Regulation of transport across cell membranes by the serum-and glucocorticoid-inducible kinase SGK1

Molecular Membrane Biology

Volumn 31, Issue 1, 2014, Pages 29-36

  Lang, Florian ^a   Stournaras, Christos ^b   Alesutan, Ioana ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Ca2+ release activated Ca2+ channel ORAI STIM; Epithelial Na+ channel ENaC; Na + K+ ATPase; Na+ coupled glucose transporter SGLT1; Na+ H+ exchanger NHE1; Renal outer medullary K+ channel ROMK; Voltage gated K+ channel KCNQ1

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM CHANNEL; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

APOPTOSIS; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; DIABETES MELLITUS; FIBROSIS; HUMAN; HYPERTENSION; INFLAMMATION; INTESTINE ABSORPTION; KIDNEY TUBULE ABSORPTION; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; THROMBOCYTE FUNCTION; THROMBOSIS; TUMOR GROWTH; UPREGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; IMMEDIATE-EARLY PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES;

EID: 84893096826     PISSN: 09687688     EISSN: 14645203     Source Type: Journal    
DOI: 10.3109/09687688.2013.874598     Document Type: Review

References (96)

1. Abbruzzese C, Mattarocci S, Pizzuti L, Mileo AM, Visca P, Antoniani B, et al. 2012. Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas. J Exp Clin Cancer Res 31:4.
2. Ackermann TF, Boini KM, Beier N, Scholz W, Fuchss T, Lang F. 2011. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem 28:137-146.
3. Akhurst RJ, Hata A. 2012. Targeting the TGFbeta signaling pathway in disease. Nat Rev Drug Discov 11:790-811.
4. Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, et al. 2013. Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells. Oncogene 32: 4572-4578.
5. Andrukhova O, Zeitz U, Goetz R, Mohammadi M, Lanske B, Erben RG. 2012. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. Bone 51:621-628.
6. Arroyo JP, Lagnaz D, Ronzaud C, Vazquez N, Ko BS, Moddes L, et al. 2011. Nedd4-2 modulates renal Na+-Cl-co-otransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 22: 1707-1719.
7. Baskin R, Sayeski PP. 2012. Angiotensin II mediates cell survival through upregulation and activation of the serum and gluco-corticoid inducible kinase 1. Cell Signal 24:435-442.
8. Borst O, Schmidt EM, Munzer P, Schonberger T, Towhid ST, Elvers M, et al. 2012. The serum-and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 119:251-261.
9. Chen H, Zhou Y, Chen KQ, An G, Ji SY, Chen QK. 2012a. Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells. Cell Physiol Biochem 29:51-60.
10. Chen L, Wei TQ, Wang Y, Zhang J, Li H, Wang KJ. 2012b. Simulated bladder pressure stimulates human bladder smooth muscle cell proliferation via the PI3K/SGK1 signaling pathway. J Urol 188: 661-667.
11. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J. 2010. Serum-and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition.Kidney Int 78:668-678.
12. Chilukoti RK, Mostertz J, Bukowska A, Aderkast C, Felix SB, Busch M, et al. 2013. Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo. Int J Cardiol 168:2100-2108.
13. Dahlberg J, Smith G, Norrving B, Nilsson P, Hedblad B, Engstrom G, et al. 2011. Genetic variants in serum and gluco-cortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke. J Hypertens 29:884-889.
14. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, et al. 2012. Pathological role of serum-and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation 126:2208-2219.
15. Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, et al. 2010. Serum-and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol 24: 370-380.
16. Diakov A, Nesterov V, Mokrushina M, Rauh R, Korbmacher C. 2010. Protein kinase B alpha (PKBalpha) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms. Cell Physiol Biochem 26:913-924.
17. Dynia DW, Steinmetz AG, Kocinsky HS. 2010. NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol 298:F745-F753.
18. Eylenstein A, Gehring EM, Heise N, Shumilina E, Schmidt S, Szteyn K, et al. 2011. Stimulation of Ca2+-channel Orai1/STIM1 by serum-and glucocorticoid-inducible kinase 1 (SGK1). FASEB J 25:2012-2021.
19. Eylenstein A, Schmidt S, Gu S, Yang W, Schmid E, Schmidt EM, et al. 2012. Transcription factor NF-kappaB regulates expression of poreforming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem 287:2719-2730.
20. Fagerli UM, Ullrich K, Stuhmer T, Holien T, Kochert K, Holt RU, et al. 2011. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells. Oncogene 30: 3198-3206.
21. Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, et al. 2012. Inducible kidney-specific SGK1 knockout mice show a salt-losing phenotype. Am J Physiol Renal Physiol 302: F977-F985.
22. Firestone GL, Giampaolo JR, O'Keeffe BA. 2003 Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12. (Pubitemid 36362001)
23. Gu S, Papadopoulou N, Nasir O, Foller M, Alevizopoulos K, Lang F, et al. 2011. Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling. Mol Med 17:48-58.
24. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, et al. 2010. Phosphopeptide screen uncovers novel phos-phorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem 285:21671-21678.
25. Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, et al. 2012. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev 133:556-562.
26. He P, Lee SJ, Lin S, Seidler U, Lang F, Fejes-Toth G, et al. 2011. Serum-and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell 22:3812-3825.
27. Hryciw DH, Kruger WA, Briffa JF, Slattery C, Bolithon A, Lee A, et al. 2012. Sgk-1 is a positive regulator of constitutive albumin uptake in renal proximal tubule cells. Cell Physiol Biochem 30: 1215-1226.
28. Hua SZ. 2013. Mapped! A machinery of degranulation in mast cells. Focus on 'Serum-and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation'. Am J Physiol Cell Physiol 304: C36-C37.
29. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, et al. 2006a. Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum-and glucocorticoid-inducible kinase SGK1. Am J Physiol Regul Integr Comp Physiol 290:R935-R944.
30. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, et al. 2006b. Resistance of mice lacking the serum-and glucocorticoidinducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet. Am J Physiol Renal Physiol 291:F1264-F1273. (Pubitemid 44887240)
31. Kawarazaki H, Ando K, Shibata S, Muraoka K, Fujita M, Kawarasaki C, et al. 2012. Mineralocorticoid receptor-Rac1 activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats. J Hypertens 30:1977-1985.
32. Ke Y, Butt AG, Swart M, Liu YF, McDonald FJ. 2010. COMMD1 downregulates the epithelial sodium channel through Nedd4-2. Am J Physiol Renal Physiol 298:F1445-F1456.
33. Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, et al. 2013. Sodium chloride drives autoimmune disease by the induction of pathogenic T17 cells. Nature 496:518-522.
34. Lamothe S, Zhang S. 2013. The serum-and glucocorticoid-inducible kinase SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. J Biol Chem 288: 15075-15084.
35. Lang F, Artunc F, Vallon V. 2009a. The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 18:439-448.
36. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. 2006 (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 86:1151-1178. (Pubitemid 44521650)
37. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, et al. 1998. Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247-306. (Pubitemid 28070981)
38. Lang F, Eylenstein A, Shumilina E. 2012. Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK. Cell Calcium 52: 347-354.
39. Lang F, Gorlach A, Vallon V. 2009b. Targeting SGK1 in diabetes. Expert Opin Ther Targets 13:1303-1311.
40. Lang F, Perrotti N, Stournaras C. 2010a. Colorectal carcinoma cells-regulation of survival and growth by SGK1. Int J Biochem Cell Biol 42:1571-1575.
41. Lang F, Shumilina E. 2013. Regulation of ion channels by the serumand glucocorticoid-inducible kinase SGK1. FASEB J 27:3-12.
42. Lang F, Stournaras C. 2013. Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth. Hormones (Athens) 12:160-171.
43. Lang F, Strutz-Seebohm N, Seebohm G, Lang UE. 2010b. Significance of SGK1 in the regulation of neuronal function. J Physiol 588: 3349-3354.
44. Lang F, Vallon V. 2012. Serum-and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport. Clin Exp Nephrol 16:73-80.
45. Lang F, Voelkl J. 2013. Therapeutic potential of serum and glucocorticoid inducible kinase inhibition. Expert Opin Investig Drugs 22: 701-714.
46. Li W, Cui M, Wei Y, Kong X, Tang L, Xu D. 2012. Inhibition of the expression of TGF-beta1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist. Cell Physiol Biochem 30:749-757.
47. Lin DH, Yue P, Rinehart J, Sun P, Wang Z, Lifton R, et al. 2012. Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels. Am J Physiol Renal Physiol 303:F110-F119.
48. MacDonald EM, Cohn RD. 2012. TGFbeta signaling: its role in fibrosis formation and myopathies. Curr Opin Rheumatol 24:628-634.
49. McCaig C, Potter L, Abramczyk O, Murray JT. 2011. Phosphor-ylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochem Biophys Res Commun 411:227-234
50. Miranda P, Cadaveira-Mosquera A, Gonzalez-Montelongo R, Villarroel A, Gonzalez-Hernandez T, Lamas JA, et al. 2013. The neuronal serum-and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current. J Neurosci 33:2684-2696.
51. Murakami Y, Hosoi F, Izumi H, Maruyama Y, Ureshino H, Watari K, et al. 2010. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. Biochem Biophys Res Commun 396:376-381.
52. Na T, Wu G, Zhang W, Dong WJ, Peng JB. 2013. Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites. Am J Physiol Renal Physiol 304:F8-F18.
53. Nakagaki T, Hirooka Y, Matsukawa R, Nishihara M, Nakano M, Ito K, et al. 2012. Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 35: 470-476.
54. Nakano M, Hirooka Y, Matsukawa R, Ito K, Sunagawa K. 2013. Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res 36:277-284.
55. Notch EG, Chapline C, Flynn E, Lameyer T, Lowell A, Sato D, et al. 2012. Mitogen activated protein kinase 14-1 regulates serum glucocorticoid kinase 1 during seawater acclimation in Atlantic killifish, Fundulus heteroclitus. Comp Biochem Physiol A Mol Integr Physiol 162:443-448.
56. Pakladok T, Almilaji A, Munoz C, Alesutan I, Lang F. 2013. PIKfyve sensitivity of hERG channels. Cell Physiol Biochem 31:785-794.
57. Pakladok T, Hosseinzadeh Z, Alesutan I, Lang F. 2012. Stimulation of the Na(+)-coupled glucose transporter SGLT1 by B-RAF. Biochem Biophys Res Commun 427:689-693.
58. Panchapakesan U, Pollock C, Saad S. 2011. Renal epidermal growth factor receptor: its role in sodium and water homeo-stasis in diabetic nephropathy. Clin Exp Pharmacol Physiol 38:84-88.
59. Pao AC. 2012. SGK regulation of renal sodium transport. Curr Opin Nephrol Hypertens 21:534-540.
60. Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, et al. 2010. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Am J Physiol Renal Physiol 299: F1496-F1506.
61. Pasham V, Rotte A, Gu S, Yang W, Bhandaru M, Rexhepaj R, et al. 2013. Upregulation of intestinal NHE3 following saline ingestion. Kidney Blood Press Res 37:48-57.
62. Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. 2011. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J 436:169-179.
63. Pelzl L, Tolios A, Schmidt EM, Alesutan I, Walker B, Munzer P, et al. 2012. Translational regulation of the serum-and glucocorticoidinducible kinase-1 (SGK1) in platelets. Biochem Biophys Res Commun 425:1-5.
64. Raikwar NS, Liu KZ, Thomas CP. 2012. A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct. Am J Physiol Renal Physiol 303:F1527-F1533.
65. Rao AD, Sun B, Saxena A, Hopkins PN, Jeunemaitre X, Brown NJ, et al. 2013. Polymorphisms in the serum-and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens 27:176-180.
66. Rassler B, Marx G, Schierle K, Zimmer HG. 2012. Catecholamines can induce pulmonary remodeling in rats. Cell Physiol Biochem 30: 1134-1147.
67. Reiter MH, Vila G, Knosp E, Baumgartner-Parzer SM, Wagner L, Stalla GK, et al. 2011. Opposite effects of serum-and glucocorticoidregulated kinase-1 and glucocorticoids on POMC transcription and ACTH release. Am J Physiol Endo-crinol Metab 301:E336-E341.
68. Resch M, Bergler T, Fredersdorf S, Griese DP, Weil J, Kreuzer P, et al. 2010. Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure. Hypertens Res 33:1082-1088.
69. Rexhepaj R, Alesutan I, Gu S, Pelzl L, Eichenmuller M, Pathare G, et al. 2011. SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D. Pflugers Arch 462:489-494.
70. Rexhepaj R, Dermaku-Sopjani M, Gehring EM, Sopjani M, Kempe DS, Foller M, et al. 2010. Stimulation of electrogenic glucose transport by glycogen synthase kinase 3. Cell Physiol Biochem 26:641-646.
71. Ronchi CL, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, et al. 2012a. Single nucleotide polymorphism micro-array analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia 14:206-218.
72. Ronchi CL, Sbiera S, Leich E, Tissier F, Steinhauer S, Deutschbein T, et al. 2012b. Low SGK1 expression in human adrenocortical tumors is associated with ACTH-independent glucocorticoid secretion and poor prognosis. J Clin Endocrinol Metab 97:E2251-E2260.
73. Roos M, Heinemann FM, Lindemann M, Horn PA, Lutz J, Stock K, et al. 2011. Fetuin-A pretransplant serum levels, kidney allograft function and rejection episodes: a 3-year post-transplantation follow-up. Kidney Blood Press Res 34:328-333.
74. Rotin D, Staub O. 2012. Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol 3:212.
75. Rotte A, Pasham V, Eichenmuller M, Yang W, Bhandaru M, Lang F. 2011. Influence of dexamethasone on na+/h+ exchanger activity in dendritic cells. Cell Physiol Biochem 28:305-314.
76. Rusai K, Prokai A, Szebeni B, Fekete A, Treszl A, Vannay A, et al. 2010. Role of serum and glucocorticoid-regulated kinase-1 in the protective effects of erythropoietin during renal ischemia/reperfusion injury. Biochem Pharmacol 79:1173-1181.
77. Sahin P, McCaig C, Jeevahan J, Murray JT, Hainsworth AH. 2013. The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain. Neuropathol Appl Neurobiol 39:623-633.
78. Schmid E, Gu S, Yang W, Munzer P, Schaller M, Lang F, et al. 2013.Serum-and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol 304:C49-C55.
79. Schmidt EM, Gu S, Anagnostopoulou V, Alevizopoulos K, Foller M, Lang F, et al. 2012a. Serum-and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor. FEBS J 279:1231-1242.
80. Schmidt EM, Kraemer BF, Borst O, Munzer P, Schonberger T, Schmidt C, et al. 2012b. SGK1 sensitivity of platelet migration. Cell Physiol Biochem 30:259-268.
81. Shih VF, Tsui R, Caldwell A, Hoffmann A. 2011. A single NFkap-paB system for both canonical and non-canonical signaling. Cell Res 21: 86-102.
82. Slattery C, Jenkin KA, Lee A, Simcocks AC, McAinch AJ, Poronnik P, et al. 2011. Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Cell Physiol Biochem 27:171-178.
83. Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR. 2013. Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. Biochem J 452:499-508.
84. Soundararajan R, Lu M, Pearce D. 2012. Organization of the ENaCregulatory machinery. Crit Rev Biochem Mol Biol 47:349-359.
85. Stone KP, Kastin AJ, Pan W. 2011. NFkB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia. Cell Physiol Biochem 28:115-124.
86. Szebeni B, Vannay A, Sziksz E, Prokai A, Cseh A, Veres G, et al. 2010. Increased expression of serum-and glucocorticoidregulated kinase-1 in the duodenal mucosa of children with coeliac disease. J Pediatr Gastroenterol Nutr 50:147-153.
87. Szmulewitz RZ, Chung E, Al Ahmadie H, Daniel S, Kocherginsky M, Razmaria A, et al. 2012. Serum/glucocorti-coid-regulated kinase 1 expression in primary human prostate cancers. Prostate 72:157-164.
88. Towhid ST, Liu GL, Ackermann TF, Beier N, Scholz W, Fuchss T, et al. 2013. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem 32:838-848.
89. Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, et al. 2012. Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb Cortex in press; doi: 10.1093/cercor/bhs310.
90. Umbach AT, Pathare G, Foller M, Brosens JJ, Artunc F, Lang F. 2011. SGK1-dependent salt appetite in pregnant mice. Acta Physiol (Oxf) 202:39-45.
91. Verma P, Kumar A, Goswami C. 2010. TRPV4-mediated channelopathies. Channels (Austin) 4:319-328.
92. Voelkl J, Lin Y, Alesutan I, Ahmed MS, Pasham V, Mia S, et al. 2012. Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload. Basic Res Cardiol 107:236.
93. Voelkl J, Pasham V, Ahmed MS, Walker B, Szteyn K, Kuhl D, et al. 2013. Sgk1-dependent stimulation of cardiac Na+/H+ exchanger Nhe1 by dexamethasone. Cell Physiol Biochem 32:25-38.
94. Wang HR, Chen DL, Zhao M, Shu SW, Xiong SX, Gan XD, et al. 2012. C-reactive protein induces interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor-kB in HK-2 cells. Kidney Blood Press Res 35:211-219.
95. Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, et al. 2013. Induction of pathogenic T17 cells by inducible salt-sensing kinase SGK1. Nature 496:513-517.
96. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, et al. 2012. Serumglucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol 32:1675-1686.