Opposite effects of serum- and glucocorticoid-regulated kinase-1 and glucocorticoids on POMC transcription and ACTH release

American Journal of Physiology - Endocrinology and Metabolism

Volumn 301, Issue 2, 2011, Pages

  Reiter, Marie Helene ^a   Vila, Greisa ^a   Knosp, Engelbert ^a   Baumgartner Parzer, Sabina M ^a   Wagner, Ludwig ^a   Stalla, Günter K ^b   Luger, Anton ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Adrenocorticotropic hormone; AtT 20 cells; Corticotropin releasing hormone; Pituitary; Proopiomelanocortin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CORTICOTROPIN; CYCLIC AMP; DEXAMETHASONE; GLUCOCORTICOID; MESSENGER RNA; MIFEPRISTONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROOPIOMELANOCORTIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ACTH SECRETING CELL; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CORTICOTROPIN RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL LINE, TUMOR; CORTICOTROPIN-RELEASING HORMONE; CREB-BINDING PROTEIN; CYCLIC AMP; DEXAMETHASONE; DRUG SYNERGISM; GENE EXPRESSION; GLUCOCORTICOIDS; IMMEDIATE-EARLY PROTEINS; MICE; PITUITARY GLAND; PRO-OPIOMELANOCORTIN; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 79960825678     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00155.2011     Document Type: Article

References (21)

1. Boutillier AL, Monnier D, Lorang D, Lundblad JR, Roberts JL, Loeffler JP. Corticotropin-releasing hormone stimulates proopiomelanocortin transcription by cFos-dependent and -independent pathways: characterization of an AP1 site in exon 1. Mol Endocrinol 9: 745-755, 1995.
2. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 21: 952-965, 2001.
3. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension 43: 866-871, 2004.
4. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96: 2514-2519, 1999.
5. Chrousos GP, Kino T. Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders. Ann NY Acad Sci 1179: 153-66, 2009.
6. Drouin J, Sun YL, Chamberland M, Gauthier Y, De Léan A, Nemer M, Schmidt TJ. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 12: 145-156, 1993.
7. Gartner W, Vila G, Daneva T, Nabokikh A, Koc-Saral F, Ilhan A, Majdic O, Luger A, Wagner L. New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog. Am J Physiol Endocrinol Metab 293: E347-E354, 2007.
8. Itani OA, Liu KZ, Cornish KL, Campbell JR, Thomas CP. Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region. Am J Physiol Endocrinol Metab 283: E971-E979, 2002.
9. Kobayashi T, Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phophatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339: 319-328, 1999.
10. Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid- inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006.
11. Lee E, Lein ES, Firestone GL. Tissue-specific expression of the transcriptionally regulated serum and glucocorticoid-inducible protein kinase (Sgk) during mouse embryogenesis. Mech Dev 1-2: 177-181, 2001.
12. Leong MLL, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 278: 5871-5882, 2003.
13. Maiyar AC, Leong MLL, Firestone GL. Importin-α mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol Biol Cell 14: 1221-1239, 2003.
14. Nabokikh A, Ilhan A, Bilban M, Gartner W, Vila G, Niederle B, Nielsen JH, Wagner O, Base W, Luger A, Wagner L. Reduced TGF-beta1 expression and its target genes in human insulinomas. Exp Clin Endocrinol Diabetes 115: 674-682, 2007.
15. Park J, Leong MLL, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18: 3024-3033, 1999.
16. Simon P, Schneck M, Hochstetter T, Koutsouki E, Mittelbronn M, Merseburger AS, Weigert C, Niess AM, Lang F. Differential regulation of serum- and glucocorticoid- inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription. Cell Physiol Biochem 20: 715-728, 2007.
17. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci USA 106: 7804-7809, 1999.
18. Vila G, Papazoglou M, Stalla J, Theodoropoulou M, Stalla GK, Holsboer F, Paez-Pereda M. Sonic hedgehog regulates CRH signal transduction in the adult pituitary. FASEB J 19: 281-283, 2005.
19. Waldegger S, Barth P, Raber G, Lang F. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 94: 4440-4445, 1997.
20. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serin/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13: 2031-2040, 1993.
21. Zhang L, Cui R, Cheng X, Du J. Antiapoptotic effect of Serum and Glucocorticoid-inducible kinase is mediated by novel mechanism activating IκB kinase. Cancer Res 65: 457-464, 2005.