MiR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells

Cancer Letters

Volumn 301, Issue 2, 2011, Pages 151-160

  Liu, Ming ^a   Lang, Nan ^a   Chen, Xiangzhen ^a   Tang, Qiulin ^a   Liu, Surui ^a   Huang, Juan ^a   Zheng, Yi ^b   Bi, Feng ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Cdc42; Colorectal cancer; MiRNA 185; RhoA; Small G protein

Indexed keywords

LUCIFERASE; MICRORNA 185; PROTEIN CDC42; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INVASION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ASSAY; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; GENETIC CONSERVATION; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SEQUENCE ANALYSIS;

3' UNTRANSLATED REGIONS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CDC42 GTP-BINDING PROTEIN; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; HELA CELLS; HUMANS; LUCIFERASES; MICRORNAS; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE;

EID: 78651465898     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.11.009     Document Type: Article

References (29)

1. Chi S.W., Zang J.B., Mele A., Darnell R.B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 2009, 460:479-486.
2. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
3. Wang J., Wang Q., Liu H., Hu B., Zhou W., Cheng Y. MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer. Cancer Lett. 2010, 297:137-143.
4. Carrington J.C., Ambros V. Role of microRNAs in plant and animal development. Science 2003, 301:336-338.
5. Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer 2006, 6:857-866.
6. Yu F., Yao H., Zhu P., Zhang X., Pan Q., Gong C., Huang Y., Hu X., Su F., Lieberman J., Song E. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
7. Cimmino A., Calin G.A., Fabbri M., Iorio M.V., Ferracin M., Shimizu M., Wojcik S.E., Aqeilan R.I., Zupo S., Dono M., Rassenti L., Alder H., Volinia S., Liu C.G., Kipps T.J., Negrini M., Croce C.M. MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA 2005, 102:13944-13949.
8. Asangani I.A., Rasheed S.A., Nikolova D.A., Leupold J.H., Colburn N.H., Post S., Allgayer H. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27:2128-2136.
9. Papagiannakopoulos T., Shapiro A., Kosik K.S. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res. 2008, 68:8164-8172.
10. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
11. Sahai E., Marshall C.J. RHO-GTPases and cancer. Nat. Rev. Cancer 2002, 2:133-142.
12. Gómez Del Pulgar T., Valdés-Mora F., Bandrés E., Pérez-Palacios R., Espina C., Cejas P., García-Cabezas M.A., Nistal M., Casado E., González-Barón M., García-Foncillas J., Lacal J.C. Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int. J. Oncol. 2008, 33:185-193.
13. Takami Y., Higashi M., Kumagai S., Kuo P.C., Kawana H., Koda K., Miyazaki M., Harigaya K. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Dig. Dis. Sci. 2008, 53:467-473.
14. Wang H.B., Liu X.P., Liang J., Yang K., Sui A.H., Liu Y.J. Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters. Clin. Chem. Lab. Med. 2009, 47:811-817.
15. Fritz G., Just I., Kaina B. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 1999, 81:682-687.
16. Kamai T., Yamanishi T., Shirataki H., Takagi K., Asami H., Ito Y., Yoshida K. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin. Cancer Res. 2004, 10:4799-4805.
17. Fukui K., Tamura S., Wada A., Kamada Y., Sawai Y., Imanaka K., Kudara T., Shimomura I., Hayashi N. Expression and prognostic role of RhoA GTPases in hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2006, 132:627-633.
18. Tucci M.G., Lucarini G., Brancorsini D., Zizzi A., Pugnaloni A., Giacchetti A., Ricotti G., Biagini G. Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma. Br. J. Dermatol. 2007, 157:1212-1216.
19. Pan Y., Bi F., Liu N., Xue Y., Yao X., Zheng Y., Fan D. Expression of seven main Rho family members in gastric carcinoma. Biochem. Biophys. Res. Commun. 2004, 315:686-691.
20. Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 2005, 21:247-269.
21. Liu N., Bi F., Pan Y., Sun L., Xue Y., Shi Y., Yao X., Zheng Y., Fan D. Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin. Cancer Res. 2004, 10:6239-6247.
22. Zhang S., Tang Q., Xu F., Xue Y., Zhen Z., Deng Y., Liu M., Chen J., Liu S., Qiu M., Liao Z., Li Z., Luo D., Shi F., Zheng Y., Bi F. RhoA regulates G1/S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. Mol. Cancer Res. 2009, 7:481-491.
23. Yang L., Wang L., Zheng Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol. Biol. Cell 2006, 17:4675-4685.
24. Marques C.A., Hahnel P.S., Wolfel C., Thaler S., Huber C., Theobald M., Schuler M. An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression. Blood 2008, 111:1413-1419.
25. Perona R., Montaner S., Saniger L., Sanchez-Perez I., Bravo R., Lacal J.C. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 1997, 11:463-475.
26. Chou M.M., Masuda-Robens J.M., Gupta M.L. Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression. J. Biol. Chem. 2003, 278:35241-35247.
27. Takahashi Y., Forrest A.R., Maeno E., Hashimoto T., Daub C.O., Yasuda J. MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One 2009, 4:e6677.
28. Patel S., Takagi K.I., Suzuki J., Imaizumi A., Kimura T., Mason R.M., Kamimura T., Zhang Z. RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation. J. Am. Soc. Nephrol. 2005, 16:1977-1984.
29. Herrero J., Al-Shahrour F., DÃaz-Uriarte R., Mateos A., Vaquerizas J.M., Santoyo J., Dopazo J. GEPAS, a web-based resource for microarray gene expression data analysis. Nucleic Acids Res. 2003, 31:3461-3467.