Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder

NeuroImmunoModulation

Volumn 9, Issue 4, 2001, Pages 209-217

  Baker, Dewleen G ^a,c   Ekhator, Nosa N ^a   Kasckow, John W ^a   Hill, Kelly K ^a   Zoumakis, Emmanouil ^b   Dashevsky, Boris A ^a   Chrousos, George P ^b   Geracioti, Jr , Thomas D ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Adrenocorticotropin; Cerebrospinal fluid; Corticotropin releasing hormone; Cortisol; Cytokines; Hypothalamic pituitary adrenocortical axis; Interleukin 6; Norepinephrine; Posttraumatic stress disorder

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; INTERLEUKIN 6; NORADRENALIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NERVE DEGENERATION; NEUROPROTECTION; NORADRENALIN BLOOD LEVEL; NORADRENERGIC SYSTEM; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; SOLDIER;

ADRENOCORTICOTROPIC HORMONE; ADULT; BIOLOGICAL MARKERS; CORTICOTROPIN-RELEASING HORMONE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERLEUKIN-6; MALE; MIDDLE AGED; MILITARY PERSONNEL; NEUROIMMUNOMODULATION; NOREPINEPHRINE; PITUITARY-ADRENAL SYSTEM; PSYCHONEUROIMMUNOLOGY; STRESS DISORDERS, POST-TRAUMATIC; WAR;

EID: 0035722747     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000049028     Document Type: Article

References (126)

1. Immune-neuroendocrine circuits: Integrative role of cytokines
2. 1 Immune-neuroendocrine interactions: Facts and hypotheses
3. Regulation of the HPA axis by cytokines
4. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
5. The pathophysiological roles of interleukin-6 in human disease
6. Pathways and mechanisms for cytokine signaling of the central nervous system
7. Corticotropin-releasing factor producing neurons in the rat activated by interleukin-1
8. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
9. Interleukin-6 stimulates the secretion of adrenocorticotropic, freely-moving rats
10. The effects of recombinant human interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation
11. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans
12. Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man
13. Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men
14. Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression
15. Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge
16. Interactions between cytokines and the hypothalamic-pituitary-adrenal axis during stress
17. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure
18. Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: Dose the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency
19. Exercise stimulates interleukin-6 secretion: Inhibition by glucocorticoids and correlation with catecholamines
20. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia
21. The relation among stress, adrenaline, interleukin-6 and acute phase proteins in the rat
22. Induction of plasma interleukin-6 by circulating adrenaline in the rat
23. Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines
24. Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of the hypothalamic-pituitary-adrenal axis
25. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone
26. Low cerebrospinal fluid corticotropin releasing hormone concentrations in eucortisolemic depression
27. Elevated CSF corticotropin-releasing factor concentration in posttraumatic stress disorder
28. Serial cerebrospinal fluid corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder
29. Cerebrospinal fluid norepinephrine concentrations in post-traumatic stress disorder
30. The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection
31. What is the evidence for a role of cytokines in depression?
32. Interleukin-6 is an essential, corticotropin releasing hormone-independent stimulator of the adrenal axis during immune system activation
33. Modulation by cytokines of glucocorticoid action
34. Central lipolysaccharide elevates plasma IL-6 concentration by an alpha-adrenoreceptor mediated mechanism
35. Central noradrenergic system modulates plasma interleukin-6 production by peripheral interleukin-1
36. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients
37. Central injection of nitric oxide synthase inhibitors increases peripheral interleukin-6 and serum amayloid A: Involvement of adrenaline from adrenal medulla
38. Synergistic effects of interleukin-1β, interleukin-6 and tumor necrosis factor-α: Central monoamine, corticosterone, and behavioral variations
39. Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells
40. The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol and ACTH responses in patients undergoing total abdominal hysterectomy
41. Interleukin-6 in biology and medicine
42. Molecular and cellular biology of interleukin-6 and its receptor
43. Interleukin-6 expression and regulation in astrocytes
44. Phosphorylation of secreted forms of human β2-interferon/hepatocyte-stimulating factor/interleukin-6
45. Novel path to activation of vascular smooth muscle cells: Up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
46. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses
47. Interleukin-6 receptor signaling. II. Bioavailability of interleukin-6 in serum
48. Sympathetic neurons can produce and respond to interleukin 6
49. Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression
50. Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons
51. Expression of immunoregulatory cytokines in neurons of the lateral hypothalamic area and amygdaloid nuclear complex of rats immunized against human IgG
52. Blood interleukin-6 and tumor necrosis factor-alpha elevation after intracerebroventricular injection of Escherichia coliendotoxin in the rat is determined by two opposing factors: Peripheral induction of LPS transferred from brain to blood and inhibition of peripheral response by a brain mediated mechanism
53. Interleukin-1 beta differentially affects interleukin-6 and soluble interleukin-6 receptor in the blood and central nervous system of the monkey
54. Resistance of central nervous system interleukin-6 to glucocorticoid inhibition in monkeys
55. Cerebrospinal fluid cytokine levels after surgery or general anesthesia
56. The organum vasculosum laminae terminalis (OVLT) is critical for fever induced in guinea pigs by blood-borne cytokines
57. Penetration of interleukin-6 across the murine blood-brain barrier
58. Interleukin-1beta in immune cells of the abdominal vagus nerve: A link between the immune and nervous system?
59. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
60. 125I-labeled interleukin-6 from brain into blood following intracerebroventricular injection in rats
61. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
62. Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland
63. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression
64. Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: Comparison between the acute state and after remission
65. Indicators of immune activation in major depression
66. Cytokine production and treatment response in major depressive disorder
67. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: Effects of confounding factors and diagnosis
68. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events
69. Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: No alteration of soluble gp130
70. Cerebrospinal cytokine levels in patients with acute depression
71. The development of a clinician administered PTSD scale
72. Serial cerebrospinal fluid corticotropin-releasing hormone concentrations in healthy and depressed humans
73. Cholecystokinin in human cerebrospinal fluid: Concentration, dynamics, molecular forms, and relationship to fasting and feeding in health, depression and alcoholism
74. Temporary control of cerebrospinal fluid volume and pressure by means of an externalized valve-drainage system
75. Rapid radioimmunoassay for corticotropin releasing factor
76. Qualitative and quantitative high performance liquid chromatographic analysis of monoamine neurotransmitters and metabolites in cerebrospinal fluid and brain tissue using reductive electrochemical detection
77. Time-dependent sensitization of corticotropin-releasing hormone, arginine vasopressin and c-fos immunoreactivity within the mouse brain in response to tumor necrosis factor-alpha
78. Interleukin-6 increases sensitivity to locomotor-stimulating effects of amphetamine in rats
79. Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: A regional microdialysis study
80. An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioral, neurochemical, endocrine and immune parameters in the rat
81. Effects of cytokines on cerebral neurotransmission: Comparison with effects of stress
82. Effects of interleukin-1 beta on sleep are mediated by the type I receptor
83. Humoral regulation of physiological sleep: Cytokines and GHRH
84. Stress, learned helplessness, and brain interleukin-1 beta
85. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
86. Human immunodeficiency virus-1 coat protein gp 120 impairs contextual fear conditioning: A potential role in AIDS related learning and memory impairments
87. Anhedonic and anxiogenic effects of cytokine exposure
88. Endocrine and cytokine corelates of major depression and dysthymia with typical or atypical features
89. Cytokine-associated emotional and cognitive disturbances in humans
90. Relationship between posttraumatic stress disorder and self-reported physical symptoms in Persian gulf war veterans
91. Posttraumatic stress disorder: Somatic comorbidity and effort tolerance
92. Combat exposure, post-traumatic stress disorder symptoms, health behaviors as predictors of self-reported physical health in older veterans
93. Increased interleukin-6 levels in cerebrospinal fluid following subarachnoid hemorrhage
94. Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma
95. Proinflammatory cytokines and early neurological worsening in ischemic stroke
96. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures
97. Inflammatory cytokines IL-1α, IL-1β, IL-6, TBF-α impart neuroprotection to an excitotoxin through distinct pathways
98. Interleukin-6 inhibits neurotransmitter release and the spread excitation in the rat cerebral cortex
99. Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease
100. Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: Finding and clinical implications
101. Low urinary cortisol excretion in patients with posttraumatic stress disorder
102. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder
103. Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis
104. Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder
105. Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle
106. Circadian characteristics of interleukin-6 in blood and urine of clinically healthy men
107. Effects of sleep and circadian rhythm on human circulating immune cells
108. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: Failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis
109. Nocturnal plasma levels of cytokines in healthy men
110. Circadian interrelationships among levels of plasma fibrinogen platelets, and serum interleukin-6
111. Circadian secretions of IL-2, IL-12, IL-6, and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans
112. Diurnal rhythms of proinflammatory cytokines: Regulation of plasma cortisol and therapeutic implications
113. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans
114. Biological variation of interleukin 6 (IL-6) and soluble interleukin 2 receptor (sIL2R) in serum of healthy individuals
115. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men
116. Is depression associated with immune activation?
117. Increase of plasma IL-6 concentration with age in healthy subjects
118. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
119. Short-term variability in the concentration of serum interleukin-6 and its soluble receptor in subjectively healthy persons
120. Age-associated increased interleukin-6, gene expression, late-life diseases, and frailty
121. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
122. Rapid eye movement sleep correlates with the overall activities of the hypothalamic-pituitary-adrenal axis and sympathetic system in healthy humans
123. Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance and hypercytokinemia
124. Chronic systemic inflammation in overweight and obese adults
125. The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man