Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine

Journal of Biological Chemistry

Volumn 289, Issue 4, 2014, Pages 2148-2156

  McFarlane, Matthew R ^a   Liang, Guosheng ^a   Engelking, Luke J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL HOMEOSTASIS; CHOLESTEROL SYNTHESIS; CULTURED CELL; ENTEROCYTES; FEEDBACK INHIBITION; FEEDBACK REGULATION;

BIOCHEMISTRY; BIOLOGY;

PROTEINS;

CALNEXIN; CELL PROTEIN; CHOLESTEROL; CHYLOMICRON; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSIG1 PROTEIN; INSIG2A PROTEIN; INSIG2B PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN NPC1L1; PROTEIN SCAP; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL HOMEOSTASIS; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION REGULATION; HOMEOSTASIS; IN VIVO STUDY; INTESTINE; INTESTINE CELL; LIPID ABSORPTION; LIPID STORAGE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

CHOLESTEROL REGULATION; DYSLIPIDEMIA; EZETIMIBE; GENE KNOCKOUT; HMG-COA REDUCTASE; INSIG; INTESTINE; LIPID ABSORPTION; LIPID SYNTHESIS; SREBP;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; ENTEROCYTES; LIPIDOSES; LIVER; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84893140728     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.524041     Document Type: Article

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