Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor

Journal of Cell Biology

Volumn 160, Issue 4, 2003, Pages 487-493

  Rangarajan, Savithri ^a   Enserink, Jorrit M ^a   Kuiperij, H Bea ^a   De Rooij, Johan ^a   Price, Leo S ^a   Schwede, Frank ^b   Bos, Johannes L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Biolog Life Science Institute GmbH   (Germany)

Author keywords

Cell adhesion; Cyclic nucleotides; GTPases; Guanine nucleotide exchange factor; Integrins

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; 8 BROMO CYCLIC AMP; BETA ADRENERGIC RECEPTOR; CELL SURFACE RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBRONECTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTEGRIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN; PROTEIN EPAC; RAP PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL ADHESION; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SECOND MESSENGER; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADRENERGIC BETA-AGONISTS; CARCINOMA; CELL ADHESION; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; FIBRONECTINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTEGRINS; ISOPROTERENOL; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; RAP1 GTP-BINDING PROTEINS; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0037450725     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200209105     Document Type: Article

References (32)

1. Arai, A., Y. Nosaka, E. Kanda, K. Yamamoto, N. Miyasaka, and O. Miura. 2001. Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of β1 integrin-mediated hematopoietic cell adhesion. J. Biol. Chem. 276:10453-10462.
2. Bertoni, A., S. Tadokoro, K. Eto, N. Pampori, L.V. Parise, G.C. White, and S.J. Shattil. 2002. Relationships between Rap1b, affinity modulation of integrin α IIbβ 3, and the actin cytoskeleton. J. Biol. Chem. 277:25715-25721.
3. Bos, J.L., J. de Rooij, and K.A. Reedquist. 2001. Rap1 signalling: adhering to new models. Nat. Rev. Mol. Cell Biol. 2:369-377.
4. Brakebusch, C., D. Bouvard, F. Stanchi, T. Sakai, and R. Fassler. 2002. Integrins in invasive growth. J. Clin. Invest. 109:999-1006.
5. Buczek-Thomas, J.A., N. Chen, and T. Hasan. 1998. Integrin-mediated adhesion and signalling in ovarian cancer cells. Cell. Signal. 10:55-63.
6. Cannistra, S.A., C. Ottensmeier, J. Niloff, B. Orta, and J. DiCarlo. 1995. Expression and function of β1 and αVβ3 integrins in ovarian cancer. Gynecol. Oncol. 58:216-225.
7. Caron, E., A.J. Self, and A. Hall. 2000. The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr. Biol. 10:974-978.
8. 2+- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion. J. Biol. Chem. 277:29468-29476.
9. de Rooij, J., F.J. Zwartkruis, M.H. Verheijen, R.H. Cool, S.M. Nijman, A. Wittinghofer, and J.L. Bos. 1998. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 396:474-477.
10. de Rooij, J., H. Rehmann, M. van Triest, R.H. Cool, A. Wittinghofer, and J.L. Bos. 2000. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. J. Biol. Chem. 275:20829-20836.
11. Enserink, J.M., A.E. Christensen, J. de Rooij, M. van Triest, F. Schwede, H.G. Genieser, S.O. Doskeland, J.L. Blank, and J.L. Bos. 2002. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat. Cell Biol. 4:901-906.
12. +-mediated activation of Rap1 in human platelets. EMBO J. 16:252-259.
13. Gonzalez, G.A., and M.R. Montminy. 1989. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:675-680.
14. Howe, A.K., and R.L. Juliano. 2000. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat. Cell Biol. 2:593-600.
15. Katagiri, K., M. Hattori, N. Minato, S. Irie, K. Takatsu, and T. Kinashi. 2000. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol. Cell. Biol. 20:1956-1969.
16. Kawasaki, H., G.M. Springett, N. Mochizuki, S. Toki, M. Nakaya, M. Matsuda, D.E. Housman, and A.M. Graybiel. 1998. A family of cAMP-binding proteins that directly activate Rap1. Science. 282:2275-2279.
17. Kitayama, H., Y. Sugimoto, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A ras-related gene with transformation suppressor activity. Cell. 56:77-84.
18. Knox, A.L., and N.H. Brown. 2002. Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science. 295:1285-1288.
19. Marinissen, M.J., and J.S. Gutkind. 2001. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol. Sci. 22:368-376.
20. Mochizuki, N., Y. Ohba, E. Kiyokawa, T. Kurata, T. Murakami, T. Ozaki, A. Kitabatake, K. Nagashima, and M. Matsuda. 1999. Activation of the ERK/MAPK pathway by an isoform of Rap1GAP associated with G α(i). Nature. 400:891-894.
21. Morgan, A., M. Wilkinson, and R.D. Burgoyne. 1993. Identification of Exo2 as the catalytic subunit of protein kinase A reveals a role for cyclic AMP in Ca(2+)-dependent exocytosis in chromaffin cells. EMBO J. 12:3747-3752.
22. Neves, S.R., P.T. Ram, and R. Iyengar. 2002. G protein pathways. Science. 296:1636-1639.
23. Ohba, Y., K. Ikuta, A. Oguta, J. Matsuda, N. Mochizuki, K. Nagashima, K. Kurokawa, B.J. Mayer, K. Maki, J. Miyazaki, and M. Matsuda. 2001. Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J. 20:3333-3341.
24. Porter, J.C., and N. Hogg. 1998. Integrins take partners: cross-talk between integrins and other membrane receptors. Trends Cell Biol. 8:390-396.
25. Reedquist, K.A., E. Ross, E.A. Koop, R.M. Wolthuis, F.J. Zwartkruis, Y. van Kooyk, M. Salmon, C.D. Buckley, and J.L. Bos. 2000. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J. Cell Biol. 148:1151-1158.
26. Sebzda, E., M. Bracke, T. Tugal, N. Hogg, and D.A. Cantrell. 2002. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat. Immunol. 3:251-258.
27. Stewart, M., and N. Hogg. 1996. Regulation of leukocyte integrin function: affinity vs. avidity. J. Cell. Biochem. 61:554-561.
28. Strobel, T., and S.A. Cannistra. 1999. β1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro. Gynecol. Oncol. 73:362-367.
29. Tsukamoto, N., M. Hattori, H. Yang, J.L. Bos, and N. Minato. 1999. Rap1 GTP-ase-activating protein SPA-1 negatively regulates cell adhesion. J. Biol. Chem. 274:18463-18469.
30. van Kooyk, Y., and C.G. Figdor. 2000. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol. 12:542-547.
31. van Triest, M., J. de Rooij, and J.L. Bos. 2001. Measurement of GTP-bound Ras-like GTPases by activation-specific probes. Methods Enzymol. 333:343-348.
32. Whittard, J.D., and S.K. Akiyama. 2001. Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. J. Cell Sci. 114:3265-3272.