High nitric oxide production in autistic disorder: A possible role for interferon-γ

Biological Psychiatry

Volumn 55, Issue 4, 2004, Pages 434-437

  Sweeten, Thayne L ^a,b   Posey, David J ^a,b   Shankar, Sudha ^a   McDougle, Christopher J ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b RILEY HOSPITAL FOR CHILDREN   (United States)

Author keywords

Autism; Cytokines; Immunology; Interferon; Nitric oxide; Pathophysiology

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; ENZYME ASSAY; FEMALE; GAS ANALYSIS; HUMAN; IMMUNOREACTIVITY; MALE; NERVE CELL DIFFERENTIATION; NEUROIMMUNOLOGY; PATHOPHYSIOLOGY; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 1042289313     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2003.09.001     Document Type: Article

References (50)

1. Adamson D.C., Wildemann B., Sasaki M., Glass J.D., McArthur J.C., Christov V.I., et al. Immunologic NO synthase Elevation in severe AIDS dementia and induction by HIV-1 gp41 . Science. 274:1996;1917-1921.
2. Diagnostic and Statistical Manual of Mental Disorders. 4th ed :1994;American Psychiatric Association, Washington, DC.
3. Bailey A., Luthert P., Dean A., Harding B., Janota I., Montgomery M., et al. A clinicopathological study of autism. Brain. 121:1998;889-905.
4. Belmont H.M., Levartovsky D., Goel A., Amin A., Giorno R., Rediske J., et al. Increased nitric oxide production accompanied by the up-regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus. Arthritis Rheum. 40:1997;1810-1816.
5. Broadley S.A., Dean J., Sawcer S.J., Clayton D., Compston D.A.S. Autoimmune disease in first-degree relatives of patients with multiple sclerosis. Brain. 123:2000;1102-1111.
6. Brundin L., Svenungsson E., Morcos E., Andersson M., Olsson T., Lundberg I., et al. Central nervous system nitric oxide formation in cerebral systemic lupus erythematosus. Ann Neurol. 44:1998;704-706.
7. Comi A.M., Zimmerman A.W., Frye V.H., Law P.A., Peeden J.N. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol. 14:1999;388-394.
8. Connolly A.M., Chez M.G., Pestronk A., Arnold S.T., Mehta S., Deuel R.K. Serum autoantibodies to brain in Landau-Kleffner variant, autism and other neurologic disorders. J Pediatr. 134:1999;607-613.
9. Croonenberghs J., Bosmans E., Deboutte D., Kenis G., Maes M. Activation of the inflammatory response system in autism. Neuropsychobiology. 45:2002;1-6.
10. Croonenberghs J., Wauters A., Devreese K., Verkerk R., Scharpe S., Bosmans E., et al. Increased serum albumin, gammaglobulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychol Med. 32:2002;1457-1463.
11. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A. 88:1991;6368-6371.
12. Garthwaite J., Garthwaite G., Palmer R.M., Moncada S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol. 172:1989;413-416.
13. Giovannoni G. Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis. Mult Scler. 4:1998;27-30.
14. Giovannoni G., Silver N.C., O'Riordan J., Miller R.F., Heales S.J., Land J.M., et al. Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. Mult Scler. 5:1999;335-341.
15. Gruetter C.A., Barry B.K., McNamara D.B., Gruetter D.Y., Kadowitz P.J., Ignarro L.J. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res. 5:1979;211-224.
16. Guerin P., Lyon G., Barthelemy C., Sostak E., Chevrollier V., Garreau B., et al. Neuropathological study of a case of autistic syndrome with severe mental retardation. Dev Med Child Neurol. 38:1996;203-211.
17. Hess D.T., Patterson S.I., Smith D.S., Skene J.H.P. Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide. Nature. 366:1993;562-565.
18. Hibbs J.B., Taintor R.R., Vavrin Z., Rachlin E.M. Nitric oxide A cytotoxic activated macrophage effector molecule . Biochem Biophys Res Commun. 157:1988;87-94.
19. Hindley S., Juurlink B.H.J., Gysbers J.W., Middlemiss P.J., Herman M.A.R., Rathbone M.P. Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism. J Neurosci Res. 47:1997;427-439.
20. Holscher C., Rose S.P. An inhibitor of nitric oxide synthesis prevents memory formation in the chick. Neurosci Lett. 145:1992;165-167.
21. Huber C., Batchelor J.R., Fuchs D., Hausen A., Lang A., Niederwieser D., et al. Immune response-associated production of neopterin Release from macrophages primarily under control of interferon-gamma . J Exp Med. 160:1984;310-316.
22. Johnson S. Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson's disease? Med Hypotheses. 56:2001;641-645.
23. Jyonouchi H., Sun S., Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 120:2001;170-179.
24. Kilbourn R.G., Belloni P. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer Inst. 82:1990;772-776.
25. Lizasoain I., Weiner C.P., Knowles R.G., Moncada S. The ontogeny of cerebral and cerebellar nitric oxide synthase in the guinea pig and rat. Pediatr Res. 39:1996;779-783.
26. Lombard J. Autism A mitochondrial disorder? Med Hypotheses. 50:1998;497-500.
27. Lonart G., Wang J., Johnson K.M. Nitric oxide induces neurotransmitter release from hippocampal slices. Eur J Pharmacol. 220:1992;271-272.
28. Lord C., Risi S., Lambrecht L., Cook E.H., Leventhal B.L., DiLavore P.C., et al. The Autism Diagnostic Observation Schedule - Generic A standard measure of social and communication deficits associated with the spectrum of autism . J Autism Dev Disord. 30:2000;205-223.
29. Lord C., Rutter M., Le Courteur A. Autism Diagnostic Interview - Revised A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders . J Autism Dev Disord. 24:1994;659-685.
30. Lyons C.R., Orloff G.J., Cunningham J.M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 267:1992;6370-6374.
31. Marletta M.A., Yoon P.S., Iyengar R., Leaf C.D., Wishnok J.S. Macrophage oxidation of L-arginine to nitrite and nitrate Nitric oxide is an intermediate . Biochemistry. 27:1988;8706-8711.
32. Nussler A.K., Di Silvio M., Billiar T.R., Hoffman R.A., Geller D.A., Selby R., et al. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med. 176:1992;261-264.
33. Plioplys A.V., Greaves A., Kazemi K., Silverman E. Immunoglobin reactivity in autism and Rett's syndrome. Dev Brain Dysfunct. 7:1994;12-16.
34. Plioplys A.V., Greaves A., Kazemi K., Silverman E. Lymphocyte function in autism and Rett syndrome. Neuropsychobiology. 29:1994;12-16.
35. Prahalad S., Shear E.S., Thompson S.D., Giannini E.H., Glass D.N. Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis. Arthritis Rheum. 46:2002;1851-1856.
36. Schuman E.M., Madison D.V. A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science. 254:1991;1503-1506.
37. Shibuki K., Okada D. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature. 349:1991;326-328.
38. Simmons M.L., Murphy S. Induction of nitric oxide synthase in glial cells. J Neurochem. 59:1992;897-905.
39. Sögüt S., Zoroglu S.S., Özyurt H., Yilmaz H.R., Özugurlu F., Sivash E., et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clin Chim Acta. 331:2003;111-117.
40. Sweeten T.L., Bowyer S.L., Posey D.J., Halberstadt G.M., McDougle C.J. Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics. 112:2003;e420-e424.
41. Sweeten T.L., Posey D.J., McDougle C.J. High blood monocyte counts and neopterin levels in children with autistic disorder. Am J Psychiatry. 160:2003;1691-1693.
42. Tanaka R., Iwasaki Y., Koprowski H. Ultrastructural studies of perivascular cuffing cells in multiple sclerosis brain. Am J Pathol. 81:1975;467-478.
43. Torres A.R., Maciulis A., Stubbs E.G., Cutler A., Odell D. The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder. Hum Immunol. 63:2002;311-316.
44. Truman J.W., De Vente J., Ball E.E. Nitric oxide-sensitive guanylate cyclase activity is associated with the maturational phase of neuronal development in insects. Development. 122:1996;3949-3958.
45. Warren R.P., Margaretten N.C., Pace N.C., Foster A. Immune abnormalities in patients with autism. J Autism Dev Disord. 16:1986;189-197.
46. Warren R.P., Singh V.K., Cole P., Odell J.D., Pingree C.B., Warren W.L., et al. Increased frequency of the null allele at the complement C4b locus in autism. Clin Exp Immunol. 83:1991;438-440.
47. Warren R.P., Yonk J., Burger R.W., Odell D., Warren W.L. DR-positive T cells in autism Association with decreased plasma levels of the complement C4B protein . Neuropsychobiology. 31:1995;53-57.
48. Zangerle R., Fuchs D., Reibnegger G., Werner-Felmayer G., Gallati H., Wachter H., et al. Serum nitrite plus nitrate in infection with human immunodeficiency virus type-1. Immunobiology. 193:1995;59-70.
49. Zhu X.Z., Luo L.G. Effect of nitroprusside (nitric oxide) on endogenous dopamine release from rat striatal slices. J Neurochem. 59:1992;932-935.
50. Zoroglu S.S., Yürekli M., Meram I., Söggüt S., Tutkun H., Özer Y., et al. Pathophysiological role of nitric oxide and adrenomedullin in autism. Cell Biochem Funct. 21:2003;55-60.