메뉴 건너뛰기




Volumn 118, Issue 1-2, 2004, Pages 11-18

Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum

Author keywords

Gastrointestinal hormones; Glucagon; Insulin; Regulation of secretion; Somatostatin

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; INSULIN; PEPTIDE YY; PROGLUCAGON; SOMATOSTATIN;

EID: 0842346386     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2003.10.021     Document Type: Article
Times cited : (80)

References (49)
  • 2
    • 0026510891 scopus 로고
    • Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man
    • Eissele R., Goke R., Willemer S., Harthus H.P., Vermeer H., Arnold R.et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur. J. Clin. Invest. 22:1992;283-291.
    • (1992) Eur. J. Clin. Invest. , vol.22 , pp. 283-291
    • Eissele, R.1    Goke, R.2    Willemer, S.3    Harthus, H.P.4    Vermeer, H.5    Arnold, R.6
  • 3
    • 0032756827 scopus 로고    scopus 로고
    • Immunocytochemical evidence for a paracrine interaction between GIP and GLP-1-producing cells in canine small intestine
    • Damholt A.B., Kofod H., Buchan A.M. Immunocytochemical evidence for a paracrine interaction between GIP and GLP-1-producing cells in canine small intestine. Cell Tissue Res. 298:1999;287-293.
    • (1999) Cell Tissue Res. , vol.298 , pp. 287-293
    • Damholt, A.B.1    Kofod, H.2    Buchan, A.M.3
  • 4
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
    • Orskov C., Holst J.J., Nielsen O.V. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology. 123:1988;2009-2013.
    • (1988) Endocrinology , vol.123 , pp. 2009-2013
    • Orskov, C.1    Holst, J.J.2    Nielsen, O.V.3
  • 6
    • 0029011447 scopus 로고
    • Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans
    • Layer P., Holst J.J., Grandt D., Goebell H. Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans. Dig. Dis. Sci. 40:1995;1074-1082.
    • (1995) Dig. Dis. Sci. , vol.40 , pp. 1074-1082
    • Layer, P.1    Holst, J.J.2    Grandt, D.3    Goebell, H.4
  • 7
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck M.A., Niedereichholz U., Ettler R., Holst J.J., Orskov C., Ritzel R.et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am. J. Physiol. 273:1997;E981-E988.
    • (1997) Am. J. Physiol. , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3    Holst, J.J.4    Orskov, C.5    Ritzel, R.6
  • 8
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A., Raben A., Astrup A., Holst J.J. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J. Clin. Invest. 101:1998;515-520.
    • (1998) J. Clin. Invest. , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 10
    • 0037198482 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats
    • Hartmann B., Thulesen J., Hare K.J., Kissow H., Orskov C., Poulsen S.S. et al. Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats. Regul. Pept. 105:2002;173-179.
    • (2002) Regul. Pept. , vol.105 , pp. 173-179
    • Hartmann, B.1    Thulesen, J.2    Hare, K.J.3    Kissow, H.4    Orskov, C.5    Poulsen, S.S.6
  • 11
    • 0022971804 scopus 로고
    • Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
    • Orskov C., Holst J.J., Knuhtsen S., Baldissera F.G., Poulsen S.S., Nielsen O.V. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology. 119:1986;1467-1475.
    • (1986) Endocrinology , vol.119 , pp. 1467-1475
    • Orskov, C.1    Holst, J.J.2    Knuhtsen, S.3    Baldissera, F.G.4    Poulsen, S.S.5    Nielsen, O.V.6
  • 14
    • 0029558262 scopus 로고
    • PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon
    • Wen J., Phillips S.F., Sarr M.G., Kost L.J., Holst J.J. PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon. Am. J. Physiol. 269:1995;G945-G952.
    • (1995) Am. J. Physiol. , vol.269
    • Wen, J.1    Phillips, S.F.2    Sarr, M.G.3    Kost, L.J.4    Holst, J.J.5
  • 15
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen K., Christensen L.L., Holst J.J., Orskov C. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul. Pept. 114:2003;189-196.
    • (2003) Regul. Pept. , vol.114 , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 16
    • 0023104848 scopus 로고
    • Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2)
    • Orskov C., Holst J.J. Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). Scand. J. Clin. Lab. Invest. 47:1987;165-174.
    • (1987) Scand. J. Clin. Lab. Invest. , vol.47 , pp. 165-174
    • Orskov, C.1    Holst, J.J.2
  • 17
    • 0027227370 scopus 로고
    • Glucagon-like peptide-1 (7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: Acute post-prandial and 24-h secretion patterns
    • Elliott R.M., Morgan L.M., Tredger J.A., Deacon S., Wright J., Marks V. Glucagon-like peptide-1 (7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J. Endocrinol. 138:1993;159-166.
    • (1993) J. Endocrinol. , vol.138 , pp. 159-166
    • Elliott, R.M.1    Morgan, L.M.2    Tredger, J.A.3    Deacon, S.4    Wright, J.5    Marks, V.6
  • 18
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • Orskov C., Wettergren A., Holst J.J. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand. J. Gastroenterol. 31:1996;665-670.
    • (1996) Scand. J. Gastroenterol. , vol.31 , pp. 665-670
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 19
    • 0026076306 scopus 로고
    • Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy
    • Miholic J., Orskov C., Holst J.J., Kotzerke J., Meyer H.J. Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy. Dig. Dis. Sci. 36:1991;1361-1370.
    • (1991) Dig. Dis. Sci. , vol.36 , pp. 1361-1370
    • Miholic, J.1    Orskov, C.2    Holst, J.J.3    Kotzerke, J.4    Meyer, H.J.5
  • 20
    • 0027303167 scopus 로고
    • Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop
    • Roberge J.N., Brubaker P.L. Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop. Endocrinology. 133:1993;233-240.
    • (1993) Endocrinology , vol.133 , pp. 233-240
    • Roberge, J.N.1    Brubaker, P.L.2
  • 21
    • 0029125052 scopus 로고
    • Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides
    • Herrmann-Rinke C., Voge A., Hess M., Goke B. Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides. J. Endocrinol. 147:1995;25-31.
    • (1995) J. Endocrinol. , vol.147 , pp. 25-31
    • Herrmann-Rinke, C.1    Voge, A.2    Hess, M.3    Goke, B.4
  • 22
    • 0028791530 scopus 로고
    • Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum
    • Dumoulin V., Dakka T., Plaisancie P., Chayvialle J.A., Cuber J.C. Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum. Endocrinology. 136:1995;5182-5188.
    • (1995) Endocrinology , vol.136 , pp. 5182-5188
    • Dumoulin, V.1    Dakka, T.2    Plaisancie, P.3    Chayvialle, J.A.4    Cuber, J.C.5
  • 23
    • 0028113497 scopus 로고
    • Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon
    • Plaisancie P., Bernard C., Chayvialle J.A., Cuber J.C. Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon. Endocrinology. 135:1994;2398-2403.
    • (1994) Endocrinology , vol.135 , pp. 2398-2403
    • Plaisancie, P.1    Bernard, C.2    Chayvialle, J.A.3    Cuber, J.C.4
  • 24
    • 0031732608 scopus 로고    scopus 로고
    • Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic peptide but unaffected by glucose
    • Damholt A.B., Buchan A.M., Kofod H. Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic peptide but unaffected by glucose. Endocrinology. 139:1998;2085-2091.
    • (1998) Endocrinology , vol.139 , pp. 2085-2091
    • Damholt, A.B.1    Buchan, A.M.2    Kofod, H.3
  • 25
    • 0037207057 scopus 로고    scopus 로고
    • The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop?
    • Hansen L., Holst J.J. The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop? Regul. Pept. 110:2002;39-45.
    • (2002) Regul. Pept. , vol.110 , pp. 39-45
    • Hansen, L.1    Holst, J.J.2
  • 26
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck M.A., Heimesaat M.M., Orskov C., Holst J.J., Ebert R., Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J. Clin. Invest. 91:1993;301-307.
    • (1993) J. Clin. Invest. , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 27
    • 0033921741 scopus 로고    scopus 로고
    • Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum
    • Hansen L., Hartmann B., Bisgaard T., Mineo H., Jorgensen P.N., Holst J.J. Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum. Am. J. Physiol. 278:2000;E1010-E1018.
    • (2000) Am. J. Physiol. , vol.278
    • Hansen, L.1    Hartmann, B.2    Bisgaard, T.3    Mineo, H.4    Jorgensen, P.N.5    Holst, J.J.6
  • 28
    • 0021839941 scopus 로고
    • The intestinal mucosa preferentially releases somatostatin-28 in pigs
    • Baldissera F.G., Nielsen O.V., Holst J.J. The intestinal mucosa preferentially releases somatostatin-28 in pigs. Regul. Pept. 11:1985;251-262.
    • (1985) Regul. Pept. , vol.11 , pp. 251-262
    • Baldissera, F.G.1    Nielsen, O.V.2    Holst, J.J.3
  • 29
    • 0018850721 scopus 로고
    • Oxygen supply, oxygen consumption, and endocrine and exocrine secretions of the isolated, perfused, porcine pancreas
    • Holst J.J., Jensen S.L., Nielsen O.V., Schwartz T.W. Oxygen supply, oxygen consumption, and endocrine and exocrine secretions of the isolated, perfused, porcine pancreas. Acta Physiol. Scand. 109:1980;7-13.
    • (1980) Acta Physiol. Scand. , vol.109 , pp. 7-13
    • Holst, J.J.1    Jensen, S.L.2    Nielsen, O.V.3    Schwartz, T.W.4
  • 30
    • 0030993303 scopus 로고    scopus 로고
    • Use of antagonists to define tachykininergic control of intestinal motility in pigs
    • Schmidt P.T., Holst J.J. Use of antagonists to define tachykininergic control of intestinal motility in pigs. Peptides. 18:1997;373-379.
    • (1997) Peptides , vol.18 , pp. 373-379
    • Schmidt, P.T.1    Holst, J.J.2
  • 31
    • 0028281773 scopus 로고
    • Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans
    • Orskov C., Rabenhoj L., Wettergren A., Kofod H., Holst J.J. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes. 43:1994;535-539.
    • (1994) Diabetes , vol.43 , pp. 535-539
    • Orskov, C.1    Rabenhoj, L.2    Wettergren, A.3    Kofod, H.4    Holst, J.J.5
  • 33
    • 0021211623 scopus 로고
    • The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera
    • Krarup T., Holst J.J. The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera. Regul. Pept. 9:1984;35-46.
    • (1984) Regul. Pept. , vol.9 , pp. 35-46
    • Krarup, T.1    Holst, J.J.2
  • 35
    • 0024851494 scopus 로고
    • Release of PYY from pig intestinal mucosa; Luminal and neural regulation
    • Sheikh S.P., Holst J.J., Orskov C., Ekman R., Schwartz T.W. Release of PYY from pig intestinal mucosa; luminal and neural regulation. Regul. Pept. 26:1989;253-266.
    • (1989) Regul. Pept. , vol.26 , pp. 253-266
    • Sheikh, S.P.1    Holst, J.J.2    Orskov, C.3    Ekman, R.4    Schwartz, T.W.5
  • 36
    • 0018840189 scopus 로고
    • Inhibition of gastric inhibitory polypeptide (GIP) release by insulin and glucose in juvenile diabetes
    • Creutzfeldt W., Talaulicar M., Ebert R., Willms B. Inhibition of gastric inhibitory polypeptide (GIP) release by insulin and glucose in juvenile diabetes. Diabetes. 29:1980;140-145.
    • (1980) Diabetes , vol.29 , pp. 140-145
    • Creutzfeldt, W.1    Talaulicar, M.2    Ebert, R.3    Willms, B.4
  • 37
    • 0026027919 scopus 로고
    • Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine
    • Orskov C., Jeppesen J., Madsbad S., Holst J.J. Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J. Clin. Invest. 87:1991;415-423.
    • (1991) J. Clin. Invest. , vol.87 , pp. 415-423
    • Orskov, C.1    Jeppesen, J.2    Madsbad, S.3    Holst, J.J.4
  • 39
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck M.A., Bartels E., Orskov C., Ebert R., Creutzfeldt W. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J. Clin. Endocrinol. Metab. 76:1993;912-917.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Orskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 40
    • 0027491183 scopus 로고
    • Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation
    • Nauck M.A., Busing M., Orskov C., Siegel E.G., Talartschik J., Baartz A.et al. Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation. Acta Diabetol. 30:1993;39-45.
    • (1993) Acta Diabetol. , vol.30 , pp. 39-45
    • Nauck, M.A.1    Busing, M.2    Orskov, C.3    Siegel, E.G.4    Talartschik, J.5    Baartz, A.6
  • 41
    • 0025830648 scopus 로고
    • Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides
    • Brubaker P.L. Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides. Endocrinology. 128:1991;3175-3182.
    • (1991) Endocrinology , vol.128 , pp. 3175-3182
    • Brubaker, P.L.1
  • 42
    • 0031034854 scopus 로고    scopus 로고
    • Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: Cholinergic control of GLP-1 secretion via muscarinic receptors
    • Balks H.J., Holst J.J., von zur M., Brabant G. Rapid oscillations in plasma glucagon-like peptide-1 (GLP-1) in humans: cholinergic control of GLP-1 secretion via muscarinic receptors. J. Clin. Endocrinol. Metab. 82:1997;786-790.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 786-790
    • Balks, H.J.1    Holst, J.J.2    Von Zur, M.3    Brabant, G.4
  • 43
    • 0032792838 scopus 로고    scopus 로고
    • Tachykinins stimulate release of peptide hormones (glucagon-like peptide-1) and paracrine (somatostatin) and neurotransmitter (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors
    • Schmidt P.T., Rickelt L.F., Holst J.J. Tachykinins stimulate release of peptide hormones (glucagon-like peptide-1) and paracrine (somatostatin) and neurotransmitter (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors. Dig. Dis. Sci. 44:1999;1273-1281.
    • (1999) Dig. Dis. Sci. , vol.44 , pp. 1273-1281
    • Schmidt, P.T.1    Rickelt, L.F.2    Holst, J.J.3
  • 44
    • 0025114417 scopus 로고
    • Distribution of somatostatin-14 and somatostatin-28 gastrointestinal- pancreatic cells of rats and humans
    • Francis B.H., Baskin D.G., Saunders D.R., Ensinck J.W. Distribution of somatostatin-14 and somatostatin-28 gastrointestinal-pancreatic cells of rats and humans. Gastroenterology. 99:1990;1283-1291.
    • (1990) Gastroenterology , vol.99 , pp. 1283-1291
    • Francis, B.H.1    Baskin, D.G.2    Saunders, D.R.3    Ensinck, J.W.4
  • 45
    • 0036329378 scopus 로고    scopus 로고
    • Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures
    • Chisholm C., Greenberg G.R. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am. J. Physiol. Endocrinol. Metab. 283:2002;E311-E317.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • Chisholm, C.1    Greenberg, G.R.2
  • 46
    • 0029893530 scopus 로고    scopus 로고
    • Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells
    • Harbeck M.C., Louie D.C., Howland J., Wolf B.A., Rothenberg P.L. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes. 45:1996;711-717.
    • (1996) Diabetes , vol.45 , pp. 711-717
    • Harbeck, M.C.1    Louie, D.C.2    Howland, J.3    Wolf, B.A.4    Rothenberg, P.L.5
  • 47
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • Toft-Nielsen M.B., Madsbad S., Holst J.J. Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care. 22:1999;1137-1143.
    • (1999) Diabetes Care , vol.22 , pp. 1137-1143
    • Toft-Nielsen, M.B.1    Madsbad, S.2    Holst, J.J.3
  • 48
    • 0036188070 scopus 로고    scopus 로고
    • Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
    • Deacon C.F., Wamberg S., Bie P., Hughes T.E., Holst J.J. Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs. J. Endocrinol. 172:2002;355-362.
    • (2002) J. Endocrinol. , vol.172 , pp. 355-362
    • Deacon, C.F.1    Wamberg, S.2    Bie, P.3    Hughes, T.E.4    Holst, J.J.5
  • 49
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • Yamamoto H., Lee C.E., Marcus J.N., Williams T.D., Overton J.M., Lopez M.E.et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J. Clin. Invest. 110:2002;43-52.
    • (2002) J. Clin. Invest. , vol.110 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3    Williams, T.D.4    Overton, J.M.5    Lopez, M.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.