 로고
    • Meantime as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability
    • Chez M.G., Burton Q., Dowling T., Chang M., Khanna P., Kramer C. Meantime as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J. Child Neurol. 2007, 22:574-579.
    • (2007) J. Child Neurol. , vol.22 , pp. 574-579
    • Chez, M.G.1    Burton, Q.2    Dowling, T.3    Chang, M.4    Khanna, P.5    Kramer, C.6
  • 8
    • 41149098534 scopus 로고    scopus 로고
    • Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
    • Conus S., Perozzo R., Reinheckel T., Peters C., Scapozza L., Yousefi S., Simon H.U. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J. Exp. Med. 2008, 205:685-698.
    • (2008) J. Exp. Med. , vol.205 , pp. 685-698
    • Conus, S.1    Perozzo, R.2    Reinheckel, T.3    Peters, C.4    Scapozza, L.5    Yousefi, S.6    Simon, H.U.7
  • 10
    • 0028831202 scopus 로고
    • Identification of a novel serine/threonine kinase and a novel 15-kDa protein as potential mediators of gamma interferon-induced cell death
    • Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A. Identification of a novel serine/threonine kinase and a novel 15-kDa protein as potential mediators of gamma interferon-induced cell death. Genes Dei. 1995, 9:15-30.
    • (1995) Genes Dei. , vol.9 , pp. 15-30
    • Deiss, L.P.1    Feinstein, E.2    Berissi, H.3    Cohen, O.4    Kimchi, A.5
  • 11
    • 0029782494 scopus 로고    scopus 로고
    • Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α
    • Deiss L.P., Galinka H., Berissi H., Cohen O., Kimchi A. Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α. EMBO J. 1996, 15:3861-3870.
    • (1996) EMBO J. , vol.15 , pp. 3861-3870
    • Deiss, L.P.1    Galinka, H.2    Berissi, H.3    Cohen, O.4    Kimchi, A.5
  • 13
    • 0033646608 scopus 로고    scopus 로고
    • Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression
    • Fatemi S.H., Earle J.A., McMenomy T. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatry 2000, 5(6). pp. 654-663, 571.
    • (2000) Mol. Psychiatry , vol.5 , Issue.6 , pp. 654-663
    • Fatemi, S.H.1    Earle, J.A.2    McMenomy, T.3
  • 14
    • 0035892301 scopus 로고    scopus 로고
    • Altered levels of Bcl-2 and P53 proteins in parietal cortex reflect deranged apoptotic regulation in autism
    • Fatemi S.H., Halt A.R. Altered levels of Bcl-2 and P53 proteins in parietal cortex reflect deranged apoptotic regulation in autism. Synapse 2001, 15:281-284.
    • (2001) Synapse , vol.15 , pp. 281-284
    • Fatemi, S.H.1    Halt, A.R.2
  • 16
    • 0035653670 scopus 로고    scopus 로고
    • Genetics of autism: complex aetiology for a heterogeneous disorder
    • Folstein S.E., Rosen-Sheidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nat. Rev. Genet. 2001, 2:943-955.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 943-955
    • Folstein, S.E.1    Rosen-Sheidley, B.2
  • 17
    • 33947246508 scopus 로고    scopus 로고
    • Secretion of cytokines in breast cancer cells: the molecular mechanism of procathepsin D proliferative effects
    • Fusek M., Vetvickova J., Vetvicka V. Secretion of cytokines in breast cancer cells: the molecular mechanism of procathepsin D proliferative effects. J. Interferon Cytokine Res. 2007, 27:191-199.
    • (2007) J. Interferon Cytokine Res. , vol.27 , pp. 191-199
    • Fusek, M.1    Vetvickova, J.2    Vetvicka, V.3
  • 19
    • 0034525374 scopus 로고    scopus 로고
    • The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
    • Harris M.H., Thompson C.B. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ. 2000, 7(12):1182-1191.
    • (2000) Cell Death Differ. , vol.7 , Issue.12 , pp. 1182-1191
    • Harris, M.H.1    Thompson, C.B.2
  • 20
    • 9644295619 scopus 로고    scopus 로고
    • Recurrent mania associated with repeated brain injury
    • Heinrich T.W., Junig J.T. Recurrent mania associated with repeated brain injury. Gen. Hosp. Psychiatry 2004, 26(6):490-492.
    • (2004) Gen. Hosp. Psychiatry , vol.26 , Issue.6 , pp. 490-492
    • Heinrich, T.W.1    Junig, J.T.2
  • 23
    • 0034307192 scopus 로고    scopus 로고
    • Cortical Bcl2 protein expression and apoptotic regulation in schizophrenia
    • Jarskog L.F., Gilmore J.H., Selinger E.S., Lieberman J.A. Cortical Bcl2 protein expression and apoptotic regulation in schizophrenia. Biol. Psychiatry 2000, 48:641-650.
    • (2000) Biol. Psychiatry , vol.48 , pp. 641-650
    • Jarskog, L.F.1    Gilmore, J.H.2    Selinger, E.S.3    Lieberman, J.A.4
  • 24
    • 0034750434 scopus 로고    scopus 로고
    • Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
    • Jyonouchi H., Sun S., Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J. Neuroimmunol. 2001, 120:170-179.
    • (2001) J. Neuroimmunol. , vol.120 , pp. 170-179
    • Jyonouchi, H.1    Sun, S.2    Le, H.3
  • 25
    • 0036970874 scopus 로고    scopus 로고
    • Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder
    • Jyonouchi H., Sun S., Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 2002, 46:76-84.
    • (2002) Neuropsychobiology , vol.46 , pp. 76-84
    • Jyonouchi, H.1    Sun, S.2    Itokazu, N.3
  • 26
    • 0023697978 scopus 로고
    • Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis
    • Laster S.M., Wood J.G., Gooding L.R. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J. Immunol. 1988, 141:2629-2634.
    • (1988) J. Immunol. , vol.141 , pp. 2629-2634
    • Laster, S.M.1    Wood, J.G.2    Gooding, L.R.3
  • 28
    • 71549127208 scopus 로고    scopus 로고
    • BDNF-Akt-Bcl2 anti-apoptotic signaling pathway is compromised in the brain of autistic children
    • Li X., Sheikh A., Chauhan A., Chauhan V., Gong C.X., Liu F., Brown W.T., Malik M. BDNF-Akt-Bcl2 anti-apoptotic signaling pathway is compromised in the brain of autistic children. IMFAR 2009, 2009.
    • (2009) IMFAR , pp. 2009
    • Li, X.1    Sheikh, A.2    Chauhan, A.3    Chauhan, V.4    Gong, C.X.5    Liu, F.6    Brown, W.T.7    Malik, M.8
  • 29
    • 0026584374 scopus 로고
    • In vitro apoptosis in the hepatoma cell line induced by transforming growth factor-beta
    • Lin J.K., Chou C.K. In vitro apoptosis in the hepatoma cell line induced by transforming growth factor-beta. Cancer Res. 1992, 52:385-388.
    • (1992) Cancer Res. , vol.52 , pp. 385-388
    • Lin, J.K.1    Chou, C.K.2
  • 30
    • 0030840917 scopus 로고    scopus 로고
    • CDNAs with long CAG trinucleotide repeats from human brain
    • Margolis R.L. cDNAs with long CAG trinucleotide repeats from human brain. Hum. Genet. 1997, 100:114-122.
    • (1997) Hum. Genet. , vol.100 , pp. 114-122
    • Margolis, R.L.1
  • 32
    • 0022553788 scopus 로고
    • A routine method for the establishment of permanent growing lymphoblastoid cell lines
    • Neitzel H. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum. Genet. 1986, 73(4):320-326.
    • (1986) Hum. Genet. , vol.73 , Issue.4 , pp. 320-326
    • Neitzel, H.1
  • 33
    • 0035021249 scopus 로고    scopus 로고
    • Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation
    • Nelson K.B., Grether J.K., Croen L.A. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann. Neurol. 2001, 49:597-606.
    • (2001) Ann. Neurol. , vol.49 , pp. 597-606
    • Nelson, K.B.1    Grether, J.K.2    Croen, L.A.3
  • 34
    • 0028205312 scopus 로고
    • Environmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis
    • Novelli F., Di Pierro F., Francia di Celle P., Bertini S., Affaticati P., Garotta G., Forni G. Environmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis. J. Immunol. 1994, 152:496-504.
    • (1994) J. Immunol. , vol.152 , pp. 496-504
    • Novelli, F.1    Di Pierro, F.2    Francia di Celle, P.3    Bertini, S.4    Affaticati, P.5    Garotta, G.6    Forni, G.7
  • 35
    • 26044438460 scopus 로고    scopus 로고
    • Actions of TNF-α on glutaminergic synaptic transmission in the central nervous system
    • Pickering M., Cumiskey D., O'Connor J.J. Actions of TNF-α on glutaminergic synaptic transmission in the central nervous system. Exp. Physiol. 2005, 90:663-670.
    • (2005) Exp. Physiol. , vol.90 , pp. 663-670
    • Pickering, M.1    Cumiskey, D.2    O'Connor, J.J.3
  • 36
    • 0022927903 scopus 로고
    • Immunolocalization of cathepsin D in normal and neoplastic human tissues
    • Reid W.A., Valler M.J., Kay J. Immunolocalization of cathepsin D in normal and neoplastic human tissues. J. Clin. Pathol. 1986, 39:1323-1330.
    • (1986) J. Clin. Pathol. , vol.39 , pp. 1323-1330
    • Reid, W.A.1    Valler, M.J.2    Kay, J.3
  • 37
    • 0022572835 scopus 로고
    • Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report
    • Ritvo E.R., Freeman B.J., Schweibel A.B., Duong T., Robinson H., Guthrie D., Ritvo A. Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report. Am. J. Psychiatry 1986, 143:862-866.
    • (1986) Am. J. Psychiatry , vol.143 , pp. 862-866
    • Ritvo, E.R.1    Freeman, B.J.2    Schweibel, A.B.3    Duong, T.4    Robinson, H.5    Guthrie, D.6    Ritvo, A.7
  • 38
    • 0029083689 scopus 로고
    • Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
    • Saftig P., Hetman M., Schmahl W., Weber K., Heine L., Peters C. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J. 1995, 14:3599-3608.
    • (1995) EMBO J. , vol.14 , pp. 3599-3608
    • Saftig, P.1    Hetman, M.2    Schmahl, W.3    Weber, K.4    Heine, L.5    Peters, C.6
  • 39
    • 0029946317 scopus 로고    scopus 로고
    • Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism
    • Singh V.K. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J. Neuroimmunol. 1996, 66:143-145.
    • (1996) J. Neuroimmunol. , vol.66 , pp. 143-145
    • Singh, V.K.1
  • 40
    • 0028097822 scopus 로고
    • Purification and characterization of the Fas-ligand that induces apoptosis
    • Suda T., Nagata S. Purification and characterization of the Fas-ligand that induces apoptosis. J. Exp. Med. 1994, 179:873-879.
    • (1994) J. Exp. Med. , vol.179 , pp. 873-879
    • Suda, T.1    Nagata, S.2
  • 42
  • 43
    • 0020522838 scopus 로고
    • The distribution of cathepsin D in rat tissues determined by immunocytochemistry
    • Whitaker J.N., Rhodes R.H. The distribution of cathepsin D in rat tissues determined by immunocytochemistry. Am. J. Anat. 1983, 166:417-428.
    • (1983) Am. J. Anat. , vol.166 , pp. 417-428
    • Whitaker, J.N.1    Rhodes, R.H.2
  • 45
    • 56649123313 scopus 로고    scopus 로고
    • Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy
    • Zheng X., Chu F., Mirkin B.L., Thangirala S., Mousa S.A., Rebbaa A. Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy. Biochim. Biophys. Acta 2008, 1783(12):2294-2300.
    • (2008) Biochim. Biophys. Acta , vol.1783 , Issue.12 , pp. 2294-2300
    • Zheng, X.1    Chu, F.2    Mirkin, B.L.3    Thangirala, S.4    Mousa, S.A.5    Rebbaa, A.6


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