Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo

International Journal of Cardiology

Volumn 168, Issue 3, 2013, Pages 2100-2108

  Chilukoti, Ravi Kumar ^a   Mostertz, Jörg ^a   Bukowska, Alicja ^b   Aderkast, Christoph ^a   Felix, Stephan B ^a   Busch, Matthias ^a   Völker, Uwe ^a   Goette, Andreas ^b,c   Wolke, Carmen ^a   Homuth, Georg ^a   Lendeckel, Uwe ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^c St Vincenz Hospital   (Germany)

Author keywords

Acute atrial tachyarrhythmia; Angiotensin; Atrial fibrillation; CTGF; Endothelin; SGK1

Indexed keywords

ANGIOTENSIN RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; IRBESARTAN; MESSENGER RNA; PREPROENDOTHELIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; TRANSCRIPTOME; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; BIPHENYL DERIVATIVE; TETRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CTGF GENE; DRUG EFFECT; EDN1 GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART RIGHT ATRIUM; IMMUNOBLOTTING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SGK1 GENE; SIGNAL TRANSDUCTION; SWINE; ANIMAL; ATRIAL FIBRILLATION; BIOSYNTHESIS; CELL LINE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HEART ATRIUM; HEART RATE; METABOLISM; MICROARRAY ANALYSIS; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; WESTERN BLOTTING;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ATRIAL FIBRILLATION; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL LINE; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART ATRIA; HEART RATE; MICE; MICROARRAY ANALYSIS; MYOCYTES, CARDIAC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE; TETRAZOLES;

EID: 84885637176     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.01.007     Document Type: Article

References (71)

1. U. Schotten, S. Verheule, P. Kirchhof, and A. Goette Pathophysiological mechanisms of atrial fibrillation: a translational appraisal Physiol Rev 91 2011 265 325
2. D. Li, K. Shinagawa, and L. Pang Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure Circulation 104 2001 2608 2614
3. K. Kumagai, H. Nakashima, H. Urata, N. Gondo, K. Arakawa, and K. Saku Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation J Am Coll Cardiol 41 2003 2197 2204
4. Y.-T. Chiu, T.-J. Wu, and H.-J. Wei Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained atrial fibrillation J Cardiovasc Electrophysiol 16 2005 753 759
5. C.-T. Tsai, J.-L. Lin, L.-P. Lai, C.-S. Lin, and S.K.S. Huang Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation Heart Rhythm 5 2008 1285 1293
6. C.-T. Tsai, L.-P. Lai, and J.-J. Hwang Renin-angiotensin system component expression in the HL-1 atrial cell line and in a pig model of atrial fibrillation J Hypertens 26 2008 570 582
7. A. Goette, T. Staack, and C. Röcken Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation J Am Coll Cardiol 35 2000 1669 1677
8. D.V. Unverferth, R.H. Fertel, B.J. Unverferth, and C.V. Leier Atrial fibrillation in mitral stenosis: histologic, hemodynamic and metabolic factors Int J Cardiol 5 1984 143 154
9. M.J. Mihm, F. Yu, and C.A. Carnes Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation Circulation 104 2001 174 180
10. J. Shirani, and J. Alaeddini Structural remodeling of the left atrial appendage in patients with chronic non-valvular atrial fibrillation: implications for thrombus formation, systemic embolism, and assessment by transesophageal echocardiography Cardiovasc Pathol 9 2000 95 101
11. C. Aimé-Sempé, T. Folliguet, and C. Rücker-Martin Myocardial cell death in fibrillating and dilated human right atria J Am Coll Cardiol 34 1999 1577 1586
12. D. Li, S. Fareh, T.K. Leung, and S. Nattel Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort Circulation 100 1999 87 95
13. C.-T. Tsai, L.-P. Lai, and K.-T. Kuo Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling Circulation 117 2008 344 355
14. S. Cardin, D. Li, N. Thorin-Trescases, T.-K. Leung, E. Thorin, and S. Nattel Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways Cardiovasc Res 60 2003 315 325
15. A.K. Doughan, D.G. Harrison, and S.I. Dikalov Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction Circ Res 102 2008 488 496
16. A. Goette, A. Bukowska, and D. Dobrev Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles Eur Heart J 30 2009 1411 1420
17. A. Oudot, C. Vergely, A. Ecarnot-Laubriet, and L. Rochette Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusion Eur J Pharmacol 462 2003 145 154
18. O. Adam, D. Lavall, and K. Theobald Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation J Am Coll Cardiol 55 2010 469 480
19. S.C. Dudley Jr., N.E. Hoch, and L.A. McCann Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases Circulation 112 2005 1266 1273
20. C.-T. Tsai, C.-D. Tseng, and J.-J. Hwang Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor {beta}1 Cardiovasc. Res. 89 2011 805 815
21. S.N. Reilly, R. Jayaram, and K. Nahar Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins Circulation 124 2011 1107 1117
22. W.-C. Ko, C.-Y. Hong, and S.-M. Hou Elevated expression of connective tissue growth factor in human atrial fibrillation and angiotensin II-treated cardiomyocytes Circ J 75 2011 1592 1600
23. A.N. Panek, M.G. Posch, and N. Alenina Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload PLoS One 4 2009 e6743
24. M.S. Ahmed, T.G. von Lueder, E. Oie, H. Kjekshus, and H. Attramadal Induction of myocardial connective tissue growth factor in pacing-induced heart failure in pigs Acta Physiol Scand 184 2005 27 36
25. O. Couture, K. Callenberg, and N. Koul ANEXdb: an integrated animal ANnotation and microarray EXpression database Mamm Genome 20 2009 768 777
26. W.C. Claycomb, N.A. Lanson, and B.S. Stallworth HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte Proc Natl Acad Sci U S A 95 1998 2979 2984
27. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
28. A. Schroeder, O. Mueller, and S. Stocker The RIN: an RNA integrity number for assigning integrity values to RNA measurements BMC Mol Biol 7 2006 3
29. S.C. Wolf, M. Schultze, and T. Risler Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1 Biochem Pharmacol 71 2006 1175 1183
30. A. Hussain, A.W. Wyatt, and K. Wang SGK1-dependent upregulation of connective tissue growth factor by angiotensin II Kidney Blood Press Res 31 2008 80 86
31. L.C. Mace, L.V. Yermalitskaya, Y. Yi, Z. Yang, A.M. Morgan, and K.T. Murray Transcriptional remodeling of rapidly stimulated HL-1 atrial myocytes exhibits concordance with human atrial fibrillation J Mol Cell Cardiol 47 2009 485 492
32. T. Kietzmann, A. Samoylenko, and S. Immenschuh Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes J Biol Chem 278 2003 17927 17936
33. M.-L. Wu, Y.-C. Ho, C.-Y. Lin, and S.-F. Yet Heme oxygenase-1 in inflammation and cardiovascular disease Am J Cardiovasc Dis 1 2011 150 158
34. F. Katsuoka, H. Motohashi, T. Ishii, H. Aburatani, J.D. Engel, and M. Yamamoto Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes Mol Cell Biol 25 2005 8044 8051
35. T. Fukai, and M. Ushio-Fukai Superoxide dismutases: role in redox signaling, vascular function, and diseases Antioxid Redox Signal 15 2011 1583 1606
36. E.S. Suvorova, O. Lucas, and C.M. Weisend Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes PLoS One 4 2009 e6158
37. Y. Matsui, and J. Sadoshima Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy J Mol Cell Cardiol 37 2004 477 481
38. N. Shukla, J. Maher, J. Masters, G.D. Angelini, and J.Y. Jeremy Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor? Atherosclerosis 187 2006 238 250
39. S.-G. Ahn, and D.J. Thiele Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress Genes Dev 17 2003 516 528
40. E. Chorianopoulos, T. Heger, and M. Lutz FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK Basic Res Cardiol 105 2010 301 313
41. C.A. Carnes, M.K. Chung, and T. Nakayama Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation Circ Res 89 2001 E32 E38
42. P. Korantzopoulos, T.M. Kolettis, D. Galaris, and J.A. Goudevenos The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation Int J Cardiol 115 2007 135 143
43. C.-X. Huang, Y. Liu, W.-F. Xia, Y.-H. Tang, and H. Huang Oxidative stress: a possible pathogenesis of atrial fibrillation Med Hypotheses 72 2009 466 467
44. Y.H. Kim, D.S. Lim, and J.H. Lee Gene expression profiling of oxidative stress on atrial fibrillation in humans Exp Mol Med 35 2003 336 349
45. Y.M. Kim, H. Kattach, C. Ratnatunga, R. Pillai, K.M. Channon, and B. Casadei Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery J Am Coll Cardiol 51 2008 68 74
46. R.E. Clempus, D. Sorescu, and A.E. Dikalova Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype Arterioscler Thromb Vasc Biol 27 2007 42 48
47. R.P. Brandes, and K. Schröder Differential vascular functions of Nox family NADPH oxidases Curr Opin Lipidol 19 2008 513 518
48. T. Honjo, K. Otsui, and R. Shiraki Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells Endothelium 15 2008 137 141
49. 2 + activation of the NADPH oxidase 5 (NOX5) J Biol Chem 279 2004 18583 18591
50. H. Li, A. Mittal, and P.K. Paul Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy J Biol Chem 284 2009 4439 4450
51. G.J. Dusting, P. Fennessy, Z.L. Yin, and V. Gurevich Nitric oxide in atherosclerosis: vascular protector or villain? Clin Exp Pharmacol Physiol Suppl 25 1998 S34 S41
52. J. Zicha, Z. Dobesová, and J. Kunes Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions J Hypertens 19 2001 247 254
53. C. Cantó, and J. Auwerx PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure Curr Opin Lipidol 20 2009 98 105
54. E.H. Jeninga, M. Gurnell, and E. Kalkhoven Functional implications of genetic variation in human PPARgamma Trends Endocrinol Metab 20 2009 380 387
55. S. Jäger, C. Handschin, J. St-Pierre, and B.M. Spiegelman AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha Proc Natl Acad Sci U S A 104 2007 12017 12022
56. M. Suwa, H. Nakano, and S. Kumagai Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles J Appl Physiol 95 2003 960 968
57. Z. Lu, X. Xu, and X. Hu PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload Antioxid Redox Signal 13 2010 1011 1022
58. B.F. Holmes, E.J. Kurth-Kraczek, and W.W. Winder Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle J Appl Physiol 87 1999 1990 1995
59. J. Stoppani, A.L. Hildebrandt, K. Sakamoto, D. Cameron-Smith, L.J. Goodyear, and P.D. Neufer AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle Am J Physiol Endocrinol Metab 283 2002 E1239 E1248
60. 2 +/Pi transporter) reduces physical endurance and metabolic efficiency in mice J Biol Chem 286 2011 11659 11671
61. M. Rupérez, M. Ruiz-Ortega, and V. Esteban Angiotensin II increases connective tissue growth factor in the kidney Am J Pathol 163 2003 1937 1947
62. M. Kiryu, S. Niwano, and H. Niwano Angiotensin II-mediated up-regulation of connective tissue growth factor promotes atrial tissue fibrosis in the canine atrial fibrillation model Europace 14 8 2012 Aug 1206 1214
63. T.J. Kemp, I.-K. Aggeli, P.H. Sugden, and A. Clerk Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes J Mol Cell Cardiol 37 2004 603 606
64. J. Rodriguez-Vita, M. Ruiz-Ortega, and M. Rupérez Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells Circ Res 97 2005 125 134
65. A.G. Recchia, E. Filice, D. Pellegrino, A. Dobrina, M.C. Cerra, and M. Maggiolini Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes J Mol Cell Cardiol 46 2009 352 359
66. V. Vallon, A.W. Wyatt, and K. Klingel SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment J Mol Med 84 2006 396 404
67. B.J. Brundel, I.C. Van Gelder, and A.E. Tuinenburg Endothelin system in human persistent and paroxysmal atrial fibrillation J Cardiovasc Electrophysiol 12 2001 737 742
68. F. Mayyas, M. Niebauer, and A. Zurick Association of left atrial endothelin-1 with atrial rhythm, size, and fibrosis in patients with structural heart disease Circ Arrhythm Electrophysiol 3 2010 369 379
69. P.A. Modesti, S. Vanni, and R. Paniccia Endothelin receptors in adult human and swine isolated ventricular cardiomyocytes Biochem Pharmacol 58 1999 369 374
70. F. Lang, C. Böhmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms Physiol Rev 86 2006 1151 1178
71. A. Bukowska, L. Schild, and G. Keilhoff Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia Exp Biol Med (Maywood) 233 2008 558 574