β-Blockers alprenolol and carvedilol stimulate β-arrestin- mediated EGFR transactivation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 38, 2008, Pages 14555-14560

  Kim, Il Man ^a   Tilley, Douglas G ^a   Chen, Juhsien ^a   Salazar, Natasha C ^a   Whalen, Erin J ^a   Violin, Jonathan D ^a   Rockman, Howard A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

adrenergic receptor; G protein coupled receptor; Signaling

Indexed keywords

ALPRENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ARRESTIN; CARVEDILOL; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ADRENERGIC BETA-ANTAGONISTS; ALPRENOLOL; ANIMALS; ARRESTINS; CARBAZOLES; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYMES; GENES, ERBB-1; HEART; HUMANS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROPANOLAMINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 55749084393     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804745105     Document Type: Article

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