Differential signaling of the endogenous agonists at the β2-adrenergic receptor

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 36188-36198

  Reiner, Susanne ^a   Ambrosio, Manuela ^a,b   Hoffmann, Carsten ^a   Lohse, Martin J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYL CYCLASE; ADRENERGIC RECEPTORS; CELL SURFACES; CONFORMATIONAL CHANGE; DIFFERENTIAL SIGNALING; FENOTEROL; ISOPROTERENOL; MODEL SYSTEM; SIGNALING PATHWAYS; TERBUTALINE;

ARGON; CELL MEMBRANES; LIGANDS; RATE CONSTANTS; SENSORS;

SIGNALING;

ADENYLATE CYCLASE; ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; FENOTEROL; ISOPRENALINE; LIGAND; NORADRENALIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TERBUTALINE;

ARTICLE; ASSAY; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SENSOR; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADRENERGIC AGONISTS; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; EPINEPHRINE; FENOTEROL; HEK293 CELLS; HUMANS; ISOPROTERENOL; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NOREPINEPHRINE; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 78149243364     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.175604     Document Type: Article

References (49)

1. Kenakin, T. (2005) Nat. Rev. Drug Discov. 4, 919-927
2. Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M., and Mailman, R. B. (2007) J. Pharmacol. Exp. Ther. 320, 1-13
3. Benovic, J. L., Strasser, R. H., Caron, M. G., and Lefkowitz, R. J. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 2797-2801
4. Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G., and Lefkowitz, R. J. (1990) Science 248, 1547-1550
5. Krasel, C., Bünemann, M., Lorenz, K., and Lohse, M. J. (2005) J. Biol. Chem. 280, 9528-9535
6. Ferguson, S. S., Downey, W. E., 3rd, Colapietro, A. M., Barak, L. S., Ménard, L., and Caron, M. G. (1996) Science 271, 363-366
7. Goodman, O. B., Jr., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) Nature 383, 447-450
8. Benovic, J. L., Staniszewski, C., Mayor, F., Jr., Caron, M. G., and Lefkowitz, R. J. (1988) J. Biol. Chem. 263, 3893-3897
9. Violin, J. D., and Lefkowitz, R. J. (2007) Trends Pharmacol. Sci. 28, 416-422
10. Swaminath, G., Xiang, Y., Lee, T. W., Steenhuis, J., Parnot, C., and Kobilka, B. K. (2004) J. Biol. Chem. 279, 686-691
11. Whistler, J. L., Chuang, H. H., Chu, P., Jan, L. Y., and von Zastrow, M. (1999) Neuron 23, 737-746
12. Kohout, T. A., Nicholas, S. L., Perry, S. J., Reinhart, G., Junger, S., and Struthers, R. S. (2004) J. Biol. Chem. 279, 23214-23222
13. Lewis, M. M., Watts, V. J., Lawler, C. P., Nichols, D. E., and Mailman, R. B. (1998) J. Pharmacol. Exp. Ther. 286, 345-353
14. Urban, J. D., Vargas, G. A., von Zastrow, M., and Mailman, R. B. (2007) Neuropsychopharmacology 32, 67-77
15. January, B., Seibold, A., Whaley, B., Hipkin, R. W., Lin, D., Schonbrunn, A., Barber, R., and Clark, R. B. (1997) J. Biol. Chem. 272, 23871-23879
16. Galandrin, S., and Bouvier, M. (2006) Mol. Pharmacol. 70, 1575-1584
17. Drake, M. T., Violin, J. D., Whalen, E. J., Wisler, J. W., Shenoy, S. K., and Lefkowitz, R. J. (2008) J. Biol. Chem. 283, 5669-5676
18. Wang, Y., De Arcangelis, V., Gao, X., Ramani, B., Jung, Y. S., and Xiang, Y. (2008) J. Biol. Chem. 283, 1799-1807
19. Kobilka, B. K., and Deupi, X. (2007) Trends Pharmacol. Sci. 28, 397-406
20. Hoffmann, C., Zürn, A., Bünemann, M., and Lohse, M. J. (2008) Br. J. Pharmacol. 153, Suppl. 1, S358-S366
21. Azzi, M., Charest, P. G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., and Piñeyro, G. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 11406-11411
22. Blanpain, C., Vanderwinden, J. M., Cihak, J., Wittamer, V., Le Poul, E., Issafras, H., Stangassinger, M., Vassart, G., Marullo, S., Schlöndorff, D., Parmentier, M., and Mack, M. (2002) Mol. Biol. Cell 13, 723-737
23. Whistler, J. L., and von Zastrow, M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 9914-9919
24. Swaminath, G., Deupi, X., Lee, T. W., Zhu, W., Thian, F. S., Kobilka, T. S., and Kobilka, B. (2005) J. Biol. Chem. 280, 22165-22171
25. Nikolaev, V. O., Hoffmann, C., Bünemann, M., Lohse, M. J., and Vilardaga, J. P. (2006) J. Biol. Chem. 281, 24506-24511
26. Lohse, M. J., Nikolaev, V. O., Hein, P., Hoffmann, C., Vilardaga, J. P., and Bünemann, M. (2008) Trends Pharmacol. Sci. 29, 159-165
27. Vilardaga, J. P., Bünemann, M., Krasel, C., Castro, M., and Lohse, M. J. (2003) Nat. Biotechnol. 21, 807-812
28. Hoffmann, C., Gaietta, G., Bünemann, M., Adams, S. R., Oberdorff-Maass, S., Behr, B., Vilardaga, J. P., Tsien, R. Y., Ellisman, M. H., and Lohse, M. J. (2005) Nat. Methods 2, 171-176
29. Lohse, M. J., Bünemann, M., Hoffmann, C., Vilardaga, J. P., and Nikolaev, V. O. (2007) Curr. Opin. Pharmacol. 7, 547-553
30. Bünemann, M., Frank, M., and Lohse, M. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 16077-16082
31. Hein, P., Rochais, F., Hoffmann, C., Dorsch, S., Nikolaev, V. O., Engelhardt, S., Berlot, C. H., Lohse, M. J., and Bünemann, M. (2006) J. Biol. Chem. 281, 33345-33351
32. Nikolaev, V. O., Bünemann, M., Hein, L., Hannawacker, A., and Lohse, M. J. (2004) J. Biol. Chem. 279, 37215-37218
33. Hoffmann, C., Leitz, M. R., Oberdorf-Maass, S., Lohse, M. J., and Klotz, K. N. (2004) Naunyn Schmiedebergs Arch. Pharmacol. 369, 151-159
34. Lohse, M. J. (1992) Naunyn Schmiedebergs Arch. Pharmacol. 345, 444-451
35. Oakley, R. H., Laporte, S. A., Holt, J. A., Barak, L. S., and Caron, M. G. (2001) J. Biol. Chem. 276, 19452-19460
36. Rochais, F., Vilardaga, J. P., Nikolaev, V. O., Bünemann, M., Lohse, M. J., and Engelhardt, S. (2007) J. Clin. Invest. 117, 229-235
37. Chachisvilis, M., Zhang, Y. L., and Frangos, J. A. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 15463-15468
38. Hein, P., Frank, M., Hoffmann, C., Lohse, M. J., and Bünemann, M. (2005) EMBO J. 24, 4106-4114
39. Janetopoulos, C., Jin, T., and Devreotes, P. (2001) Science 291, 2408-2411
40. Nikolaev, V. O., Boettcher, C., Dees, C., Bünemann, M., Lohse, M. J., and Zenk, M. H. (2007) J. Biol. Chem. 282, 27126-27132
41. Barak, L. S., Ferguson, S. S., Zhang, J., and Caron, M. G. (1997) J. Biol. Chem. 272, 27497-27500
42. Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., and Dixon, R. A. (1994) Annu. Rev. Biochem. 63, 101-132
43. Liapakis, G., Chan, W. C., Papadokostaki, M., and Javitch, J. A. (2004) Mol. Pharmacol. 65, 1181-1190
44. Wieland, K., Zuurmond, H. M., Krasel, C., Ijzerman, A. P., and Lohse, M. J. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 9276-9281
45. Levitzki, A., Marbach, I., and Bar-Sinai, A. (1993) Life Sci. 52, 2093-2100
46. Galés, C., Rebois, R. V., Hogue, M., Trieu, P., Breit, A., Hébert, T. E., and Bouvier, M. (2005) Nat. Methods 2, 177-184
47. Hoffmann, C., Ziegler, N., Reiner, S., Krasel, C., and Lohse, M. J. (2008) J. Biol. Chem. 283, 30933-30941
48. Reiner, S., Ziegler, N., Leon, C., Lorenz, K., von Hayn, K., Gachet, C., Lohse, M. J., and Hoffmann, C. (2009) Mol. Pharmacol. 76, 1162-1171
49. Shenoy, S. K., Drake, M. T., Nelson, C. D., Houtz, D. A., Xiao, K., Madabushi, S., Reiter, E., Premont, R. T., Lichtarge, O., and Lefkowitz, R. J. (2006) J. Biol. Chem. 281, 1261-1273