-
1
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drewsm, J. Drug discovery: a historical perspective. Science 287, 1960-1964 (2000)
-
(2000)
Science
, vol.287
, pp. 1960-1964
-
-
Drewsm, J.1
-
2
-
-
33751547539
-
How many drug targets are there?
-
DOI 10.1038/nrd2199, PII NRD2199
-
Overington, J. P., Al-Lazikani, B. & Hopkins, A. L. How many drug targets are there? Nat. Rev. Drug Discov. 5, 993-996 (2006) (Pubitemid 44835126)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.12
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
3
-
-
77951844975
-
Teaching old receptors new tricks: Biasing seven-transmembrane receptors
-
Rajagopal, S., Rajagopal, K. & Lefkowitz, R. J. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat. Rev. Drug Discov. 9, 373-386 (2010)
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 373-386
-
-
Rajagopal, S.1
Rajagopal, K.2
Lefkowitz, R.J.3
-
4
-
-
77952354490
-
Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
-
Kenakin, T. & Miller, L. J. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol. Rev. 62, 265-304 (2010)
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 265-304
-
-
Kenakin, T.1
Miller, L.J.2
-
5
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
DOI 10.1124/jpet.106.104463
-
Urban, J. D. et al. Functional selectivity and classical concepts of quantitative pharmacology. J. Pharmacol. Exp. Ther. 320, 1-13 (2007) (Pubitemid 46025713)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.1
, pp. 1-13
-
-
Urban, J.D.1
Clarke, W.P.2
Von Zastrow, M.3
Nichols, D.E.4
Kobilka, B.5
Weinstein, H.6
Javitch, J.A.7
Roth, B.L.8
Christopoulos, A.9
Sexton, P.M.10
Miller, K.J.11
Spedding, M.12
Mailman, R.B.13
-
6
-
-
84857497773
-
Biased signalling and allosteric machines: New vistas and challenges for drug discovery
-
Kenakin, T. P. Biased signalling and allosteric machines: new vistas and challenges for drug discovery. Br. J. Pharmacol. 165, 1659-1669 (2012)
-
(2012)
Br. J. Pharmacol
, vol.165
, pp. 1659-1669
-
-
Kenakin, T.P.1
-
7
-
-
84880311864
-
Efficacy and ligand bias at the m-opioid receptor
-
Kelly, E. Efficacy and ligand bias at the m-opioid receptor. Br. J. Pharmacol. 169, 1430-1446 (2013)
-
(2013)
Br. J. Pharmacol
, vol.169
, pp. 1430-1446
-
-
Kelly, E.1
-
8
-
-
0032770658
-
2- adrenergic receptor/G(s) interactions: Evidence for multiple receptor conformations
-
Seifert, R., Gether, U., Wenzel-Seifert, K. & Kobilka, B. K. Effects of guanine, inosine, and xanthine nucleotides on b2-adrenergic receptor/Gs interactions: evidence for multiple receptor conformations. Mol. Pharmacol. 56, 348-358 (1999) (Pubitemid 29347611)
-
(1999)
Molecular Pharmacology
, vol.56
, Issue.2
, pp. 348-358
-
-
Seifert, R.1
Gether, U.2
Wenzel-Seifert, K.3
Kobilka, B.K.4
-
9
-
-
0141593597
-
β-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
DOI 10.1073/pnas.1936664100
-
Azzi, M. et al. b-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein coupled receptors. Proc. Natl. Acad. Sci. USA 100, 11406-11411 (2003) (Pubitemid 37205948)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.20
, pp. 11406-11411
-
-
Azzi, M.1
Charest, P.G.2
Angers, S.3
Rousseau, G.4
Kohout, T.5
Bouvier, M.6
Pineyro, G.7
-
10
-
-
0345735773
-
2-Adrenoceptor Provide Evidence for Agonist-Directed Signaling
-
DOI 10.1124/mol.64.6.1357
-
Baker, J. G.,Hall, I. P. & Hill, S. J. Agonist and inverse agonist actions of b-blockers at the human b2-adrenoceptor provide evidence for agonist-directed signaling. Mol. Pharmacol. 64, 1357-1369 (2003) (Pubitemid 37532226)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.6
, pp. 1357-1369
-
-
Baker, J.G.1
Hall, I.P.2
Hill, S.J.3
-
11
-
-
33751162165
-
Distinct signaling profiles of b1 and b2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
-
Galandrin, S. & Bouvier, M. Distinct signaling profiles of b1 and b2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol. Pharmacol. 70, 1575-1584 (2006)
-
(2006)
Mol. Pharmacol
, vol.70
, pp. 1575-1584
-
-
Galandrin, S.1
Bouvier, M.2
-
15
-
-
77949417868
-
Liganddirected Signalling at b2-adrenoceptors
-
Evans, B. A., Sato, M., Sarwar, M., Hutchinson, D. S. & Summers, R. J. Liganddirected signalling at b2-adrenoceptors. Br. J. Pharmacol. 159, 1022-1038 (2010)
-
(2010)
Br. J. Pharmacol
, vol.159
, pp. 1022-1038
-
-
Evans, B.A.1
Sato, M.2
Sarwar, M.3
Hutchinson, D.S.4
Summers, R.J.5
-
16
-
-
78149243364
-
Differential signaling of the endogenous agonists at the b2-adrenergic receptor
-
Reiner, S., Ambrosio, M.,Hoffmann, C. & Lohse, M. J. Differential signaling of the endogenous agonists at the b2-adrenergic receptor. J. Biol. Chem. 285, 36188-36198 (2010)
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36188-36198
-
-
Reiner, S.1
Ambrosio, M.2
Hoffmann, C.3
Lohse, M.J.4
-
17
-
-
78649918839
-
Functional selectivity in adrenergic and angiotensin signaling systems
-
Patel, C. B., Noor, N. & Rockman, H. A. Functional selectivity in adrenergic and angiotensin signaling systems. Mol. Pharmacol. 78, 983-992 (2010)
-
(2010)
Mol. Pharmacol
, vol.78
, pp. 983-992
-
-
Patel, C.B.1
Noor, N.2
Rockman, H.A.3
-
18
-
-
84855901533
-
Molecular mechanism of barrestin- biased agonism at seven-transmembrane receptors
-
Reiter, E., Ahn, S., Shukla, A. K. & Lefkowitz, R. J. Molecular mechanism of barrestin- biased agonism at seven-transmembrane receptors. Ann. Rev. Pharmacol. Tox. 52, 179-197 (2012)
-
(2012)
Ann. Rev. Pharmacol. Tox
, vol.52
, pp. 179-197
-
-
Reiter, E.1
Ahn, S.2
Shukla, A.K.3
Lefkowitz, R.J.4
-
19
-
-
84878573306
-
Dissociations in the effects of b2-adrenergic receptor agonists on cAMP formation and superoxide formation in human neutrophils: Support for the concept of functional selectivity
-
Brunskole, H. I. et al. Dissociations in the effects of b2-adrenergic receptor agonists on cAMP formation and superoxide formation in human neutrophils: Support for the concept of functional selectivity. PLoS One 8, e64556 (2013)
-
(2013)
PLoS One
, vol.8
-
-
Brunskole, H.I.1
-
20
-
-
39649108870
-
Label-free optical biosensor for ligand-directed functional selectivity acting on b2 adrenoceptor in living cells
-
Fang, Y.& Ferrie, A. M. Label-free optical biosensor for ligand-directed functional selectivity acting on b2 adrenoceptor in living cells. FEBS Lett. 582, 558-564 (2008)
-
(2008)
FEBS Lett
, vol.582
, pp. 558-564
-
-
Fang, Y.1
Ferrie, A.M.2
-
21
-
-
79955631465
-
Agonist-directed desensitization of the b2-adrenergic receptor
-
Goral, V. et al. Agonist-directed desensitization of the b2-adrenergic receptor. PLoS One 6, e19282 (2011)
-
(2011)
PLoS One
, vol.6
-
-
Goral, V.1
-
22
-
-
84855398689
-
Impedance responses reveal b2-adrenergic receptor signalling pluridimensionality and allow classification of ligands with distinct signalling profiles
-
Stallaert, W., Dorn, J. F., van Westhuizen, E., Audet, M. & Bouvier, M. Impedance responses reveal b2-adrenergic receptor signalling pluridimensionality and allow classification of ligands with distinct signalling profiles. PLoS One 7, e29420 (2012)
-
(2012)
PLoS One
, vol.7
-
-
Stallaert, W.1
Dorn, J.F.2
Van Westhuizen, E.3
Audet, M.4
Bouvier, M.5
-
23
-
-
84884681390
-
Label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the b2- adrerengic receptor
-
Ferrie, A. M., Wang, C., Deng, H. & Fang, Y. Label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the b2- adrerengic receptor. Integr. Biol. 5, 1253-1261 (2013)
-
(2013)
Integr. Biol
, vol.5
, pp. 1253-1261
-
-
Ferrie, A.M.1
Wang, C.2
Deng, H.3
Fang, Y.4
-
24
-
-
80052967337
-
Multiple ligand-specific conformations of the b2-adrenergic receptor
-
Kahsai, A. et al. Multiple ligand-specific conformations of the b2-adrenergic receptor. Nature Chem. Biol. 7, 692-700 (2011)
-
(2011)
Nature Chem. Biol
, vol.7
, pp. 692-700
-
-
Kahsai, A.1
-
25
-
-
80054081804
-
Ligand-dependent perturbation of the conformational ensemble for the GPCR b2-adrenergic receptor revealed by HDX
-
West, G. M. et al. Ligand-dependent perturbation of the conformational ensemble for the GPCR b2-adrenergic receptor revealed by HDX. Structure 19, 1424-1432 (2011)
-
(2011)
Structure
, vol.19
, pp. 1424-1432
-
-
West, G.M.1
-
26
-
-
80051658642
-
Crystal structure of the b2 adrenergic receptor-Gs protein complex
-
Rasmussen, S. G. et al. Crystal structure of the b2 adrenergic receptor-Gs protein complex. Nature 477, 549-555 (2011)
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
-
27
-
-
84864853215
-
-
Zocher, M., Fung, J. J., Kobilka, B. K. & Muller, D. J. Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human b2 adrenergic receptor. Structure 20, 1391-1402 (2012)
-
(2012)
J. Ligand-specific Interactions Modulate Kinetic, Energetic, and Mechanical Properties of the Human b2 Adrenergic Receptor. Structure
, vol.20
, pp. 1391-1402
-
-
Zocher, M.1
Fung, J.J.2
Kobilka, B.K.3
Muller, D.4
-
28
-
-
84862776738
-
Biased signalling pathways in b2-adrenergic receptor characterized by 19F-NMR
-
Liu, J. J., Horst, R., Katritch, V., Stevens, R. C. & Wuthrich, K. Biased signalling pathways in b2-adrenergic receptor characterized by 19F-NMR. Science 335, 1106-1110 (2012)
-
(2012)
Science
, vol.335
, pp. 1106-1110
-
-
Liu, J.J.1
Horst, R.2
Katritch, V.3
Stevens, R.C.4
Wuthrich, K.5
-
29
-
-
84858228474
-
Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the b2- adrenergic receptor
-
Kolinski, M., Plazinska, A. & Jozwiak, K. Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the b2- adrenergic receptor. Curr. Med. Chem. 19, 1155-1163 (2012)
-
(2012)
Curr. Med. Chem
, vol.19
, pp. 1155-1163
-
-
Kolinski, M.1
Plazinska, A.2
Jozwiak, K.3
-
30
-
-
84866976467
-
Efficacy of the b2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
-
Kofuku, Y. et al. Efficacy of the b2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region. Nature Comm. 3, e1045 (2012)
-
(2012)
Nature Comm
, vol.3
-
-
Kofuku, Y.1
-
31
-
-
84873298278
-
The dynamic process of b2-adrenergic receptor activation
-
Nygaard, R. et al. The dynamic process of b2-adrenergic receptor activation. Cell 152, 532-542 (2013)
-
(2013)
Cell
, vol.152
, pp. 532-542
-
-
Nygaard, R.1
-
32
-
-
84873685831
-
Molecular signatures of G-protein-coupled receptors
-
Venkatakrishnan, A. J. et al.Molecular signatures of G-protein-coupled receptors. Nature 494, 185-194 (2013)
-
(2013)
Nature
, vol.494
, pp. 185-194
-
-
Venkatakrishnan, A.J.1
-
33
-
-
77958039571
-
Energy landscape as a tool to integrate GPCR structure, dynamics and function
-
Deupi, X. & Kobilka, B. K. Energy landscape as a tool to integrate GPCR structure, dynamics and function. Physiology 25, 293-303 (2010)
-
(2010)
Physiology
, vol.25
, pp. 293-303
-
-
Deupi, X.1
Kobilka, B.K.2
-
34
-
-
84872048999
-
The potential for selective pharmacological therapies through biased receptor signaling
-
Kenakin, T. The potential for selective pharmacological therapies through biased receptor signaling. BMC Pharmacol. Tox. 13, 3 (2012)
-
(2012)
BMC Pharmacol. Tox
, vol.13
, pp. 3
-
-
Kenakin, T.1
-
35
-
-
84875227396
-
Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
-
Kenakin, T. & Christopoulos, A. Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat. Rev. Drug Discov. 12, 205-216 (2013)
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 205-216
-
-
Kenakin, T.1
Christopoulos, A.2
-
36
-
-
33748469378
-
Resonant waveguide grating biosensor for living cell sensing
-
DOI 10.1529/biophysj.105.077818
-
Fang, Y., Ferrie, A. M., Fontaine, N. H., Mauro, J. & Balakrishnan, J. Resonant waveguide grating biosensor for living cell sensing. Biophys. J. 91, 1925-1940 (2006) (Pubitemid 44352454)
-
(2006)
Biophysical Journal
, vol.91
, Issue.5
, pp. 1925-1940
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Mauro, J.4
Balakrishnan, J.5
-
37
-
-
83455169708
-
The development of label-free cellular assays for drug discovery
-
Fang, Y. The development of label-free cellular assays for drug discovery. Expert Opin. Drug Discov. 6, 1285-1298 (2011)
-
(2011)
Expert Opin. Drug Discov
, vol.6
, pp. 1285-1298
-
-
Fang, Y.1
-
38
-
-
24644496122
-
Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors
-
DOI 10.1021/ac050887n
-
Fang, Y., Ferrie, A. M., Fontaine, N. H. & Yuen, P. K. Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors. Anal. Chem. 77, 5720-5725 (2005) (Pubitemid 41266070)
-
(2005)
Analytical Chemistry
, vol.77
, Issue.17
, pp. 5720-5725
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Yuen, P.K.4
-
39
-
-
77956657852
-
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements
-
Schroder, R. et al. Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 28, 943-949 (2010)
-
(2010)
Nat. Biotechnol
, vol.28
, pp. 943-949
-
-
Schroder, R.1
-
40
-
-
81355148507
-
G protein-coupled receptor signaling regulates the dynamics of a metabolic multienzyme complex
-
Verrier, F. et al. G protein-coupled receptor signaling regulates the dynamics of a metabolic multienzyme complex. Nature Chem. Biol. 7, 909-915 (2011)
-
(2011)
Nature Chem. Biol
, vol.7
, pp. 909-915
-
-
Verrier, F.1
-
41
-
-
68249113457
-
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
-
Kenakin, T. Cellular assays as portals to seven-transmembrane receptor-based drug discovery. Nat. Rev. Drug Discov. 8, 617-626 (2009)
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 617-626
-
-
Kenakin, T.1
-
42
-
-
80053899050
-
Label-free integrative pharmacology on-target of drugs at the b2-adrenergic receptor
-
Ferrie, A. M., Sun, H. & Fang, Y. Label-free integrative pharmacology on-target of drugs at the b2-adrenergic receptor. Sci. Rep. 1, 33 (2011)
-
(2011)
Sci. Rep
, vol.1
, pp. 33
-
-
Ferrie, A.M.1
Sun, H.2
Fang, Y.3
-
43
-
-
80053928946
-
Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free on-target pharmacology
-
Morse, M., Tran, E., Levension, R. L. & Fang, Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free on-target pharmacology. PLoS One 6, e25643 (2011)
-
(2011)
PLoS One
, vol.6
-
-
Morse, M.1
Tran, E.2
Levension, R.L.3
Fang, Y.4
-
44
-
-
84879825146
-
Label-free integrative pharmacology ontarget of opioid ligands at the opioid receptor family
-
Morse, M., Sun, H., Tran, E., Levenson, R. & Fang, Y. Label-free integrative pharmacology ontarget of opioid ligands at the opioid receptor family. BMC Pharmacol. Tox. 14, 17 (2013)
-
(2013)
BMC Pharmacol. Tox
, vol.14
, pp. 17
-
-
Morse, M.1
Sun, H.2
Tran, E.3
Levenson, R.4
Fang, Y.5
-
45
-
-
0026662535
-
Ligand-regulated internalization and recycling of human b2-adrenergic receptors between the plasmamembrane and endosomes containing transferrin receptors
-
von Zastrow, M. & Kobilka, B. K. Ligand-regulated internalization and recycling of human b2-adrenergic receptors between the plasmamembrane and endosomes containing transferrin receptors. J. Biol. Chem. 267, 3530-3538 (1992)
-
(1992)
J. Biol. Chem
, vol.267
, pp. 3530-3538
-
-
Von Zastrow, M.1
Kobilka, B.K.2
-
46
-
-
0032441150
-
Cluster analysis and display of genome-wide expression patterns
-
DOI 10.1073/pnas.95.25.14863
-
Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14863-14868 (1998) (Pubitemid 29003722)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.25
, pp. 14863-14868
-
-
Eisen, M.B.1
Spellman, P.T.2
Brown, P.O.3
Botstein, D.4
-
47
-
-
84976363966
-
-
PDSP Ki database. . http://pdsp.med.unc.edu/pdsp.php
-
PDSP Ki Database
-
-
-
48
-
-
0034611135
-
(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents
-
DOI 10.1016/S0960-894X(00)00016-0, PII S0960894X00000160
-
Cecchetti, V., Schiaffella, F., Tabarrini, O. & Fravolini, A. (1,4-Benzothiazinyloxy) alkylpiperazine derivatives as potential antihypertensive agents. Bioorg. Med. Chem. Lett. 10, 465-468 (2000) (Pubitemid 30153614)
-
(2000)
Bioorganic and Medicinal Chemistry Letters
, vol.10
, Issue.5
, pp. 465-468
-
-
Cecchetti, V.1
Schiaffella, F.2
Tabarrini, O.3
Fravolini, A.4
-
49
-
-
0019972619
-
Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist
-
Ruffolo, R. R. Jr. & Waddell, J. E. Receptor interactions of imidazolines. IX. Cirazoline is an a1 adrenergic agonist and an a2 adrenergic antagonist. J. Pharmacol. Exp. Ther. 222, 29-36 (1982) (Pubitemid 12096994)
-
(1982)
Journal of Pharmacology and Experimental Therapeutics
, vol.222
, Issue.1
, pp. 29-36
-
-
Ruffolo Jr., R.R.1
Waddell, J.E.2
-
50
-
-
84883480191
-
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion
-
Zaytseva, Z. et al. Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens. Actuators B: Chem. 188, 1064-1072 (2013)
-
(2013)
Sens. Actuators B: Chem
, vol.188
, pp. 1064-1072
-
-
Zaytseva, Z.1
-
52
-
-
84877977567
-
Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology
-
Chen, M. et al. Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology. Appl. Phys. Lett. 102, 193702 (2013)
-
(2013)
Appl. Phys. Lett
, vol.102
, pp. 193702
-
-
Chen, M.1
-
53
-
-
33751241720
-
Epac proteins: Multi-purpose cAMP targets
-
DOI 10.1016/j.tibs.2006.10.002, PII S0968000406002921
-
Bos, J. L. Epac proteins: multi-purpose cAMP targets. Trends Biochem. Sci. 31, 680-686 (2006) (Pubitemid 44791945)
-
(2006)
Trends in Biochemical Sciences
, vol.31
, Issue.12
, pp. 680-686
-
-
Bos, J.L.1
-
54
-
-
66349090219
-
Direct spatial control of Epac1 by cyclic AMP
-
Ponsioen, B., Gloerich, M., Ritsma, L. & Rehmann, H. Direct spatial control of Epac1 by cyclic AMP. Mol. Cell. Biol. 29, 2521-2531 (2009)
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 2521-2531
-
-
Ponsioen, B.1
Gloerich, M.2
Ritsma, L.3
Rehmann, H.4
-
55
-
-
12144255117
-
CAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction
-
DOI 10.1523/JNEUROSCI.3703-04.2005
-
Zhong, N. & Zucker, R. S. cAMP acts on exchange protein activated by cAMP/ cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction. J. Neurosci. 25, 208-214 (2005) (Pubitemid 40110782)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.1
, pp. 208-214
-
-
Zhong, N.1
Zucker, R.S.2
-
56
-
-
58149295113
-
Epac mediates pacap-dependent long-term depression in the hippocampus
-
Ster, J. et al. Epac mediates PACAP-dependent long-term depression in the hippocampus. J. Physiol. 587, 101-113 (2009)
-
(2009)
J. Physiol
, vol.587
, pp. 101-113
-
-
Ster, J.1
-
57
-
-
33846503153
-
Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of G protein-coupled receptor signaling
-
Kinzer-Ursem, T. L. & Linderman, J. J. Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of G protein-coupled receptor signaling. PLoS Comput. Biol. 3, e6 (2007)
-
(2007)
PLoS Comput. Biol
, vol.3
-
-
Kinzer-Ursem, T.L.1
Linderman, J.J.2
-
58
-
-
0030613761
-
2-adrenergic receptor to different g proteins by protein kinase A
-
DOI 10.1038/36362
-
Daaka, Y., Luttrell, L. M. & Lefkowitz, R. J. Switching of the coupling of the b2- adrenergic receptor to differentGproteins by protein kinase A. Nature 390, 88-91 (1997) (Pubitemid 27494762)
-
(1997)
Nature
, vol.390
, Issue.6655
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
59
-
-
0036841033
-
i switching
-
DOI 10.1124/mol.62.5.1094
-
Friedman, J., Babu, B. & Clark, R. B. b2-Adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signalregulated kinase 1/2 in human embryonic kidney 293 cells: Lack of evidence for Gs/Gi switching. Mol. Pharmacol. 62, 1094-1102 (2002) (Pubitemid 35222500)
-
(2002)
Molecular Pharmacology
, vol.62
, Issue.5
, pp. 1094-1102
-
-
Friedman, J.1
Babu, B.2
Clark, R.B.3
-
60
-
-
58149391231
-
Duplexed label-freeGprotein-coupled receptor assays for high throughput screening
-
Tran, E. & Fang, Y. Duplexed label-freeGprotein-coupled receptor assays for high throughput screening. J. Biomol. Screen. 13, 975-985 (2008)
-
(2008)
J. Biomol. Screen
, vol.13
, pp. 975-985
-
-
Tran, E.1
Fang, Y.2
-
61
-
-
77952903562
-
Signalling ballet in space and time
-
Kholodenko, B. N., Hancock, J. F. & Kolch, W. Signalling ballet in space and time. Nat. Rev. Mol. Cell Biol. 11, 414-426 (2010)
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 414-426
-
-
Kholodenko, B.N.1
Hancock, J.F.2
Kolch, W.3
-
62
-
-
50249108916
-
On the fitting of binding data when receptor dimerization is suspected
-
Giraldo, J. On the fitting of binding data when receptor dimerization is suspected. Br. J. Pharmacol. 155, 17-23 (2008)
-
(2008)
Br. J. Pharmacol
, vol.155
, pp. 17-23
-
-
Giraldo, J.1
-
63
-
-
33644897341
-
1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: A randomized crossover study
-
DOI 10.1111/j.1464-410X.2006.06030.x
-
Nishino, Y. et al. Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study. BJU Int. 97, 747-751 (2006) (Pubitemid 43383507)
-
(2006)
BJU International
, vol.97
, Issue.4
, pp. 747-751
-
-
Nishino, Y.1
Masue, T.2
Miwa, K.3
Takahashi, Y.4
Ishihara, S.5
Deguchi, T.6
-
64
-
-
8744232106
-
s-coupled receptors
-
DOI 10.1074/jbc.M403604200
-
Keiper, M. et al. Epac- and Ca21-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J. Biol. Chem. 279, 46497-46508 (2004) (Pubitemid 39518293)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.45
, pp. 46497-46508
-
-
Keiper, M.1
Stope, M.B.2
Szatkowski, D.3
Bohm, A.4
Tysack, K.5
Vom Dorp, F.6
Saur, O.7
Oude Weernink, P.A.8
Evellin, S.9
Jakobs, K.H.10
Schmidt, M.11
-
65
-
-
75649097760
-
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function
-
Grandoch, M., Roscioni, S. S. & Schmidt, M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br. J. Pharmacol. 159, 265-284 (2010)
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 265-284
-
-
Grandoch, M.1
Roscioni, S.S.2
Schmidt, M.3
-
66
-
-
0037450725
-
2-adrenergic receptor
-
DOI 10.1083/jcb.200209105
-
Rangarajan, S. et al. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the b2-adrenergic receptor. J. Cell Biol. 160, 487-493 (2003) (Pubitemid 36254387)
-
(2003)
Journal of Cell Biology
, vol.160
, Issue.4
, pp. 487-493
-
-
Rangarajan, S.1
Enserink, J.M.2
Kuiperij, H.B.3
De Rooij, J.4
Price, L.S.5
Schwede, F.6
Bos, J.L.7
-
67
-
-
84875279578
-
Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery
-
Fang, Y. Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery. J. Pharmacol. Tox. Methods 67, 69-81 (2013)
-
(2013)
J. Pharmacol. Tox. Methods
, vol.67
, pp. 69-81
-
-
Fang, Y.1
-
68
-
-
33746918047
-
Label-Free Profiling of Ligands for Endogenous GPCRs Using a Cell-Based High-Throughput Screening Technology
-
DOI 10.1016/j.jala.2006.06.001, PII S1535553506002218
-
Li, G., Ferrie, A. M. & Fang, Y. Label-free profiling of endogenous G proteincoupled receptors using a cell-based high throughput screening technology. J. Assoc. Lab. Autom. 11, 181-187 (2006) (Pubitemid 44184986)
-
(2006)
JALA - Journal of the Association for Laboratory Automation
, vol.11
, Issue.4
, pp. 181-187
-
-
Li, G.1
Ferrie, A.M.2
Fang, Y.3
|