EMD638683, a novel SGK inhibitor with antihypertensive potency

Cellular Physiology and Biochemistry

Volumn 28, Issue 1, 2011, Pages 137-146

  Ackermann, Teresa F ^a   Boini, Krishna M ^a,b   Beier, Norbert ^c,d   Scholz, Wolfgang ^c,d   Fuchß, Thomas ^d   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MERCK KGAA   (Germany)

^d Merck Serono GmbH   (Germany)

Author keywords

Blood pressure; Hyperinsulinism; Metabolic syndrome; Salt sensitivity; Type II diabetes

Indexed keywords

ANTIHYPERTENSIVE AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; EMD 638683; FRUCTOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEIC ACID BINDING PROTEIN; PLACEBO; PROTEIN KINASE C RELATED KINASE 2; PROTEIN NDRG1; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 2; SERUM AND GLUCOCORTICOID REGULATED KINASE 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FLUID INTAKE; HELA CELL; HUMAN; HUMAN CELL; HYPERINSULINISM; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SODIUM EXCRETION; URINARY EXCRETION; URINE FLOW RATE;

ANIMALIA; MUS;

EID: 80051984861     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000331722     Document Type: Article

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