MTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK

Pain

Volumn 154, Issue 7, 2013, Pages 1080-1091

  Melemedjian, Ohannes K ^a   Khoutorsky, Arkady ^b   Sorge, Robert E ^c   Yan, Jin ^a   Asiedu, Marina N ^a   Valdez, Arely ^d   Ghosh, Sourav ^a,d   Dussor, Gregory ^a,d   Mogil, Jeffrey S ^c   Sonenberg, Nahum ^b   Price, Theodore J ^a,d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

AMPK; ERK; mTOR; Rapamycin; Sensory neurons

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; LONG TERM CARE; MALE; MOUSE; NEGATIVE FEEDBACK; NERVE CELL EXCITABILITY; NEUROPATHIC PAIN; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

EID: 84878808774     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.03.021     Document Type: Article

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