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Volumn 78, Issue 6, 2010, Pages 983-992

Functional selectivity in adrenergic and angiotensin signaling systems

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; BETAXOLOL; BISOPROLOL; CAD PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CANDESARTAN; CARVEDILOL; CHIMERIC PROTEIN; CYCLIC AMP; EPIDERMAL GROWTH FACTOR RECEPTOR; ESMOLOL; G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; LABETALOL; METOPROLOL; MITOGEN ACTIVATED PROTEIN KINASE; NADOLOL; OXPRENOLOL; PENBUTOLOL; PINDOLOL; PRACTOLOL; PROPAFENONE; PROPANOL; SOTALOL; TIMOLOL; UNINDEXED DRUG;

EID: 78649918839     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.067066     Document Type: Short Survey
Times cited : (59)

References (70)
  • 1
    • 67649797371 scopus 로고    scopus 로고
    • {beta}-Arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation
    • Ahn S, Kim J, Hara MR, Ren XR, and Lefkowitz RJ (2009) {beta}-Arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation. J Biol Chem 284:8855-8865.
    • (2009) J Biol Chem , vol.284 , pp. 8855-8865
    • Ahn, S.1    Kim, J.2    Hara, M.R.3    Ren, X.R.4    Lefkowitz, R.J.5
  • 2
    • 4143070533 scopus 로고    scopus 로고
    • Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor
    • DOI 10.1074/jbc.M405878200
    • Ahn S, Shenoy SK, Wei H, and Lefkowitz RJ (2004) Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem 279:35518-35525. (Pubitemid 39100552)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.34 , pp. 35518-35525
    • Ahn, S.1    Shenoy, S.K.2    Wei, H.3    Lefkowitz, R.J.4
  • 6
    • 34247351122 scopus 로고    scopus 로고
    • The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts
    • DOI 10.1111/j.1742-7843.2007.00063.x
    • Aplin M, Christensen GL, Schneider M, Heydorn A, Gammeltoft S, Kjølbye AL, Sheikh SP, and Hansen JL (2007) The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts. Basic Clin Pharmacol Toxicol 100:289-295. (Pubitemid 46633483)
    • (2007) Basic and Clinical Pharmacology and Toxicology , vol.100 , Issue.5 , pp. 289-295
    • Aplin, M.1    Christensen, G.L.2    Schneider, M.3    Heydorn, A.4    Gammeltoft, S.5    Kjolbye, A.L.6    Sheikh, S.P.7    Hansen, J.L.8
  • 7
    • 0345735773 scopus 로고    scopus 로고
    • Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling
    • Baker JG, Hall IP, and Hill SJ (2003) Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Mol Pharmacol 64:1357-1369.
    • (2003) Mol Pharmacol , vol.64 , pp. 1357-1369
    • Baker, J.G.1    Hall, I.P.2    Hill, S.J.3
  • 9
    • 17644391412 scopus 로고    scopus 로고
    • Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET
    • Charest PG, Terrillon S, and Bouvier M (2005) Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET. EMBO Rep 6:334-340.
    • (2005) EMBO Rep , vol.6 , pp. 334-340
    • Charest, P.G.1    Terrillon, S.2    Bouvier, M.3
  • 11
    • 0030613761 scopus 로고    scopus 로고
    • 2-adrenergic receptor to different g proteins by protein kinase a
    • DOI 10.1038/36362
    • Daaka Y, Luttrell LM, and Lefkowitz RJ (1997) Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 390:88-91. (Pubitemid 27494762)
    • (1997) Nature , vol.390 , Issue.6655 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 16
    • 0141811657 scopus 로고    scopus 로고
    • The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling
    • Gáborik Z, Jagadeesh G, Zhang M, Spät A, Catt KJ, and Hunyady L (2003) The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Endocrinology 144:2220-2228.
    • (2003) Endocrinology , vol.144 , pp. 2220-2228
    • Gáborik, Z.1    Jagadeesh, G.2    Zhang, M.3    Spät, A.4    Catt, K.J.5    Hunyady, L.6
  • 17
    • 33751162165 scopus 로고    scopus 로고
    • Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
    • Galandrin S and Bouvier M (2006) Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70:1575-1584.
    • (2006) Mol Pharmacol , vol.70 , pp. 1575-1584
    • Galandrin, S.1    Bouvier, M.2
  • 18
    • 34447642715 scopus 로고    scopus 로고
    • The evasive nature of drug efficacy: Implications for drug discovery
    • Galandrin S, Oligny-Longpré G, and Bouvier M (2007) The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol Sci 28:423-430.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 423-430
    • Galandrin, S.1    Oligny-Longpré, G.2    Bouvier, M.3
  • 19
    • 0035816704 scopus 로고    scopus 로고
    • Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
    • Ghanouni P, Gryczynski Z, Steenhuis JJ, Lee TW, Farrens DL, Lakowicz JR, and Kobilka BK (2001) Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. J Biol Chem 276:24433-24436.
    • (2001) J Biol Chem , vol.276 , pp. 24433-24436
    • Ghanouni, P.1    Gryczynski, Z.2    Steenhuis, J.J.3    Lee, T.W.4    Farrens, D.L.5    Lakowicz, J.R.6    Kobilka, B.K.7
  • 20
    • 34250376066 scopus 로고    scopus 로고
    • Structure and conformational changes in the C-terminal domain of the beta2- adrenoceptor: Insights from fluorescence resonance energy transfer studies
    • Granier S, Kim S, Shafer AM, Ratnala VR, Fung JJ, Zare RN, and Kobilka B (2007) Structure and conformational changes in the C-terminal domain of the beta2- adrenoceptor: insights from fluorescence resonance energy transfer studies. J Biol Chem 282:13895-13905.
    • (2007) J Biol Chem , vol.282 , pp. 13895-13905
    • Granier, S.1    Kim, S.2    Shafer, A.M.3    Ratnala, V.R.4    Fung, J.J.5    Zare, R.N.6    Kobilka, B.7
  • 22
    • 0034104565 scopus 로고    scopus 로고
    • Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: The Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF)
    • MERIT-HF Study Group
    • Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, Wikstrand J, El Allaf D, Vítovec J, Aldershvile J, et al. (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 283:1295-1302.
    • (2000) JAMA , vol.283 , pp. 1295-1302
    • Hjalmarson, A.1    Goldstein, S.2    Fagerberg, B.3    Wedel, H.4    Waagstein, F.5    Kjekshus, J.6    Wikstrand, J.7    El Allaf, D.8    Vítovec, J.9    Aldershvile, J.10
  • 24
    • 0035083109 scopus 로고    scopus 로고
    • Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
    • Kenakin T (2001) Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J 15:598-611.
    • (2001) FASEB J , vol.15 , pp. 598-611
    • Kenakin, T.1
  • 25
    • 0043235844 scopus 로고    scopus 로고
    • Ligand-selective receptor conformations revisited: The promise and the problem
    • Kenakin T (2003) Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol Sci 24:346-354.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 346-354
    • Kenakin, T.1
  • 26
    • 1942517868 scopus 로고    scopus 로고
    • Principles: Receptor theory in pharmacology
    • Kenakin T (2004) Principles: receptor theory in pharmacology. Trends Pharmacol Sci 25:186-192.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 186-192
    • Kenakin, T.1
  • 27
    • 27844519281 scopus 로고    scopus 로고
    • New concepts in drug discovery: Collateral efficacy and permissive antagonism
    • Kenakin T (2005) New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat Rev Drug Discov 4:919-927.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 919-927
    • Kenakin, T.1
  • 28
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin T and Miller LJ (2010) Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev 62:265-304.
    • (2010) Pharmacol Rev , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 29
    • 69649097791 scopus 로고    scopus 로고
    • '7TM receptor allostery: Putting numbers to shapeshifting proteins
    • Kenakin TP (2009) '7TM receptor allostery: putting numbers to shapeshifting proteins. Trends Pharmacol Sci 30:460-469.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 460-469
    • Kenakin, T.P.1
  • 31
    • 66449134043 scopus 로고    scopus 로고
    • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor
    • Kim J, Ahn S, Rajagopal K, and Lefkowitz RJ (2009) Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem 284:11953-11962.
    • (2009) J Biol Chem , vol.284 , pp. 11953-11962
    • Kim, J.1    Ahn, S.2    Rajagopal, K.3    Lefkowitz, R.J.4
  • 33
    • 25144508158 scopus 로고    scopus 로고
    • 2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome
    • DOI 10.1001/jama.294.12.1526
    • Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, and Spertus JA (2005) Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA 294:1526-1533. (Pubitemid 41362690)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.12 , pp. 1526-1533
    • Lanfear, D.E.1    Jones, P.G.2    Marsh, S.3    Cresci, S.4    McLeod, H.L.5    Spertus, J.A.6
  • 34
    • 0032563291 scopus 로고    scopus 로고
    • G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
    • Lefkowitz RJ (1998) G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 273:18677-18680.
    • (1998) J Biol Chem , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 35
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by betaarrestins
    • Lefkowitz RJ and Shenoy SK (2005) Transduction of receptor signals by betaarrestins. Science 308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 37
    • 0242521470 scopus 로고    scopus 로고
    • Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
    • Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, and Auberger P (2003) Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 22:6785-6793.
    • (2003) Oncogene , vol.22 , pp. 6785-6793
    • Luciano, F.1    Jacquel, A.2    Colosetti, P.3    Herrant, M.4    Cagnol, S.5    Pages, G.6    Auberger, P.7
  • 38
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases
    • Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, and Lefkowitz RJ (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem 271:19443-19450.
    • (1996) J Biol Chem , vol.271 , pp. 19443-19450
    • Luttrell, L.M.1    Hawes, B.E.2    Van Biesen, T.3    Luttrell, D.K.4    Lansing, T.J.5    Lefkowitz, R.J.6
  • 39
    • 77951872871 scopus 로고    scopus 로고
    • beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation
    • Mangmool S, Shukla AK, and Rockman HA (2010) beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. J Cell Biol 189:573-587.
    • (2010) J Cell Biol , vol.189 , pp. 573-587
    • Mangmool, S.1    Shukla, A.K.2    Rockman, H.A.3
  • 40
    • 4644298923 scopus 로고    scopus 로고
    • PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching
    • Martin NP, Whalen EJ, Zamah MA, Pierce KL, and Lefkowitz RJ (2004) PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. Cell Signal 16:1397-1403.
    • (2004) Cell Signal , vol.16 , pp. 1397-1403
    • Martin, N.P.1    Whalen, E.J.2    Zamah, M.A.3    Pierce, K.L.4    Lefkowitz, R.J.5
  • 41
    • 0034737483 scopus 로고    scopus 로고
    • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor
    • Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y, Lefkowitz RJ, and Luttrell LM (2000) The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem 275:9572-9580.
    • (2000) J Biol Chem , vol.275 , pp. 9572-9580
    • Maudsley, S.1    Pierce, K.L.2    Zamah, A.M.3    Miller, W.E.4    Ahn, S.5    Daaka, Y.6    Lefkowitz, R.J.7    Luttrell, L.M.8
  • 42
    • 34248575149 scopus 로고    scopus 로고
    • Integrating signals from RTKs to ERK/MAPK
    • McKay MM and Morrison DK (2007) Integrating signals from RTKs to ERK/MAPK. Oncogene 26:3113-3121.
    • (2007) Oncogene , vol.26 , pp. 3113-3121
    • McKay, M.M.1    Morrison, D.K.2
  • 45
    • 0037159310 scopus 로고    scopus 로고
    • Effect of carvedilol on the morbidity of patients with severe chronic heart failure: Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
    • Packer M, Fowler MB, Roecker EB, Coats AJ, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Staiger C, et al. (2002) Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106:2194-2199.
    • (2002) Circulation , vol.106 , pp. 2194-2199
    • Packer, M.1    Fowler, M.B.2    Roecker, E.B.3    Coats, A.J.4    Katus, H.A.5    Krum, H.6    Mohacsi, P.7    Rouleau, J.L.8    Tendera, M.9    Staiger, C.10
  • 46
    • 0034652310 scopus 로고    scopus 로고
    • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
    • Pierce KL, Maudsley S, Daaka Y, Luttrell LM, and Lefkowitz RJ (2000) Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci USA 97:1489-1494.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1489-1494
    • Pierce, K.L.1    Maudsley, S.2    Daaka, Y.3    Luttrell, L.M.4    Lefkowitz, R.J.5
  • 48
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seven-transmembrane receptors
    • Rajagopal S, Rajagopal K, and Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 9:373-386.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 49
    • 77953819826 scopus 로고    scopus 로고
    • beta- Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress
    • Rakesh K, Yoo B, Kim IM, Salazar N, Kim KS, and Rockman HA (2010) beta- Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci Signal 3:ra46.
    • (2010) Sci Signal , vol.3
    • Rakesh, K.1    Yoo, B.2    Kim, I.M.3    Salazar, N.4    Kim, K.S.5    Rockman, H.A.6
  • 50
    • 33845973320 scopus 로고    scopus 로고
    • Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
    • Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, and Engelhardt S (2007) Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest 117:229-235.
    • (2007) J Clin Invest , vol.117 , pp. 229-235
    • Rochais, F.1    Vilardaga, J.P.2    Nikolaev, V.O.3    Bünemann, M.4    Lohse, M.J.5    Engelhardt, S.6
  • 51
    • 0037050009 scopus 로고    scopus 로고
    • Seven-transmembrane-spanning receptors and heart function
    • Rockman HA, Koch WJ, and Lefkowitz RJ (2002) Seven-transmembrane-spanning receptors and heart function. Nature 415:206-212.
    • (2002) Nature , vol.415 , pp. 206-212
    • Rockman, H.A.1    Koch, W.J.2    Lefkowitz, R.J.3
  • 52
    • 35848943698 scopus 로고    scopus 로고
    • Mitogenic signaling pathways induced by G protein-coupled receptors
    • Rozengurt E (2007) Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 213:589-602.
    • (2007) J Cell Physiol , vol.213 , pp. 589-602
    • Rozengurt, E.1
  • 57
    • 0033813040 scopus 로고    scopus 로고
    • Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet
    • Spiering W, Kroon AA, Fuss-Lejeune MM, Daemen MJ, and de Leeuw PW (2000) Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 36:411-416.
    • (2000) Hypertension , vol.36 , pp. 411-416
    • Spiering, W.1    Kroon, A.A.2    Fuss-Lejeune, M.M.3    Daemen, M.J.4    De Leeuw, P.W.5
  • 58
    • 33344474082 scopus 로고    scopus 로고
    • Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
    • DOI 10.1016/j.molcel.2006.01.023, PII S1097276506000451
    • Stefanovsky V, Langlois F, Gagnon-Kugler T, Rothblum LI, and Moss T (2006) Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling. Mol Cell 21:629-639. (Pubitemid 43290730)
    • (2006) Molecular Cell , vol.21 , Issue.5 , pp. 629-639
    • Stefanovsky, V.1    Langlois, F.2    Gagnon-Kugler, T.3    Rothblum, L.I.4    Moss, T.5
  • 59
    • 77149128972 scopus 로고    scopus 로고
    • Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity
    • Strachan RT, Sciaky N, Cronan MR, Kroeze WK, and Roth BL (2010) Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity. Mol Pharmacol 77:327-338.
    • (2010) Mol Pharmacol , vol.77 , pp. 327-338
    • Strachan, R.T.1    Sciaky, N.2    Cronan, M.R.3    Kroeze, W.K.4    Roth, B.L.5
  • 60
    • 0037458614 scopus 로고    scopus 로고
    • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
    • Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, and Luttrell LM (2003) The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 278:6258-6267.
    • (2003) J Biol Chem , vol.278 , pp. 6258-6267
    • Tohgo, A.1    Choy, E.W.2    Gesty-Palmer, D.3    Pierce, K.L.4    Laporte, S.5    Oakley, R.H.6    Caron, M.G.7    Lefkowitz, R.J.8    Luttrell, L.M.9
  • 62
    • 33746012381 scopus 로고    scopus 로고
    • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer
    • Violin JD, Ren XR, and Lefkowitz RJ (2006) G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem 281:20577-20588.
    • (2006) J Biol Chem , vol.281 , pp. 20577-20588
    • Violin, J.D.1    Ren, X.R.2    Lefkowitz, R.J.3
  • 63
    • 0030977269 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
    • Waskiewicz AJ, Flynn A, Proud CG, and Cooper JA (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J 16:1909-1920.
    • (1997) EMBO J , vol.16 , pp. 1909-1920
    • Waskiewicz, A.J.1    Flynn, A.2    Proud, C.G.3    Cooper, J.A.4
  • 64
    • 0141703263 scopus 로고    scopus 로고
    • Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
    • Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, and Lefkowitz RJ (2003) Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci USA 100:10782-10787.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10782-10787
    • Wei, H.1    Ahn, S.2    Shenoy, S.K.3    Karnik, S.S.4    Hunyady, L.5    Luttrell, L.M.6    Lefkowitz, R.J.7
  • 68
    • 27644468385 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    • Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, et al. (2005) Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest 115:3045-3056.
    • (2005) J Clin Invest , vol.115 , pp. 3045-3056
    • Zhai, P.1    Yamamoto, M.2    Galeotti, J.3    Liu, J.4    Masurekar, M.5    Thaisz, J.6    Irie, K.7    Holle, E.8    Yu, X.9    Kupershmidt, S.10
  • 69
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    • Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, and Xiao RP (2001) Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci USA 98:1607-1612.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3    Lefkowitz, R.J.4    Kobilka, B.K.5    Xiao, R.P.6
  • 70
    • 0032559587 scopus 로고    scopus 로고
    • Cell type-specific angiotensin II-evoked signal transduction pathways: Critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts
    • Zou Y, Komuro I, Yamazaki T, Kudoh S, Aikawa R, Zhu W, Shiojima I, Hiroi Y, Tobe K, Kadowaki T, et al. (1998) Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. Circ Res 82:337-345.
    • (1998) Circ Res , vol.82 , pp. 337-345
    • Zou, Y.1    Komuro, I.2    Yamazaki, T.3    Kudoh, S.4    Aikawa, R.5    Zhu, W.6    Shiojima, I.7    Hiroi, Y.8    Tobe, K.9    Kadowaki, T.10


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