TNF-alpha polymorphisms are associated with obsessive-compulsive disorder

Neuroscience Letters

Volumn 442, Issue 2, 2008, Pages 86-90

  Hounie, Ana Gabriela ^a   Cappi, Carolina ^a   Cordeiro, Quirino ^a   Sampaio, Aline Santos ^a   Moraes, Ivanil ^a   Rosário, Maria Conceição do ^a,e   Palácios, Selma A ^b   Goldberg, Anna Carla ^b   Vallada, Homero Pinto ^a   Machado Lima, Ariane ^a,c   Nakano, Eduardo ^a,c   Kalil, Jorge ^b   Pauls, David ^d   Pereira, Carlos Alberto B ^c   Guilherme, Luiza ^b   Miguel, Eurípedes Constantino ^a  

^a Clinical Hospital   (Brazil)

^b Section of Pediatric Urology   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d HARVARD MEDICAL SCHOOL   (United States)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Autoimmune; Case control study; Cytokine; Molecular genetics; Rheumatic fever

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BRAZIL; CYTOKINE PRODUCTION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; OBSESSIVE COMPULSIVE DISORDER; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; RHEUMATIC FEVER; STATISTICAL SIGNIFICANCE;

ADULT; BRAZIL; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48149113611     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.07.022     Document Type: Article

References (53)

1. Alvarenga P.G., Hounie A.G., Mercadante M.T., Diniz J.B., Vasconcelos M.S., Spina G., and Miguel E.C. Obsessive-compulsive symptoms in heart disease patients with and without history of rheumatic fever. J. Neuropsychiatry Clin. Neurosci. 18 3 (2006) 405-408
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. fourth edition (1994), American Psychiatric Association, Washington, DC p. 886
3. Balkwill F.R., and Burke F. The cytokine network. Immunol. Today 10 9 (1989) 299-304
4. Bayley J.P., de Rooij H., van den Elsen P.J., Huizinga T.W., and Verweij C.L. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine 14 (2001) 316-323
5. Berdeli A., Tabel Y., Celik H.A., Ozyurek R., Dogrusoz B., and Aydin H.H. Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. Scand. J. Rheumatol. 35 (2006) 44-47
6. Beutler B., and Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu. Rev. Immunol. 7 (1989) 625-655
7. Brambilla F., Perna G., Bellodi L., Arancio C., Bertani A., Perini G., Carraro C., and Gava F. Plasma interleukin-1 beta and tumor necrosis factor concentrations in obsessive-compulsive disorders. Biol. Psychiatry 42 11 (1997) 976-981
8. Brebner K., Hayley S., Zacharko R., Merali Z., and Anisman H. Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology 22 6 (2000) 566-580
9. Brinkman B.M., Zuijdeest D., Kaijzel E.L., Breedveld F.C., and Verweij C.L. Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation. J. Inflamm. 46 (1995) 32-41
10. Carpenter L.L., Heninger G.R., McDougle C.J., Tyrka A.R., Epperson C.N., and Price L.H. Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res. 112 3 (2002) 257-262
11. Denys D., Fluitman S., Kavelaars A., Heijnen C., and Westenberg H. Decreased TNF-alpha NK activity in obsessivecompulsive disorder. Psychoneuroendocrinology 29 7 (2004) 945-952
12. Drouet C., Shakhov A.N., and Jongeneel C.V. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages. J. Immunol. 147 (1991) 1694-1700
13. Duan S., Xu Y., Chen W., Liu Z., Guo T., Gao J., Bian L., Zhen Y., Li X., Zhang X., Pan Y., Gu N., Feng G., and He L. No association between the promoter variants of tumor necrosis factor alpha (TNF-alpha) and schizophrenia in Chinese Han population. Neurosci. Lett. 366 2 (2004) 139-143
14. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 (2003) 115-221
15. Fong C.L., Siddiqui A.H., and Mark D.F. Identification and characterization of a novel repressor site in the human tumor necrosis factor alpha gene. Nucl. Acids Res. 22 (1994) 1108-1114
16. Guilherme L., Ramasawmy R., and Kalil J. Rheumatic fever and rheumatic heart disease: genetics and pathogenesis. Scand. J. Immunol. 66 2-3 (2007) 199-207
17. Haddy N., Sass C., Maumus S., Marie B., Droesch S., Siest G., Lambert D., and Visvikis S. Biological variations, genetic polymorphisms and familial resemblance of TNF-alpha and IL-6 concentrations: STANISLAS cohort. Eur. J. Hum. Genet. 13 (2005) 109-117
18. Handoko H.Y., Nancarrow D.J., Hayward N.K., Ohaeri J.U., Aghanwa H., McGrath J.J., Levinson D.F., Johns C., Walters M.K., Nertney D.A., Srinivasan T.N., Thara R., and Mowry B.J. Tumor necrosis factor haplotype analysis amongst schizophrenia probands from four distinct populations in the Asia-Pacific region. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 121 1 (2003) 1-6
19. Hemmings M.J., and Stein D.J. The current status of association studies in obsessive-compulsive disorder. Psychiatr. Clin. N. Am. 29 (2006) 411-444
20. Hernandez-Pacheco G., Flores-Dominguez C., Rodriguez-Perez J.M., Perez-Hernandez N., Fragoso J.M., Saul A., Alvarez-Leon E., Granados J., Reyes P.A., and Vargas-Alarcon G. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease. J. Autoimmun. 21 (2003) 59-63
21. Hounie A.G., Pauls D.L., do Rosario-Campos M.C., Mercadante M.T., Diniz J.B., De Mathis M.A., De Mathis M.E., Chacon P., Shavitt R.G., Curi M., Guilherme L., and Miguel E.C. Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. Biol. Psychiatry 61 3 (2007) 266-272
22. Hounie A.G., Pauls D.L., Mercadante M.T., Rosario-Campos M.C., Shavitt R.G., de Mathis M.A., de Alvarenga P.G., Curi M., and Miguel E.C. Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea. J. Clin. Psychiatry 65 7 (2004) 994-999
23. Jun T.Y., Pae C.U., Hoon-Han J.H., Chae W.M., Bahk K.S., Kim A., and Serretti. Possible association between-G308A tumor necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. Psychiatr. Genet. 13 3 (2003) 178-179
24. Jun T.Y., Pae C.U., Chae J.H., Bahk W.M., Kim K.S., Pyo C.W., and Han H. Tumor necrosis factor-beta gene polymorphism may not be associated with major depressive disorder in the Korean population. Psychiatry Clin. Neurosci. 57 1 (2003) 31-35
25. Kaluza W., Reuss E., Grossmann S., Hug R., Schopf R.E., Galle P.R., Hermann M.E., and Hoehler T. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism. J. Invest. Dermatol. 114 (2000) 1180-1183
26. Konuk N., Teki{dotless}n I.O., Ozturk U., Atik L., Atasoy N., Bektas S., and Erdogan A. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Hindawi Publ. Corp. Med. Inflamm. 27 (2007) 1-5
27. Kroeger K.M., Carville K.S., and Abraham L.J. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol. Immunol. 34 (1997) 391-399
28. Luger T.A., and Schwarz T. Evidence for an epidermal cytokine network. J. Invest. Dermatol. 95 Suppl. 6 (1990) 100S-104S
29. McKeigue P.M., Carpenter J.R., Parra E.J., and Shriver M.D. Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African American populations. Ann. Hum. Genet. 64 (2000) 171-186
30. Meira-Lima I.V., Pereira A.C., Mota G.F., Floriano M., Araújo F., Mansur A.J., Krieger J.E., and Vallada H. Analysis of a polymorphism in the promoter region of the tumor necrosis factor alpha gene in schizophrenia and bipolar disorder: further support for an association with schizophrenia. Mol. Psychiatry 8 (2003) 718-720
31. Mercadante M.T., Busatto G.F., Lombroso P.J., Prado H., Rosário-Campos M.C., do Valle R., Marques-Dias M.J., Kiss M.H., Leckman J.F., and Miguel E.C. The psychiatric symptoms of rheumatic fever. Am. J. Psychiatry 157 12 (2000) 2036-2038
32. Migot-Nabias F., Mombo L.E., Luty A.J., Dubois B., Nabias R., Bisseye C., Millet P., Lu C.Y., and Deloron P. Human genetic factors related to susceptibility to mild malaria in Gabon. Genes Immun. 1 (2000) 435-441
33. Miguel E.C., Leckman J.F., Rauch S., do Rosario-Campos M.C., Hounie A.G., Mercadante M.T., Chacon P., and Pauls D.L. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol. Psychiatry 10 3 (2005) 258-275
34. Mittleman B.B., Castellanos F.X., Jacobsen L.K., Rapoport J.L., Swedo S.E., and Shearer G.M. Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J. Immunol. 159 6 (1997) 2994-2999
35. Monteleone P., Catapano F., Fabrazzo M., Tortorella A., and Maj M. Decreased blood levels of tumor necrosis factor alpha in patients with obsessive-compulsive disorder. Neuropsychobiology 37 4 (1998) 182-185
36. Mössner R., Heils A., Stöber G., Okladnova O., Daniel S., and Lesch K.P. Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6. Neurochem. Int. 33 3 (1998) 251-254
37. Ott J. Methods of analysis and resources available for genetic trait mapping. J. Heredity 90 (1999) 68-70
38. Parra F.C., Amado R.C., Lambertucci J.R., Rocha J., Antunes C.M., and Pena S.D. Color and genomic ancestry in Brazilians. Proc. Natl. Acad. Sci. 100 (2003) 177-182
39. Pociot F., D'Alfonso S., Compasso S., Scorz R., and Richiardi P.M. Functional analysis of a new polymorphism in the human TNF alpha gene promoter. Scand. J. Immunol. 42 (1995) 501-504
40. R. Development Core Team, R: A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, 2007, ISBN 3-900051-07-0, URL http://www.R-project.org.
41. Ramasawmy R., Faé K.C., Spina G., Victora G.D., Tanaka A.C., Palácios S.A., Hounie A.G., Miguel E.C., Oshiro S.E., Goldberg A.C., Kalil J., and Guilherme L. Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. Mol. Immunol. 44 8 (2007) 1873-1878
42. Sallakci N., Akcurin G., Koksoy S., Kardelen F., Uguz A., Coskun M., Ertug H., and Yegin O. TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J. Autoimmun. 25 (2005) 150-154
43. Sawada M., Imamura K., and Nagatsu T. Role of cytokines in inflammatory process in Parkinson's disease. J. Neural Transm. Suppl. 70 (2006) 373-381
44. Settin A., Abdel-Hady H., El-Baz R., and Saber I. Gene polymorphisms of TNF-alpha (-308), IL-10(-1082), IL-6(-174), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr. Cardiol. 28 5 (2007) 363-371
45. Suarez-Kurtz G., Vargens D.D., Struchiner C.J., Bastos-Rodrigues L., and Pena S.D. Self-reported skin color genomic ancestry and the distribution of GST polymorphisms. Pharmacogenet. Genom. 17 (2007) 765-771
46. Swedo S.E. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Mol. Psychiatry 7 (2002) S24-S25
47. Szeszko J.S., Howson J.M., Cooper J.D., Walker N.M., Twells R.C., Stevens H.E., Nutland S.L., and Todd J.A. Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing. Diabetes 55 2 (2006) 559-562
48. Uglialoro A.M., Turbay D., Pesavento P.A., Delgado J.C., McKenzie F.E., Gribben J.G., Hartl D., Yunis E.J., and Goldfeld A.E. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-gene promoter. Tissue Antigens 52 (1998) 359-367
49. Westendorp R.G., Langermans J.A., Huizinga T.W., Verweij C.L., and Sturk A. Genetic influence on cytokine production in meningococcal disease. Lancet 349 (1997) 1912-1913
50. Zai G., Arnold P.D., Burroughs E., Richter M.A., and Kennedy J.L. Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder. Psychiatr. Genet. 16 1 (2006) 43-45
51. Zai G., Bezchlibnyk Y.B., Richter M.A., Arnold P., Burroughs E., Barr C.L., and Kennedy J.L. Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 129 1 (2004) 64-68
52. Zohar J., Kennedy J.L., Hollander E., and Koran L.M. Serotonin-1D hypothesis of obsessive-compulsive disorder: an update. J. Clin. Psychiatry 65 Suppl. 14 (2004) 18-21
53. Zúñiga J., Vargas-Alarcón G., Hernández-Pacheco G., Portal-Celhay C., Yamamoto-Furusho J.K., and Granados J. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with systemic lupus erythematosus (SLE). Genes Immun. 2 7 (2001) 363-366