OSBP is a cholesterol-regulated scaffolding protein in control of ERK1/2 activation

Science

Volumn 307, Issue 5714, 2005, Pages 1472-1476

  Wang, Ping Yuan ^a   Weng, Jian ^a   Anderson, Richard G W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; CHOLESTEROL; ENZYME KINETICS; LIPIDS; METABOLISM; OLIGOMERS;

EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK); LIPID METABOLISM; OXYSTEROL-BINDING PROTEIN (OSBP); SIGNAL TRANSDUCTION;

PROTEINS;

CHOLESTEROL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OLIGOMER; PHOSPHATASE; PROTEIN OSBP; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSPORT VESICLE;

BETA-CYCLODEXTRINS; BINDING SITES; CHOLESTEROL; CYTOSOL; ENZYME ACTIVATION; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, STEROID; RNA INTERFERENCE; TRANSFECTION;

EID: 14644391519     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1107710     Document Type: Article

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14. We thank C. Hall and M. Zhu for valuable technical assistance and B. Pallares for administrative assistance. We are indebted to E. Sontag for advice and reagents. This work was supported by NIH (HL 20948, GM 52016), the Perot Family Foundation, and the Cecil H. Green Distinguished Chair in Cellular and Molecular Biology. Molecular interaction data have been deposited in the Biomolecular Interaction Network Database with accession code 196938.