CB 2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1198-1209

  Palazuelos, Javier ^a,b   Ortega, Zaira ^a   Díaz Alonso, Javier ^a   Guzmán, Manuel ^a   Galve Roperh, Ismael ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; ANIMAL MODEL; CANNABINOID RECEPTORS; COMPLEX 1; DEOXYURIDINE; DOWNSTREAM TARGET; ENDOCANNABINOID; EXCITOTOXICITY; IN-VIVO; MECHANISM OF ACTION; NEURAL PROGENITOR CELLS; NEUROGENESIS; NOVEL STRATEGIES; ORGANOTYPIC CULTURE; PHOSPHATIDYLINOSITOL 3-KINASE; RAPAMYCIN; RIBOSOMAL PROTEINS; SIGNAL TRANSDUCTION MECHANISM; TARGET OF RAPAMYCIN; WILD TYPES;

BRAIN MODELS; CELL CULTURE; CELL PROLIFERATION; CELLS; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MOLECULAR BIOLOGY;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; BROXURIDINE; CANNABINOID 2 RECEPTOR; ENZYME INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN S6; RAPAMYCIN; BORNANE DERIVATIVE; CANNABINOID; CDKN1B PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; IMMUNOSUPPRESSIVE AGENT; MTORC1 COMPLEX, MOUSE; PROTEIN; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EXCITOTOXICITY; GENETIC TRANSFECTION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HIPPOCAMPUS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BORNANES; CANNABINOIDS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, KNOCKOUT; NEURAL STEM CELLS; NEUROGENESIS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 84855496796     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.291294     Document Type: Article

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