메뉴 건너뛰기




Volumn 76, Issue , 2014, Pages 535-559

Glucagon-like peptide-1: Glucose homeostasis and beyond

Author keywords

Diabetes mellitus; Dipeptidyl peptidase 4 inhibitor; Glucose metabolism; Incretin

Indexed keywords

ANIMALS; BIOMIMETICS; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HOMEOSTASIS; HUMANS; PANCREAS;

EID: 84894148643     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021113-170315     Document Type: Review
Times cited : (141)

References (161)
  • 1
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • McIntyre N, Holdsworth CD, Turner DS. 1964. New interpretation of oral glucose tolerance. Lancet 2:20-211
    • (1964) Lancet , vol.2 , pp. 20-211
    • McIntyre, N.1    Holdsworth, C.D.2    Turner, D.S.3
  • 2
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, et al. 1986. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J. Clin. Endocrinol. Metab. 63:492-988
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 492-988
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3    Allen, R.C.4    Eaton, R.P.5
  • 6
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre J, Ross SA, Watson D, Brown JC. 1973. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J. Clin. Endocrinol. Metab. 37:826-288
    • (1973) J. Clin. Endocrinol. Metab. , vol.37 , pp. 826-288
    • Dupre, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 8
    • 0018758893 scopus 로고
    • The incretin concept today
    • CreutzfeldtW. 1979. The incretin concept today. Diabetologia 16:75-855
    • (1979) Diabetologia , vol.16 , pp. 75-855
    • Creutzfeldt, W.1
  • 9
    • 84864479943 scopus 로고    scopus 로고
    • Targeting the glucagon receptor family for diabetes and obesity therapy
    • Cho YM, Merchant CE, Kieffer TJ. 2012. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacol. Ther. 135:247-788
    • (2012) Pharmacol. Ther. , vol.135 , pp. 247-788
    • Cho, Y.M.1    Merchant, C.E.2    Kieffer, T.J.3
  • 10
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired β-cell function?
    • Meier JJ, Nauck MA. 2010. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired β-cell function? Diabetes 59:1117-255
    • (2010) Diabetes , vol.59 , pp. 1117-1255
    • Meier, J.J.1    Ma, N.2
  • 11
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. 1993. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J. Clin. Investig. 91:301-77
    • (1993) J. Clin. Investig. , vol.91 , pp. 301-377
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 12
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes:What is up, what is down?
    • Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ. 2011. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes:What is up, what is down? Diabetologia 54:10-188
    • (2011) Diabetologia , vol.54 , pp. 10-188
    • Nauck, M.A.1    Vardarli, I.2    Deacon, C.F.3    Holst, J.J.4    Meier, J.J.5
  • 13
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen K, Christensen LL, Holst JJ, Orskov C. 2003. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul. Pept. 114:189-966
    • (2003) Regul. Pept. , vol.114 , pp. 189-966
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 14
    • 53149095439 scopus 로고    scopus 로고
    • Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells
    • Fujita Y, Chui JW, King DS, Zhang T, Seufert J, et al. 2008. Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells. Am. J. Physiol. Endocrinol. Metab. 295:E648-577
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Fujita, Y.1    Chui, J.W.2    King, D.S.3    Zhang, T.4    Seufert, J.5
  • 15
    • 0020596734 scopus 로고
    • Hamster preproglucagon contains the sequence of glucagon and two related peptides
    • Bell GI, Santerre RF,Mullenbach GT. 1983. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302:716-188
    • (1983) Nature , vol.302 , pp. 716-188
    • Bell, G.I.1    Santerre, R.F.2    Mullenbach, G.T.3
  • 16
    • 0028799007 scopus 로고
    • Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide
    • Rouille Y, Martin S, Steiner DF. 1995. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J. Biol. Chem. 270:26488-966
    • (1995) J. Biol. Chem. , vol.270 , pp. 26488-26966
    • Rouille, Y.1    Martin, S.2    Steiner, D.F.3
  • 18
    • 0036679173 scopus 로고    scopus 로고
    • Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
    • Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, et al. 2002. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc. Natl. Acad. Sci. USA 99:10293-988
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10293-10988
    • Zhu, X.1    Zhou, A.2    Dey, A.3    Norrbom, C.4    Carroll, R.5
  • 19
    • 84871261217 scopus 로고    scopus 로고
    • TheWnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis
    • ShaoW,Wang D, Chiang YT, Ip W, Zhu L, et al. 2013. TheWnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes 62:789-8000
    • (2013) Diabetes , vol.62 , pp. 789-8000
    • Shaowwang, D.1    Chiang, Y.T.2    Ip, W.3    Zhu, L.4
  • 20
    • 0033305721 scopus 로고    scopus 로고
    • Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription
    • Hill ME, Asa SL, Drucker DJ. 1999. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Mol. Endocrinol. 13:1474-866
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1474-1866
    • Hill, M.E.1    Asa, S.L.2    Drucker, D.J.3
  • 21
    • 79955435707 scopus 로고    scopus 로고
    • PPAR β/ activation induces enteroendocrine L cell GLP-1 production
    • Daoudi M, Hennuyer N, Borland MG, Touche V, Duhem C, et al. 2011. PPAR β/ activation induces enteroendocrine L cell GLP-1 production. Gastroenterology 140:1564-744
    • (2011) Gastroenterology , vol.140 , pp. 1564-1744
    • Daoudi, M.1    Hennuyer, N.2    Borland, M.G.3    Touche, V.4    Duhem, C.5
  • 22
    • 33746076698 scopus 로고    scopus 로고
    • Role of the exchange protein directly activated by cyclic adenosine 5 -monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells
    • Lotfi S, Li Z, Sun J, Zuo Y, Lam PP, et al. 2006. Role of the exchange protein directly activated by cyclic adenosine 5 -monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells. Endocrinology 147:3727-366
    • (2006) Endocrinology , vol.147 , pp. 3727-3376
    • Lotfi, S.1    Li, Z.2    Sun, J.3    Zuo, Y.4    Lam, P.P.5
  • 23
    • 0020501561 scopus 로고
    • Endocrine cells in human intestine: An immunocytochemical study
    • Sjolund K, Sanden G, Hakanson R, Sundler F. 1983. Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology 85:1120-300
    • (1983) Gastroenterology , vol.85 , pp. 1120-1300
    • Sjolund, K.1    Sanden, G.2    Hakanson, R.3    Sundler, F.4
  • 24
    • 0027303167 scopus 로고
    • Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop
    • Roberge JN, Brubaker PL. 1993. Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop. Endocrinology 133:233-400
    • (1993) Endocrinology , vol.133 , pp. 233-400
    • Roberge, J.N.1    Brubaker, P.L.2
  • 25
    • 0037207057 scopus 로고    scopus 로고
    • The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop?
    • Hansen L, Holst JJ. 2002. The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop? Regul. Pept. 110:39-455
    • (2002) Regul. Pept. , vol.110 , pp. 39-455
    • Hansen, L.1    Holst, J.J.2
  • 26
    • 0025116147 scopus 로고
    • Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops
    • Shima K, Suda T, Nishimoto K, Yoshimoto S. 1990. Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops. Acta Endocrinol. 123:464-700
    • (1990) Acta Endocrinol. , vol.123 , pp. 464-700
    • Shima, K.1    Suda, T.2    Nishimoto, K.3    Yoshimoto, S.4
  • 27
    • 0036347912 scopus 로고    scopus 로고
    • Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes
    • Vozzo R, Baker B, Wittert GA, Wishart JM, Morris H, et al. 2002. Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes. Metabolism 51:949-577
    • (2002) Metabolism , vol.51 , pp. 949-577
    • Vozzo, R.1    Baker, B.2    Wittert, G.A.3    Wishart, J.M.4    Morris, H.5
  • 28
    • 84555186977 scopus 로고    scopus 로고
    • Na+-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    • Gorboulev V, Schurmann A, Vallon V, Kipp H, Jaschke A, et al. 2012. Na+-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61:187-966
    • (2012) Diabetes , vol.61 , pp. 187-966
    • Gorboulev, V.1    Schurmann, A.2    Vallon, V.3    Kipp, H.4    Jaschke, A.5
  • 29
    • 72249113386 scopus 로고    scopus 로고
    • Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice
    • Moriya R, Shirakura T, Ito J, Mashiko S, Seo T. 2009. Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am. J. Physiol. Endocrinol. Metab. 297:E1358-655
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Moriya, R.1    Shirakura, T.2    Ito, J.3    Mashiko, S.4    Seo, T.5
  • 31
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, et al. 2009. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10:167-777
    • (2009) Cell Metab. , vol.10 , pp. 167-777
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3    Strehle, A.4    Oury, J.5
  • 33
    • 35448995622 scopus 로고    scopus 로고
    • T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
    • Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, et al. 2007. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc.Natl. Acad. Sci. USA 104:15075-800
    • (2007) Proc.Natl. Acad. Sci. USA , vol.104 , pp. 15075-15800
    • Margolskee, R.F.1    Dyer, J.2    Kokrashvili, Z.3    Salmon, K.S.4    Ilegems, E.5
  • 34
    • 12944280251 scopus 로고    scopus 로고
    • Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/ carbohydrate meal in type 2 diabetes
    • O'Donovan D, Horowitz M, Russo A, Feinle-Bisset C, Murolo N, et al. 2004. Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/ carbohydrate meal in type 2 diabetes. Diabetologia 47:2208-144
    • (2004) Diabetologia , vol.47 , pp. 2208-2154
    • O'Donovan, D.1    Horowitz, M.2    Russo, A.3    Feinle-Bisset, C.4    Murolo, N.5
  • 35
    • 33847037154 scopus 로고    scopus 로고
    • Protein kinase C is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells
    • Iakoubov R, Izzo A, Yeung A, Whiteside CI, Brubaker PL. 2007. Protein kinase C is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells. Endocrinology 148:1089-988
    • (2007) Endocrinology , vol.148 , pp. 1089-1988
    • Iakoubov, R.1    Izzo, A.2    Yeung, A.3    Whiteside, C.I.4    Brubaker, P.L.5
  • 36
    • 79953214920 scopus 로고    scopus 로고
    • Essential role for protein kinase Cin oleic acid-induced glucagon-like peptide-1 secretion in vivo in the rat
    • Iakoubov R, Ahmed A, Lauffer LM, Bazinet RP, Brubaker PL. 2011. Essential role for protein kinase Cin oleic acid-induced glucagon-like peptide-1 secretion in vivo in the rat. Endocrinology 152:1244-522
    • (2011) Endocrinology , vol.152 , pp. 1244-1522
    • Iakoubov, R.1    Ahmed, A.2    Lauffer, L.M.3    Bazinet, R.P.4    Brubaker, P.L.5
  • 37
    • 52749098923 scopus 로고    scopus 로고
    • Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    • Edfalk S, Steneberg P, Edlund H. 2008. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 57:2280-877
    • (2008) Diabetes , vol.57 , pp. 2280-2877
    • Edfalk, S.1    Steneberg, P.2    Edlund, H.3
  • 38
    • 84862589520 scopus 로고    scopus 로고
    • A multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel GPR40 agonist, TAK-875, in subjects with type 2 diabetes
    • Leifke E, Naik H, Wu J, Viswanathan P, Demanno D, et al. 2012. A multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel GPR40 agonist, TAK-875, in subjects with type 2 diabetes. Clin. Pharmacol. Ther. 92:29-399
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 29-399
    • Leifke, E.1    Naik, H.2    Wu, J.3    Viswanathan, P.4    Demanno, D.5
  • 39
    • 45849153782 scopus 로고    scopus 로고
    • Cloning and characterization of the rat free fatty acid receptor GPR120: In vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic βcells
    • Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G. 2008. Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic βcells. Naunyn Schmiedeb. Arch. Pharmacol. 377:515-222
    • (2008) Naunyn Schmiedeb. Arch. Pharmacol. , vol.377 , pp. 515-222
    • Tanaka, T.1    Yano, T.2    Adachi, T.3    Koshimizu, T.A.4    Hirasawa, A.5    Tsujimoto, G.6
  • 40
    • 56349100059 scopus 로고    scopus 로고
    • Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion
    • Morishita M, Tanaka T, Shida T, Takayama K. 2008. Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. J. Control. Release 132:99-1044
    • (2008) J. Control. Release , vol.132 , pp. 99-1044
    • Morishita, M.1    Tanaka, T.2    Shida, T.3    Takayama, K.4
  • 41
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    • Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, et al. 2005. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11:90-944
    • (2005) Nat. Med. , vol.11 , pp. 90-944
    • Hirasawa, A.1    Tsumaya, K.2    Awaji, T.3    Katsuma, S.4    Adachi, T.5
  • 42
    • 42449126696 scopus 로고    scopus 로고
    • A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide release
    • Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, et al. 2008. A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide release. Endocrinology 149:2038-477
    • (2008) Endocrinology , vol.149 , pp. 2038-2477
    • Chu, Z.L.1    Carroll, C.2    Alfonso, J.3    Gutierrez, V.4    He, H.5
  • 43
    • 65549142522 scopus 로고    scopus 로고
    • GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    • Lauffer LM, Iakoubov R, Brubaker PL. 2009. GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes 58:1058-666
    • (2009) Diabetes , vol.58 , pp. 1058-1666
    • Lauffer, L.M.1    Iakoubov, R.2    Brubaker, P.L.3
  • 44
    • 84863307279 scopus 로고    scopus 로고
    • Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes
    • Katz LB, Gambale JJ, Rothenberg PL, Vanapalli SR, Vaccaro N, et al. 2012. Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes. Diabetes Obes. Metab. 14:709-166
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 709-166
    • Katz, L.B.1    Gambale, J.J.2    Rothenberg, P.L.3    Vanapalli, S.R.4    Vaccaro, N.5
  • 45
    • 84868293826 scopus 로고    scopus 로고
    • The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
    • Gribble FM. 2012. The gut endocrine system as a coordinator of postprandial nutrient homoeostasis. Proc. Nutr. Soc. 71:456-622
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 456-622
    • Gribble, F.M.1
  • 46
    • 84866125785 scopus 로고    scopus 로고
    • Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
    • Adrian TE, Gariballa S, Parekh KA, Thomas SA, Saadi H, et al. 2012. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. Diabetologia 55:2343-477
    • (2012) Diabetologia , vol.55 , pp. 2343-2477
    • Adrian, T.E.1    Gariballa, S.2    Parekh, K.A.3    Thomas, S.A.4    Saadi, H.5
  • 47
    • 13844299425 scopus 로고    scopus 로고
    • Bile acids promote glucagon-like peptide-1 secretion through TGR5 in amurine enteroendocrine cell line STC-1
    • Katsuma S, Hirasawa A, Tsujimoto G. 2005. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in amurine enteroendocrine cell line STC-1. Biochem. Biophys. Res. Commun. 329:386-900
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , pp. 386-900
    • Katsuma, S.1    Hirasawa, A.2    Tsujimoto, G.3
  • 48
    • 51449119654 scopus 로고    scopus 로고
    • Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions
    • Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki SI, Kuwahara A. 2008. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J. Physiol. Pharmacol. 59(Suppl. 2):251-622
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 2 , pp. 251-622
    • Tazoe, H.1    Otomo, Y.2    Kaji, I.3    Tanaka, R.4    Karaki, S.I.5    Kuwahara, A.6
  • 49
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, et al. 2012. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61:364-711
    • (2012) Diabetes , vol.61 , pp. 364-711
    • Tolhurst, G.1    Heffron, H.2    Lam, Y.S.3    Parker, H.E.4    Habib, A.M.5
  • 50
    • 0029838401 scopus 로고    scopus 로고
    • Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats
    • Reimer RA,McBurneyMI. 1996. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology 137:3948-566
    • (1996) Endocrinology , vol.137 , pp. 3948-3576
    • Reimer, R.A.1    McBurney, M.I.2
  • 51
    • 0031664421 scopus 로고    scopus 로고
    • Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs
    • Massimino SP, McBurney MI, Field CJ, Thomson AB, Keelan M, et al. 1998. Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J. Nutr. 128:1786-933
    • (1998) J. Nutr. , vol.128 , pp. 1786-1933
    • Massimino, S.P.1    McBurney, M.I.2    Field, C.J.3    Thomson, A.B.4    Keelan, M.5
  • 52
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve inmediating proximal nutrient-induced glucagonlike peptide-1 secretion
    • Rocca AS, Brubaker PL. 1999. Role of the vagus nerve inmediating proximal nutrient-induced glucagonlike peptide-1 secretion. Endocrinology 140:1687-944
    • (1999) Endocrinology , vol.140 , pp. 1687-1944
    • Rocca, A.S.1    Brubaker, P.L.2
  • 53
    • 0036090456 scopus 로고    scopus 로고
    • Muscarinic receptors control postprandial release of glucagonlike peptide-1: In vivo and in vitro studies in rats
    • Anini Y,Hansotia T, Brubaker PL. 2002. Muscarinic receptors control postprandial release of glucagonlike peptide-1: in vivo and in vitro studies in rats. Endocrinology 143:2420-266
    • (2002) Endocrinology , vol.143 , pp. 2420-2276
    • Anini Yhansotia, T.1    Brubaker, P.L.2
  • 54
    • 0038310124 scopus 로고    scopus 로고
    • Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells
    • Anini Y, Brubaker PL. 2003. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology 144:3244-500
    • (2003) Endocrinology , vol.144 , pp. 3244-3500
    • Anini, Y.1    Brubaker, P.L.2
  • 55
    • 0036329378 scopus 로고    scopus 로고
    • Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures
    • Chisholm C, Greenberg GR. 2002. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am. J. Physiol. Endocrinol. Metab. 283:E311-177
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • Chisholm, C.1    Greenberg, G.R.2
  • 56
    • 84866425326 scopus 로고    scopus 로고
    • Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities
    • Liu S, Liu R, Chiang YT, Song L, Li X, et al. 2012. Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities. Am. J. Physiol. Endocrinol. Metab. 303:E740-511
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303
    • Liu, S.1    Liu, R.2    Chiang, Y.T.3    Song, L.4    Li, X.5
  • 57
    • 0037315423 scopus 로고    scopus 로고
    • Role of leptin in the regulation of glucagon-like peptide-1 secretion
    • Anini Y, Brubaker PL. 2003. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 52:252-599
    • (2003) Diabetes , vol.52 , pp. 252-599
    • Anini, Y.1    Brubaker, P.L.2
  • 58
    • 34548487959 scopus 로고    scopus 로고
    • Cyclic AMP triggers glucagonlike peptide-1 secretion from the GLUTag enteroendocrine cell line
    • Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, et al. 2007. Cyclic AMP triggers glucagonlike peptide-1 secretion from the GLUTag enteroendocrine cell line. Diabetologia 50:2181-899
    • (2007) Diabetologia , vol.50 , pp. 2181-2899
    • Simpson, A.K.1    Ward, P.S.2    Wong, K.Y.3    Collord, G.J.4    Habib, A.M.5
  • 59
    • 0842346386 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum
    • Hansen L, Hartmann B, Mineo H, Holst JJ. 2004. Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum. Regul. Pept. 118:11-188
    • (2004) Regul. Pept. , vol.118 , pp. 11-188
    • Hansen, L.1    Hartmann, B.2    Mineo, H.3    Holst, J.J.4
  • 60
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman GA, Bergman A, Stevens C, Kotey P, Yi B, et al. 2006. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 91:4612-199
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4612-4199
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3    Kotey, P.4    Yi, B.5
  • 61
    • 35948941910 scopus 로고    scopus 로고
    • The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucoseinduced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
    • El-Ouaghlidi A, Rehring E, Holst JJ, Schweizer A, Foley J, et al. 2007. The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucoseinduced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion. J. Clin. Endocrinol. Metab. 92:4165-711
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 4165-4711
    • El-Ouaghlidi, A.1    Rehring, E.2    Holst, J.J.3    Schweizer, A.4    Foley, J.5
  • 64
    • 33748603481 scopus 로고    scopus 로고
    • Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
    • Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, et al. 2006. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc. Natl. Acad. Sci. USA 103:13468-733
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 13468-13733
    • Wideman, R.D.1    Yu, I.L.2    Webber, T.D.3    Verchere, C.B.4    Johnson, J.D.5
  • 65
    • 80052523733 scopus 로고    scopus 로고
    • Upregulation of cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus-an adaptive response to hyperglycaemia?
    • Hansen AM, Bodvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, et al. 2011. Upregulation of cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus -an adaptive response to hyperglycaemia? Diabetologia 54:1379-877
    • (2011) Diabetologia , vol.54 , pp. 1379-1877
    • Hansen, A.M.1    Bodvarsdottir, T.B.2    Nordestgaard, D.N.3    Heller, R.S.4    Gotfredsen, C.F.5
  • 67
    • 0034129091 scopus 로고    scopus 로고
    • Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats
    • Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, et al. 2000. Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J. Clin. Investig. 105:955-655
    • (2000) J. Clin. Investig. , vol.105 , pp. 955-655
    • Nie, Y.1    Nakashima, M.2    Brubaker, P.L.3    Li, Q.L.4    Perfetti, R.5
  • 68
    • 0037417984 scopus 로고    scopus 로고
    • Lower blood glucose, hyperglucagonemia, and pancreatic cell hyperplasia in glucagon receptor knockout mice
    • Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, et al. 2003. Lower blood glucose, hyperglucagonemia, and pancreatic cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. USA 100:1438-433
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1438-1443
    • Gelling, R.W.1    Du, X.Q.2    Dichmann, D.S.3    Romer, J.4    Huang, H.5
  • 70
    • 80054699140 scopus 로고    scopus 로고
    • Chronic treatment with a glucagon receptor antagonist lowers glucose andmoderately raises circulating glucagon and glucagon-like peptide 1without severe cell hypertrophy in diet-induced obese mice
    • Mu J, Jiang G, Brady E, Dallas-Yang Q, Liu F, et al. 2011. Chronic treatment with a glucagon receptor antagonist lowers glucose andmoderately raises circulating glucagon and glucagon-like peptide 1without severe cell hypertrophy in diet-induced obese mice. Diabetologia 54:2381-911
    • (2011) Diabetologia , vol.54 , pp. 2381-2911
    • Mu, J.1    Jiang, G.2    Brady, E.3    Dallas-Yang, Q.4    Liu, F.5
  • 71
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and cells
    • Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, et al. 2011. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and cells. Nat. Med. 17:1481-899
    • (2011) Nat. Med. , vol.17 , pp. 1481-1899
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3    Habib, A.M.4    Baggio, L.L.5
  • 72
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T, Agerso H, Krarup T, Holst JJ. 2003. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J. Clin. Endocrinol. Metab. 88:220-244
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 220-244
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 73
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36) is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L, Deacon CF, Orskov C, Holst JJ. 1999. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140:5356-633
    • (1999) Endocrinology , vol.140 , pp. 5356-5633
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 75
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    • Ban K, Kim KH, Cho CK, Sauve M, Diamandis EP, et al. 2010. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 151:1520-311
    • (2010) Endocrinology , vol.151 , pp. 1520-1321
    • Ban, K.1    Kim, K.H.2    Cho, C.K.3    Sauve, M.4    Diamandis, E.P.5
  • 76
    • 33744945766 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans
    • Meier JJ, Gethmann A, Nauck MA, Gotze O, Schmitz F, et al. 2006. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. Am. J. Physiol. Endocrinol. Metab. 290:E1118-233
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Meier, J.J.1    Gethmann, A.2    Nauck, M.A.3    Gotze, O.4    Schmitz, F.5
  • 77
    • 15044341261 scopus 로고    scopus 로고
    • What do we know about the secretion and degradation of incretin hormones?
    • Deacon CF. 2005. What do we know about the secretion and degradation of incretin hormones? Regul. Pept. 128:117-244
    • (2005) Regul Pept. , vol.128 , pp. 117-244
    • Deacon, C.F.1
  • 78
    • 0028900758 scopus 로고
    • Tissue-specific expression of the human receptor for glucagon-like peptide-I: Brain, heart and pancreatic forms have the same deduced amino acid sequences
    • Wei Y, Mojsov S. 1995. Tissue-specific expression of the human receptor for glucagon-like peptide-I: Brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 358:219-244
    • (1995) FEBS Lett. , vol.358 , pp. 219-244
    • Wei, Y.1    Mojsov, S.2
  • 79
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock BP, Heller RS, Habener JF. 1996. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-788
    • (1996) Endocrinology , vol.137 , pp. 2968-2798
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 80
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE mice
    • Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, et al. 2013. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE mice. Endocrinology 154:127-399
    • (2013) Endocrinology , vol.154 , pp. 127-399
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3    Yusta, B.4    Campbell, J.E.5
  • 81
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. 2004. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 127:546-588
    • (2004) Gastroenterology , vol.127 , pp. 546-588
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 82
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, Maclusky N, Brubaker PL, Auerbach AB, et al. 1996. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2:1254-588
    • (1996) Nat. Med. , vol.2 , pp. 1254-1588
    • Scrocchi, L.A.1    Brown, T.J.2    Maclusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5
  • 83
    • 84855465547 scopus 로고    scopus 로고
    • Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
    • Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. 2012. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. J. Clin. Investig. 122:388-4022
    • (2012) J. Clin. Investig. , vol.122 , pp. 388-4022
    • Lamont, B.J.1    Li, Y.2    Kwan, E.3    Brown, T.J.4    Gaisano, H.5    Drucker, D.J.6
  • 84
    • 34249724553 scopus 로고    scopus 로고
    • Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes
    • Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, et al. 2007. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 56:1551-588
    • (2007) Diabetes , vol.56 , pp. 1551-1588
    • Xu, G.1    Kaneto, H.2    Laybutt, D.R.3    Duvivier-Kali, V.F.4    Trivedi, N.5
  • 85
    • 78951476273 scopus 로고    scopus 로고
    • Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-in mice
    • Maida A, Lamont BJ, Cao X, Drucker DJ. 2011. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-in mice. Diabetologia 54:339-499
    • (2011) Diabetologia , vol.54 , pp. 339-499
    • Maida, A.1    Lamont, B.J.2    Cao, X.3    Drucker, D.J.4
  • 86
    • 84878755846 scopus 로고    scopus 로고
    • Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the βcell in mouse models of diabetes
    • Kang ZF, Deng Y, Zhou Y, Fan RR, Chan JC, et al. 2013. Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the βcell in mouse models of diabetes. Diabetologia 56:423-333
    • (2013) Diabetologia , vol.56 , pp. 423-333
    • Kang, Z.F.1    Deng, Y.2    Zhou, Y.3    Fan, R.R.4    Chan, J.C.5
  • 87
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired β-cell function
    • Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. 2009. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired β-cell function. Hum. Mol. Genet. 18:2388-999
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2388-2999
    • Shu, L.1    Matveyenko, A.V.2    Kerr-Conte, J.3    Cho, J.H.4    McIntosh, C.H.5    Maedler, K.6
  • 88
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau J, Foisy S, JolyE,PrentkiM.2003. Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52:124-322
    • (2003) Diabetes , vol.52 , pp. 124-322
    • Buteau, J.1    Foisy, S.2    Joly, E.3    Prentki, M.4
  • 89
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, et al. 2003. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144:5149-588
    • (2003) Endocrinology , vol.144 , pp. 5149-5588
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3    Li Calzi, S.4    Khoury, N.5
  • 90
    • 33750448469 scopus 로고    scopus 로고
    • GLP-1 receptor activation improves βcell function and survival following induction of endoplasmic reticulum stress
    • Yusta B, Baggio LL, Estall JL, Koehler JA, Holland DP, et al. 2006. GLP-1 receptor activation improves βcell function and survival following induction of endoplasmic reticulum stress. Cell Metab. 4:391-4066
    • (2006) Cell Metab. , vol.4 , pp. 391-4066
    • Yusta, B.1    Baggio, L.L.2    Estall, J.L.3    Koehler, J.A.4    Holland, D.P.5
  • 91
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. 2013. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 62:2595-6044
    • (2013) Diabetes , vol.62 , pp. 2595-6044
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3    Dawson, D.W.4    Atkinson, M.5    Butler, P.C.6
  • 92
    • 77954250537 scopus 로고    scopus 로고
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
    • Hare KJ, Vilsboll T, Asmar M, Deacon CF, Knop FK, Holst JJ. 2010. The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes 59:1765-700
    • (2010) Diabetes , vol.59 , pp. 1765-1710
    • Hare, K.J.1    Vilsboll, T.2    Asmar, M.3    Deacon, C.F.4    Knop, F.K.5    Holst, J.J.6
  • 93
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, et al. 2002. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J. Clin. Endocrinol. Metab. 87:1239-466
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1239-1466
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3    Holst, J.J.4    Nauck, M.S.5
  • 95
    • 0030975613 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide i receptor expression in glucagon-producing cells of the rat endocrine pancreas
    • Heller RS, Kieffer TJ, Habener JF. 1997. Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing cells of the rat endocrine pancreas. Diabetes 46:785-911
    • (1997) Diabetes , vol.46 , pp. 785-911
    • Heller, R.S.1    Kieffer, T.J.2    Habener, J.F.3
  • 96
    • 33846856711 scopus 로고    scopus 로고
    • Cells of the endocrine pancreas: 35 years of research but the enigma remains
    • Gromada J, Franklin I, Wollheim CB. 2007. Cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr. Rev. 28:84-1166
    • (2007) Endocr. Rev. , vol.28 , pp. 84-1166
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 97
    • 77953939472 scopus 로고    scopus 로고
    • Molecular pathways underlying the pathogenesis of pancreatic cell dysfunction
    • Kawamori D, Welters HJ, Kulkarni RN. 2010. Molecular pathways underlying the pathogenesis of pancreatic cell dysfunction. Adv. Exp. Med. Biol. 654:421-455
    • (2010) Adv. Exp. Med. Biol. , vol.654 , pp. 421-455
    • Kawamori, D.1    Welters, H.J.2    Kulkarni, R.N.3
  • 98
    • 77952758235 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1 on and β-cell function in C-peptide-negative type 1 diabetic patients
    • Kielgast U, Asmar M, Madsbad S, Holst JJ. 2010. Effect of glucagon-like peptide-1 on and β-cell function in C-peptide-negative type 1 diabetic patients. J. Clin. Endocrinol. Metab. 95:2492-966
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2492-2966
    • Kielgast, U.1    Asmar, M.2    Madsbad, S.3    Holst, J.J.4
  • 99
    • 0024355498 scopus 로고
    • Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures
    • D'Alessio DA, Fujimoto WY, Ensinck JW. 1989. Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. Diabetes 38:1534-388
    • (1989) Diabetes , vol.38 , pp. 1534-1398
    • D'Alessio, D.A.1    Fujimoto, W.Y.2    Ensinck, J.W.3
  • 100
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • de Heer J, Rasmussen C, Coy DH, Holst JJ. 2008. Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51:2263-700
    • (2008) Diabetologia , vol.51 , pp. 2263-2700
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 102
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, et al. 2005. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res. 1044:127-311
    • (2005) Brain Res. , vol.1044 , pp. 127-311
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5
  • 103
    • 84883754628 scopus 로고    scopus 로고
    • Incretin hormones and the satiation signal
    • Holst JJ. 2013. Incretin hormones and the satiation signal. Int. J. Obes. 37:1161-688
    • (2013) Int. J. Obes. , vol.37 , pp. 1161-1688
    • Holst, J.J.1
  • 104
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, et al. 2012. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 61:2753-622
    • (2012) Diabetes , vol.61 , pp. 2753-2632
    • Lockie, S.H.1    Heppner, K.M.2    Chaudhary, N.3    Chabenne, J.R.4    Morgan, D.A.5
  • 106
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier JJ, Gallwitz B, Salmen S, Goetze O, Holst JJ, et al. 2003. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 88:2719-255
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2719-2265
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5
  • 108
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck MA, Kemmeries G, Holst JJ, Meier JJ. 2011. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 60:1561-655
    • (2011) Diabetes , vol.60 , pp. 1561-1655
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 109
    • 9444231814 scopus 로고    scopus 로고
    • Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuateGLP-1R-dependent glucose homeostasis in vivo
    • Baggio LL, Kim JG, Drucker DJ. 2004. Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuateGLP-1R-dependent glucose homeostasis in vivo. Diabetes 53(Suppl. 3):205-144
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3 , pp. 205-144
    • Baggio, L.L.1    Kim, J.G.2    Drucker, D.J.3
  • 110
    • 0024338802 scopus 로고
    • GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans
    • Schjoldager BT, Mortensen PE, Christiansen J, Orskov C, Holst JJ. 1989. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans. Dig. Dis. Sci. 34:703-88
    • (1989) Dig. Dis. Sci. , vol.34 , pp. 703-788
    • Schjoldager, B.T.1    Mortensen, P.E.2    Christiansen, J.3    Orskov, C.4    Holst, J.J.5
  • 111
    • 0030962231 scopus 로고    scopus 로고
    • The inhibitory effect of glucagonlike peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation
    • Wettergren A, Wojdemann M, Meisner S, Stadil F, Holst JJ. 1997. The inhibitory effect of glucagonlike peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation. Gut 40:597-6011
    • (1997) Gut , vol.40 , pp. 597-6011
    • Wettergren, A.1    Wojdemann, M.2    Meisner, S.3    Stadil, F.4    Holst, J.J.5
  • 112
    • 17644373076 scopus 로고    scopus 로고
    • GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats
    • Qin X, Shen H, Liu M, Yang Q, Zheng S, et al. 2005. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 288:G943-499
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288
    • Qin, X.1    Shen, H.2    Liu, M.3    Yang, Q.4    Zheng, S.5
  • 113
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • Meier JJ, Gethmann A, Gotze O, Gallwitz B, Holst JJ, et al. 2006. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia 49:452-588
    • (2006) Diabetologia , vol.49 , pp. 452-588
    • Meier, J.J.1    Gethmann, A.2    Gotze, O.3    Gallwitz, B.4    Holst, J.J.5
  • 114
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh J, Longuet C, Baker CL,Qin B, Federico LM, et al. 2010. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 53:552-611
    • (2010) Diabetologia , vol.53 , pp. 552-611
    • Hsieh, J.1    Longuet, C.2    Baker Clqin, B.3    Federico, L.M.4
  • 115
  • 116
    • 0036305993 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes
    • Luque MA, Gonzalez N, Marquez L, Acitores A, Redondo A, et al. 2002. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes. J. Endocrinol. 173:465-733
    • (2002) J. Endocrinol. , vol.173 , pp. 465-733
    • Luque, M.A.1    Gonzalez, N.2    Marquez, L.3    Acitores, A.4    Redondo, A.5
  • 118
    • 0031910411 scopus 로고    scopus 로고
    • Inositolphosphoglycans possiblymediate the effects of glucagon-like peptide-1(7-36) on rat liver and adipose tissue
    • Marquez L, Trapote MA, Luque MA, Valverde I, Villanueva-Penacarrillo ML. 1998. Inositolphosphoglycans possiblymediate the effects of glucagon-like peptide-1(7-36)amide on rat liver and adipose tissue. Cell Biochem. Funct. 16:51-566
    • (1998) Cell Biochem. Funct. , vol.16 , pp. 51-566
    • Marquez, L.1    Trapote, M.A.2    Luque, M.A.3    Valverde, I.4    Villanueva-Penacarrillo, M.L.5
  • 119
    • 23844526330 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats
    • Sancho V, Trigo MV, Gonzalez N, Valverde I, Malaisse WJ, Villanueva-Penacarrillo ML. 2005. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. J. Mol. Endocrinol. 35:27-388
    • (2005) J. Mol. Endocrinol. , vol.35 , pp. 27-388
    • Sancho, V.1    Trigo, M.V.2    Gonzalez, N.3    Valverde, I.4    Malaisse, W.J.5    Villanueva-Penacarrillo, M.L.6
  • 120
    • 0036496551 scopus 로고    scopus 로고
    • Exendin-4 increases insulin sensitivity via a PI-3-kinasedependent mechanism: Contrasting effects of GLP-1
    • Idris I, Patiag D, Gray S, Donnelly R. 2002. Exendin-4 increases insulin sensitivity via a PI-3-kinasedependent mechanism: contrasting effects of GLP-1. Biochem. Pharmacol. 63:993-966
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 993-966
    • Idris, I.1    Patiag, D.2    Gray, S.3    Donnelly, R.4
  • 121
    • 80052096595 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome
    • Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, et al. 2011. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes 60:1917-255
    • (2011) Diabetes , vol.60 , pp. 1917-2255
    • Lamers, D.1    Famulla, S.2    Wronkowitz, N.3    Hartwig, S.4    Lehr, S.5
  • 122
    • 33745685236 scopus 로고    scopus 로고
    • Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects
    • Sancho V, Trigo MV, Martn-Duce A, Gonzalez N, Acitores A, et al. 2006. Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects. Int. J. Mol. Med. 17:1133-377
    • (2006) Int. J. Mol. Med. , vol.17 , pp. 1133-1377
    • Sancho, V.1    Trigo, M.V.2    Martn-Duce, A.3    Gonzalez, N.4    Acitores, A.5
  • 123
    • 0035044628 scopus 로고    scopus 로고
    • Action of glucagon and glucagon-like peptide-1-(7-36) amide on lipolysis in human subcutaneous adipose tissue and skeletal muscle in vivo
    • Bertin E, Arner P, Bolinder J, Hagstrom-Toft E. 2001. Action of glucagon and glucagon-like peptide-1-(7-36) amide on lipolysis in human subcutaneous adipose tissue and skeletal muscle in vivo. J. Clin. Endocrinol. Metab. 86:1229-344
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1229-1344
    • Bertin, E.1    Arner, P.2    Bolinder, J.3    Hagstrom-Toft, E.4
  • 124
    • 84866055251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes
    • Lee YS, Park MS, Choung JS, Kim SS, Oh HH, et al. 2012. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia 55:2456-688
    • (2012) Diabetologia , vol.55 , pp. 2456-2688
    • Lee, Y.S.1    Park, M.S.2    Choung, J.S.3    Kim, S.S.4    Oh, H.H.5
  • 125
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • Nogueiras R, Perez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, et al. 2009. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J. Neurosci. 29:5916-255
    • (2009) J. Neurosci. , vol.29 , pp. 5916-5265
    • Nogueiras, R.1    Perez-Tilve, D.2    Veyrat-Durebex, C.3    Morgan, D.A.4    Varela, L.5
  • 128
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. 2006. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43:173-811
    • (2006) Hepatology , vol.43 , pp. 173-811
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 129
    • 84857185142 scopus 로고    scopus 로고
    • Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice
    • Lee J, Hong SW, Chae SW, Kim DH, Choi JH, et al. 2012. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PLoS ONE 7:e313944
    • (2012) PLoS ONE , vol.7
    • Lee, J.1    Hong, S.W.2    Chae, S.W.3    Kim, D.H.4    Choi, J.H.5
  • 131
    • 0031668166 scopus 로고    scopus 로고
    • GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor
    • Yang H, Egan JM, Wang Y, Moyes CD, Roth J, et al. 1998. GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am. J. Physiol. Cell Physiol. 275:C675-833
    • (1998) Am. J. Physiol. Cell Physiol. , vol.275
    • Yang, H.1    Egan, J.M.2    Wang, Y.3    Moyes, C.D.4    Roth, J.5
  • 132
    • 35148832136 scopus 로고    scopus 로고
    • Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels
    • Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, et al. 2007. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Am. J. Physiol. Endocrinol. Metab. 293:E1085-911
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Johnson, K.M.1    Edgerton, D.S.2    Rodewald, T.3    Scott, M.4    Farmer, B.5
  • 133
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • Chai W, Dong Z, Wang N, Wang W, Tao L, et al. 2012. Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes 61:888-966
    • (2012) Diabetes , vol.61 , pp. 888-966
    • Chai, W.1    Dong, Z.2    Wang, N.3    Wang, W.4    Tao, L.5
  • 134
    • 79951884751 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-based therapies and cardiovascular disease: Looking beyond glycaemic control
    • Anagnostis P, Athyros VG, Adamidou F, Panagiotou A, Kita M, et al. 2011. Glucagon-like peptide-1-based therapies and cardiovascular disease: looking beyond glycaemic control. Diabetes Obes. Metab. 13:302-122
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 302-122
    • Anagnostis, P.1    Athyros, V.G.2    Adamidou, F.3    Panagiotou, A.4    Kita, M.5
  • 135
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher JR, Drucker DJ. 2012. Cardiovascular biology of the incretin system. Endocr. Rev. 33:187-2155
    • (2012) Endocr. Rev. , vol.33 , pp. 187-2155
    • Ussher, J.R.1    Drucker, D.J.2
  • 136
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, et al. (SAVOR-TIMI 53 Steer. Comm. Investig.). 2013. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N. Engl. J. Med. 369:1317-266
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1317-1276
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3    Steg, P.G.4    Davidson, J.5
  • 137
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, et al. (EXAMINE Investig.). 2013. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N. Engl. J. Med. 369:1327-355
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1327-1355
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3    Nissen, S.E.4    Bergenstal, R.M.5
  • 138
    • 68349084564 scopus 로고    scopus 로고
    • Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo
    • Nathanson D, Erdogdu O, Pernow J, Zhang Q, Nystrom T. 2009. Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo. Regul. Pept. 157:8-133
    • (2009) Regul. Pept. , vol.157 , pp. 8-133
    • Nathanson, D.1    Erdogdu, O.2    Pernow, J.3    Zhang, Q.4    Nystrom, T.5
  • 139
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP. 2006. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J. Cardiac Fail. 12:694-999
    • (2006) J. Cardiac Fail. , vol.12 , pp. 694-999
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 140
  • 141
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, et al. 2013. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat. Med. 19:567-755
    • (2013) Nat. Med. , vol.19 , pp. 567-755
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3    Quaggin, S.E.4    Backx, P.H.5
  • 142
    • 84867136387 scopus 로고    scopus 로고
    • Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice
    • Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, et al. 2012. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am. J. Physiol. Ren. Physiol. 303:F963-711
    • (2012) Am. J. Physiol. Ren. Physiol. , vol.303
    • Rieg, T.1    Gerasimova, M.2    Murray, F.3    Masuda, T.4    Tang, T.5
  • 143
    • 79951626557 scopus 로고    scopus 로고
    • Neuroprotective properties ofGLP-1: Theoretical and practical applications
    • Holst JJ, Burcelin R, Nathanson E. 2011. Neuroprotective properties ofGLP-1: theoretical and practical applications. Curr. Med. Res. Opin. 27:547-588
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 547-588
    • Holst, J.J.1    Burcelin, R.2    Nathanson, E.3
  • 144
    • 38549146030 scopus 로고    scopus 로고
    • The murine glucagon-like peptide-1 receptor is essential for control of bone resorption
    • Yamada C, Yamada Y, Tsukiyama K, Yamada K, Udagawa N, et al. 2008. The murine glucagon-like peptide-1 receptor is essential for control of bone resorption. Endocrinology 149:574-799
    • (2008) Endocrinology , vol.149 , pp. 574-799
    • Yamada, C.1    Yamada, Y.2    Tsukiyama, K.3    Yamada, K.4    Udagawa, N.5
  • 145
    • 77956496046 scopus 로고    scopus 로고
    • Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor
    • Nuche-Berenguer B, Portal-Nunez S, Moreno P, Gonzalez N, Acitores A, et al. 2010. Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor. J. Cell. Physiol. 225:585-922
    • (2010) J. Cell. Physiol. , vol.225 , pp. 585-922
    • Nuche-Berenguer, B.1    Portal-Nunez, S.2    Moreno, P.3    Gonzalez, N.4    Acitores, A.5
  • 149
    • 84885473538 scopus 로고    scopus 로고
    • The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes
    • Jørgensen NB, Dirksen C, Bojsen-Møller KN, Jacobsen SH, Worm D, et al. 2013. The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes. Diabetes 62:3044-522
    • (2013) Diabetes , vol.62 , pp. 3044-3522
    • Jørgensen, N.B.1    Dirksen, C.2    Bojsen-Møller, K.N.3    Jacobsen, S.H.4    Worm, D.5
  • 150
    • 84885469835 scopus 로고    scopus 로고
    • GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery
    • Jimenez A, Casamitjana R, Viaplana-Masclans J, Lacy A, Vidal J. 2013. GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery. Diabetes Care 36:2062-699
    • (2013) Diabetes Care , vol.36 , pp. 2062-2699
    • Jimenez, A.1    Casamitjana, R.2    Viaplana-Masclans, J.3    Lacy, A.4    Vidal, J.5
  • 151
    • 65449189175 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics and pharmacokinetics of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in healthy subjects
    • Bush MA, Matthews JE, De Boever EH, Dobbins RL, Hodge RJ, et al. 2009. Safety, tolerability, pharmacodynamics and pharmacokinetics of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in healthy subjects. Diabetes Obes. Metab. 11:498-5055
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 498-5055
    • Bush, M.A.1    Matthews, J.E.2    De Boever, E.H.3    Dobbins, R.L.4    Hodge, R.J.5
  • 152
    • 67649523294 scopus 로고    scopus 로고
    • Treatmentwith the human onceweekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R. 2009. Treatmentwith the human onceweekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 32:1237-433
    • (2009) Diabetes Care , vol.32 , pp. 1237-1433
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 153
    • 3843059231 scopus 로고    scopus 로고
    • Identification of CJC-1131-albumin bioconjugate as a stable and bioactiveGLP-1(7-36) analog
    • Leger R, Thibaudeau K, Robitaille M, Quraishi O, vanWyk P, et al. 2004. Identification of CJC-1131-albumin bioconjugate as a stable and bioactiveGLP-1(7-36) analog. Bioorg.Med. Chem. Lett. 14:4395-988
    • (2004) Bioorg.Med. Chem. Lett. , vol.14 , pp. 4395-4988
    • Leger, R.1    Thibaudeau, K.2    Robitaille, M.3    Quraishi, O.4    Van Wyk, P.5
  • 154
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen LB, Nielsen PF, Huusfeldt PO, Johansen NL, Madsen K, et al. 2000. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J. Med. Chem. 43:1664-699
    • (2000) J. Med. Chem. , vol.43 , pp. 1664-1699
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3    Johansen, N.L.4    Madsen, K.5
  • 155
    • 78249249300 scopus 로고    scopus 로고
    • Treatment of diabetes with glucagon-like peptide-1 gene therapy
    • Riedel MJ, Kieffer TJ. 2010. Treatment of diabetes with glucagon-like peptide-1 gene therapy. Expert Opin. Biol. Ther. 10:1681-922
    • (2010) Expert Opin. Biol. Ther. , vol.10 , pp. 1681-1922
    • Riedel, M.J.1    Kieffer, T.J.2
  • 156
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review
    • Deacon CF. 2011. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes. Metab. 13:7-188
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 7-188
    • Deacon, C.F.1
  • 157
    • 84876063836 scopus 로고    scopus 로고
    • Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: A population-based matched case-control study
    • Singh S, Chang HY, Richards TM,Weiner JP, Clark JM, Segal JB. 2013. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern. Med. 173:534-399
    • (2013) JAMA Intern. Med. , vol.173 , pp. 534-399
    • Singh, S.1    Chang, H.Y.2    Richards, T.M.3    Weiner, J.P.4    Clark, J.M.5    Segal, J.B.6
  • 158
    • 84878185729 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe?
    • Butler PC, Elashoff M, Elashoff R, Gale EA 2013. A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe? Diabetes Care 36:2118-255
    • (2013) Diabetes Care , vol.36 , pp. 2118-2255
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.4
  • 159
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: The benefits by far outweigh the potential risks
    • Nauck MA. 2013. A critical analysis of the clinical use of incretin-based therapies: The benefits by far outweigh the potential risks. Diabetes Care 36:2126-322
    • (2013) Diabetes Care , vol.36 , pp. 2126-2322
    • Ma, N.1
  • 161
    • 33846536365 scopus 로고    scopus 로고
    • A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice
    • Chen D, Liao J, Li N, Zhou C, Liu Q, et al. 2007. A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc. Natl. Acad. Sci. USA 104:943-488
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 943-488
    • Chen, D.1    Liao, J.2    Li, N.3    Zhou, C.4    Liu, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.