Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells

FEBS Letters

Volumn 582, Issue 5, 2008, Pages 558-564

  Fang, Ye ^a   Ferrie, Ann M ^a  

^a Corning Incorporated ^*  (United States)

Author keywords

2 adrenoceptor; G protein coupled receptor; Ligand directed functional selectivity; Optical biosensor

Indexed keywords

5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ADRENALIN; ALPRENOLOL; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOL; CATECHOLAMINE DERIVATIVE; DOPAMINE; DYNAMIN; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; LABETALOL; LIGAND; NORADRENALIN; PHENETHYLAMINE; PINDOLOL; SALBUTAMOL; SALMETEROL; TYRAMINE; XAMOTEROL;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; OPTICAL BIOSENSOR; PRIORITY JOURNAL; PROTEIN STRUCTURE; SQUAMOUS CELL CARCINOMA;

ADRENERGIC BETA-ANTAGONISTS; ALBUTEROL; BIOSENSING TECHNIQUES; CATECHOLS; CELL LINE; CELL SURVIVAL; EPINEPHRINE; HUMANS; KINETICS; LIGANDS; OPTICS; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 39649108870     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.01.021     Document Type: Article

References (28)

1. 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268 (1993) 4625-4636
2. Hermans E. Biochemical and pharmacological control of the multiplicity of coupling at G protein-coupled receptors. Pharmacol. Ther. 99 (2003) 25-44
3. Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signaling by β-arrestins. Science 308 (2005) 512-517
4. Azzi M., Charest P.G., Angers S., Rousseau G., Kohout T., Bouvier M., and Pineyro G. β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc. Natl. Acad. Sci. USA 100 (2003) 11406-11411
5. Sun Y., Huang J., Xiang Y., Bastepe M., Juppner H., Kobilka B.K., Zhang J.J., and Huang X.Y. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 26 (2007) 53-64
6. Kenakin T. New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat. Rev. Drug Discov. 4 (2005) 919-927
7. Perez D.M., and Karnik S.S. Multiple signaling states of G protein-coupled receptors. Pharmacol. Rev. 57 (2005) 147-161
8. Galandrin S., Oligny-Longpre G., and Bouvier M. The evasive nature of drug efficacy: implications for drug discovery. Trends Pharmacol. Sci. 8 (2007) 423-430
9. Milligan G. High-content assays for ligand regulation of G protein-coupled receptors. Drug Discov. Today 8 (2003) 579-585
10. Mailman R.B. Ligand-selective signaling and high content for GPCR drugs. Trends Pharmacol. Sci. 8 (2007) 390-396
11. Cooper M.A. Optical biosensors in drug discovery. Nature Rev. Drug Discov. 1 (2002) 515-528
12. Tollin G., Salamon Z., and Hruby V.J. Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions. Trends Pharmacol. Sci. 24 (2003) 655-659
13. 2 receptor signaling in A431 cells. FEBS Lett. 579 (2005) 6365-6374
14. Fang Y., Ferrie A.M., Fontaine N.H., and Yuen P.K. Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors. Anal. Chem. 77 (2005) 5720-5725
15. Fang Y., Ferrie A.M., Fontaine N.H., Mauro J., and Balakrishnan J. Resonant waveguide grating biosensor for living cell sensing. Biophys. J. 91 (2006) 1925-1940
16. Fang Y., Li G., and Ferrie A.M. Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J. Pharmacol. Toxicol. Meth. 55 (2007) 314-322
17. Fang Y. Non-invasive optical biosensor for probing cell signaling. Sensors 7 (2007) 2316-2329
18. Barer R., and Joseph S. Refractometry of living cells. Part I. Basic principles. Quart. J. Microsc. Sci. 95 (1954) 399-423
19. 2-adrenergic receptor. Biochemistry 43 (2004) 3280-3288
20. 2 adrenoceptor: kinetic evidence for intermediate conformational states. J. Biol. Chem. 279 (2004) 686-691
21. 2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J. Biol. Chem. 274 (1999) 1185-1188
22. 2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J. Biol. Chem. 280 (2005) 22165-22171
23. 2 in A431 cells. BMC Cell Biol. 8 (2007) 24
24. 2-adrenergic receptor. Mol. Pharmacol. 65 (2004) 1181-1190
25. Zaccolo M., and Pozzan T. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295 (2002) 1711-1715
26. 2-adrenergic receptors and β-arrestin 2 using β-galactosidase complementation in C2C12 cells. J. Pharmacol. Exp. Ther. 315 (2005) 839-848
27. 2-adrenergic receptor phosphorylation and internalization. Am. J. Respir. Cell Mol. Biol. 36 (2007) 254-261
28. 2-adrenoceptor. Br. J. Pharmacol. 137 (2002) 400-408