Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport

Clinical and Experimental Nephrology

Volumn 16, Issue 1, 2012, Pages 73-80

  Lang, Florian ^a   Vallon, Volker ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aldosterone; Gastric acid secretion; Glucocorticoids; Intestinal transport; Mast cells; Pancreatic beta cells; Potassium

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM ION; GLUCOCORTICOID; GROWTH FACTOR; INSULIN; MINERALOCORTICOID; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.5; POTASSIUM ION; POTASSIUM TRANSPORTER; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; CELL FUNCTION; CELL HYPOXIA; CELL STRESS; HEART REPOLARIZATION; HOMEOSTASIS; HYPOKALEMIA; INSULIN RELEASE; MAST CELL DEGRANULATION; NONHUMAN; POTASSIUM EXCRETION; POTASSIUM HOMEOSTASIS; POTASSIUM INTAKE; POTASSIUM METABOLISM; POTASSIUM TRANSPORT; REVIEW; STOMACH ACID SECRETION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; GASTROINTESTINAL TRANSIT; HEART; HOMEOSTASIS; HUMANS; HYPOKALEMIA; IMMEDIATE-EARLY PROTEINS; INSULIN; ION TRANSPORT; KIDNEY; KV1.5 POTASSIUM CHANNEL; NEURONS; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN-SERINE-THREONINE KINASES;

EID: 84858288599     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-011-0488-z     Document Type: Review

References (162)

1. Lang F. SGK1 in the regulation of renal tubular transport and blood pressure control. Kitasato Med J. 2009;39:1-12.
2. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev. 2006;86: 1151-78. (Pubitemid 44521650)
3. Vallon V, Wulff P, Huang DY, Loffing J, Volkl H, Kuhl D, et al. Role of Sgk1 in salt and potassium homeostasis. Am J Physiol Regul Integr Comp Physiol. 2005;288:R4-10.
4. Firestone GL, Giampaolo JR, O'Keeffe BA. Stimulus-dependent regulation of the serum and glucocorticoid inducible protein kinase (Sgk) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem. 2003;13:1-12. (Pubitemid 36362001)
5. Webster MK, Goya L, Firestone GL. Immediate-early transcriptional regulation and rapid MRNA turnover of a putative serine/threonine protein kinase. J Biol Chem. 1993;268: 11482-5. (Pubitemid 23168084)
6. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of Sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol. 1993;13:2031-40. (Pubitemid 23097682)
7. Waldegger S, Barth P, Raber G, Lang F. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA. 1997;94:4440-5. (Pubitemid 27194260)
8. Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344: 189-97.
9. Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 2001;20:4380-90. (Pubitemid 32772032)
10. Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR. In vivo role of the PIF-binding docking site of PDK1 defined by knockin mutation. EMBO J. 2003;22:4202-11. (Pubitemid 37021748)
11. Frodin M, Antal TL, Dummler BA, Jensen CJ, Deak M, Gammeltoft S, et al. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J. 2002;21:5396-407. (Pubitemid 35231019)
12. Kobayashi T, Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositidedependent protein kinase-1 (PDK1) and PDK2. Biochem J. 1999;339:319-28. (Pubitemid 29209961)
13. Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004;15:161-70. (Pubitemid 38251644)
14. Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S. Peroxisomal targeting as a tool for assaying poteinprotein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation- dependent manner. J Biol Chem. 2004;279:4794-801. (Pubitemid 38199074)
15. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) isa target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 1999;18:3024-33. (Pubitemid 29255611)
16. Palmada M, Embark HM, Yun C, Bohmer C, Lang F. Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoidinducible kinase SGK1. Biochem Biophys Res Commun. 2003;311:629-34. (Pubitemid 37377701)
17. Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, et al. The serum and glucocorticoid-inducible kinase SGK1 and the Na(+)/H(+) exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K(+) channel ROMK1. J Am Soc Nephrol. 2002;13:2823-30. (Pubitemid 35386901)
18. Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, et al. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem. 2003;278:23066-75. (Pubitemid 36830372)
19. Shenolikar S, Weinman EJ. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol. 2001;280: F389-95.
20. + exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. Cell Physiol Biochem. 2003;13:29-40.
21. Palmada M, Embark HM, Wyatt AW, Bohmer C, Lang F. Negative charge at the consensus sequence for the serum- and glucocorticoid-inducible kinase, SGK1, determines PH sensitivity of the renal outer medullary K+ channel, ROMK1. Biochem Biophys Res Commun. 2003;307:967-72. (Pubitemid 36871667)
22. Embark HM, Bohmer C, Vallon V, Luft F, Lang F. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid- inducible kinase (SGK) isoforms. Pflugers Arch Eur J Physiol. 2003;445:601-6. (Pubitemid 36286895)
23. Takumi T, Ohkubo H, Nakanishi S. Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science. 1988;242:1042-5.
24. Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, et al. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001;20:7052-9. (Pubitemid 34062297)
25. Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, et al. 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J Biol Chem. 2005;280: 13187-94.
26. Liang X, Peters KW, Butterworth MB, Frizzell RA. 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem. 2006;281: 16323-32.
27. Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, et al. 14-3-3 mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels. Biochemistry. 2006;45:6733-40. (Pubitemid 43825374)
28. Seebohm G, Strutz-Seebohm N, Baltaev R, Korniychuk G, Knirsch M, Engel J, et al. Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes. Cell Physiol Biochem. 2005;16:255-62. (Pubitemid 41643025)
29. Hougaard C, Klaerke DA, Hoffmann EK, Olesen SP, Jorgensen NK. Modulation of KCNQ4 channel activity by changes in cell volume. Biochim Biophys Acta. 2004;1660:1-6. (Pubitemid 38125226)
30. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El Amraoui A, Marlin S, et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell. 1999;96:437-46. (Pubitemid 29077597)
31. Marcotti W, Kros CJ. Developmental expression of the potassium current IK, n contributes to maturation of mouse outer hair cells. J Physiol. 1999;520(Pt 3):653-60. (Pubitemid 29533025)
32. Aronzon A, Ruckenstein MJ, Bigelow DC. The efficacy of corticosteroids in restoring hearing in patients undergoing conservative management of acoustic neuromas. Otol Neurotol. 2003;24:465-8. (Pubitemid 36618170)
33. Hillman TM, Arriaga MA, Chen DA. Intratympanic steroids: do they acutely improve hearing in cases of cochlear hydrops? Laryngoscope. 2003;113:1903-7. (Pubitemid 37409673)
34. Shulman A, Goldstein B. Intratympanic drug therapy with steroids for tinnitus control: a preliminary report. Int Tinnitus J. 2000;6:10-20. (Pubitemid 30661106)
35. Gamper N, Fillon S, Huber SM, Feng Y, Kobayashi T, Cohen P, et al. IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1. Pflugers Arch Eur J Physiol. 2002;443:625-34. (Pubitemid 34185067)
36. Henke G, Maier G, Wallisch S, Boehmer C, Lang F. Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1. J Cell Physiol. 2004;199:194-9. (Pubitemid 38436745)
37. Wärntges S, Friedrich B, Henke G, Duranton C, Lang PA, Waldegger S, et al. Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1. Pflugers Arch Eur J Physiol. 2002;443:617-24. (Pubitemid 34185066)
38. Boehmer C, Laufer J, Jeyaraj S, Klaus F, Lindner R, Lang F, et al. Modulation of the voltage-gated potassium channel Kv1.5 by the SGK1 protein kinase involves inhibition of channel ubiquitination. Cell Physiol Biochem. 2008;22:591-600.
39. Laufer J, Boehmer C, Jeyaraj S, Knuwer M, Klaus F, Lindner R, et al. The C-terminal PDZ-binding motif in the Kv1.5 potassium channel governs its modulation by the Na+/H+ exchanger regulatory factor 2. Cell Physiol Biochem. 2009;23:25-36.
40. Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, et al. Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion. Diabetes. 2005;54:1090-9. (Pubitemid 40446323)
41. Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Arch. 2005;450:26-33. (Pubitemid 40558529)
42. Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, et al. K(+) channel activation by all three isoforms of serumand glucocorticoid-dependent protein kinase SGK. Pflugers Arch Eur J Physiol. 2002;445:60-6. (Pubitemid 35370415)
43. Shumilina E, Lampert A, Lupescu A, Myssina S, Strutz-Seebohm N, Henke G, et al. Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. J Cell Physiol. 2005;204:87-98. (Pubitemid 40776810)
44. Alvarez dlR, Coric T, Todorovic N, Shao D, Wang T, Canessa CM. Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney. J Physiol. 2003;551:455-66.
45. Setiawan I, Henke G, Feng Y, Bohmer C, Vasilets LA, Schwarz W, et al. Stimulation of Xenopus Oocyte Na(+), K(+)ATPase by the serum and glucocorticoid-dependent kinase Sgk1. Pflugers Arch Eur J Physiol. 2002;444:426-31. (Pubitemid 35447418)
46. Verrey F, Summa V, Heitzmann D, Mordasini D, Vandewalle A, Feraille E, et al. Short-term aldosterone action on Na, K-ATPase surface expression: role of aldosterone-induced SGK1? Ann N Y Acad Sci. 2003;986:554-61. (Pubitemid 36584173)
47. Zecevic M, Heitzmann D, Camargo SM, Verrey F. SGK1 increases Na, K-ATP cell-surface expression and function in Xenopus laevis oocytes. Pflugers Arch. 2004;448:29-35. (Pubitemid 38657202)
48. Alvarez dlR, Gimenez I, Forbush B, Canessa CM. SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells. Am J Physiol Cell Physiol. 2006;290:C492-8.
49. Ullrich S, Zhang Y, Avram D, Ranta F, Kuhl D, Haring HU, et al. Dexamethasone increases Na+/K+ ATPase activity ininsulin secreting cells through SGK1. Biochem Biophys Res Commun. 2007;352:662-7. (Pubitemid 44880305)
50. Henke G, Setiawan I, Bohmer C, Lang F. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. Kidney Blood Press Res. 2002;25:370-4. (Pubitemid 36206674)
51. Ali S, Wei Y, Lerea KM, Becker L, Rubin CS, Wang W. PKA-induced stimulation of ROMK1 channel activity is governed by both tethering and non-tethering domains of an A kinase anchor protein. Cell Physiol Biochem. 2001;11:135-42. (Pubitemid 32623423)
52. Giebisch G. Renal potassium transport: mechanisms and regulation. Am J Physiol. 1998;274:F817-33.
53. Wang W. Regulation of the ROMK channel: interaction of the ROMK with associate proteins. Am J Physiol. 1999;277: F826-31. (Pubitemid 30046056)
54. Wald H, Garty H, Palmer LG, Popovtzer MM. Differential regulation of ROMK expression in kidney cortex and medulla by aldosterone and potassium. Am J Physiol. 1998;275: F239-45.
55. - cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol. 2009;297:F704-12.
56. Huang DY, Wulff P, Volkl H, Loffing J, Richter K, Kuhl D, et al. Impaired regulation of renal K+ elimination in the Sgk1- knockout mouse. J Am Soc Nephrol. 2004;15:885-91. (Pubitemid 38375307)
57. Fejes-Toth G, Frindt G, Naray-Fejes-Toth A, Palmer LG. Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008;294:F1298-305.
58. Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, et al. Impaired renal Na(+) retention in the Sgk1-knockout mouse. J Clin Invest. 2002;110:1263-8. (Pubitemid 35285752)
59. Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, et al. Renal Ca2+ handling in Sgk1 knockout mice. Pflugers Arch. 2006;452:444-52. (Pubitemid 43962054)
60. Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV. Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. J Clin Invest. 1996;97:2525-33. (Pubitemid 26187340)
61. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, et al. Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serumand glucocorticoid-inducible kinase SGK1. Am J Physiol Regul Integr Comp Physiol. 2006;290:R935-44.
62. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, et al. Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet. Am J Physiol Renal Physiol. 2006;291:F1264-73. (Pubitemid 44887240)
63. Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, et al. Deranged transcriptional regulation of cell-volumesensitive kinase HSGK in diabetic nephropathy. Proc Natl Acad Sci USA. 2000;97:8157-62. (Pubitemid 30460789)
64. Ackermann TF, Boini KM, Volkl H, Bhandaru M, Bareiss PM, Just L, et al. SGK1-sensitive renal tubular glucose reabsorption in diabetes. Am J Physiol Renal Physiol. 2009;296:F859-66.
65. Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, et al. Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obes Res. 2004;12:862-70. (Pubitemid 41127323)
66. Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, et al. Role of KCNE1-dependent K+ fluxes in mouse proximal tubule. J Am Soc Nephrol. 2001;12:2003-11. (Pubitemid 32880336)
67. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, et al. KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci USA. 2005;102: 17864-9. (Pubitemid 41803588)
68. Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension. 2007;49:355-64. (Pubitemid 46143013)
69. Nagase M, Yoshida S, Shibata S, Nagase T, Gotoda T, Ando K, et al. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fatderived factors. J Am Soc Nephrol. 2006;17:3438-46. (Pubitemid 44865286)
70. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, et al. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med. 2006;84:737-46. (Pubitemid 44328065)
71. Coric T, Hernandez N, Alvarez dlR, Shao D, Wang T, Canessa CM. Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2004;286:G663-70. (Pubitemid 38374986)
72. Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R, et al. H-Sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology. 1999;116:1081-8. (Pubitemid 29203018)
73. Palmada M, Dieter M, Speil A, Bohmer C, Mack AF, Wagner HJ, et al. Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid- dependent kinase 1. Am J Physiol Gastrointest Liver Physiol. 2004;287:G143-50. (Pubitemid 38802128)
74. Rotte A, Bhandaru M, Foller M, Biswas R, Mack AF, Friedrich B, et al. APC sensitive gastric acid secretion. Cell Physiol Biochem. 2009;23:133-42.
75. Rotte A, Mack AF, Bhandaru M, Kempe DS, Beier N, Scholz W, et al. Pioglitazone induced gastric acid secretion. Cell Physiol Biochem. 2009;24:193-200.
76. Sandu C, Artunc F, Grahammer F, Rotte A, Boini KM, Friedrich B, et al. Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion. Pflugers Arch. 2007;455:493-503. (Pubitemid 47624199)
77. Rotte A, Bhandaru M, Ackermann TF, Boini KM, Lang F. Role of PDK1 in regulation of gastric acid secretion. Cell Physiol Biochem. 2008;22:725-34.
78. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, et al. Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol. 2006;290:R945-50.
79. Rexhepaj R, Rotte A, Kempe DS, Sopjani M, Foller M, Gehring EM, et al. Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone. Pflugers Arch. 2009;459:191-202.
80. Boehmer C, Palmada M, Klaus F, Jeyaraj S, Lindner R, Laufer J, et al. The peptide transporter PEPT2 is targeted by the protein kinase SGK1 and the scaffold protein NHERF2. Cell Physiol Biochem. 2008;22:705-14.
81. Yun CC, Chen Y, Lang F. Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem. 2002;277:7676-83. (Pubitemid 34968213)
82. Wang D, Sun H, Lang F, Yun CC. Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. Am J Physiol Cell Physiol. 2005;289:C802-10. (Pubitemid 41361635)
83. Rauz S, Walker EA, Murray PI, Stewart PM. Expression and distribution of the serum and glucocorticoid regulated kinase and the epithelial sodium channel subunits in the human cornea. Exp Eye Res. 2003;77:101-8. (Pubitemid 36776279)
84. Rauz S, Walker EA, Hughes SV, Coca-Prados M, Hewison M, Murray PI, et al. Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium. Invest Ophthalmol Vis Sci. 2003;44: 1643-51. (Pubitemid 36378593)
85. Pondugula SR, Raveendran NN, Ergonul Z, Deng Y, Chen J, Sanneman JD, et al. Glucocorticoid regulation of genes in theamiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat. Physiol Genomics. 2006;24:114-23.
86. Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, et al. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med. 2004;350: 1314-9. (Pubitemid 38375366)
87. Wangemann P. K(+) cycling and its regulation in the cochlea and the vestibular labyrinth. Audiol Neurootol. 2002;7:199-205.
88. Klip A, Ramlal T, Cragoe EJ Jr. Insulin-induced cytoplasmic alkalinization and glucose transport in muscle cells. Am J Physiol. 1986;250:C720-8.
89. Zhao H, Hyde R, Hundal HS. Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells. J Physiol. 2004;560:123-36. (Pubitemid 39406021)
90. Cleland SJ, Petrie JR, Ueda S, Elliott HL, Connell JM. Insulin as a vascular hormone: implications for the pathophysiology of cardiovascular disease.Clin Exp Pharmacol Physiol. 1998;25:175-84. (Pubitemid 28162280)
91. Haussinger D, Lang F. Cell volume and hormone action. Trends Pharmacol Sci. 1992;13:371-3.
92. Bobulescu IA, Dubree M, Zhang J, McLeroy P, Moe OW. Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion. Am J Physiol Renal Physiol. 2008;294:F1315-22.
93. Sjaastad MD, Zettl KS, Parry G, Firestone GL, Machen TE. Hormonal regulation of the polarized function and distribution of Na/H exchange and Na/HCO3 cotransport in cultured mammary epithelial cells. J Cell Biol. 1993;122:589-600. (Pubitemid 23226676)
94. - cotransporter in renal epithelium. Biochem Biophys Res Commun. 2005;332:1042-52.
95. - cotransporter of human fibroblasts. Biochim Biophys Acta. 1996;1281:38-44.
96. Pouyssegur J, Chambard JC, Franchi A, Paris S, Obberghen- Schilling E. Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation. Proc Natl Acad Sci USA. 1982;79:3935-9.
97. Tupper JT, Smith JW. Growth factor regulation of membrane transport in human fibroblasts and its relationship to stimulation of DNA synthesis. J Cell Physiol. 1985;125:443-8. (Pubitemid 16200940)
98. - ATPase and the Na(+)-K(+)-2Cl- cotransporter in 3T3-L1 adipocytes. Am J Physiol. 1995;269:C217-25.
99. Ceolotto G, Conlin P, Clari G, Semplicini A, Canessa M. Protein kinase C and insulin regulation of red blood cell Na+/H+ exchange. Am J Physiol. 1997;272:C818-26.
100. Kaloyianni M, Bourikas D, Koliakos G. The effect of insulin on Na+-H+ antiport activity of obese and normal subjects erythrocytes. Cell Physiol Biochem. 2001;11:253-8. (Pubitemid 34701859)
101. Romero JR, Rivera A, Conlin PR. Red blood cell Na+/H+ exchange activity is insulin resistant in hypertensive patients. Clin Exp Hypertens. 2002;24:277-87. (Pubitemid 34602702)
102. Sauvage M, Maziere P, Fathallah H, Giraud F. Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes. Eur J Biochem. 2000;267:955-62. (Pubitemid 30108311)
103. Haussinger D, Hallbrucker C, vom DS, Lang F, Gerok W. Cell swelling inhibits proteolysis in perfused rat liver. Biochem J. 1990;272:239-42.
104. Benziane B, Chibalin AV. Frontiers: skeletal muscle sodium pump regulation: a translocation paradigm. Am J Physiol Endocrinol Metab. 2008;295:E553-8.
105. Ewart HS, Klip A. Hormonal regulation of the Na(+)-K(+)- ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am J Physiol. 1995;269:C295-311.
106. Graf J, Haussinger D. Ion transport in hepatocytes: mechanisms and correlations to cell volume, hormone actions and metabolism. J Hepatol. 1996;24(Suppl 1):53-77. (Pubitemid 26090188)
107. McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005;25:335-42.
108. Sweeney G, Klip A. Regulation of the Na+/K+-ATPase by insulin: why and how? Mol Cell Biochem. 1998;182:121-33. (Pubitemid 28181655)
109. Sweeney G, Klip A. Mechanisms and consequences of Na+, K+-pump regulation by insulin and leptin. Cell Mol Biol (Noisy -le-grand). 2001;47:363-72.
110. Rosenbloom AL, Hanas R. Diabetic ketoacidosis (DKA): treatment guidelines. Clin Pediatr (Phila). 1996;35:261-6. (Pubitemid 26164157)
111. Bia MJ, Tyler K, DeFronzo R. The effect of dexamethasone on renal potassium excretion and acute potassium tolerance. Endocrinology. 1983;113:1690-6. (Pubitemid 13023808)
112. Boini KM, Graf D, Kuhl D, Haussinger D, Lang F. SGK1 dependence of insulin induced hypokalemia. Pflugers Arch. 2009;457:955-61.
113. Klingel K, Warntges S, Bock J, Wagner CA, Sauter M, Waldegger S, et al. Expression of cell volume-regulated kinase H-Sgk in pancreatic tissue. Am J Physiol Gastrointest Liver Physiol. 2000;279:G998-1002.
114. Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol. 2002;2:773-86. (Pubitemid 37328717)
115. Kawakami T, Kitaura J. Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol. 2005;175:4167-73. (Pubitemid 41361947)
116. Bradding P, Okayama Y, Kambe N, Saito H. Ion channel gene expression in human lung, skin, and cord blood-derived mast cells. J Leukoc Biol. 2003;73:614-20. (Pubitemid 38040474)
117. Bradding P. Mast cell ion channels. Chem Immunol Allergy. 2005;87:163-78. (Pubitemid 43093187)
118. Duffy SM, Cruse G, Lawley WJ, Bradding P. Beta2-adrenoceptor regulation of the K+ channel ikca1 in human mast cells. FASEB J. 2005;19:1006-8.
119. Mark DS, Berger P, Cruse G, Yang W, Bolton SJ, Bradding P. The K+ channel IKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol. 2004;114:66-72. (Pubitemid 39005119)
120. Shumilina E, Lam RS, Wolbing F, Matzner N, Zemtsova IM, Sobiesiak M, et al. Blunted IgE-mediated activation of mast cells in mice lacking the Ca2+-activated K+ channel KCa3.1. J Immunol. 2008;180:8040-7.
121. Lam RS, Shumilina E, Matzner N, Zemtsova IM, Sobiesiak M, Lang C, et al. Phosphatidylinositol-3-kinase regulates mast cell ion channel activity. Cell Physiol Biochem. 2008;22:169-76.
122. Sobiesiak M, Shumilina E, Lam RS, Wolbing F, Matzner N, Kaesler S, et al. Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1. J Immunol. 2009;183:4395-402.
123. Vincent GM. The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. Annu Rev Med. 1998;49:263-74. (Pubitemid 28197453)
124. Busjahn A, Seebohm G, Maier G, Toliat MR, Nurnberg P, Aydin A, et al. Association of the serum and glucocorticoid regulated kinase (Sgk1) gene with QT interval. Cell Physiol Biochem. 2004;14:135-42. (Pubitemid 38586114)
125. Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, et al. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res. 2007;100: 686-92. (Pubitemid 46594883)
126. Busjahn A, Aydin A, Uhlmann R, Krasko C, Bahring S, Szelestei T, et al. Serum- and glucocorticoid-regulated kinase(SGK1) gene and blood pressure. Hypertension. 2002;40: 256-60. (Pubitemid 35006707)
127. Busjahn A, Luft FC. Twin studies in the analysis of minor physiological differences between individuals. Cell Physiol Biochem. 2003;13:51-8. (Pubitemid 36359381)
128. Schwab M, Lupescu A, Mota M, Mota E, Frey A, Simon P, et al. Association of SGK1 gene polymorphisms with type 2 diabetes. Cell Physiol Biochem. 2008;21:151-60.
129. Maier G, Palmada M, Rajamanickam J, Shumilina E, Bohmer C, Lang F. Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. Cell Physiol Biochem. 2006;18:177-86. (Pubitemid 44946974)
130. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, et al. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet. 1998;18:53-5. (Pubitemid 28027879)
131. Eunson LH, Rea R, Zuberi SM, Youroukos S, Panayiotopoulos CP, Liguori R, et al. Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability. Ann Neurol. 2000;48:647-56.
132. Lau D, Vega-Saenz de Miera EC, Contreras D, Ozaita A, Harvey M, Chow A, et al. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. J Neurosci. 2000;20: 9071-85. (Pubitemid 32042909)
133. Leppert MF, Singh N. Susceptibility genes in human epilepsy. Semin Neurol. 1999;19:397-405. (Pubitemid 30023035)
134. Pongs O. Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett. 1999;452:31-5. (Pubitemid 29257864)
135. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet. 1998;18:25-9. (Pubitemid 28027874)
136. Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, et al. Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron. 1998;20:809-19. (Pubitemid 28199058)
137. Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, et al. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol. 2005;565:391-401. (Pubitemid 40872470)
138. Contractor A, Swanson GT, Sailer A, O'Gorman S, Heinemann SF. Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J Neurosci. 2000;20:8269-78.
139. Contractor A, Swanson G, Heinemann SF. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron. 2001;29:209-16. (Pubitemid 32108733)
140. Huettner JE. Kainate receptors: knocking out plasticity. Trends Neurosci. 2001;24:365-6. (Pubitemid 32938528)
141. Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, Bureau I, et al. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature. 1998;392:601-5. (Pubitemid 28207716)
142. Kaufer D, Ogle WO, Pincus ZS, Clark KL, Nicholas AC, Dinkel KM, et al. Restructuring the neuronal stress response with antiglucocorticoid gene delivery. Nat Neurosci. 2004;7:947-53. (Pubitemid 39129503)
143. McEwen BS, Albeck D, Cameron H, Chao HM, Gould E, Hastings N, et al. Stress and the brain: a paradoxical role for adrenal steroids. Vitam Horm. 1995;51:371-402.
144. Reagan LP, McEwen BS. Controversies surrounding glucocorticoid- mediated cell death in the hippocampus. J Chem Neuroanat. 1997;13:149-67. (Pubitemid 27424931)
145. Lee CT, Ma YL, Lee EH. Serum- and glucocorticoid-inducible kinase1 enhances contextual fear memory formation through down-regulation of the expression of Hes5. J Neurochem. 2007;100:1531-42.
146. von Hertzen LS, Giese KP. Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. J Neurosci. 2005;25:1935-42.
147. Koya E, Spijker S, Homberg JR, Voorn P, Schoffelmeer AN, De Vries TJ, et al. Molecular reactivity of mesocorticolimbic brain areas of high and low
148. Lee EH, Hsu WL, Ma YL, Lee PJ, Chao CC. Enrichment enhances the expression of Sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Eur J Neurosci. 2003;18:2842-52. (Pubitemid 37542137)
149. Chao CC, Ma YL, Lee EH. Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1. J Neurosci. 2007;27:6243-8. (Pubitemid 46890011)
150. David S, Stegenga SL, Hu P, Xiong G, Kerr E, Becker KB, et al. Expression of serum- and glucocorticoid-inducible kinase is regulated in an experience-dependent manner and can cause dendrite growth. J Neurosci. 2005;25:7048-53. (Pubitemid 41077013)
151. Yang YC, Lin CH, Lee EH. Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol. 2006;26:8357-70. (Pubitemid 44748570)
152. Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH. Sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc Natl Acad Sci USA. 2002;99: 3990-5. (Pubitemid 34252218)
153. Buse P, Tran SH, Luther E, Phu PT, Aponte GW, Firestone GL. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. J Biol Chem. 1999;274:7253-63.
154. Amato R, Menniti M, Agosti V, Boito R, Costa N, Bond HM, et al. IL-2 signals through sgk1 and inhibits proliferation and apoptosis in kidney cancer cells. J Mol Med. 2007;85:707-21. (Pubitemid 47064383)
155. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol. 2001;21:952-65. (Pubitemid 32104742)
156. Shelly C, Herrera R. Activation of SGK1 by HGF, Rac1 and integrin-mediated cell adhesion in MDCK cells: PI-3K-dependent and -independent pathways. J Cell Sci. 2002;115:1985-93. (Pubitemid 34567259)
157. Zhang L, Cui R, Cheng X, Du J. Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{Kappa}B kinase. Cancer Res. 2005;65:457-64.
158. Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, et al. Functional significance of cell volume regulatory mechanisms. Physiol Rev. 1998;78:247-306. (Pubitemid 28070981)
159. Lewis RS, Cahalan MD. Subset-specific expression of potassium channels in developing murine T lymphocytes. Science. 1988;239:771-5. (Pubitemid 18070930)
160. Ouadid-Ahidouch H, Chaussade F, Roudbaraki M, Slomianny C, Dewailly E, Delcourt P, et al. KV1.1 K(+) channels identification in human breast carcinoma cells: involvement in cell proliferation. Biochem Biophys Res Commun. 2000;278:272-7.
161. Ritter M, Wöll E. Modification of cellular ion transport by the Ha-Ras oncogene: steps towards malignant transformation. Cell Physiol Biochem. 1996;6:245-70. (Pubitemid 26419327)
162. Sobko A, Peretz A, Shirihai O, Etkin S, Cherepanova V, Dagan D, et al. Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. J Neurosci. 1998;18:10398-408. (Pubitemid 29016559)