-
1
-
-
44449085539
-
Paul Ehrlich's magic bullet concept: 100 Years of progress
-
DOI 10.1038/nrc2394, PII NRC2394
-
Strebhardt, K. & Ullrich, A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 8, 473-480 (2008). (Pubitemid 351752547)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 473-480
-
-
Strebhardt, K.1
Ullrich, A.2
-
2
-
-
20844432908
-
Can cell systems biology rescue drug discovery?
-
DOI 10.1038/nrd1754
-
Butcher, E. Can cell systems biology rescue drug discovery? Nat. Rev. Drug Discov. 4, 461-467 (2005). (Pubitemid 40861988)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.6
, pp. 461-467
-
-
Butcher, E.C.1
-
3
-
-
79952171625
-
Probing the links between in vitro potency, ADMET and physicochemical parameters
-
Gleeson, M., Hersey, A., Montanari, D. & Overington, J. Probing the links between in vitro potency, ADMET and physicochemical parameters. Nat. Rev. Drug Discov. 10, 197-208 (2011).
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 197-208
-
-
Gleeson, M.1
Hersey, A.2
Montanari, D.3
Overington, J.4
-
4
-
-
12244275244
-
-
Fliri, A. F., Loging, W. T., Thadeio, P. F. & Volkmann, R. A. Proc. Natl. Acad. Sci. USA 102, 261-266 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 261-266
-
-
Fliri, A.F.1
Loging, W.T.2
Thadeio, P.F.3
Volkmann, R.A.4
-
5
-
-
33749335282
-
The connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J. P., Subramanian, A., Ross, K. N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S. A., Haggarty, S. J., Clemons, P. A., Wei, R., Carr, S. A., Lander, E. S. & Golub, T. R. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 929-35 (2006).
-
(2006)
Science
, vol.313
, pp. 929-35
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.P.8
Subramanian, A.9
Ross, K.N.10
Reich, M.11
Hieronymus, H.12
Wei, G.13
Armstrong, S.A.14
Haggarty, S.J.15
Clemons, P.A.16
Wei, R.17
Carr, S.A.18
Lander, E.S.19
Golub, T.R.20
more..
-
6
-
-
47649093352
-
An integrated platform of genomic assays reveals small-molecule bioactivities
-
Hoon, S., Smith, A. M., Wallace, I. M., Suresh, S., Miranda, M., Fung, E., Proctor, M., Shokat, K. M., Zhang, C., Davis, R. W., Giaever, G., St Onge, R. P. & Nislow, C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat. Chem. Biol. 4, 498-506 (2008).
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 498-506
-
-
Hoon, S.1
Smith, A.M.2
Wallace, I.M.3
Suresh, S.4
Miranda, M.5
Fung, E.6
Proctor, M.7
Shokat, K.M.8
Zhang, C.9
Davis, R.W.10
Giaever, G.11
St Onge, R.P.12
Nislow, C.13
-
7
-
-
37249026328
-
Integrating high-content screening and ligand-target prediction to identify mechanism of action
-
DOI 10.1038/nchembio.2007.53, PII NCHEMBIO200753
-
Young, D. W., Bender, A., Hoyt, J., McWhinnie, E., Chirn, G.-W., Tao, C. Y., Tallarico, J. A., Labow, M., Jenkins, J. L., Mitchison, T. J. & Feng, Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat. Chem. Biol. 4, 59-68 (2008). (Pubitemid 350273652)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.1
, pp. 59-68
-
-
Young, D.W.1
Bender, A.2
Hoyt, J.3
McWhinnie, E.4
Chirn, G.-W.5
Tao, C.Y.6
Tallarico, J.A.7
Labow, M.8
Jenkins, J.L.9
Mitchison, T.J.10
Feng, Y.11
-
8
-
-
47249146126
-
Drug target identification using side-effect similarity
-
DOI 10.1126/science.1158140
-
Campillos, M., Kuhn, M., Gavin, A., Jensen, L. & Bork, P. Drug target identification using side-effect similarity. Science 321, 263-266 (2008). (Pubitemid 351989100)
-
(2008)
Science
, vol.321
, Issue.5886
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.-C.3
Jensen, L.J.4
Bork, P.5
-
9
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., Jensen, N. H., Kuijer, M. B., Matos, R. C., Tran, T. B., Whaley, R., Glennon, R. A., Hert, J., Thomas, K. L. H., Edwards, D. D., Shoichet, B. K. & Roth, B. L. Predicting new molecular targets for known drugs. Nature 462, 175-181 (2009).
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
Whaley, R.11
Glennon, R.A.12
Hert, J.13
Thomas, K.L.H.14
Edwards, D.D.15
Shoichet, B.K.16
Roth, B.L.17
-
10
-
-
77955628292
-
Network-based relating pharmacological and genomic spaces for drug target identification
-
Zhao, S. & Li, S. Network-based relating pharmacological and genomic spaces for drug target identification. PLoS One 5, e11764 (2010).
-
(2010)
PLoS One
, vol.5
-
-
Zhao, S.1
Li, S.2
-
11
-
-
33751162165
-
Distinct signaling profiles of b1 and b2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
-
Galandrin, S. & Bouvier, M. Distinct signaling profiles of b1 and b2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol. Pharmacol. 70, 1575-1584 (2006).
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1575-1584
-
-
Galandrin, S.1
Bouvier, M.2
-
12
-
-
77952354490
-
Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
-
Kenakin, T. & Miller, L. J. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol. Rev. 62, 265-304 (2010).
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 265-304
-
-
Kenakin, T.1
Miller, L.J.2
-
13
-
-
3442901436
-
Expert consensus document on b-adrenergic receptor blockers: The task force on beta-blockers of the European society of cardiology
-
Expert consensus document on b-adrenergic receptor blockers: The task force on beta-blockers of the European Society of Cardiology. Euro. Heart J. 25, 1341-1362 (2004).
-
(2004)
Euro. Heart J.
, vol.25
, pp. 1341-1362
-
-
-
14
-
-
51749089518
-
Current and prospective pharmacological targets in relation to antimigraine action
-
Mehrotra, S., Gupta, S., Chan, K. Y., Villalon, C. M., Centurion, D., Saxena, P. R., Maassen, A. Current and prospective pharmacological targets in relation to antimigraine action. Naunyn-Schmiedeberg's Arch Pharmacol. 378, 371-394 (2008).
-
(2008)
Naunyn-Schmiedeberg's Arch Pharmacol.
, vol.378
, pp. 371-394
-
-
Mehrotra, S.1
Gupta, S.2
Chan, K.Y.3
Villalon, C.M.4
Centurion, D.5
Saxena, P.R.6
Maassen, A.7
-
15
-
-
0032877851
-
Beta-blocker eyedrops and nocturnal arterial hypotension
-
DOI 10.1016/S0002-9394(99)00160-9, PII S0002939499001609
-
Hayreh, S. S., Podhajsky, P. & Zimmerman, M. B. Beta-blocker eyedrops and nocturnal arterial hypotension. Am. J. Ophthalmol. 128, 301-309 (1999). (Pubitemid 29413226)
-
(1999)
American Journal of Ophthalmology
, vol.128
, Issue.3
, pp. 301-309
-
-
Hayreh, S.S.1
Podhajsky, P.2
Zimmerman, M.B.3
-
16
-
-
0033982083
-
Beta-blockers continue to surprise us
-
DOI 10.1053/euhj.1999.1717
-
Cruickshank, J. M. Beta-blockers continue to surprise us. Euro. Heart J. 21, 354-364 (2000). (Pubitemid 30107552)
-
(2000)
European Heart Journal
, vol.21
, Issue.5
, pp. 354-364
-
-
Cruickshank, J.M.1
-
17
-
-
60549103882
-
B2-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model
-
Nguyen, L. P., Lin, R., Parra, S., Omoluabi, O., Hanania, N. A., Tuvim, M. J., Knoll, B. J., Dickey, B. F. & Bond, R. A. b2-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc. Natl. Acad. Sci. USA 106, 2435-2440 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2435-2440
-
-
Nguyen, L.P.1
Lin, R.2
Parra, S.3
Omoluabi, O.4
Hanania, N.A.5
Tuvim, M.J.6
Knoll, B.J.7
Dickey, B.F.8
Bond, R.A.9
-
19
-
-
68249113457
-
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
-
Kenakin, T. Cellular assays as portals to seven-transmembrane receptor-based drug discovery. Nat. Rev. Drug Discov. 8, 617-626 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 617-626
-
-
Kenakin, T.1
-
20
-
-
33748469378
-
Resonant waveguide grating biosensor for living cell sensing
-
DOI 10.1529/biophysj.105.077818
-
Fang, Y., Ferrie, A. M., Fontaine, N. H., Mauro, J. & Balakrishnan, J. Resonant waveguide grating biosensor for living cell sensing. Biophys. J. 91, 1925-1940 (2006). (Pubitemid 44352454)
-
(2006)
Biophysical Journal
, vol.91
, Issue.5
, pp. 1925-1940
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Mauro, J.4
Balakrishnan, J.5
-
21
-
-
24644496122
-
Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors
-
DOI 10.1021/ac050887n
-
Fang, Y., Ferrie, A. M., Fontaine, N. H. & Yuen, P. K. Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors. Anal. Chem. 77, 5720-5725 (2005). (Pubitemid 41266070)
-
(2005)
Analytical Chemistry
, vol.77
, Issue.17
, pp. 5720-5725
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Yuen, P.K.4
-
23
-
-
77956657852
-
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements
-
Schröder, R., Janssen, N., Schmidt, K., Kebig, A., Merten, N., Hennen, S., Müller, A., Blättermann, S., Mohr-Andrä, M., Zahn, S., Wenzel, J., Smith, N. J., Gomeza, J., Drewke, C., Milligan, G., Mohr, K., Kostenis, E. Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 28, 943-949 (2010).
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 943-949
-
-
Schröder, R.1
Janssen, N.2
Schmidt, K.3
Kebig, A.4
Merten, N.5
Hennen, S.6
Müller, A.7
Blättermann, S.8
Mohr-Andrä, M.9
Zahn, S.10
Wenzel, J.11
Smith, N.J.12
Gomeza, J.13
Drewke, C.14
Milligan, G.15
Mohr, K.16
Kostenis, E.17
-
24
-
-
1642576974
-
2-Adrenergic Receptor Using Phosphoserine-Specific Antibodies
-
DOI 10.1124/mol.65.1.196
-
Tran, T. M., Friedman, J., Qunaibi, E., Baameur, F., Moore, R. H. & Clark, R. B. Characterization of agonist stimulation of cAMP-dependent protein kinase andG protein-coupled receptor kinase phosphorylation of the b2-adrenergic receptor using phosphoserine-specific antibodies. Mol. Pharmacol. 65, 196-206 (2004). (Pubitemid 38113900)
-
(2004)
Molecular Pharmacology
, vol.65
, Issue.1
, pp. 196-206
-
-
Tran, T.M.1
Friedman, J.2
Qunaibi, E.3
Baameur, F.4
Moore, R.H.5
Clark, R.B.6
-
25
-
-
0032441150
-
Cluster analysis and display of genome-wide expression patterns
-
DOI 10.1073/pnas.95.25.14863
-
Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14863-14868 (1998). (Pubitemid 29003722)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.25
, pp. 14863-14868
-
-
Eisen, M.B.1
Spellman, P.T.2
Brown, P.O.3
Botstein, D.4
-
26
-
-
38549151817
-
Drug Bank: A knowledgebase for drugs, drug actions and drug targets
-
Wishart, D. S., Knox, C., Guo, A. C., Cheng, D., Shrivastava, S., Tzur, D., Gautam, B. & Hassanali, M. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucl. Acids Res. 36, D901-D906 (2007).
-
(2007)
Nucl. Acids Res.
, vol.36
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
27
-
-
33646805362
-
Emerging drugs for migraine prophylaxis and treatment
-
Bigal, M. E. & Krymchantowski, A. V. Emerging drugs for migraine prophylaxis and treatment. Med. Gen. Med. 8, 31 (2006).
-
(2006)
Med. Gen. Med.
, vol.8
, pp. 31
-
-
Bigal, M.E.1
Krymchantowski, A.V.2
-
28
-
-
48249143990
-
Chemmine R: A compound mining framework for R
-
Cao, Y., Charisi, A., Cheng, L. C., Jiang, T., Girke, T. ChemmineR: a compound mining framework for R. Bioinformatics 24, 1733-1734 (2008).
-
(2008)
Bioinformatics
, vol.24
, pp. 1733-1734
-
-
Cao, Y.1
Charisi, A.2
Cheng, L.C.3
Jiang, T.4
Girke, T.5
-
29
-
-
39649108870
-
Label-free optical biosensor for ligand-directed functional selectivity acting on b2 adrenoceptor in living cells
-
Fang, Y. & Ferrie, A. M. Label-free optical biosensor for ligand-directed functional selectivity acting on b2 adrenoceptor in living cells. FEBS Lett. 582, 558-564 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 558-564
-
-
Fang, Y.1
Ferrie, A.M.2
-
30
-
-
79955631465
-
Agonist-directed desensitization of the b2-adrenergic receptor
-
Goral, V., Jin, Y., Sun, H., Ferrie, A. M., Wu, Q. & Fang, Y. Agonist-directed desensitization of the b2-adrenergic receptor. PLoS One 6, e19282 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Goral, V.1
Jin, Y.2
Sun, H.3
Ferrie, A.M.4
Wu, Q.5
Fang, Y.6
-
31
-
-
77952707904
-
B-blockers may reduce mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease
-
Rutten, F. H., Zuithoff, N., Hak, E., Grobbee, D. E. & Hoes, A. W. b-blockers may reduce mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease. Arch. Intern. Med. 170, 880-887 (2010).
-
(2010)
Arch. Intern. Med.
, vol.170
, pp. 880-887
-
-
Rutten, F.H.1
Zuithoff, N.2
Hak, E.3
Grobbee, D.E.4
Hoes, A.W.5
-
32
-
-
60549104043
-
Agonizing over agonism: Should asthmatics turn their b-receptors on or off?
-
Penn, R. B. Agonizing over agonism: should asthmatics turn their b-receptors on or off? Proc. Natl. Acad. Sci. USA 106, 2095-2096 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2095-2096
-
-
Penn, R.B.1
|