메뉴 건너뛰기




Volumn 55, Issue 2, 2014, Pages 226-238

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

Author keywords

Cholesterol; Metabolism; MicroRNA; Sterol response element binding protein; Transcription

Indexed keywords

CHOLESTEROL; METABOLISM; MICRORNA; STEROL RESPONSE ELEMENT BINDING PROTEIN; TRANSCRIPTION;

EID: 84893357948     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M041335     Document Type: Article
Times cited : (84)

References (83)
  • 1
    • 1842787963 scopus 로고    scopus 로고
    • Role of cholesterol in cardiovascular dysfunction
    • Saini, H. K., A. S. Arneja, and N. S. Dhalla.2004.Role of cholesterol in cardiovascular dysfunction. Can. J. Cardiol. 20 : 333-346.
    • (2004) Can. J. Cardiol , vol.20 , pp. 333-346
    • Saini, H.K.1    Arneja, A.S.2    Dhalla, N.S.3
  • 2
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis, the road ahead
    • Glass, C. K., and J. L. Witztum.2001.Atherosclerosis, the road ahead. Cell.104 : 503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 3
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown, M. S., and J. L. Goldstein.1986.A receptor-mediated pathway for cholesterol homeostasis. Science.232 : 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 0017239547 scopus 로고
    • Receptor-mediated control of cholesterol metabolism
    • Brown, M. S., and J. L. Goldstein.1976.Receptor-mediated control of cholesterol metabolism. Science.191 : 150-154.
    • (1976) Science , vol.191 , pp. 150-154
    • Brown, M.S.1    Goldstein, J.L.2
  • 5
    • 0020648725 scopus 로고
    • Sterol structure and membrane function
    • Bloch, K. E. 1983.Sterol structure and membrane function. CRC Crit. Rev. Biochem. 14 : 47-92.
    • (1983) CRC Crit. Rev. Biochem , vol.14 , pp. 47-92
    • Bloch, K.E.1
  • 6
    • 0015487958 scopus 로고
    • Hmg coa reductase of intestinal mucosa and liver of the rat
    • Shefer, S., S. Hauser, V. Lapar, and E. H. Mosbach.1972.HMG CoA reductase of intestinal mucosa and liver of the rat. J. Lipid Res. 13 : 402-412.
    • (1972) J. Lipid Res , vol.13 , pp. 402-412
    • Shefer, S.1    Hauser, S.2    Lapar, V.3    Mosbach, E.H.4
  • 7
    • 0015992965 scopus 로고
    • Determination of hepatic 3-hydroxy-3-methylglutaryl coa reductase activity in man
    • Nicolau, G., S. Shefer, G. Salen, and E. H. Mosbach.1974.Determination of hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity in man. J. Lipid Res. 15 : 94-98.
    • (1974) J. Lipid Res , vol.15 , pp. 94-98
    • Nicolau, G.1    Shefer, S.2    Salen, G.3    Mosbach, E.H.4
  • 8
    • 0030941803 scopus 로고    scopus 로고
    • The srebp pathway: Regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor
    • Brown, M. S., and J. L. Goldstein.1997.The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor. Cell.89 : 331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 9
    • 0028236524 scopus 로고
    • Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule
    • Gasic, G. P. 1994.Basic-helix-loop-helix transcription factor and sterol sensor in a single membrane-bound molecule. Cell.77 : 17-19.
    • (1994) Cell , vol.77 , pp. 17-19
    • Gasic, G.P.1
  • 10
    • 0028875426 scopus 로고
    • Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
    • Bennett, M. K., J. M. Lopez, H. B. Sanchez, and T. F. Osborne.995.Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270 : 25578-25583.
    • (1995) J. Biol. Chem , vol.270 , pp. 25578-25583
    • Bennett, M.K.1    Lopez, J.M.2    Sanchez, H.B.3    Osborne, T.F.4
  • 11
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mrnas for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura, I., H. Shimano, J. D. Horton, J. L. Goldstein, and M. S. Brown.1997.Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99 : 838-845.
    • (1997) J. Clin. Invest , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 12
    • 0034681260 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
    • Brown, M. S., J. Ye, R. B. Rawson, and J. L. Goldstein.2000.Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell.100 : 391-398.
    • (2000) Cell , vol.100 , pp. 391-398
    • Brown, M.S.1    Ye, J.2    Rawson, R.B.3    Goldstein, J.L.4
  • 13
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • Brown, M. S., and J. L. Goldstein.1999.A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. USA.96 : 11041-11048.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 14
    • 14644391519 scopus 로고    scopus 로고
    • Osbp is a cholesterol-regulated scaffolding protein in control of erk 1/2 activation
    • Wang, P. Y., J. Weng, and R. G. Anderson.2005.OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science.307 : 1472-1476.
    • (2005) Science , vol.307 , pp. 1472-1476
    • Wang, P.Y.1    Weng, J.2    Anderson, R.G.3
  • 15
    • 65549140251 scopus 로고    scopus 로고
    • A phosphorylation cascade controls the degradation of active srebp1
    • Bengoechea-Alonso, M. T., and J. Ericsson.2009.A phosphorylation cascade controls the degradation of active SREBP1. J. Biol. Chem. 284 : 5885-5895.
    • (2009) J. Biol. Chem , vol.284 , pp. 5885-5895
    • Bengoechea-Alonso, M.T.1    Ericsson, J.2
  • 16
    • 23844530704 scopus 로고    scopus 로고
    • Control of lipid metabolism by phosphorylation-dependent degradation of the srebp family of transcription factors by scf(fbw7)
    • Sundqvist, A., M. T. Bengoechea-Alonso, X. Ye, V. Lukiyanchuk, J. Jin, J. W. Harper, and J. Ericsson.2005.Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab. 1 : 379-391.
    • (2005) Cell Metab , vol.1 , pp. 379-391
    • Sundqvist, A.1    Bengoechea-Alonso, M.T.2    Ye, X.3    Lukiyanchuk, V.4    Jin, J.5    Harper, J.W.6    Ericsson, J.7
  • 18
    • 2542418816 scopus 로고    scopus 로고
    • Insulin-Activated erk-mitogen-Activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo
    • Kotzka, J., S. Lehr, G. Roth, H. Avci, B. Knebel, and D. Muller-Wieland.2004.Insulin-Activated Erk-mitogen-Activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo. J. Biol. Chem. 279 : 22404-22411.
    • (2004) J. Biol. Chem , vol.279 , pp. 22404-22411
    • Kotzka, J.1    Lehr, S.2    Roth, G.3    Avci, H.4    Knebel, B.5    Drazul-Schrader, D.6
  • 19
    • 78149500681 scopus 로고    scopus 로고
    • Insulin signaling in fatty acid and fat synthesis: A transcriptional perspective
    • Wong, R. H., and H. S. Sul.2010.Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective. Curr. Opin. Pharmacol. 10 : 684-691.
    • (2010) Curr. Opin. Pharmacol , vol.10 , pp. 684-691
    • Wong, R.H.1    Sul, H.S.2
  • 20
    • 0034721772 scopus 로고    scopus 로고
    • Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro
    • Roth, G., J. Kotzka, L. Kremer, S. Lehr, C. Lohaus, H. E. Meyer, W. Krone, and D. Muller-Wieland.2000.MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J. Biol. Chem. 275 : 33302-33307.
    • (2000) J. Biol. Chem , vol.275 , pp. 33302-33307
    • Roth, G.1    Kotzka, J.2    Kremer, L.3    Lehr, S.4    Lohaus, C.5    Meyer, H.E.6    Krone, W.7    Drazul-Schrader, D.8
  • 21
    • 33744821064 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein 1 is negatively modulated by pka phosphorylation
    • Lu, M., and J. Y. Shyy.2006.Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am. J. Physiol. Cell Physiol. 290 : C1477-C1486.
    • (2006) Am. J. Physiol. Cell Physiol , vol.290
    • Lu, M.1    Shyy, J.Y.2
  • 22
    • 33748751591 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to dna binding
    • Punga, T., M. T. Bengoechea-Alonso, and J. Ericsson.2006.Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J. Biol. Chem. 281 : 25278-25286.
    • (2006) J. Biol. Chem , vol.281 , pp. 25278-25286
    • Punga, T.1    Bengoechea-Alonso, M.T.2    Ericsson, J.3
  • 23
    • 33747813851 scopus 로고    scopus 로고
    • Cdk1/cyclin b-mediated phosphorylation stabilizes srebp1 during mitosis
    • Bengoechea-Alonso, M. T., and J. Ericsson.2006.Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis. Cell Cycle.5 : 1708-1718.
    • (2006) Cell Cycle , vol.5 , pp. 1708-1718
    • Bengoechea-Alonso, M.T.1    Ericsson, J.2
  • 24
    • 84857548618 scopus 로고    scopus 로고
    • Preventing phosphorylation of sterol regulatory element-binding protein 1a by map-kinases protects mice from fatty liver and visceral obesity
    • Kotzka, J., B. Knebel, J. Haas, L. Kremer, S. Jacob, S. Hartwig, U. Nitzgen, and D. Muller-Wieland.2012.Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity. PLoS ONE.7 : e32609.
    • (2012) PLoS ONE , vol.7
    • Kotzka, J.1    Knebel, B.2    Haas, J.3    Kremer, L.4    Jacob, S.5    Hartwig, S.6    Nitzgen, U.7    Drazul-Schrader, D.8
  • 25
    • 77958471996 scopus 로고    scopus 로고
    • Phosphorylation of sterol regulatory element-binding protein (srebp)-1a links growth hormone action to lipid metabolism in hepatocytes
    • Kotzka, J., B. Knebel, H. Avci, S. Jacob, U. Nitzgen, F. Jockenhovel, J. Heeren, J. Haas, and D. Muller-Wieland.2010.Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes. Atherosclerosis.213 : 156-165.
    • (2010) Atherosclerosis , vol.213 , pp. 156-165
    • Kotzka, J.1    Knebel, B.2    Avci, H.3    Jacob, S.4    Nitzgen, U.5    Jockenhovel, F.6    Heeren, J.7    Haas, J.8    Drazul-Schrader, D.9
  • 26
    • 67449084097 scopus 로고    scopus 로고
    • Salt-inducible kinase regulates hepatic lipogenesis by controlling srebp-1c phosphorylation
    • Yoon, Y. S., W. Y. Seo, M. W. Lee, S. T. Kim, and S. H. Koo.2009.Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J. Biol. Chem. 284 : 10446-10452.
    • (2009) J. Biol. Chem , vol.284 , pp. 10446-10452
    • Yoon, Y.S.1    Seo, W.Y.2    Lee, M.W.3    Kim, S.T.4    Koo, S.H.5
  • 27
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by micrornas: Are the answers in sight?
    • Filipowicz, W., S. N. Bhattacharyya, and N. Sonenberg.2008.Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9 : 102-114.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 28
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: Microrna biogenesis pathways and their regulation
    • Winter, J., S. Jung, S. Keller, R. I. Gregory, and S. Diederichs.2009.Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 11 : 228-234.
    • (2009) Nat. Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 32
    • 84863147229 scopus 로고    scopus 로고
    • Discovering dysfunction of multiple micrornas cooperation in disease by a conserved microrna co-expression network
    • Xiao, Y., C. Xu, J. Guan, Y. Ping, H. Fan, Y. Li, H. Zhao, and X. Li.2012.Discovering dysfunction of multiple microRNAs cooperation in disease by a conserved microRNA co-expression network. PLoS ONE.7 : e32201.
    • (2012) PLoS ONE , vol.7
    • Xiao, Y.1    Xu, C.2    Guan, J.3    Ping, Y.4    Fan, H.5    Li, Y.6    Zhao, H.7    Li, X.8
  • 34
    • 84859171807 scopus 로고    scopus 로고
    • Myc on the path to cancer
    • Dang, C. V. 2012.MYC on the path to cancer. Cell.149 : 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 37
    • 84875646958 scopus 로고    scopus 로고
    • Microrna-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor
    • Qu, F., X. Cui, Y. Hong, J. Wang, Y. Li, L. Chen, Y. Liu, Y. Gao, D. Xu, and Q. Wang.2013.MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor. Mol. Cell. Biochem. 377 : 121-130.
    • (2013) Mol. Cell. Biochem , vol.377 , pp. 121-130
    • Qu, F.1    Cui, X.2    Hong, Y.3    Wang, J.4    Li, Y.5    Chen, L.6    Liu, Y.7    Gao, Y.8    Xu, D.9    Wang, Q.10
  • 38
    • 84892652850 scopus 로고    scopus 로고
    • Mir-152 and mir-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting dnmt1 directly: A novel epigenetic therapy independent of decitabine
    • Epub ahead of print. January doi:10.1038/ onc.2012.575
    • Xiang, Y., N. Ma, D. Wang, Y. Zhang, J. Zhou, G. Wu, R. Zhao, H. Huang, X. Wang, Y. Qiao, et al.MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine. Oncogene.Epub ahead of print. January 13, 2013; doi:10.1038/ onc.2012.575.
    • (2013) Oncogene , vol.13
    • Xiang, Y.1    Ma, N.2    Wang, D.3    Zhang, Y.4    Zhou, J.5    Wu, G.6    Zhao, R.7    Huang, H.8    Wang, X.9    Qiao, Y.10
  • 39
    • 84892779985 scopus 로고    scopus 로고
    • Association of germline microrna snps in pre-mirna flanking region and breast cancer risk and survival: The carolina breast cancer study
    • Bensen, J. T., C. K. Tse, S. J. Nyante, J. S. Barnholtz-Sloan, S. R. Cole, and R. C. Millikan.2013.Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study. Cancer Causes Control.24: 1099-1109.
    • (2013) Cancer Causes Control , vol.24 , pp. 1099-1109
    • Bensen, J.T.1    Tse, C.K.2    Nyante, S.J.3    Barnholtz-Sloan, J.S.4    Cole, S.R.5    Millikan, R.C.6
  • 40
    • 77956342464 scopus 로고    scopus 로고
    • Microrna-185 suppresses tumor growth and progression by targeting the six1 oncogene in human cancers
    • Imam, J. S., K. Buddavarapu, J. S. Lee-Chang, S. Ganapathy, C. Camosy, Y. Chen, and M. K. Rao.2010.MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene.29 : 4971-4979.
    • (2010) Oncogene , vol.29 , pp. 4971-4979
    • Imam, J.S.1    Buddavarapu, K.2    Lee-Chang, J.S.3    Ganapathy, S.4    Camosy, C.5    Chen, Y.6    Rao, M.K.7
  • 41
    • 78651465898 scopus 로고    scopus 로고
    • Mir-185 targets rhoa and cdc42 expression and inhibits the proliferation potential of human colorectal cells
    • Liu, M., N. Lang, X. Chen, Q. Tang, S. Liu, J. Huang, Y. Zheng, and F. Bi.2011.miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. Cancer Lett. 301 : 151-160.
    • (2011) Cancer Lett , vol.301 , pp. 151-160
    • Liu, M.1    Lang, N.2    Chen, X.3    Tang, Q.4    Liu, S.5    Huang, J.6    Zheng, Y.7    Bi, F.8
  • 42
    • 80053355727 scopus 로고    scopus 로고
    • Mir-185 targets the dna methyltransferases 1 and regulates global dna methylation in human glioma
    • Zhang, Z., H. Tang, Z. Wang, B. Zhang, W. Liu, H. Lu, L. Xiao, X. Liu, R. Wang, X. Li, et al.2011.MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma. Mol. Cancer.10 : 124.
    • (2011) Mol. Cancer , vol.10 , pp. 124
    • Zhang, Z.1    Tang, H.2    Wang, Z.3    Zhang, B.4    Liu, W.5    Lu, H.6    Xiao, L.7    Liu, X.8    Wang, R.9    Li, X.10
  • 43
    • 84878967914 scopus 로고    scopus 로고
    • Micrornas 185 96 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition
    • Wang, L., X. J. Jia, H. J. Jiang, Y. Du, F. Yang, S. Y. Si, and B. Hong.2013.MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol. Cell. Biol. 33 : 1956-1964.
    • (2013) Mol. Cell. Biol , vol.33 , pp. 1956-1964
    • Wang, L.1    Jia, X.J.2    Jiang, H.J.3    Du, Y.4    Yang, F.5    Si B. Hong, S.Y.6
  • 44
    • 84871887481 scopus 로고    scopus 로고
    • Micrornas 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class b type i in steroidogenic cells
    • Hu, Z., W. J. Shen, F. B. Kraemer, and S. Azhar.2012.MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells. Mol. Cell. Biol. 32 : 5035-5045.
    • (2012) Mol. Cell. Biol , vol.32 , pp. 5035-5045
    • Hu, Z.1    Shen, W.J.2    Kraemer, F.B.3    Azhar, S.4
  • 45
    • 0030930330 scopus 로고    scopus 로고
    • The cholesterol-lowering effect of guar gum is not the result of a simple diversion of bile acids toward fecal excretion
    • Favier, M. L., P. E. Bost, C. Guittard, C. Demigne, and C. Remesy.997.The cholesterol-lowering effect of guar gum is not the result of a simple diversion of bile acids toward fecal excretion. Lipids.32 : 953-959.
    • (1997) Lipids , vol.32 , pp. 953-959
    • Favier, M.L.1    Bost, P.E.2    Guittard, C.3    Demigne, C.4    Remesy, C.5
  • 46
    • 0031886036 scopus 로고    scopus 로고
    • Development, validation, and interlaboratory comparison of an hmg-coa reductase inhibition assay for quantitation of atorvastatin in plasma matrices
    • Shum, Y. Y., N. Huang, G. Walter, A. Black, C. Sekerke, T. Chang, and L. R. Whitfield.1998.Development, validation, and interlaboratory comparison of an HMG-CoA reductase inhibition assay for quantitation of atorvastatin in plasma matrices. Ther. Drug Monit. 20 : 41-49.
    • (1998) Ther. Drug Monit , vol.20 , pp. 41-49
    • Shum, Y.Y.1    Huang, N.2    Walter, G.3    Black, A.4    Sekerke, C.5    Chang, T.6    Whitfield, L.R.7
  • 47
    • 34249861927 scopus 로고    scopus 로고
    • Sterol-regulated transport of srebps from endoplasmic reticulum to golgi: Insig renders sorting signal in scap inaccessible to copii proteins
    • Sun, L. P., J. Seemann, J. L. Goldstein, and M. S. Brown.2007.Sterol- regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc. Natl. Acad. Sci. USA.104 : 6519-6526.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 6519-6526
    • Sun, L.P.1    Seemann, J.2    Goldstein, J.L.3    Brown, M.S.4
  • 48
    • 77956511868 scopus 로고    scopus 로고
    • Accessibility of cholesterol in endoplasmic reticulum membranes and activation of srebp-2 switch abruptly at a common cholesterol threshold
    • Sokolov, A., and A. Radhakrishnan.2010.Accessibility of cholesterol in endoplasmic reticulum membranes and activation of SREBP-2 switch abruptly at a common cholesterol threshold. J. Biol. Chem. 285 : 29480-29490.
    • (2010) J. Biol. Chem , vol.285 , pp. 29480-29490
    • Sokolov, A.1    Radhakrishnan, A.2
  • 49
    • 56449110891 scopus 로고    scopus 로고
    • Switch-like control of srebp-2 transport triggered by small changes in er cholesterol: A delicate balance
    • Radhakrishnan, A., J. L. Goldstein, J. G. McDonald, and M. S. Brown.2008.Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab. 8 : 512-521.
    • (2008) Cell Metab , vol.8 , pp. 512-521
    • Radhakrishnan, A.1    Goldstein, J.L.2    McDonald, J.G.3    Brown, M.S.4
  • 50
    • 18844472258 scopus 로고
    • Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme a reductase
    • Rodwell, V. W. 1972.Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochem. J. 128 : 16P.
    • (1972) Biochem. J , vol.128
    • Rodwell, V.W.1
  • 51
    • 0015438659 scopus 로고
    • Cholesterol regulation of hepatic hmg-coa reductase
    • Rodwell, V. W. 1972.Cholesterol regulation of hepatic HMG-CoA reductase. Biochem. Soc. Symp. 35 : 295-301.
    • (1972) Biochem. Soc. Symp , vol.35 , pp. 295-301
    • Rodwell, V.W.1
  • 53
    • 84867099976 scopus 로고    scopus 로고
    • Expanding roles for srebp in metabolism
    • Shao, W., and P. J. Espenshade.2012.Expanding roles for SREBP in metabolism. Cell Metab. 16 : 414-419.
    • (2012) Cell Metab , vol.16 , pp. 414-419
    • Shao, W.1    Espenshade, P.J.2
  • 54
    • 84856471735 scopus 로고    scopus 로고
    • Srebps: Metabolic integrators in physiology and metabolism
    • Jeon, T. I., and T. F. Osborne.2012.SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol. Metab. 23 : 65-72.
    • (2012) Trends Endocrinol. Metab , vol.23 , pp. 65-72
    • Jeon, T.I.1    Osborne, T.F.2
  • 56
    • 79960523356 scopus 로고    scopus 로고
    • The role of micrornas in cholesterol efflux and hepatic lipid metabolism
    • Moore, K. J., K. J. Rayner, Y. Suarez, and C. Fernandez-Hernando.2011.The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu. Rev. Nutr. 31 : 49-63.
    • (2011) Annu. Rev. Nutr , Issue.31 , pp. 49-63
    • Moore, K.J.1    Rayner, K.J.2    Suarez, Y.3    Erlanson-Albertsson, C.4
  • 57
    • 23844523406 scopus 로고    scopus 로고
    • Mir-122, a mammalian liver-specific microrna, is processed from hcr mrna and may downregulate the high affinity cationic amino acid transporter cat-1
    • Chang, J., E. Nicolas, D. Marks, C. Sander, A. Lerro, M. A. Buendia, C. Xu, W. S. Mason, T. Moloshok, R. Bort, et al.2004.miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol. 1 : 106-113.
    • (2004) Rna Biol , vol.1 , pp. 106-113
    • Chang, J.1    Nicolas, E.2    Marks, D.3    Sander, C.4    Lerro, A.5    Buendia, M.A.6    Xu, C.7    Mason, W.S.8    Moloshok, T.9    Bort, R.10
  • 60
    • 79953755370 scopus 로고    scopus 로고
    • Ampk phosphorylates and inhibits srebp activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li, Y., S. Xu, M. M. Mihaylova, B. Zheng, X. Hou, B. Jiang, O. Park, Z. Luo, E. Lefai, J. Y. Shyy, et al.2011.AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13 : 376-388.
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6    Park, O.7    Luo, Z.8    Lefai, E.9    Shyy, J.Y.10
  • 61
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • Horton, J. D., Y. Bashmakov, I. Shimomura, and H. Shimano.1998.Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA.95 : 5987-5992.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 63
    • 0037977708 scopus 로고    scopus 로고
    • Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats
    • Bizeau, M. E., P. S. MacLean, G. C. Johnson, and Y. Wei.2003.Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats. J. Nutr. 133 : 1787-1792.
    • (2003) J. Nutr , vol.133 , pp. 1787-1792
    • Bizeau, M.E.1    MacLean, P.S.2    Johnson, G.C.3    Wei, Y.4
  • 64
    • 3042846012 scopus 로고    scopus 로고
    • In vivo regulation of srebp-1c in skeletal muscle: Effects of nutritional status, glucose, insulin, and leptin
    • Commerford, S. R., L. Peng, J. J. Dube, and R. M. O'Doherty.2004.In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 : R218-R227.
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.287
    • Commerford, S.R.1    Peng, L.2    Dube, J.J.3    O'Doherty, R.M.4
  • 65
    • 0034283596 scopus 로고    scopus 로고
    • Insulin effects on sterol regulatory-elementbinding protein-1c (srebp-1c) transcriptional activity in rat hepatocytes
    • Azzout-Marniche, D., D. Becard, C. Guichard, M. Foretz, P. Ferre, and F. Foufelle.2000.Insulin effects on sterol regulatory-elementbinding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem. J. 350 : 389-393.
    • (2000) Biochem. J , vol.350 , pp. 389-393
    • Azzout-Marniche, D.1    Becard, D.2    Guichard, C.3    Foretz, M.4    Ferre, P.5    Foufelle, F.6
  • 69
    • 0037503924 scopus 로고    scopus 로고
    • Liver x receptor signaling pathways in cardiovascular disease
    • Tontonoz, P., and D. J. Mangelsdorf.2003.Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17 : 985-993.
    • (2003) Mol. Endocrinol , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 70
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu, J., M. T. Nakamura, H. P. Cho, and S. D. Clarke.1999.Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J. Biol. Chem. 274 : 23577-23583.
    • (1999) J. Biol. Chem , vol.274 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4
  • 71
    • 0035971159 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
    • Xu, J., M. Teran-Garcia, J. H. Park, M. T. Nakamura, and S. D. Clarke.2001.Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J. Biol. Chem. 276 : 9800-9807.
    • (2001) J. Biol. Chem , vol.276 , pp. 9800-9807
    • Xu, J.1    Orho-Melander, M.2    Park, J.H.3    Nakamura, M.T.4    Clarke, S.D.5
  • 72
    • 0035830840 scopus 로고    scopus 로고
    • Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in hek-293 cells
    • Hannah, V. C., J. Ou, A. Luong, J. L. Goldstein, and M. S. Brown.2001.Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276 : 4365-4372.
    • (2001) J. Biol. Chem , Issue.276 , pp. 4365-4372
    • Hannah, V.C.1    Ou, J.2    Luong, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 73
    • 0034021691 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acid regulation of gene expression
    • Price, P. T., C. M. Nelson, and S. D. Clarke.2000.Omega-3 polyunsaturated fatty acid regulation of gene expression. Curr. Opin. Lipidol. 11 : 3-7.
    • (2000) Curr. Opin. Lipidol , vol.11 , pp. 3-7
    • Price, P.T.1    Nelson, C.M.2    Clarke, S.D.3
  • 74
    • 12344254782 scopus 로고    scopus 로고
    • Mechanisms of regulation of gene expression by fatty acids
    • Nakamura, M. T., Y. Cheon, Y. Li, and T. Y. Nara.2004.Mechanisms of regulation of gene expression by fatty acids. Lipids.39 : 1077-1083.
    • (2004) Lipids , vol.39 , pp. 1077-1083
    • Nakamura, M.T.1    Cheon, Y.2    Li, Y.3    Nara, T.Y.4
  • 75
    • 0023136059 scopus 로고
    • Effect of dietary n-3 fatty acids on hmg-coa reductase and acat activities in liver and intestine of the rabbit
    • Field, F. J., E. J. Albright, and S. N. Mathur.1987.Effect of dietary n-3 fatty acids on HMG-CoA reductase and ACAT activities in liver and intestine of the rabbit. J. Lipid Res. 28 : 50-58.
    • (1987) J. Lipid Res , vol.28 , pp. 50-58
    • Field, F.J.1    Albright, E.J.2    Mathur, S.N.3
  • 76
    • 0020452213 scopus 로고
    • Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-coa: Cholesterol acyltransferase activity in rabbit intestinal microsomes
    • Field, F. J., and R. G. Salome.1982.Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-CoA: cholesterol acyltransferase activity in rabbit intestinal microsomes. Biochim. Biophys. Acta.712 : 557-570.
    • (1982) Biochim. Biophys. Acta , vol.712 , pp. 557-570
    • Field, F.J.1    Salome, R.G.2
  • 77
    • 0030829812 scopus 로고    scopus 로고
    • Elevated levels of srebp-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the srebp-1 gene
    • Shimano, H., I. Shimomura, R. E. Hammer, J. Herz, J. L. Goldstein, M. S. Brown, and J. D. Horton.1997.Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100 : 2115-2124.
    • (1997) J. Clin. Invest , vol.100 , pp. 2115-2124
    • Shimano, H.1    Shimomura, I.2    Hammer, R.E.3    Herz, J.4    Goldstein, J.L.5    Brown, M.S.6    Horton, J.D.7
  • 78
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver x receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • Liang, G., J. Yang, J. D. Horton, R. E. Hammer, J. L. Goldstein, and M. S. Brown.2002.Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J. Biol. Chem. 277 : 9520-9528.
    • (2002) J. Biol. Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 79
    • 79960698521 scopus 로고    scopus 로고
    • Mechanisms regulating hepatic sr-bi expression their impact on hdl metabolism
    • Leiva, A., H. Verdejo, M. L. Benitez, A. Martinez, D. Busso, and A. Rigotti.2011.Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism. Atherosclerosis.217 : 299-307.
    • (2011) Atherosclerosis , vol.217 , pp. 299-307
    • Leiva, A.1    Verdejo, H.2    Benitez, M.L.3    Martinez, A.4    Drazul-Schrader, D.5
  • 83
    • 78650861117 scopus 로고    scopus 로고
    • Inhibition of srebp by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques
    • Tang, J. J., J. G. Li, W. Qi, W. W. Qiu, P. S. Li, B. L. Li, and B. L. Song.2011.Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab. 13 : 44-56.
    • (2011) Cell Metab , vol.13 , pp. 44-56
    • Tang, J.J.1    Li, J.G.2    Qi, W.3    Qiu, W.W.4    Li, P.S.5    Li, B.L.6    Song, B.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.