Impaired Intestinal Proglucagon Processing in Mice Lacking Prohormone Convertase 1

Endocrinology

Volumn 145, Issue 3, 2004, Pages 1349-1355

  Ugleholdt, Randi ^a   Zhu, Xiaorong ^b   Deacon, Carolyn F ^a   Ørskov, Cathrine ^a   Steiner, Donald F ^b   Holst, Jens J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; GLICENTIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; OXYNTOMODULIN; PROGLUCAGON;

ACID PRECIPITATION; AGE DETERMINATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCAGON RELEASE; HORMONE SYNTHESIS; INTESTINE CELL; L CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SECRETORY GRANULE; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; TISSUE DISTRIBUTION; WILD TYPE;

ANIMALS; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; IMMUNOHISTOCHEMISTRY; INTESTINES; MICE; MICE, MUTANT STRAINS; PANCREAS; PEPTIDE FRAGMENTS; PEPTIDES; PROGLUCAGON; PROPROTEIN CONVERTASE 1; PROTEIN PRECURSORS;

EID: 1442274636     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0801     Document Type: Article

References (37)

1. Steiner DF, Smeekens SP, Ohagi S, Chan SJ 1992 The new enzymology of precursor processing endoproteases. J Biol Chem 267:23435-23438
2. Zhou A, Webb G, Zhu X, Steiner DF 1999 Proteolytic processing in the secretory pathway. J Biol Chem 274:20745-20748
3. Seidah NG, Chretien M, Day R 1994 The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Biochimie (Paris) 76:197-209
4. Rouille Y, Duguay SJ, Lund K, Furuta M, Gong Q, Lipkind G, Oliva Jr AA, Chan SJ, Steiner DF 1995 Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol 16:322-361
5. Steiner DF 1998 The proprotein convertases. Curr Opin Chem Biol 2:31-39
6. Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF 2002 Severe block in processing of proinsulin to insulin accompanied by elevation of des-64, 65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci USA 99:10299-10304
7. Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF 2002 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA 99:10293-10298
8. Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF 2001 Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. J Biol Chem 276:27197-27202
9. Holst JJ, Orskov C, Hartmann B, Deacon C 1997 Posttranslational processing of proglucagon and postsecretory fate of proglucagon products. In: Fehmann HC, Goeke B, eds. The insulinotropic gut hormone glucagon-like peptide 1. Frontiers in Diabetes. Vol 13. Basel, Switzerland: Karger; 24-48
10. Holst JJ, Orskov C 1994 Glucagon and other proglucagon-derived peptides. In: Walsh JH, Dockray GJ, eds. Gut peptides: biochemistry and physiology. New York Raven Press, Ltd.; 305-340
11. Holst JJ 1997 Enteroglucagon. Annu Rev Physiol 59:257-271
12. Rouille Y, Martin S, Steiner DF 1995 Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J Biol Chem 270:26488-26496
13. Rouille Y, Kantengwa S, Irminger JC, Halban PA 1997 Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem 272:32810-32816
14. Dhanvantari S, Seidah NG, Brubaker PL 1996 Role of prohormone convertases in the tissue-specific processing of proglucagon. Mol Endocrinol 10:342-355
15. Rouille Y, Westermark G, Martin SK, Steiner DF 1994 Proglucagon is processed to glucagon by prohormone convertase PC2 in α TC1-6 cells. Proc Natl Acad Sci USA 91:3242-3246
16. Blache P, Le Nguyen D, Boegner-Lemoine C, Cohen-Solal A, Bataille D, Kervran A 1994 Immunological detection of prohormone convertases in two different proglucagon processing cell lines. FEES Lett 344:65-68
17. Scopsi L, Gullo M, Rilke F, Martin S, Steiner DF 1995 Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. J Clin Endocrinol Metab 80:294-301
18. Damholt AB, Buchan AM, Holst JJ, Kofod H 1999 Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2. Endocrinology 140:4800-4808
19. Nagamune H, Muramatsu K, Akamatsu T, Tamai Y, Izumi K, Tsuji A, Matsuda Y 1995 Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets. Endocrinology 136:357-360
20. Marcinkiewicz M, Ramla D, Seidah NG, Chretien M 1994 Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets. Endocrinology 135:1651-1660
21. Nakagawa T, Hosaka M, Torii S, Watanabe T, Murakami K, Nakayama K 1993 Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. J Biochem (Tokyo) 113:132-135
22. De Bie I, Marcinkiewicz M, Malide D, Lazure C, Nakayama K, Bendayan M, Seidah NG 1996 The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. J Cell Biol 135:1261-1275
23. Furuta M, Yano H, Zhou A, Rouille Y, Holst JJ, Carroll R, Ravazzola M, Orci L, Furuta H, Steiner DF 1997 Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci USA 94:6646-6651
24. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ 2003 Lower blood glucose, hyperglucagonemia, and pancreatic a cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci USA 100:1438-1443
25. Mortensen K, Christensen LL, Holst JJ, Orskov C 2003 GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 114:189-196
26. Holst JJ, Bersani M 1991 Assays for peptide products of somatostatin gene expression. In: Conn PM, ed. Methods in neurosciences. Vol 5. New York: Academic Press; 3-22
27. Orskov C, Holst JJ, Poulsen SS, Kirkegaard P 1987 Pancreatic and intestinal processing of proglucagon in man. Diabetologia 30:874-881
28. Orskov C, Jeppesen J, Madsbad S, Holst JJ 1991 Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 87:415-423
29. Gutniak MK, Larsson H, Heiber SJ, Juneskans OT, Holst JJ, Ahren B 1996 Potential therapeutic levels of glucagon-like peptide I achieved in humans by a buccal tablet. Diabetes Care 19:843-848
30. Orskov C, Rabenhoj L, Wettergren A, Kofod H, Holst JJ 1994 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 43:535-539
31. Hartmann B, Johnsen AH, Orskov C, Adelhorst K, Thim L, Holst JJ 2000 Structure, measurement, and secretion of human glucagon-like peptide-2. Peptides 21:73-80
32. Holst JJ 1980 Evidence that glicentin contains the entire sequence of glucagon. Biochem J 187:337-343
33. Rouille Y, Bianchi M, Irminger JC, Halban PA 1997 Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon. FEBS Lett 413:119-123
34. Rothenberg ME, Eilertson CD, Klein K, Zhou Y, Lindberg I, McDonald JK, Mackin RB, Noe BD 1995 Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro. J Biol Chem 270:10136-10146
35. Mojsov S, Kopczynski MG, Habener JF 1990 Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem 265:8001-8008
36. Dupuy A, Lindberg I, Zhou Y, Akil H, Lazure C, Chretien M, Seidah NG, Day R 1994 Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue. FEBS Lett 337:60-65
37. Rothenberg ME, Eilertson CD, Klein K, Mackin RB, Noe BD 1996 Evidence for redundancy in propeptide/prohormone convertase activities in processing proglucagon: an antisense study. Mol Endocrinol 10:331-341