On the fitting of binding data when receptor dimerization is suspected

British Journal of Pharmacology

Volumn 155, Issue 1, 2008, Pages 17-23

  Giraldo, J ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Dimer cooperativity index; Empirical models; Hill coefficient; Mathematical modelling; Mechanistic models; Model fitting; Receptor dimerization

Indexed keywords

DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; OXYTOCIN RECEPTOR; RACLOPRIDE; RADIOLIGAND; SPIPERONE; TRITIUM; VASOPRESSIN RECEPTOR;

BINDING AFFINITY; CHO CELL; DIMERIZATION; EQUILIBRIUM CONSTANT; GENOTYPE; LIGAND BINDING; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; NONHUMAN; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SYRIAN HAMSTER;

ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HUMANS; KINETICS; LIGANDS; MODELS, BIOLOGICAL; PHENOTYPE; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 50249108916     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.234     Document Type: Review

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