MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5184-5198

  Long, Justin M ^a   Ray, Balmiki ^a   Lahiri, Debomoy K ^a,b  

^a Institute of Psychiatric Research   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; ENZYMES; GLYCOPROTEINS;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BRAIN TISSUE; DRUG TARGETS; HUMAN BRAIN; PROTEIN EXPRESSIONS; RATE-LIMITING ENZYMES;

PROTEINS;

AMYLOID BETA PROTEIN; BETA SECRETASE 1; MICRORNA; MICRORNA 339 5P; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FETUS; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; RNA ANALYSIS; VALIDATION PROCESS; VERY ELDERLY;

AGING; ALZHEIMER DISEASE; DEMENTIA; GENE REGULATION; HUMAN BRAIN TISSUE; HUMAN NEURON; MICRORNA; NONCODING RNA; SECRETASES; Β-PEPTIDE;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ARGONAUTE PROTEINS; ASPARTIC ACID ENDOPEPTIDASES; BASE SEQUENCE; BRAIN; CELL LINE, TUMOR; CELL SHAPE; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DEMOGRAPHY; DOWN-REGULATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICRORNAS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 84894450407     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.518241     Document Type: Article

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