Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

Age

Volumn 36, Issue 1, 2014, Pages 199-212

  Kusne, Yael ^a   Goldberg, Emily L ^b,c   Parker, Sara S ^b   Hapak, Sophie M ^b   Maskaykina, Irina Y ^b   Chew, Wade M ^d   Limesand, Kirsten H ^c   Brooks, Heddwen L ^b   Price, Theodore J ^b   Sanai, Nader ^a,e   Nikolich Zugich, Janko ^b   Ghosh, Sourav ^a,b,e  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Metformin; MTOR; Neuronal progenitors; Rapamycin

Indexed keywords

BROXURIDINE; METFORMIN; RAPAMYCIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL CULTURE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IN VITRO STUDY; LIFESPAN; LONG TERM CARE; MALE; MOUSE; NERVE CELL; NEURAL STEM CELL; NONHUMAN; STEM CELL NICHE; SUBVENTRICULAR ZONE; SYSTEMIC THERAPY;

ANIMALS; APOPTOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; LONGEVITY; METFORMIN; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIROLIMUS; STEM CELLS; TOR SERINE-THREONINE KINASES;

EID: 84893095128     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-013-9572-5     Document Type: Article

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