Role of BDNF in bipolar and unipolar disorder: Clinical and theoretical implications

Journal of Psychiatric Research

Volumn 41, Issue 12, 2007, Pages 979-990

  Post, Robert M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

BDNF; Bipolar disorder; Polymorphism; ProBDNF; Unipolar disorder; Val66met; Val66val

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; LITHIUM; MINERALOCORTICOID; PLACEBO; PSYCHOTROPIC AGENT; QUETIAPINE; SEROTONIN UPTAKE INHIBITOR; VALPROIC ACID; VENLAFAXINE;

ALLELE; BIPOLAR DISORDER; COGNITION; CONVULSION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; EARLY INTERVENTION; ENVIRONMENTAL IMPACT; GENETICS; HUMAN; INCIDENCE; MAJOR DEPRESSION; NEUROBIOLOGY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; STIGMA; TREATMENT DURATION; TREATMENT RESPONSE;

ANIMALS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN PRECURSORS;

EID: 34548130153     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.09.009     Document Type: Review

References (132)

1. Altar C.A., Whitehead R.E., Chen R., Wortwein G., and Madsen T.M. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biological Psychiatry 54 (2003) 703-709
2. Aydemir O., Deveci A., and Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Progress in Neuropsychopharmacology & Biological Psychiatry 29 (2005) 261-265
3. Baldessarini R.J., and Tondo L. Does lithium treatment still work? Evidence of stable responses over three decades. Archives of General Psychiatry 57 (2000) 187-190
4. Baldessarini R.J., Tondo L., and Hennen J. Lithium treatment and suicide risk in major affective disorders: update and new findings. Journal of Clinical Psychiatry 64 Suppl. 5 (2003) 44-52
5. Bertolino A., Frye M., Callicott J.H., Mattay V.S., Rakow R., Shelton-Repella J., et al. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biological Psychiatry 53 (2003) 906-913
6. Berton O., McClung C.A., DiLeone R.J., Krishnan V., Renthal W., Russo S.J., et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311 (2006) 864-868
7. Blumberg H.P., Kaufman J., Martin A., Whiteman R., Zhang J.H., Gore J.C., et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry 60 (2003) 1201-1208
8. Bueller J.A., Aftab M., Sen S., Gomez-Hassan D., Burmeister M., and Zubieta J.K. BDNF val(66)met allele is associated with reduced hippocampal volume in healthy subjects. Biological Psychiatry 59 (2006) 812-815
9. Calabrese J.R., Keck Jr. P.E., Macfadden W., Minkwitz M., Ketter T.A., Weisler R.H., et al. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. American Journal of Psychiatry 162 (2005) 1351-1360
10. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
11. Castren E. Neurotrophic effects of antidepressant drugs. Current Opinion in Pharmacology 4 (2004) 58-64
12. Cavazos J.E., Golarai G., and Sutula T.P. Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence. Journal of Neuroscience 11 (1991) 2795-2803
13. Chang K., Adleman N., Dienes K., Barnea-Goraly N., Reiss A., and Ketter T. Decreased N-acetylaspartate in children with familial bipolar disorder. Biological Psychiatry 53 (2003) 1059-1065
14. Chen R.W., and Chuang D.M. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. Journal of Biological Chemistry 274 (1999) 6039-6042
15. Chen G., Zeng W.Z., Yuan P.X., Huang L.D., Jiang Y.M., Zhao Z.H., et al. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Journal of Neurochemistry 72 (1999) 879-882
16. Chen G., Rajkowska G., Du F., Seraji-Bozorgzad N., and Manji H.K. Enhancement of hippocampal neurogenesis by lithium. Journal of Neurochemistry 75 (2000) 1729-1734
17. Chen B., Dowlatshahi D., MacQueen G.M., Wang J., and Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biological Psychiatry 50 (2001) 260-265
18. Chuang D.M., Chen R.W., Chalecka-Franaszek E., Ren M., Hashimoto R., Senatorov V., et al. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disorders 4 (2002) 129-136
19. Cunha A.B., Frey B.N., Andreazza A.C., Goi J.D., Rosa A.R., Goncalves C.A., et al. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neuroscience Letters 398 (2006) 215-219
20. Demyttenaere K., Bruffaerts R., Posada-Villa J., Gasquet I., Kovess V., Lepine J.P., et al. Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA 291 (2004) 2581-2590
21. Dowlatshahi D., MacQueen G., Wang J.F., Chen B., and Young L.T. Increased hippocampal supragranular Timm staining in subjects with bipolar disorder. NeuroReport 11 (2000) 3775-3778
22. Drevets W.C., Ongur D., and Price J.L. Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders. Molecular Psychiatry 3 (1998) 220-221
23. Duman R.S. Novel therapeutic approaches beyond the serotonin receptor. Biological Psychiatry 44 (1998) 324-335
24. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
25. Einat H., Yuan P., Gould T.D., Li J., Du J., Zhang L., et al. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. Journal of Neuroscience 23 (2003) 7311-7316
26. Eisch A.J., Bolanos C.A., de Wit J., Simonak R.D., Pudiak C.M., Barrot M., et al. Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biological Psychiatry 54 (2003) 994-1005
27. Fanous A.H., Neale M.C., Straub R.E., Webb B.T., O'Neill A.F., Walsh D., et al. Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. American Journal of Medical Genetics 125B (2004) 69-78
28. Garno J.L., Goldberg J.F., Ramirez P.M., and Ritzler B.A. Impact of childhood abuse on the clinical course of bipolar disorder. British Journal of Psychiatry 186 (2005) 121-125
29. Geller B., Badner J.A., Tillman R., Christian S.L., Bolhofner K., and Cook Jr. E.H. Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. American Journal of Psychiatry 161 (2004) 1698-1700
30. Glitz D.A., Manji H.K., and Moore G.J. Mood disorders: treatment-induced changes in brain neurochemistry and structure. Semin Clin Neuropsychiatry 7 (2002) 269-280
31. Goddard G.V., and Douglas R.M. Does the engram of kindling model the engram of normal long term memory?. Canadian Journal of Neurological Sciences 2 (1975) 385-394
32. Golarai G., and Sutula T.P. Functional alterations in the dentate gyrus after induction of long-term potentiation, kindling, and mossy fiber sprouting. Journal of Neurophysiology 75 (1996) 343-353
33. Gonul A.S., Akdeniz F., Taneli F., Donat O., Eker C., and Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. European Archives of Psychiatry and Clinical Neuroscience 255 (2005) 381-386
34. Goodwin F.K., and Jamison K.R. Manic-depressive illness (1990), Springer, New York
35. Green E., and Craddock N. Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications. Current Psychosis and Therapeutics Reports 2 (2005) 153-159
36. Green E.K., Raybould R., MacGregor S., Hyde S., Young A.H., O'Donovan M.C., et al. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. British Journal of Psychiatry 188 (2006) 21-25
37. Hall D., Dhilla A., Charalambous A., Gogos J.A., and Karayiorgou M. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. American Journal of Human Genetics 73 (2003) 370-376
38. Hao Y., Creson T., Zhang L., Li P., Du F., Yuan P., et al. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. Journal of Neuroscience 24 (2004) 6590-6599
39. Hariri A.R., Goldberg T.E., Mattay V.S., Kolachana B.S., Callicott J.H., Egan M.F., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. Journal of Neuroscience 23 (2003) 6690-6694
40. Hashimoto K., Shimizu E., and Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Research, Brain Research Reviews 45 (2004) 104-114
41. He X.P., Kotloski R., Nef S., Luikart B.W., Parada L.F., and McNamara J.O. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron 43 (2004) 31-42
42. Hempstead B.L. The many faces of p75NTR. Current Opinion in Neurobiology 12 (2002) 260-267
43. Hirschfeld R.M., Lewis L., and Vornik L.A. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. Journal of Clinical Psychiatry 64 (2003) 161-174
44. Hirschfeld R.M., Weisler R.H., Raines S., and Macfadden W. Quetiapine in the treatment of anxiety in patients with bipolar I or II depression: A secondary analysis from a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychiatry 67 (2006) 355-362
45. Hong C.J., Huo S.J., Yen F.C., Tung C.L., Pan G.M., and Tsai S.J. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 8 (2003) 186-189
46. Huot R.L., Thrivikraman K.V., Meaney M.J., and Plotsky P.M. Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment. Psychopharmacology (Berlin) 158 (2001) 366-373
47. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., and Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Research 109 (2002) 143-148
48. Kaufman J., Plotsky P.M., Nemeroff C.B., and Charney D.S. Effects of early adverse experiences on brain structure and function: clinical implications. Biological Psychiatry 48 (2000) 778-790
49. Kaufman J., Yang B.Z., Douglas-Palumberi H., Grasso D., Lipschitz D., Houshyar S., et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry 59 (2006) 673-680
50. Kendler K.S., Thornton L.M., and Gardner C.O. Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis. American Journal of Psychiatry 157 (2000) 1243-1251
51. Ketter T.A., George M.S., Kimbrell T.A., Benson B.E., and Post R.M. Functional brain imaging in mood and anxiety disorders. Current Review of Mood and Anxiety Disorders 1 (1997) 95-112
52. Ketter T.A., Kimbrell T.A., George M.S., Dunn R.T., Speer A.M., Benson B.E., et al. Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biological Psychiatry 49 (2001) 97-109
53. Koizumi H., Hashimoto K., Itoh K., Nakazato M., Shimizu E., Ohgake S., et al. Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders. American Journal of Medical Genetics B, Neuropsychiatry Genetics 127 (2004) 125-127
54. Korte M., Carroll P., Wolf E., Brem G., Thoenen H., and Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America 92 (1995) 8856-8860
55. Kuma H., Miki T., Matsumoto Y., Gu H., Li H.P., Kusaka T., et al. Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus. Neuroscience Letters 372 (2004) 68-73
56. Kunugi H., Iijima Y., Tatsumi M., Yoshida M., Hashimoto R., Kato T., et al. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biological Psychiatry 56 (2004) 376-378
57. Ladd C.O., Huot R.L., Thrivikraman K.V., Nemeroff C.B., Meaney M.J., and Plotsky P.M. Long-term behavioral and neuroendocrine adaptations to adverse early experience. Progress in Brain Research 122 (2000) 81-103
58. Lang U.E., Hellweg R., and Gallinat J. BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 29 (2004) 795-798
59. Lapalme M., Hodgins S., and LaRoche C. Children of parents with bipolar disorder: a metaanalysis of risk for mental disorders. Canadian Journal of Psychiatry 42 (1997) 623-631
60. Lee R., Kermani P., Teng K.K., and Hempstead B.L. Regulation of cell survival by secreted proneurotrophins. Science 294 (2001) 1945-1948
61. Lee J., Duan W., and Mattson M.P. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. Journal of Neurochemistry 82 (2002) 1367-1375
62. Leverich G.S., and Post R.M. Course of bipolar illness after history of childhood trauma. Lancet 367 (2006) 1040-1042
63. Leverich GS, Post RM, Keck Jr PE, Altshuler LL, Frye MA, Kupka RW, et al. The poor prognosis of childhood-onset bipolar disorder: The need for earlier recognition and treatment. Journal of Pediatrics [in press].
64. Leverich G.S., McElroy S.L., Suppes T., Keck Jr. P.E., Denicoff K.D., Nolen W.A., et al. Early physical and sexual abuse associated with an adverse course of bipolar illness. Biological Psychiatry 51 (2002) 288-297
65. Leverich G.S., Perez S., Luckenbaugh D.A., and Post R.M. Early psychosocial stressors: relationship to suicidality and course of bipolar illness. Clinical Neuroscience Research 2 (2002) 161-170
66. Leverich G.S., Altshuler L.L., Frye M.A., Suppes T., Keck P.E., McElroy S.L., et al. Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network. Journal of Clinical Psychiatry 64 (2003) 506-515
67. Linnarsson S., Bjorklund A., and Ernfors P. Learning deficit in BDNF mutant mice. European Journal of Neuroscience 9 (1997) 2581-2587
68. Lohoff F.W., Sander T., Ferraro T.N., Dahl J.P., Gallinat J., and Berrettini W.H. Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. American Journal of Medical Genetics B, Neuropsychiatry Genetics 139 (2005) 51-53
69. Lyons W.E., Mamounas L.A., Ricaurte G.A., Coppola V., Reid S.W., Bora S.H., et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 15239-15244
70. Machado-Vieira R, Dietrich MO, Leke R, Cereser VH, Zanatto V, Kapczinski F, Souza DO, Portela LV, Gentil V. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biological Psychiatry [in press].
71. Malberg J.E., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience 20 (2000) 9104-9110
72. Malenka R.C. LTP and LTD: dynamic and interactive processes of synaptic plasticity. The Neuroscientist 1 (1995) 35-42
73. Manji H.K., Moore G.J., and Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biological Psychiatry 48 (2000) 740-754
74. Manji H.K., Moore G.J., Rajkowska G., and Chen G. Neuroplasticity and cellular resilience in mood disorders. Mol Psychiatry 5 (2000) 578-593
75. Mathews C.A., and Reus V.I. Genetic linkage in bipolar disorder. CNS Spectr. 8 (2003) 891-904
76. Moffitt T.E., Caspi A., and Rutter M. Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62 (2005) 473-481
77. Monkul E.S., Malhi G.S., and Soares J.C. Mood disorders - review of structural MRI studies. Acta Neuropsychiatrica 15 (2003) 368-380
78. Moore G.J., Bebchuk J.M., Hasanat K., Chen G., Seraji-Bozorgzad N., Wilds I.B., et al. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?. Biological Psychiatry 48 (2000) 1-8
79. Moore G.J., Bebchuk J.M., Wilds I.B., Chen G., and Manji H.K. Lithium-induced increase in human brain grey matter. Lancet 356 (2000) 1241-1242
80. Muller M.B., Toschi N., Kresse A.E., Post A., and Keck M.E. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacology 23 (2000) 205-215
81. Muller D.J., De Luca V., and Sicard T. The brain derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder. Br J Psychiatry 189 (2006) 317-323
82. Muller-Oerlinghausen B., Berghofer A., and Ahrens B. The antisuicidal and mortality-reducing effect of lithium prophylaxis: consequences for guidelines in clinical psychiatry. Canadian Journal of Psychiatry 48 (2003) 433-439
83. Nakata K., Ujike H., Sakai A., Uchida N., Nomura A., Imamura T., et al. Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neuroscience Letters 337 (2003) 17-20
84. Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., and Kennedy J.L. The brain-derived neurotrophic factor ene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71 (2002) 651-655
85. Neves-Pereira M., Cheung J.K., Pasdar A., Zhang F., Breen G., Yates P., et al. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10 (2005) 208-212
86. Nibuya M., Morinobu S., and Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. Journal of Neuroscience. 15 (1995) 7539-7547
87. Nolen W.A., Luckenbaugh D.A., Altshuler L.L., Suppes T., McElroy S.L., Frye M.A., et al. Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. American Journal of Psychiatry 161 (2004) 1447-1454
88. Nykjaer A., Lee R., Teng K.K., Jansen P., Madsen P., Nielsen M.S., et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature 427 (2004) 843-848
89. Pagnin D., De Q V., Pini S., and Cassano G.B. Efficacy of ECT in depression: a meta-analytic review. J ECT. 20 (2004) 13-20
90. Patapoutian A., and Reichardt L.F. Trk receptors: mediators of neurotrophin action. Current Opinion in Neurobiology 11 (2001) 272-280
91. Paykel E.S. Life events and affective disorders. Acta Psychiatrica Scand Suppl (2003) 61-66
92. Perlis R.H., Miyahara S., Marangell L.B., Wisniewski S.R., Ostacher M., DelBello M.P., et al. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry 55 (2004) 875-881
93. Pezawas L., Verchinski B.A., Mattay V.S., Callicott J.H., Kolachana B.S., Straub R.E., et al. The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. Journal of Neuroscience 24 (2004) 10099-10102
94. Plotsky P.M., and Meaney M.J. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Mol Brain Res 18 (1993) 195-200
95. Post R.M. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. American Journal of Psychiatry 149 (1992) 999-1010
96. Post R.M. Neural substrates of psychiatric syndromes. In: Mesulam M.M. (Ed). Principles of Behavioral and Cognitive Neurology. second ed. (2000), Oxford University Press, New York 406-438
97. Post R.M., Denicoff K.D., Leverich G.S., Altshuler L.L., Frye M.A., Suppes T.M., et al. Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH Life Chart Method. Journal of Clinical Psychiatry 64 (2003) 680-690
98. Post R.M., Speer A.M., Hough C.J., and Xing G. Neurobiology of bipolar illness: implications for future study and therapeutics. Ann Clin Psychiatry 15 (2003) 85-94
99. Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biological Psychiatry 48 (2000) 766-777
100. Ren-Patterson R.F., Cochran L.W., Holmes A., Sherrill S., Huang S.J., Tolliver T., et al. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. Journal of Neuroscience Res. 79 (2005) 756-771
101. Ribases M., Gratacos M., Armengol L., de Cid R., Badia A., Jimenez L., et al. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry 8 (2003) 745-751
102. Ribases M., Gratacos M., Fernandez-Aranda F., Bellodi L., Boni C., Anderluh M., et al. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet 13 (2004) 1205-1212
103. Roceri M., Hendriks W., Racagni G., Ellenbroek B.A., and Riva M.A. Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol Psychiatry 7 (2002) 609-616
104. Roceri M., Cirulli F., Pessina C., Peretto P., Racagni G., and Riva M.A. Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Biological Psychiatry 55 (2004) 708-714
105. Russo-Neustadt A. Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders. Semin Clin Neuropsychiatry 8 (2003) 109-118
106. Russo-Neustadt A., Ha T., Ramirez R., and Kesslak J.P. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res 120 (2001) 87-95
107. Rybakowski J.K., Borkowska A., Czerski P.M., Skibinska M., and Hauser J. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 5 (2003) 468-472
108. Saarelainen T., Hendolin P., Lucas G., Koponen E., Sairanen M., MacDonald E., et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. Journal of Neuroscience 23 (2003) 349-357
109. Sassi R.B., Brambilla P., Hatch J.P., Nicoletti M.A., Mallinger A.G., Frank E., et al. Reduced left anterior cingulate volumes in untreated bipolar patients. Biological Psychiatry 56 (2004) 467-475
110. Sheline Y.I., Gado M.H., and Kraemer H.C. Untreated depression and hippocampal volume loss. American Journal of Psychiatry 160 (2003) 1516-1518
111. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biological Psychiatry 54 (2003) 70-75
112. Shirayama Y., Chen A.C., Nakagawa S., Russell D.S., and Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience 22 (2002) 3251-3261
113. Siuciak J.A., Lewis D.R., Wiegand S.J., and Lindsay R.M. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56 (1997) 131-137
114. Skibinska M., Hauser J., Czerski P.M., Leszczynska-Rodziewicz A., Kosmowska M., Kapelski P., et al. Association analysis of brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in schizophrenia and bipolar affective disorder. World J Biological Psychiatry 5 (2004) 215-220
115. Sklar P., Gabriel S.B., McInnis M.G., Bennett P., Lim Y.M., Tsan G., et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 7 (2002) 579-593
116. Smith M.A., Makino S., Kim S.Y., and Kvetnansky R. Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology 136 (1995) 3743-3750
117. Smith M.A., Makino S., Kvetnansky R., and Post R.M. Effects of stress on neurotrophic factor expression in the rat brain. Ann NY Acad Sci. 771 (1995) 234-239
118. Smith M.A., Makino S., Kvetnansky R., and Post R.M. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Journal of Neuroscience 15 (1995) 1768-1777
119. Strakowski S.M., DelBello M.P., and Adler C.M. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Molecular Psychiatry 10 (2005) 105-116
120. Strauss J., Barr C.L., George C.J., King N., Shaikh S., Devlin B., et al. Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder. American Journal of Medical Genetics B, Neuropsychiatry Genetics 131 (2004) 16-19
121. Tsai S.J. Is mania caused by overactivity of central brain-derived neurotrophic factor?. Medical Hypotheses 62 (2004) 19-22
122. Tsai S.J., Hong C.J., Yu Y.W., and Chen T.J. Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 49 (2004) 13-16
123. Tsankova N.M., Berton O., Renthal W., Kumar A., Neve R.L., and Nestler E.J. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neuroscience 9 (2006) 519-525
124. Tsuchiya K.J., Agerbo E., and Mortensen P.B. Parental death and bipolar disorder: a robust association was found in early maternal suicide. Journal of Affectective Disorders 86 (2005) 151-159
125. Vaidya V.A., Siuciak J.A., Du F., and Duman R.S. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures. Neuroscience 89 (1999) 157-166
126. Videbech P., and Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. American Journal of Psychiatry 161 (2004) 1957-1966
127. Wang P.S., Berglund P., Olfson M., Pincus H.A., Wells K.B., and Kessler R.C. Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62 (2005) 603-613
128. Winsberg M.E., Sachs N., Tate D.L., Adalsteinsson E., Spielman D., and Ketter T.A. Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biological Psychiatry 47 (2000) 475-481
129. Xing G., Chavko M., Zhang L.X., Yang S., and Post R.M. Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. Schizophrenia Research 58 (2002) 21-30
130. Xu H., Qing H., Lu W., Keegan D., Richardson J.S., Chlan-Fourney J., et al. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neuroscience Letters 321 (2002) 65-68
131. Zanardini R., Gazzoli A., Ventriglia M., Perez J., Bignotti S., Maria R.P., et al. Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. Journal of Affective Disorders 91 (2006) 83-86
132. Zhang L.X., Levine S., Dent G., Zhan Y., Xing G., Okimoto D., et al. Maternal deprivation increases cell death in the infant rat brain. Brain Research, Developmental Brain Research 133 (2002) 1-11