Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

Breast Cancer Research and Treatment

Volumn 123, Issue 1, 2010, Pages 271-279

  Zakikhani, Mahvash ^a,b   Blouin, Marie José ^a,b   Piura, Esther ^b   Pollak, Michael N ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

AMPK; IRS 1; Metformin; Proliferation; Rapamycin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN KINASE B; RAPAMYCIN; SERINE; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL SEPARATION; DRUG EFFECTS; FEMALE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METFORMIN; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSFECTION; TOR SERINE-THREONINE KINASES;

EID: 77955770568     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0763-9     Document Type: Article

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