-
1
-
-
0033105864
-
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome
-
Abriel, H., Loffing, J., Rebhun, J. F., Pratt, J. H., Schild, L., Horisberger, J. D., Rotin, D., andStaub, O. (1999). Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. J. Clin. Invest. 103, 667-673.
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 667-673
-
-
Abriel, H.1
Loffing, J.2
Rebhun, J.F.3
Pratt, J.H.4
Schild, L.5
Horisberger, J.D.6
Rotin, D.7
Staub, O.8
-
2
-
-
67649865826
-
AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated
-
Almaca, J., Kongsuphol, P., Hieke, B., Ousingsawat, J., Viollet, B., Schreiber, R., Amaral, M. D., and Kunzelmann, K. (2009). AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflugers Arch. 458, 713-721.
-
(2009)
Pflugers Arch.
, vol.458
, pp. 713-721
-
-
Almaca, J.1
Kongsuphol, P.2
Hieke, B.3
Ousingsawat, J.4
Viollet, B.5
Schreiber, R.6
Amaral, M.D.7
Kunzelmann, K.8
-
3
-
-
0033621468
-
The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
-
Alvarez de la Rosa, D., Zhang, P., Naray-Fejes-Toth, A., Fejes-Toth, G., and Canessa, C. M. (1999). The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J. Biol. Chem. 274, 37834-37839.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37834-37839
-
-
Alvarez de la Rosa, D.1
Zhang, P.2
Naray-Fejes-Toth, A.3
Fejes-Toth, G.4
Canessa, C.M.5
-
4
-
-
39749098703
-
Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension
-
Araki, N., Umemura, M., Miyagi, Y., Yabana, M., Miki, Y., Tamura, K., Uchino, K., Aoki, R., Goshima, Y., Umemura, S., and Ishigami, T. (2008). Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Hypertension 51, 773-777.
-
(2008)
Hypertension
, vol.51
, pp. 773-777
-
-
Araki, N.1
Umemura, M.2
Miyagi, Y.3
Yabana, M.4
Miki, Y.5
Tamura, K.6
Uchino, K.7
Aoki, R.8
Goshima, Y.9
Umemura, S.10
Ishigami, T.11
-
5
-
-
80052320481
-
Nedd4-2 modulates renal Na+-Cl~cotransporter via the aldosterone-SGK1-Nedd4-2 pathway
-
Arroyo, J. P., Lagnaz, D., Ronzaud, C., Vazquez, N., Ko, B. S., Moddes, L., Ruffieux-Daidie, D., Hausel, R, Koesters, R., Yang, B., Stokes, J. B., Hoover, R. S., Gamba, G., and Staub, O. (2011). Nedd4-2 modulates renal Na+-Cl~cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J. Am. Soc. Nephrol. 22, 1707-1719.
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 1707-1719
-
-
Arroyo, J.P.1
Lagnaz, D.2
Ronzaud, C.3
Vazquez, N.4
Ko, B.S.5
Moddes, L.6
Ruffieux-Daidie, D.7
Hausel, R.8
Koesters, R.9
Yang, B.10
Stokes, J.B.11
Hoover, R.S.12
Gamba, G.13
Staub, O.14
-
6
-
-
0041464464
-
Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin
-
Auberson, M., Hoffmann-Pochon, N., Vandewalle, A., Kellenberger, S., and Schild, L. (2003). Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin. Am. J. Physiol Renal Physiol. 285, F459-F471.
-
(2003)
Am. J. Physiol Renal Physiol.
, vol.285
-
-
Auberson, M.1
Hoffmann-Pochon, N.2
Vandewalle, A.3
Kellenberger, S.4
Schild, L.5
-
7
-
-
28144436789
-
Serum-and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, develop-mentally down-regulated protein 4-2 by inducing interaction with 14-3-3
-
Bhalla, V., Daidie, D., Li, H., Pao, A. C., LaGrange, L. P., Wang, J., Vandewalle, A., Stockand, J. D., Staub, O., and Pearce, D. (2005). Serum-and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, develop-mentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol. Endocrinol. 19, 3073-3084.
-
(2005)
Mol. Endocrinol.
, vol.19
, pp. 3073-3084
-
-
Bhalla, V.1
Daidie, D.2
Li, H.3
Pao, A.C.4
LaGrange, L.P.5
Wang, J.6
Vandewalle, A.7
Stockand, J.D.8
Staub, O.9
Pearce, D.10
-
8
-
-
33748750919
-
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2
-
Bhalla, V., Oyster, N. M., Fitch, A. C., Wijngaarden, M. A., Neumann, D., Schlattner, U., Pearce, D., and Hallows, K. R. (2006). AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J. Biol. Chem. 281, 26159-26169.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26159-26169
-
-
Bhalla, V.1
Oyster, N.M.2
Fitch, A.C.3
Wijngaarden, M.A.4
Neumann, D.5
Schlattner, U.6
Pearce, D.7
Hallows, K.R.8
-
9
-
-
79955052957
-
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice
-
Boase, N. A., Rychkov, G. Y., Townley, S. L., Dinudom, A., Candi, E., Voss, A. K., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D. I., and Kumar, S. (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat. Commun. 2, 287.
-
(2011)
Nat. Commun.
, vol.2
, pp. 287
-
-
Boase, N.A.1
Rychkov, G.Y.2
Townley, S.L.3
Dinudom, A.4
Candi, E.5
Voss, A.K.6
Tsoutsman, T.7
Semsarian, C.8
Melino, G.9
Koentgen, F.10
Cook, D.I.11
Kumar, S.12
-
10
-
-
34047166052
-
Airway surface dehydration in cystic fibrosis: pathogenesis and therapy
-
Boucher, R. C. (2007). Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu. Rev. Med. 58, 157-170.
-
(2007)
Annu. Rev. Med.
, vol.58
, pp. 157-170
-
-
Boucher, R.C.1
-
11
-
-
84856431125
-
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
-
Boyden, L. M., Choi, M., Choate, K. A., Nelson-Williams, C. J., Farhi, A., Toka, H. R., Tikhonova, I. R., Bjornson, R., Mane, S. M., Colussi, G., Lebel, M., Gordon, R. D., Semmekrot, B. A., Poujol, A., Valimaki, M. J., De Ferrari, M. E., Sanjad, S. A., Gutkin, M., Karet, F. E., Tucci, J. R., Stockigt, J. R., Keppler-Noreuil K, M., Porter, C. C., Anand, S. K., Whiteford, M. L., Davis, I. D., Dewar, S. B., Bettinelli, A., Fadrowski, J. J., Belsha, C. W., Hunley, T. E., Nelson, R. D., Trachtman, H., Cole, T. R., Pinsk, M., Bockenhauer, D., Shenoy, M., Vaidyanathan, P., Foreman, J. W., Rasoulpour, M., Thameem, F., Al-Shahrouri, H. Z., Radhakrishnan, J., Gharavi, A. G., Goilav, B., andLifton, R. P. (2012). Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature 482, 98-102.
-
(2012)
Nature
, vol.482
, pp. 98-102
-
-
Boyden, L.M.1
Choi, M.2
Choate, K.A.3
Nelson-Williams, C.J.4
Farhi, A.5
Toka, H.R.6
Tikhonova, I.R.7
Bjornson, R.8
Mane, S.M.9
Colussi, G.10
Lebel, M.11
Gordon, R.D.12
Semmekrot, B.A.13
Poujol, A.14
Valimaki, M.J.15
De Ferrari, M.E.16
Sanjad, S.A.17
Gutkin, M.18
Karet, F.E.19
Tucci, J.R.20
Stockigt, J.R.21
Keppler-Noreuil, K.M.22
Porter, C.C.23
Anand, S.K.24
Whiteford, M.L.25
Davis, I.D.26
Dewar, S.B.27
Bettinelli, A.28
Fadrowski, J.J.29
Belsha, C.W.30
Hunley, T.E.31
Nelson, R.D.32
Trachtman, H.33
Cole, T.R.34
Pinsk, M.35
Bockenhauer, D.36
Shenoy, M.37
Vaidyanathan, P.38
Foreman, J.W.39
Rasoulpour, M.40
Thameem, F.41
Al-Shahrouri, H.Z.42
Radhakrishnan, J.43
Gharavi, A.G.44
Goilav, B.45
Lifton, R.P.46
more..
-
12
-
-
0027958441
-
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
-
Canessa, C. M., Schild, L., Buell, G., Thorens, B., Gautschi, I., Horisberger, J. D., and Rossier, B. C. (1994). Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 367, 463-467.
-
(1994)
Nature
, vol.367
, pp. 463-467
-
-
Canessa, C.M.1
Schild, L.2
Buell, G.3
Thorens, B.4
Gautschi, I.5
Horisberger, J.D.6
Rossier, B.C.7
-
13
-
-
55949119629
-
Nedd4 controls animal growth by regulating IGF-1 signaling
-
Cao, X. R., Lill, N. L., Boase, N., Shi, P. P., Croucher, D. R., Shan, H., Qu, J., Sweezer, E. M., Place, T., Kirby, P. A., Daly, R. J., Kumar, S., and Yang, B. (2008). Nedd4 controls animal growth by regulating IGF-1 signaling. Sci. Signal. 1, ra5.
-
(2008)
Sci. Signal.
, vol.1
-
-
Cao, X.R.1
Lill, N.L.2
Boase, N.3
Shi, P.P.4
Croucher, D.R.5
Shan, H.6
Qu, J.7
Sweezer, E.M.8
Place, T.9
Kirby, P.A.10
Daly, R.J.11
Kumar, S.12
Yang, B.13
-
14
-
-
23744492591
-
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells
-
Carattino, M. D., Edinger, R. S., Grieser, H. J., Wise, R., Neumann, D., Schlattner, U., Johnson, J. P., Kleyman, T. R., and Hallows, K. R. (2005). Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J. Biol Chem. 280, 17608-17616.
-
(2005)
J. Biol Chem.
, vol.280
, pp. 17608-17616
-
-
Carattino, M.D.1
Edinger, R.S.2
Grieser, H.J.3
Wise, R.4
Neumann, D.5
Schlattner, U.6
Johnson, J.P.7
Kleyman, T.R.8
Hallows, K.R.9
-
15
-
-
0033514954
-
Epithelial sodium channel regulated by aldosterone-induced protein sgk
-
Chen, S. Y., Bhargava, A., Mastrober-ardino, L., Meijer, O. C., Wang, J., Buse, P., Firestone, G. L., Verrey, F., and Pearce, D. (1999). Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc. Natl Acad. Sci. U. S. A. 96, 2514-2519.
-
(1999)
Proc. Natl Acad. Sci. U. S. A.
, vol.96
, pp. 2514-2519
-
-
Chen, S.Y.1
Bhargava, A.2
Mastrober-ardino, L.3
Meijer, O.C.4
Wang, J.5
Buse, P.6
Firestone, G.L.7
Verrey, F.8
Pearce, D.9
-
16
-
-
79955534755
-
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A mis-sense mutation are dependent on the WNK-OSR1/SPAK kinase cascade
-
Chiga, M., Rafiqi, E H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S., and Uchida, S. (2011). Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A mis-sense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J. Cell. Sci. 124, 1391-1395.
-
(2011)
J. Cell. Sci.
, vol.124
, pp. 1391-1395
-
-
Chiga, M.1
Rafiqi, E.H.2
Alessi, D.R.3
Sohara, E.4
Ohta, A.5
Rai, T.6
Sasaki, S.7
Uchida, S.8
-
17
-
-
0037810443
-
Miner-alocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome
-
Dahlmann, A., Pradervand, S., Hummler, E., Rossier, B. C., Frindt, G., and Palmer, L. G. (2003). Miner-alocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome. Am. J. Physiol. Renal Physiol. 285, F310-F318.
-
(2003)
Am. J. Physiol. Renal Physiol.
, vol.285
-
-
Dahlmann, A.1
Pradervand, S.2
Hummler, E.3
Rossier, B.C.4
Frindt, G.5
Palmer, L.G.6
-
18
-
-
18244392958
-
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression
-
Debonneville, C., Flores, S. Y., Kamynina, E., Plant, P. J., Tauxe, C., Thomas, M. A., Munster, C., Chraibi, A., Pratt, J. H., Horisberger, J. D., Pearce, D., Loffing, J., and Staub, O. (2001). Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBOJ. 20, 7052-7059.
-
(2001)
EMBOJ.
, vol.20
, pp. 7052-7059
-
-
Debonneville, C.1
Flores, S.Y.2
Kamynina, E.3
Plant, P.J.4
Tauxe, C.5
Thomas, M.A.6
Munster, C.7
Chraibi, A.8
Pratt, J.H.9
Horisberger, J.D.10
Pearce, D.11
Loffing, J.12
Staub, O.13
-
19
-
-
4644240440
-
A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit
-
Diakov, A., and Korbmacher, C. (2004). A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit. J. Biol. Chem. 279, 38134-38142.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38134-38142
-
-
Diakov, A.1
Korbmacher, C.2
-
20
-
-
83555176100
-
Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotrans-porter (NCC)
-
Dimke, H. (2011). Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotrans-porter (NCC). Pflugers Arch. 462, 767-777.
-
(2011)
Pflugers Arch.
, vol.462
, pp. 767-777
-
-
Dimke, H.1
-
21
-
-
0032499755
-
Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+
-
Dinudom, A., Harvey, K. F., Komwatana, R, Young, J. A., Kumar, S., and Cook, D. I. (1998). Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+. Proc. Natl. Acad. Sci. U. S. A. 95, 7169-7173.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 7169-7173
-
-
Dinudom, A.1
Harvey, K.F.2
Komwatana, R.3
Young, J.A.4
Kumar, S.5
Cook, D.I.6
-
22
-
-
36348979793
-
Sodium channels and cystic fibrosis
-
Donaldson, S. H., and Boucher, R. C. (2007). Sodium channels and cystic fibrosis. Chest 132, 1631-1636.
-
(2007)
Chest
, vol.132
, pp. 1631-1636
-
-
Donaldson, S.H.1
Boucher, R.C.2
-
23
-
-
0028588619
-
Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immuno-cytochemistry
-
Duc, C., Farman, N., Canessa, C. M., Bonvalet, J. P., and Rossier, B. C. (1994). Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immuno-cytochemistry. J. Cell Biol. 127, 1907-1921.
-
(1994)
J. Cell Biol.
, vol.127
, pp. 1907-1921
-
-
Duc, C.1
Farman, N.2
Canessa, C.M.3
Bonvalet, J.P.4
Rossier, B.C.5
-
24
-
-
0036947482
-
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript
-
Dunn, D. M., Ishigami, T., Pankow, J., von Niederhausern, A., Alder, J., Hunt, S. C., Leppert, M. F., Lalouel, J. M., and Weiss, R. B. (2002). Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript. J. Hum. Genet. 47, 665-676.
-
(2002)
J. Hum. Genet.
, vol.47
, pp. 665-676
-
-
Dunn, D.M.1
Ishigami, T.2
Pankow, J.3
von Niederhausern, A.4
Alder, J.5
Hunt, S.C.6
Leppert, M.F.7
Lalouel, J.M.8
Weiss, R.B.9
-
25
-
-
58649090479
-
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2
-
Edinger, R. S., Lebowitz, J., Li, H., Alzamora, R., Wang, H., Johnson, J. P., and Hallows, K. R. (2009). Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J. Biol. Chem. 284, 150-157.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 150-157
-
-
Edinger, R.S.1
Lebowitz, J.2
Li, H.3
Alzamora, R.4
Wang, H.5
Johnson, J.P.6
Hallows, K.R.7
-
26
-
-
84859758038
-
Inducible kidney specific Sgk1 knock-out mice show a salt losing phenotype
-
Faresse, N., Lagnaz, D., Debonneville, A., Ismailji, A., Maillard, M., Fejes-Toth, G., Naray-Fejes-Toth, A., and Staub, O. (2012). Inducible kidney specific Sgk1 knock-out mice show a salt losing phenotype. Am. J. Physiol. Renal Physiol. 302, F977-F985.
-
(2012)
Am. J. Physiol. Renal Physiol.
, vol.302
-
-
Faresse, N.1
Lagnaz, D.2
Debonneville, A.3
Ismailji, A.4
Maillard, M.5
Fejes-Toth, G.6
Naray-Fejes-Toth, A.7
Staub, O.8
-
27
-
-
48249127966
-
Epithelial Na+ channel activation and processing in mice lacking SGK1
-
Fejes-Toth, G., Frindt, G., Naray-Fejes-Toth, A., and Palmer, L. G. (2008). Epithelial Na+ channel activation and processing in mice lacking SGK1. Am. J. Physiol. Renal Physiol. 294, F1298-F1305.
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.294
-
-
Fejes-Toth, G.1
Frindt, G.2
Naray-Fejes-Toth, A.3
Palmer, L.G.4
-
28
-
-
28144461773
-
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells
-
Flores, S. Y., Loffing-Cueni, D., Kamynina, E., Daidie, D., Gerbex, C., Chabanel, S., Dudler, J., Loffing, J., and Staub, O. (2005). Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. J. Am. Soc. Nephrol. 16, 2279-2287.
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 2279-2287
-
-
Flores, S.Y.1
Loffing-Cueni, D.2
Kamynina, E.3
Daidie, D.4
Gerbex, C.5
Chabanel, S.6
Dudler, J.7
Loffing, J.8
Staub, O.9
-
29
-
-
4143067848
-
A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes
-
Fouladkou, F., Alikhani-Koopaei, R., Vogt, B., Flores, S. Y., Malbert-Colas, L., Lecomte, M. C., Loffing, J., Frey, F. J., Frey, B. M., and Staub, O. (2004). A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes. Am. J. Physiol Renal Physiol. 287, F550-F561.
-
(2004)
Am. J. Physiol Renal Physiol.
, vol.287
-
-
Fouladkou, F.1
Alikhani-Koopaei, R.2
Vogt, B.3
Flores, S.Y.4
Malbert-Colas, L.5
Lecomte, M.C.6
Loffing, J.7
Frey, F.J.8
Frey, B.M.9
Staub, O.10
-
30
-
-
77949888796
-
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1
-
Fouladkou, F., Lu, C., Jiang, C., Zhou, L., She, Y., Walls, J. R., Kawabe, H., Brose, N., Henkelman, R. M., Huang, A., Bruneau, B. G., and Rotin, D. (2010). The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J. Biol. Chem. 285, 6770-6780.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6770-6780
-
-
Fouladkou, F.1
Lu, C.2
Jiang, C.3
Zhou, L.4
She, Y.5
Walls, J.R.6
Kawabe, H.7
Brose, N.8
Henkelman, R.M.9
Huang, A.10
Bruneau, B.G.11
Rotin, D.12
-
31
-
-
0029092801
-
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome
-
Hansson, J. H., Nelson-Williams, C., Suzuki, H., Schild, L., Shimkets, R., Lu, Y., Canessa, C., Iwasaki, T., Rossier, B., and Lifton, R. P. (1995a). Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat. Genet. 11, 76-82.
-
(1995)
Nat. Genet.
, vol.11
, pp. 76-82
-
-
Hansson, J.H.1
Nelson-Williams, C.2
Suzuki, H.3
Schild, L.4
Shimkets, R.5
Lu, Y.6
Canessa, C.7
Iwasaki, T.8
Rossier, B.9
Lifton, R.P.10
-
32
-
-
0029586683
-
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity
-
Hansson, J. H., Schild, L., Lu, Y., Wilson, T. A., Gautschi, I., Shimkets, R., Nelson-Williams, C., Rossier, B. C., and Lifton, R. P. (1995b). A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc. Natl. Acad. Sci. U. S. A. 92, 11495-11499.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 11495-11499
-
-
Hansson, J.H.1
Schild, L.2
Lu, Y.3
Wilson, T.A.4
Gautschi, I.5
Shimkets, R.6
Nelson-Williams, C.7
Rossier, B.C.8
Lifton, R.P.9
-
33
-
-
0035896534
-
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel
-
Harvey, K. F., Dinudom, A., Cook, D. I., and Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J. Biol. Chem. 276, 8597-8601.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8597-8601
-
-
Harvey, K.F.1
Dinudom, A.2
Cook, D.I.3
Kumar, S.4
-
34
-
-
0029935712
-
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
-
Hummler, E., Barker, P., Gatzy, J., Beermann, F., Verdumo, C., Schmidt, A., Boucher, R., and Rossier, B. C. (1996). Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat. Genet. 12, 325-328.
-
(1996)
Nat. Genet.
, vol.12
, pp. 325-328
-
-
Hummler, E.1
Barker, P.2
Gatzy, J.3
Beermann, F.4
Verdumo, C.5
Schmidt, A.6
Boucher, R.7
Rossier, B.C.8
-
35
-
-
33644877842
-
Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins
-
Hummler, E., and Vallon, V. (2005). Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins. J. Am. Soc. Nephrol. 16, 3160-3166.
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 3160-3166
-
-
Hummler, E.1
Vallon, V.2
-
36
-
-
20144386846
-
14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase
-
Ichimura, T., Yamamura, H., Sasamoto, K., Tominaga, Y., Taoka, M., Kakiuchi, K., Shinkawa, T., Takahashi, N., Shimada, S., and Isobe, T. (2005). 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J. Biol. Chem. 280, 13187-13194.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13187-13194
-
-
Ichimura, T.1
Yamamura, H.2
Sasamoto, K.3
Tominaga, Y.4
Taoka, M.5
Kakiuchi, K.6
Shinkawa, T.7
Takahashi, N.8
Shimada, S.9
Isobe, T.10
-
37
-
-
79959952950
-
Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance
-
Itani, O. A., Chen, J. H., Karp, P. H., Ernat, S., Keshavjee, S., Parkeh, K., Klesney-Tate, Z. J., and Welsh, M. J. (2011). Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proc. Natl. Acad. Sci. U. S. A. 108, 10260-10265.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 10260-10265
-
-
Itani, O.A.1
Chen, J.H.2
Karp, P.H.3
Ernat, S.4
Keshavjee, S.5
Parkeh, K.6
Klesney-Tate, Z.J.7
Welsh, M.J.8
-
38
-
-
43549123915
-
Molecular physiology of the WNKkinases
-
Kahle, K. T., Ring, A. M., and Lifton, R. P. (2008). Molecular physiology of the WNKkinases. Annu. Rev. Physiol. 70, 329-355.
-
(2008)
Annu. Rev. Physiol.
, vol.70
, pp. 329-355
-
-
Kahle, K.T.1
Ring, A.M.2
Lifton, R.P.3
-
39
-
-
0035161876
-
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel
-
Kamynina, E., Debonneville, C., Bens, M., Vandewalle, A., and Staub, O. (2001). A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEBJ. 15, 204-214.
-
(2001)
FASEBJ.
, vol.15
, pp. 204-214
-
-
Kamynina, E.1
Debonneville, C.2
Bens, M.3
Vandewalle, A.4
Staub, O.5
-
40
-
-
75949126341
-
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
-
Kawabe, H., Neeb, A., Dimova, K., Young, S. M. Jr., Takeda, M., Katsurabayashi, S., Mitkovski, M., Malakhova, O. A., Zhang, D. E., Umikawa, M., Kariya, K., Goebbels, S., Nave, K. A., Rosenmund, C., Jahn, O., Rhee, J., and Brose, N. (2010). Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65, 358-372.
-
(2010)
Neuron
, vol.65
, pp. 358-372
-
-
Kawabe, H.1
Neeb, A.2
Dimova, K.3
Young Jr., S.M.4
Takeda, M.5
Katsurabayashi, S.6
Mitkovski, M.7
Malakhova, O.A.8
Zhang, D.E.9
Umikawa, M.10
Kariya, K.11
Goebbels, S.12
Nave, K.A.13
Rosenmund, C.14
Jahn, O.15
Rhee, J.16
Brose, N.17
-
41
-
-
0032526243
-
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system
-
Kellenberger, S., Gautschi, I., Rossier, B. C., and Schild, L. (1998). Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J. Clin. Invest. 101, 2741-2750.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2741-2750
-
-
Kellenberger, S.1
Gautschi, I.2
Rossier, B.C.3
Schild, L.4
-
42
-
-
79952764514
-
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease
-
Kimura, T., Kawabe, H., Jiang, C., Zhang, W., Xiang, Y Y, Lu, C., Salter, M. W., Brose, N., Lu, W. Y., andRotin, D. (2011). Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc. Natl. Acad. Sci. U. S. A. 108, 3216-3221.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 3216-3221
-
-
Kimura, T.1
Kawabe, H.2
Jiang, C.3
Zhang, W.4
Xiang, Y.Y.5
Lu, C.6
Salter, M.W.7
Brose, N.8
Lu, W.Y.9
Rotin, D.10
-
43
-
-
33749118898
-
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
-
Lalioti, M. D., Zhang, J., Volkman, H. M., Kahle, K. T., Hoffmann, K. E., Toka, H. R., Nelson-Williams, C., Ellison, D. H., Flavell, R., Booth, C. J., Lu, Y., Geller, D. S., and Lifton, R. P. (2006). Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat. Genet. 38, 1124-1132.
-
(2006)
Nat. Genet.
, vol.38
, pp. 1124-1132
-
-
Lalioti, M.D.1
Zhang, J.2
Volkman, H.M.3
Kahle, K.T.4
Hoffmann, K.E.5
Toka, H.R.6
Nelson-Williams, C.7
Ellison, D.H.8
Flavell, R.9
Booth, C.J.10
Lu, Y.11
Geller, D.S.12
Lifton, R.P.13
-
44
-
-
35649027433
-
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2
-
Lee, I. H., Dinudom, A., Sanchez-Perez, A., Kumar, S., and Cook, D. I. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282, 29866-29873.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29866-29873
-
-
Lee, I.H.1
Dinudom, A.2
Sanchez-Perez, A.3
Kumar, S.4
Cook, D.I.5
-
45
-
-
35348912600
-
Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis
-
Li, T., Koshy, S., and Folkesson, H. G. (2007). Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis. Am. J. Physiol. Lung Cell Mol. Physiol. 293, L1069-L1078.
-
(2007)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.293
-
-
Li, T.1
Koshy, S.2
Folkesson, H.G.3
-
46
-
-
33745218319
-
14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels
-
Liang, X., Peters, K. W., Butterworth, M. B., and Frizzell, R. A. (2006). 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J. Biol. Chem. 281, 16323-16332.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16323-16332
-
-
Liang, X.1
Peters, K.W.2
Butterworth, M.B.3
Frizzell, R.A.4
-
47
-
-
0035936780
-
Molecular mechanisms of human hypertension
-
Lifton, R. P., Gharavi, A. G., and Geller, D. S. (2001). Molecular mechanisms of human hypertension. Cell 104, 545-556.
-
(2001)
Cell
, vol.104
, pp. 545-556
-
-
Lifton, R.P.1
Gharavi, A.G.2
Geller, D.S.3
-
48
-
-
67349270258
-
Abnormal development of the neuromuscular junction in Nedd4-deficient mice
-
Liu, Y., Oppenheim, R. W., Sugiura, Y., and Lin, W. (2009). Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev. Biol. 330, 153-166.
-
(2009)
Dev. Biol.
, vol.330
, pp. 153-166
-
-
Liu, Y.1
Oppenheim, R.W.2
Sugiura, Y.3
Lin, W.4
-
49
-
-
64149085069
-
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)
-
Loffing, J., and Korbmacher, C. (2009). Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch. 458, 111-135.
-
(2009)
Pflugers Arch.
, vol.458
, pp. 111-135
-
-
Loffing, J.1
Korbmacher, C.2
-
50
-
-
0034997951
-
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK
-
Loffing, J., Zecevic, M., Feraille, E., Kaissling, B., Asher, C., Rossier, B. C., Firestone, G. L., Pearce, D., and Verrey, F. (2001). Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am. J. Physiol. Renal Physiol. 280, F675-F682.
-
(2001)
Am. J. Physiol. Renal Physiol.
, vol.280
-
-
Loffing, J.1
Zecevic, M.2
Feraille, E.3
Kaissling, B.4
Asher, C.5
Rossier, B.C.6
Firestone, G.L.7
Pearce, D.8
Verrey, F.9
-
51
-
-
84859425383
-
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron
-
International Consortium For Blood Pressure Icbp
-
Louis-Dit-Picard, H., Barc, J., Trujillano, D., Miserey-Lenkei, S., Bouatia-Naji, N., Pylypenko, O., Beaurain, G., Bonnefond, A., Sand, O., Simian, C., Vidal-Petiot, E., Soukaseum, C., Mandet, C., Broux, F., Chabre, O., Delahousse, M., Esnault, V., Fiquet, B., Houillier, P., Bagnis, CL, Koenig, J., Konrad, M., Landais, P., Mourani, C., Niaudet, P., Probst, V., Thauvin, C., Unwin, R. J., Soroka, S. D., Ehret, G., Ossowski, S., Caulfield, M., International Consortium For Blood Pressure Icbp, Bruneval, P., Estivill, X., Froguel, P., Hadchouel, J., Schott, J. J., and Jeunemaitre, X. (2012). KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat. Genet. 44, 456-460.
-
(2012)
Nat. Genet.
, vol.44
, pp. 456-460
-
-
Louis-Dit-Picard, H.1
Barc, J.2
Trujillano, D.3
Miserey-Lenkei, S.4
Bouatia-Naji, N.5
Pylypenko, O.6
Beaurain, G.7
Bonnefond, A.8
Sand, O.9
Simian, C.10
Vidal-Petiot, E.11
Soukaseum, C.12
Mandet, C.13
Broux, F.14
Chabre, O.15
Delahousse, M.16
Esnault, V.17
Fiquet, B.18
Houillier, P.19
Bagnis, C.L.20
Koenig, J.21
Konrad, M.22
Landais, P.23
Mourani, C.24
Niaudet, P.25
Probst, V.26
Thauvin, C.27
Unwin, R.J.28
Soroka, S.D.29
Ehret, G.30
Ossowski, S.31
Caulfield, M.32
Bruneval, P.33
Estivill, X.34
Froguel, P.35
Hadchouel, J.36
Schott, J.J.37
Jeunemaitre, X.38
more..
-
52
-
-
34547830212
-
The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool
-
Lu, C., Pribanic, S., Debonneville, A., Jiang, C., and Rotin, D. (2007). The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic 8, 1246-1264.
-
(2007)
Traffic
, vol.8
, pp. 1246-1264
-
-
Lu, C.1
Pribanic, S.2
Debonneville, A.3
Jiang, C.4
Rotin, D.5
-
53
-
-
70349675207
-
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension
-
Luo, F., Wang, Y., Wang, X., Sun, K., Zhou, X., and Hui, R. (2009). A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. Hypertension 54, 796-801.
-
(2009)
Hypertension
, vol.54
, pp. 796-801
-
-
Luo, F.1
Wang, Y.2
Wang, X.3
Sun, K.4
Zhou, X.5
Hui, R.6
-
54
-
-
2442718786
-
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
-
Mall, M., Grubb, B. R., Harkema, J. R., O'Neal, W K., and Boucher, R. C. (2004). Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat. Med. 10, 487-493.
-
(2004)
Nat. Med.
, vol.10
, pp. 487-493
-
-
Mall, M.1
Grubb, B.R.2
Harkema, J.R.3
O'Neal, W.K.4
Boucher, R.C.5
-
55
-
-
77956240072
-
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
-
Mall, M. A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R. A., Schubert, S. C., Schultz, C., O'Neal, W. K., Pradervand, S., Hummler, E., Rossier, B. C., Grubb, B. R., and Boucher, R. C. (2010). Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. J. Biol. Chem. 285, 26945-26955.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26945-26955
-
-
Mall, M.A.1
Button, B.2
Johannesson, B.3
Zhou, Z.4
Livraghi, A.5
Caldwell, R.A.6
Schubert, S.C.7
Schultz, C.8
O'Neal, W.K.9
Pradervand, S.10
Hummler, E.11
Rossier, B.C.12
Grubb, B.R.13
Boucher, R.C.14
-
56
-
-
0033546341
-
sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial Na+ channels
-
Naray-Fejes-Toth, A., Canessa, C., Cleaveland, E. S., Aldrich, G., and Fejes-Toth, G. (1999). sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial Na+ channels. J. Biol. Chem. 274, 16973-16978.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16973-16978
-
-
Naray-Fejes-Toth, A.1
Canessa, C.2
Cleaveland, E.S.3
Aldrich, G.4
Fejes-Toth, G.5
-
57
-
-
33749386424
-
The Na+:C1~ cotransporter is activated and phosphorylated at the amino-terminal domain upon intra-cellular chloride depletion
-
Pacheco-Alvarez, D., Cristobal, R S., Meade, P., Moreno, E., Vazquez, N., Munoz, E., Diaz, A., Juarez, M. E., Gimenez, I., and Gamba, G. (2006). The Na+:C1~ cotransporter is activated and phosphorylated at the amino-terminal domain upon intra-cellular chloride depletion. J. Biol. Chem. 281, 28755-28763.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 28755-28763
-
-
Pacheco-Alvarez, D.1
Cristobal, R.S.2
Meade, P.3
Moreno, E.4
Vazquez, N.5
Munoz, E.6
Diaz, A.7
Juarez, M.E.8
Gimenez, I.9
Gamba, G.10
-
58
-
-
0032523765
-
Regulation of Na+ channels by luminal Na+ in rat cortical collecting tubule
-
Palmer, L. G., Sackin, H., and Frindt, G. (1998). Regulation of Na+ channels by luminal Na+ in rat cortical collecting tubule. J. Physiol. 509(Pt 1), 151-162.
-
(1998)
J. Physiol.
, vol.509
, Issue.PART 1
, pp. 151-162
-
-
Palmer, L.G.1
Sackin, H.2
Frindt, G.3
-
59
-
-
80155192453
-
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
-
Persaud, A., Alberts, P., Hayes, M., Guettler, S., Clarke, I., Sicheri, F., Dirks, R, Ciruna, B., and Rotin, D. (2011). Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 30, 3259-3273.
-
(2011)
EMBO J.
, vol.30
, pp. 3259-3273
-
-
Persaud, A.1
Alberts, P.2
Hayes, M.3
Guettler, S.4
Clarke, I.5
Sicheri, F.6
Dirks, R.7
Ciruna, B.8
Rotin, D.9
-
60
-
-
0032749231
-
A mouse model for Liddle's syndrome
-
Pradervand, S., Wang, Q., Burnier, M., Beermann, F., Horisberger, J. D., Hummler, E., and Rossier, B. C. (1999). A mouse model for Liddle's syndrome. J. Am. Soc. Nephrol. 10, 2527-2533.
-
(1999)
J. Am. Soc. Nephrol.
, vol.10
, pp. 2527-2533
-
-
Pradervand, S.1
Wang, Q.2
Burnier, M.3
Beermann, F.4
Horisberger, J.D.5
Hummler, E.6
Rossier, B.C.7
-
61
-
-
34447267450
-
beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice
-
Randrianarison, N., Escoubet, B., Ferreira, C., Fontayne, A., Fowler-Jaeger, N., Clerici, C., Hummler, E., Rossier, B. C., and Planes, C. (2007). beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice. J. Physiol. 582, 777-788.
-
(2007)
J. Physiol.
, vol.582
, pp. 777-788
-
-
Randrianarison, N.1
Escoubet, B.2
Ferreira, C.3
Fontayne, A.4
Fowler-Jaeger, N.5
Clerici, C.6
Hummler, E.7
Rossier, B.C.8
Planes, C.9
-
62
-
-
34247205230
-
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
-
Ring, A. M., Cheng, S. X., Leng, Q., Kahle, K. T., Rinehart, J., Lalioti, M. D., Volkman, H. M., Wilson, F. H., Hebert, S. C., and Lifton, R. R (2007a). WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 104, 4020-4024.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 4020-4024
-
-
Ring, A.M.1
Cheng, S.X.2
Leng, Q.3
Kahle, K.T.4
Rinehart, J.5
Lalioti, M.D.6
Volkman, H.M.7
Wilson, F.H.8
Hebert, S.C.9
Lifton, R.R.10
-
63
-
-
34247236088
-
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
-
Ring, A. M., Leng, Q., Rinehart, J., Wilson, F. H., Kahle, K. T., Hebert, S. C., and Lifton, R. R (2007b). An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proc. Natl. Acad. Sci. U. S. A. 104, 4025-4029.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 4025-4029
-
-
Ring, A.M.1
Leng, Q.2
Rinehart, J.3
Wilson, F.H.4
Kahle, K.T.5
Hebert, S.C.6
Lifton, R.R.7
-
64
-
-
67349132223
-
Physiological functions of the HECT family of ubiquitin ligases
-
Rotin, D., andKumar, S. (2009). Physiological functions of the HECT family of ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 10, 398-409.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
65
-
-
0029948974
-
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome
-
Schild, L., Lu, Y., Gautschi, I., Schneeberger, E., Lifton, R. P., and Rossier, B. C. (1996). Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBOJ. 15, 2381-2387.
-
(1996)
EMBOJ.
, vol.15
, pp. 2381-2387
-
-
Schild, L.1
Lu, Y.2
Gautschi, I.3
Schneeberger, E.4
Lifton, R.P.5
Rossier, B.C.6
-
66
-
-
52449104628
-
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin lig-ase Nedd4-2
-
Shi, P. P., Cao, X. R., Sweezer, E. M., Kinney, T. S., Williams, N. R., Husted, R. E, Nair, R., Weiss, R. M., Williamson, R. A., Sigmund, C. D., Snyder, P. M., Staub, O., Stokes, J. B., and Yang, B. (2008). Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin lig-ase Nedd4-2. Am. J. Physiol Renal Physiol. 295, F462-F470.
-
(2008)
Am. J. Physiol Renal Physiol.
, vol.295
-
-
Shi, P.P.1
Cao, X.R.2
Sweezer, E.M.3
Kinney, T.S.4
Williams, N.R.5
Husted, R.E.6
Nair, R.7
Weiss, R.M.8
Williamson, R.A.9
Sigmund, C.D.10
Snyder, P.M.11
Staub, O.12
Stokes, J.B.13
Yang, B.14
-
67
-
-
0033994483
-
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel
-
Shigaev, A., Asher, C., Latter, H., Garty, H., and Reuveny, E. (2000). Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel. Am. J. Physiol. Renal Physiol. 278, F613-F619.
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.278
-
-
Shigaev, A.1
Asher, C.2
Latter, H.3
Garty, H.4
Reuveny, E.5
-
68
-
-
0027946089
-
Liddle's syndrome: heritable human hypertension caused by mutations in the betasubunit of the epithelial sodium channel
-
Shimkets, R. A., Warnock, D. G., Bositis, C. M., Nelson-Williams, C., Hansson, J. H., Schambelan, M., Gill, J. R. Jr., Ulick, S., Milora, R. V., Findling, J. W., Canessa, C. M., Rossier, B. C., and Lifton, R. P. (1994). Liddle's syndrome: heritable human hypertension caused by mutations in the betasubunit of the epithelial sodium channel. Cell 79, 407-414.
-
(1994)
Cell
, vol.79
, pp. 407-414
-
-
Shimkets, R.A.1
Warnock, D.G.2
Bositis, C.M.3
Nelson-Williams, C.4
Hansson, J.H.5
Schambelan, M.6
Gill Jr., J.R.7
Ulick, S.8
Milora, R.V.9
Findling, J.W.10
Canessa, C.M.11
Rossier, B.C.12
Lifton, R.P.13
-
69
-
-
9044235777
-
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
-
Simon, D. B., Nelson-Williams, C., Bia, M. J., Ellison, D., Karet, E E., Molina, A. M., Vaara, I., Iwata, E, Cushner, H. M., Koolen, M., Gainza, E J., Gitleman, H. J., and Lifton, R. P. (1996). Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat. Genet. 12, 24-30.
-
(1996)
Nat. Genet.
, vol.12
, pp. 24-30
-
-
Simon, D.B.1
Nelson-Williams, C.2
Bia, M.J.3
Ellison, D.4
Karet, E.E.5
Molina, A.M.6
Vaara, I.7
Iwata, E.8
Cushner, H.M.9
Koolen, M.10
Gainza, E.J.11
Gitleman, H.J.12
Lifton, R.P.13
-
70
-
-
8544270944
-
cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2
-
Snyder, P. M., Olson, D. R., Kabra, R., Zhou, R., and Steines, J. C. (2004a). cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2. J. Biol. Chem. 279, 45753-45758.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45753-45758
-
-
Snyder, P.M.1
Olson, D.R.2
Kabra, R.3
Zhou, R.4
Steines, J.C.5
-
71
-
-
1042278123
-
Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNAinterference
-
Snyder, P. M., Steines, J. C., and Olson, D. R. (2004b). Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNAinterference. J. Biol. Chem. 279, 5042-5046.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5042-5046
-
-
Snyder, P.M.1
Steines, J.C.2
Olson, D.R.3
-
72
-
-
0037016772
-
Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
-
Snyder, P. M., Olson, D. R., and Thomas, B. C. (2002). Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J. Biol. Chem. 277, 5-8.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5-8
-
-
Snyder, P.M.1
Olson, D.R.2
Thomas, B.C.3
-
73
-
-
0029591506
-
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel
-
Snyder, P. M., Price, M. P., McDonald, E J., Adams, C. M., Volk, K. A., Zeiher, B. G., Stokes, J. B., and Welsh, M. J. (1995). Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell 83, 969-978.
-
(1995)
Cell
, vol.83
, pp. 969-978
-
-
Snyder, P.M.1
Price, M.P.2
McDonald, E.J.3
Adams, C.M.4
Volk, K.A.5
Zeiher, B.G.6
Stokes, J.B.7
Welsh, M.J.8
-
74
-
-
0029874436
-
WW domains of Nedd4 bind to the prolinerich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome
-
Staub, O., Dho, S., Henry, P., Correa, J., Ishikawa, T., McGlade, J., and Rotin, D. (1996). WW domains of Nedd4 bind to the prolinerich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J. 15, 2371-2380.
-
(1996)
EMBO J.
, vol.15
, pp. 2371-2380
-
-
Staub, O.1
Dho, S.2
Henry, P.3
Correa, J.4
Ishikawa, T.5
McGlade, J.6
Rotin, D.7
-
75
-
-
0030731428
-
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
-
Staub, O., Gautschi, I., Ishikawa, T., Breitschopf, K., Ciechanover, A., Schild, L., and Rotin, D. (1997). Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J. 16, 6325-6336.
-
(1997)
EMBO J.
, vol.16
, pp. 6325-6336
-
-
Staub, O.1
Gautschi, I.2
Ishikawa, T.3
Breitschopf, K.4
Ciechanover, A.5
Schild, L.6
Rotin, D.7
-
76
-
-
0030970422
-
Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics
-
Stutts, M. J., Rossier, B. C., and Boucher, R. C. (1997). Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J. Biol. Chem. 272, 14037-14040.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14037-14040
-
-
Stutts, M.J.1
Rossier, B.C.2
Boucher, R.C.3
-
77
-
-
67650533826
-
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction
-
Subramanya, A. R., Liu, J., Ellison, D. H., Wade, J. B., and Welling, P. A. (2009). WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J. Biol. Chem. 284, 18471-18480.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18471-18480
-
-
Subramanya, A.R.1
Liu, J.2
Ellison, D.H.3
Wade, J.B.4
Welling, P.A.5
-
78
-
-
0027534990
-
Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
-
Webster, M. K., Goya, L., Ge, Y., Maiyar, A. C., and Firestone, G. L. (1993). Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell. Biol. 13, 2031-2040.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 2031-2040
-
-
Webster, M.K.1
Goya, L.2
Ge, Y.3
Maiyar, A.C.4
Firestone, G.L.5
-
79
-
-
34347221863
-
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
-
Wiemuth, D., Ke, Y., Rohlfs, M., and McDonald, E J. (2007). Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochem. J. 405, 147-155.
-
(2007)
Biochem. J.
, vol.405
, pp. 147-155
-
-
Wiemuth, D.1
Ke, Y.2
Rohlfs, M.3
McDonald, E.J.4
-
80
-
-
17944373014
-
Human hypertension caused by mutations in WNK kinases
-
Wilson, E H., Disse-Nicodeme, S., Choate, K. A., Ishikawa, K., Nelson-Williams, C., Desitter, I., Gunel, M., Milford, D. V., Lipkin, G. W., Achard, J. M., Feely, M. P., Dussol, B., Berland, Y., Unwin, R. J., Mayan, H., Simon, D. B., Farfel, Z., Jeunemaitre, X., and Lifton, R. P. (2001). Human hypertension caused by mutations in WNK kinases. Science 293, 1107-1112.
-
(2001)
Science
, vol.293
, pp. 1107-1112
-
-
Wilson, E.H.1
Disse-Nicodeme, S.2
Choate, K.A.3
Ishikawa, K.4
Nelson-Williams, C.5
Desitter, I.6
Gunel, M.7
Milford, D.V.8
Lipkin, G.W.9
Achard, J.M.10
Feely, M.P.11
Dussol, B.12
Berland, Y.13
Unwin, R.J.14
Mayan, H.15
Simon, D.B.16
Farfel, Z.17
Jeunemaitre, X.18
Lifton, R.P.19
-
81
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson, E H., Kahle, K. T., Sabath, E., Lalioti, M. D., Rapson, A. K., Hoover, R. S., Hebert, S. C., Gamba, G., and Lifton, R. P. (2003). Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc. Natl. Acad. Sci. U. S. A. 100, 680-684.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 680-684
-
-
Wilson, E.H.1
Kahle, K.T.2
Sabath, E.3
Lalioti, M.D.4
Rapson, A.K.5
Hoover, R.S.6
Hebert, S.C.7
Gamba, G.8
Lifton, R.P.9
-
82
-
-
0036840696
-
Impaired renal Na(+) retention in the sgk1-knockout mouse
-
Wulff, P., Vallon, V., Huang, D. Y., Volkl, H., Yu, F., Richter, K., Jansen, M., Schlunz, M., Klingel, K., Loffing, J., Kauselmann, G., Bosl, M. R., Lang, E, and Kuhl, D. (2002). Impaired renal Na(+) retention in the sgk1-knockout mouse. J. Clin. Invest. 110, 1263-1268.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1263-1268
-
-
Wulff, P.1
Vallon, V.2
Huang, D.Y.3
Volkl, H.4
Yu, F.5
Richter, K.6
Jansen, M.7
Schlunz, M.8
Klingel, K.9
Loffing, J.10
Kauselmann, G.11
Bosl, M.R.12
Lang, E.13
Kuhl, D.14
-
83
-
-
22544472397
-
WNK1 activates SGK1 to regulate the epithelial sodium channel
-
Xu, B. E., Stippec, S., Chu, P. Y., Lazrak, A., Li, X. J., Lee, B. H., English, J. M., Ortega, B., Huang, C. L., and Cobb, M. H. (2005). WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc. Natl. Acad. Sci. U. S. A. 102, 10315-10320.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 10315-10320
-
-
Xu, B.E.1
Stippec, S.2
Chu, P.Y.3
Lazrak, A.4
Li, X.J.5
Lee, B.H.6
English, J.M.7
Ortega, B.8
Huang, C.L.9
Cobb, M.H.10
-
84
-
-
56349153585
-
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells
-
Yang, B., Gay, D. L., MacLeod, M. K., Cao, X., Hala, T., Sweezer, E. M., Kappler, J., Marrack, P., and Oliver, P. M. (2008). Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat. Immunol. 9, 1356-1363.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1356-1363
-
-
Yang, B.1
Gay, D.L.2
MacLeod, M.K.3
Cao, X.4
Hala, T.5
Sweezer, E.M.6
Kappler, J.7
Marrack, P.8
Oliver, P.M.9
-
85
-
-
77449124047
-
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
-
Yang, B., and Kumar, S. (2010). Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ. 17, 68-77.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 68-77
-
-
Yang, B.1
Kumar, S.2
-
86
-
-
0037382807
-
WNK kinases regulate thiazide-sensitive Na-Cl cotransport
-
Yang, C. L., Angell, J., Mitchell, R., and Ellison, D. H. (2003). WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J. Clin. Invest. 111, 1039-1045.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1039-1045
-
-
Yang, C.L.1
Angell, J.2
Mitchell, R.3
Ellison, D.H.4
-
87
-
-
34247617951
-
Molecular pathogenesis of pseudohy-poaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model
-
Yang, S. S., Morimoto, T., Rai, T., Chiga, M., Sohara, E., Ohno, M., Uchida, K., Lin, S. H., Moriguchi, T., Shibuya, H., Kondo, Y., Sasaki, S., and Uchida, S. (2007). Molecular pathogenesis of pseudohy-poaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 5, 331-344.
-
(2007)
Cell Metab.
, vol.5
, pp. 331-344
-
-
Yang, S.S.1
Morimoto, T.2
Rai, T.3
Chiga, M.4
Sohara, E.5
Ohno, M.6
Uchida, K.7
Lin, S.H.8
Moriguchi, T.9
Shibuya, H.10
Kondo, Y.11
Sasaki, S.12
Uchida, S.13
-
88
-
-
34547107368
-
Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC
-
Zhou, R., Patel, S. V., and Snyder, P. M. (2007). Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC. J. Biol. Chem. 282, 20207-20212.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20207-20212
-
-
Zhou, R.1
Patel, S.V.2
Snyder, P.M.3
-
89
-
-
57149104917
-
Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice
-
Zhou, Z., Treis, D., Schubert, S. C., Harm, M., Schatterny, J., Hirtz, S., Duerr, J., Boucher, R. C., and Mall, M. A. (2008). Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice. Am. J. Respir. Crit. Care Med. 178, 1245-1256.
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.178
, pp. 1245-1256
-
-
Zhou, Z.1
Treis, D.2
Schubert, S.C.3
Harm, M.4
Schatterny, J.5
Hirtz, S.6
Duerr, J.7
Boucher, R.C.8
Mall, M.A.9
|