-
1
-
-
84859016311
-
The application of genomic and molecular data in the treatment of chronic cancer pain
-
Turabi, A.; Plunkett, A.R. The application of genomic and molecular data in the treatment of chronic cancer pain. J. Surg. Oncol. 2012, 105, 494-501.
-
(2012)
J. Surg. Oncol.
, vol.105
, pp. 494-501
-
-
Turabi, A.1
Plunkett, A.R.2
-
2
-
-
84858241693
-
Tetrodotoxin (TTX) as a therapeutic agent for pain
-
Nieto, F.R.; Cobos, E.J.; Tejada, M.Á.; Sánchez- Fernández, C.; González-Cano, R.; Cendán, C.M. Tetrodotoxin (TTX) as a therapeutic agent for pain. Mar. Drugs 2012, 10, 281-305.
-
(2012)
Mar. Drugs
, vol.10
, pp. 281-305
-
-
Nieto, F.R.1
Cobos, E.J.2
Tejada, M.Á.3
Sánchez-Fernández, C.4
González-Cano, R.5
Cendán, C.M.6
-
3
-
-
84872419608
-
The molecular mystique of tetrodotoxin
-
Moczydlowski, E.G. The molecular mystique of tetrodotoxin. Toxicon 2013, 63, 165-183.
-
(2013)
Toxicon
, vol.63
, pp. 165-183
-
-
Moczydlowski, E.G.1
-
4
-
-
79955369100
-
On the origins and biosynthesis of tetrodotoxin
-
Chau, R.; Kalaitzis, J.A.; Neilan, B.A. On the origins and biosynthesis of tetrodotoxin. Aquat. Toxicol. 2011, 104, 61-72.
-
(2011)
Aquat. Toxicol.
, vol.104
, pp. 61-72
-
-
Chau, R.1
Kalaitzis, J.A.2
Neilan, B.A.3
-
5
-
-
84879148880
-
Synthesis of tetrodotoxin, a classic but still fascinating natural product
-
Nishikawa, T.; Isobe, M. Synthesis of tetrodotoxin, a classic but still fascinating natural product. Chem. Rec. 2013, 13, 286-302.
-
(2013)
Chem. Rec.
, vol.13
, pp. 286-302
-
-
Nishikawa, T.1
Isobe, M.2
-
6
-
-
70949099866
-
χ-Conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain
-
Brust, A.; Palant, E.; Croker, D.E.; Colless, B.; Drinkwater, R.; Patterson, B.; Schroeder, C.I.; Wilson, D.; Nielsen, C.K.; Smith, M.T.; et al. χ-Conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 2009, 52, 6991-7002.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6991-7002
-
-
Brust, A.1
Palant, E.2
Croker, D.E.3
Colless, B.4
Drinkwater, R.5
Patterson, B.6
Schroeder, C.I.7
Wilson, D.8
Nielsen, C.K.9
Smith, M.T.10
-
7
-
-
0141924858
-
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of Action, Na+ dependence, and structure-activity relationship
-
Sharpe, I.A.; Palant, E.; Schroeder, C.I.; Kaye, D.M.; Adams, D.J.; Alewood, P.F.; Lewis, R.J. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of Action, Na+ dependence, and structure-activity relationship. J. Biol. Chem. 2003, 278, 40317-40322.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40317-40322
-
-
Sharpe, I.A.1
Palant, E.2
Schroeder, C.I.3
Kaye, D.M.4
Adams, D.J.5
Alewood, P.F.6
Lewis, R.J.7
-
8
-
-
84883257978
-
Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model
-
Jayamanne, A.; Jeong, H.J.; Schroeder, C.J.; Lewis, R.J.; Christie, M.J.; Vaughan, C.W. Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. Br. J. Pharmacol. 2013, 170, 245-254.
-
(2013)
Br. J. Pharmacol.
, vol.170
, pp. 245-254
-
-
Jayamanne, A.1
Jeong, H.J.2
Schroeder, C.J.3
Lewis, R.J.4
Christie, M.J.5
Vaughan, C.W.6
-
9
-
-
84952985593
-
Conopeptides as novel options for pain management
-
Daly, N.L.; Craik, D.J. Conopeptides as novel options for pain management. Drugs Future 2011, 36, 25-32.
-
(2011)
Drugs Future
, vol.36
, pp. 25-32
-
-
Daly, N.L.1
Craik, D.J.2
-
10
-
-
0023934840
-
Immunotherapy in bladder cancer with keyhole limpet hemocyanin: A randomized study
-
Jurincic, C.D.; Engelmann, U.; Gasch, J.; Klippel, K.F. Immunotherapy in bladder cancer with keyhole limpet hemocyanin: A randomized study. J. Urol. 1988, 139, 723-726.
-
(1988)
J. Urol.
, vol.139
, pp. 723-726
-
-
Jurincic, C.D.1
Engelmann, U.2
Gasch, J.3
Klippel, K.F.4
-
11
-
-
80052206741
-
Phase III multicenter clinical trial of the Sialyl-TN (STn)-Keyhole limpet hemocyanin (KLH) vaccine for metastatic breast cancer
-
Miles, D.; Roche, H.; Martin, M.; Perren, T.J.; Cameron, D.A.; Glaspy, J.; Dodwell, D.; Parker, J.; Mayordomo, J.; Tres, A.; et al. Phase III multicenter clinical trial of the Sialyl-TN (STn)-Keyhole limpet hemocyanin (KLH) vaccine for metastatic breast cancer. Oncologist 2011, 16, 1092-1100.
-
(2011)
Oncologist
, vol.16
, pp. 1092-1100
-
-
Miles, D.1
Roche, H.2
Martin, M.3
Perren, T.J.4
Cameron, D.A.5
Glaspy, J.6
Dodwell, D.7
Parker, J.8
Mayordomo, J.9
Tres, A.10
-
12
-
-
84863999771
-
Intracutaneous and intravesical immunotherapy with keyhole limpet hemocyanin compared with intravesical mitomycin in patients with non-muscle-invasive bladder cancer: Results from a prospective randomized phase III trial
-
Lammers, R.J.; Witjes, W.P.; Janzing-Pastors, M.H.; Caris, C.T.; Witjes, J.A. Intracutaneous and intravesical immunotherapy with keyhole limpet hemocyanin compared with intravesical mitomycin in patients with non-muscle-invasive bladder cancer: Results from a prospective randomized phase III trial. J. Clin. Oncol. 2012, 30, 2273-2279.
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 2273-2279
-
-
Lammers, R.J.1
Witjes, W.P.2
Janzing-Pastors, M.H.3
Caris, C.T.4
Witjes, J.A.5
-
13
-
-
84892881808
-
-
ClinicalTrials.gov. Available online: (accessed on 15 October 2013)
-
ClinicalTrials.gov. Available online: http://clinicaltrials.gov/ (accessed on 15 October 2013).
-
-
-
-
14
-
-
0034082239
-
The influence of natural products upon drug discovery
-
Newman, D.J.; Cragg, G.M.; Snader, K.M. The influence of natural products upon drug discovery. Nat. Prod. Rep. 2000, 17, 215-234.
-
(2000)
Nat. Prod. Rep.
, vol.17
, pp. 215-234
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
15
-
-
0026361983
-
Chemical approaches to the discovery of new drugs
-
Suckling, C.J. Chemical approaches to the discovery of new drugs. Sci. Prog. 1991, 75, 323-359.
-
(1991)
Sci. Prog.
, vol.75
, pp. 323-359
-
-
Suckling, C.J.1
-
16
-
-
33947449827
-
Isolation of a new thymine pentoside from sponges
-
Bergmann, W.; Feeney, R.J. Isolation of a new thymine pentoside from sponges. J. Am. Chem. Soc. 1950, 72, 2809-2810.
-
(1950)
J. Am. Chem. Soc.
, vol.72
, pp. 2809-2810
-
-
Bergmann, W.1
Feeney, R.J.2
-
17
-
-
0000719402
-
Marine products. XXXII. The nucleosides of sponges. I
-
Bergmann, W.; Feeney, R.J. Marine products. XXXII. The nucleosides of sponges. I. J. Org. Chem. 1951, 16, 981-987.
-
(1951)
J. Org. Chem.
, vol.16
, pp. 981-987
-
-
Bergmann, W.1
Feeney, R.J.2
-
18
-
-
0000580486
-
Marine products. XXXIX. The nucleosides of sponges. III. Spongothymidine and spongouridine
-
Bergmann, W.; Burke, D.C. Marine products. XXXIX. The nucleosides of sponges. III. Spongothymidine and spongouridine. J. Org. Chem. 1955, 20, 1501-1507.
-
(1955)
J. Org. Chem.
, vol.20
, pp. 1501-1507
-
-
Bergmann, W.1
Burke, D.C.2
-
19
-
-
84872087060
-
Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
-
Löwenberg, B. Sense and nonsense of high-dose cytarabine for acute myeloid leukemia. Blood 2013, 121, 26-28.
-
(2013)
Blood
, vol.121
, pp. 26-28
-
-
Löwenberg, B.1
-
20
-
-
0004790626
-
-
Marine Technology Society: Washington, DC, USA
-
Sigel, M.M.; Wellham, L.L.; Lichter, W.; Dudeck, L.E.; Gargus, J.L.; Lucas, L.H. Food-Drugs from the Sea: Proceedings 1969; Marine Technology Society: Washington, DC, USA, 1970.
-
(1970)
Food-Drugs from the Sea: Proceedings 1969
-
-
Sigel, M.M.1
Wellham, L.L.2
Lichter, W.3
Dudeck, L.E.4
Gargus, J.L.5
Lucas, L.H.6
-
21
-
-
84886274644
-
-
Ph.D Thesis, Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA
-
Holt, T.G. The Isolation and Structural Characterization of the Ecteinascidins. Ph.D Thesis, Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA, 1986.
-
(1986)
The Isolation and Structural Characterization of the Ecteinascidins
-
-
Holt, T.G.1
-
22
-
-
0025070774
-
Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
-
Rinehart, K.; Holt, T.G.; Fregeau, N.L.; Stroh, J.G.; Kiefer, P.A.; Sun, F.; Li, L.H.; Martin, D.G. Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem. 1990, 55, 4512-4515.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 4512-4515
-
-
Rinehart, K.1
Holt, T.G.2
Fregeau, N.L.3
Stroh, J.G.4
Kiefer, P.A.5
Sun, F.6
Li, L.H.7
Martin, D.G.8
-
23
-
-
0024995421
-
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
-
Wright, A.E.; Forleo, D.A.; Gunawardana, G.P.; Gunasekera, S.P.; Koehn, F.E.; McConnell, O.J. Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata. J. Org. Chem. 1990, 55, 4508-4512.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 4508-4512
-
-
Wright, A.E.1
Forleo, D.A.2
Gunawardana, G.P.3
Gunasekera, S.P.4
Koehn, F.E.5
McConnell, O.J.6
-
24
-
-
61549104994
-
Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
-
Cuevas, C.; Francesch, A.; Reports, N.P. Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem. Nat. Prod. Rep. 2009, 26 322-337.
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 322-337
-
-
Cuevas, C.1
Francesch, A.2
Reports, N.P.3
-
25
-
-
84885159110
-
Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway
-
Martínez, S.; Pérez, L.; Galmarini, C.M.; Aracil, M.; Tercero, J.C.; Gago, F.; Albella, B.; Bueren, J.A. Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway. Br. J. Pharmacol. 2013, 170, 871-882.
-
(2013)
Br. J. Pharmacol.
, vol.170
, pp. 871-882
-
-
Martínez, S.1
Pérez, L.2
Galmarini, C.M.3
Aracil, M.4
Tercero, J.C.5
Gago, F.6
Albella, B.7
Bueren, J.A.8
-
26
-
-
84882653569
-
Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104)
-
Romano, M.; Frapolli, R.; Zangarini, M.; Bello, E.; Porcu, L.; Galmarini, C.M.; Garcia-Fernandez, L.F.; Cuevas, C.; Allavena, P.; Erba, E.; D'Incalci, M. Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104). Int. J. Cancer 2013, 133, 2024-2033.
-
(2013)
Int. J. Cancer
, vol.133
, pp. 2024-2033
-
-
Romano, M.1
Frapolli, R.2
Zangarini, M.3
Bello, E.4
Porcu, L.5
Galmarini, C.M.6
Garcia-Fernandez, L.F.7
Cuevas, C.8
Allavena, P.9
Erba, E.10
D'Incalci, M.11
-
27
-
-
84859651995
-
First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours
-
Yap, T.A.; Cortes-Funes, H.; Shaw, H.; Rodriguez, R.; Olmo, S.D.; Lal, R.; Fong, P.C.; Tan, D.S.; Harris, D.; Capdevila, J.; et al. First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours. Br. J. Cancer 2012, 106, 1379-1385.
-
(2012)
Br. J. Cancer
, vol.106
, pp. 1379-1385
-
-
Yap, T.A.1
Cortes-Funes, H.2
Shaw, H.3
Rodriguez, R.4
Olmo, S.D.5
Lal, R.6
Fong, P.C.7
Tan, D.S.8
Harris, D.9
Capdevila, J.10
-
28
-
-
84886297369
-
Microbial natural products: Molecular blueprints for antitumor drugs
-
Giddings, L.-A.; Newman, D.J. Microbial natural products: Molecular blueprints for antitumor drugs. J. Ind. Microbiol. Biotechnol. 2013, 40, 1181-1210.
-
(2013)
J. Ind. Microbiol. Biotechnol.
, vol.40
, pp. 1181-1210
-
-
Giddings, L.-A.1
Newman, D.J.2
-
29
-
-
0034622873
-
A new antitumor isoquinoline alkaloid from teh marine numdibranch Jorunna funebris
-
Fontana, A.; Cavaliere, P.; Wahidullah, S.; Naik, C.G.; Cimino, G. A new antitumor isoquinoline alkaloid from teh marine numdibranch Jorunna funebris. Tetrahedron 2000, 56, 7305-7308.
-
(2000)
Tetrahedron
, vol.56
, pp. 7305-7308
-
-
Fontana, A.1
Cavaliere, P.2
Wahidullah, S.3
Naik, C.G.4
Cimino, G.5
-
30
-
-
84892857894
-
Hemisynthetic Methods and New Compounds
-
WO 20000069862, 23 November
-
Perez, M.; Fernandez, C.; Chicharro, J.L.; Zarzuelo, M.; de la Calle, F.; Cuevas, C.; Francesch, A.; Gallego, P.; Manzanares, I. Hemisynthetic Methods and New Compounds. WO 20000069862, 23 November 2000.
-
(2000)
-
-
Perez, M.1
Fernandez, C.2
Chicharro, J.L.3
Zarzuelo, M.4
De La Calle, F.5
Cuevas, C.6
Francesch, A.7
Gallego, P.8
Manzanares, I.9
-
31
-
-
65649141676
-
Molecular pharmacology and antitumor activity of Zalypsis® in several human cell lines
-
Leal, J.F.M.; Garcia-Hernandez, V.; Moneo, V.; Domingo, A.; Bueren-Calabuig, J.A.; Negri, A.; Gago, F.; Gulillen-Navarro, M.J.; Aviles, P.; Cuevas, C.; et al. Molecular pharmacology and antitumor activity of Zalypsis® in several human cell lines. Biochem. Pharmacol. 2009, 78, 162-170.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 162-170
-
-
Leal, J.F.M.1
Garcia-Hernandez, V.2
Moneo, V.3
Domingo, A.4
Bueren-Calabuig, J.A.5
Negri, A.6
Gago, F.7
Gulillen-Navarro, M.J.8
Aviles, P.9
Cuevas, C.10
-
32
-
-
84879100388
-
Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors
-
Massard, C.; Margetts, J.; Amellal, N.; Drew, Y.; Bahleda, R.; Stevens, P.; Armand, J.P.; Calvert, H.; Soria, J.C.; Coronado, C.; et al. Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors. Invest. New Drugs 2013, 31, 623-630.
-
(2013)
Invest. New Drugs
, vol.31
, pp. 623-630
-
-
Massard, C.1
Margetts, J.2
Amellal, N.3
Drew, Y.4
Bahleda, R.5
Stevens, P.6
Armand, J.P.7
Calvert, H.8
Soria, J.C.9
Coronado, C.10
-
33
-
-
84877923100
-
A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors
-
Capdevila, J.; Clive, S.; Casado, E.; Michie, C.; Piera, A.; Sicart, E.; Carreras, M.J.; Coronado, C.; Kahatt, C.; Soto Matos-Pita, A.; et al. A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 2013, 71, 1247-1254.
-
(2013)
Cancer Chemother. Pharmacol.
, vol.71
, pp. 1247-1254
-
-
Capdevila, J.1
Clive, S.2
Casado, E.3
Michie, C.4
Piera, A.5
Sicart, E.6
Carreras, M.J.7
Coronado, C.8
Kahatt, C.9
Soto Matos-Pita, A.10
-
34
-
-
84878818183
-
Phase II study of weekly PM00104 (ZALYPSIS®) in patients with pretreated advanced/metastatic endometrial or cervical cancer
-
Martin, L.P.; Krasner, C.; Rutledge, T.; Luque Ibanes, M.; Fernandez-García, E.M.; Kahatt, C.; Siguero Gomez, M.; McMeekin, S. Phase II study of weekly PM00104 (ZALYPSIS®) in patients with pretreated advanced/metastatic endometrial or cervical cancer. Med. Oncol. 2013, 30, 627-631.
-
(2013)
Med. Oncol.
, vol.30
, pp. 627-631
-
-
Martin, L.P.1
Krasner, C.2
Rutledge, T.3
Luque Ibanes, M.4
Fernandez- García, E.M.5
Kahatt, C.6
Siguero Gomez, M.7
McMeekin, S.8
-
35
-
-
77958587933
-
PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity
-
Leal, J.F.; Martínez-Díez, M.; García- Hernández, V.; Moneo, V.; Domingo, A.; Bueren-Calabuig, J.A.; Negri, A.; Gago, F.; Guillén-Navarro, M.J.; Avilés, P.; et al. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Br. J. Pharmacol. 2010, 161, 1099-1110.
-
(2010)
Br. J. Pharmacol.
, vol.161
, pp. 1099-1110
-
-
Leal, J.F.1
Martínez-Díez, M.2
García-Hernández, V.3
Moneo, V.4
Domingo, A.5
Bueren-Calabuig, J.A.6
Negri, A.7
Gago, F.8
Guillén-Navarro, M.J.9
Avilés, P.10
-
36
-
-
80051585674
-
Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells
-
Soares, D.G.; Machado, M.S.; Rocca, C.J.; Poindessous, V.; Ouaret, D.; Sarasin, A.; Galmarini, C.M.; Henriques, J.A.; Escargueil, A.E.; Larsen, A.K. Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells. Mol. Cancer Ther. 2011, 10, 1481-1489.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1481-1489
-
-
Soares, D.G.1
Machado, M.S.2
Rocca, C.J.3
Poindessous, V.4
Ouaret, D.5
Sarasin, A.6
Galmarini, C.M.7
Henriques, J.A.8
Escargueil, A.E.9
Larsen, A.K.10
-
37
-
-
84892881928
-
Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B
-
2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA
-
Yu, M.J.; Kishi, Y.; Littlefield, B.A. Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B. In Anticancer Agents from Natural Products, 2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA, 2012; pp. 317-345.
-
(2012)
Anticancer Agents from Natural Products
, pp. 317-345
-
-
Yu, M.J.1
Kishi, Y.2
Littlefield, B.A.3
-
38
-
-
84882354548
-
From micrograms to grams: Scale-up synthesis of eribulin mesylate
-
Yu, M.J.; Zheng, W.; Seletsky, B.M. From micrograms to grams: Scale-up synthesis of eribulin mesylate. Nat. Prod. Rep. 2013, 30, 1158-1164.
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 1158-1164
-
-
Yu, M.J.1
Zheng, W.2
Seletsky, B.M.3
-
39
-
-
84873570526
-
Commercial manufacture of Halaven®: Chemoselective transformations en route to structurally complex macrocyclic ketones
-
Austad, B.C.; Calkins, T.L.; Chase, C.E.; Fang, F.G.; Horstmann, T.E.; Hua, Y.; Lewis, B.M.; Niu, X.; Noland, T.A.; Orr, J.D.; et al. Commercial manufacture of Halaven®: Chemoselective transformations en route to structurally complex macrocyclic ketones. Synlett 2013, 24, 333-337.
-
(2013)
Synlett
, vol.24
, pp. 333-337
-
-
Austad, B.C.1
Calkins, T.L.2
Chase, C.E.3
Fang, F.G.4
Horstmann, T.E.5
Hua, Y.6
Lewis, B.M.7
Niu, X.8
Noland, T.A.9
Orr, J.D.10
-
40
-
-
34447302758
-
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
-
Udwary, D.W.; Zeigler, L.; Asolkar, R.N.; Singan, V.; Lapidus, A.; Fenical, W.; Jensen, P.R.; Moore, B.S. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Natl. Acad. Sci. USA 2007, 104, 10376-10381.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10376-10381
-
-
Udwary, D.W.1
Zeigler, L.2
Asolkar, R.N.3
Singan, V.4
Lapidus, A.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
41
-
-
31544441685
-
Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
-
Doronina, S.O.; Mendelsohn, B.A.; Bovee, T.D.; Cerveny, C.G.; Alley, S.C.; Meyer, D.L.; Oflazoglu, E.; Toki, B.E.; Sanderson, R.J.; Zabinski, R.F.; et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity. Bioconjug. Chem. 2006, 17, 114-124.
-
(2006)
Bioconjug. Chem.
, vol.17
, pp. 114-124
-
-
Doronina, S.O.1
Mendelsohn, B.A.2
Bovee, T.D.3
Cerveny, C.G.4
Alley, S.C.5
Meyer, D.L.6
Oflazoglu, E.7
Toki, B.E.8
Sanderson, R.J.9
Zabinski, R.F.10
-
42
-
-
79956195521
-
Brentuximab vedotin; Anti-CD30 antibody-drug conjugate oncolytic
-
Copeland, A.; Younes, A. Brentuximab vedotin; Anti-CD30 antibody-drug conjugate oncolytic. Drugs Future 2010, 35, 797-801.
-
(2010)
Drugs Future
, vol.35
, pp. 797-801
-
-
Copeland, A.1
Younes, A.2
-
43
-
-
78650301478
-
Brentuximab vedotin: Delivering an antimitotic drug to activated lymphoma cells
-
Ansell, S.M. Brentuximab vedotin: Delivering an antimitotic drug to activated lymphoma cells. Expert Opin. Investig. Drugs. 2011, 20, 99-105.
-
(2011)
Expert Opin. Investig. Drugs.
, vol.20
, pp. 99-105
-
-
Ansell, S.M.1
-
44
-
-
84860736736
-
Brentuximab vedotin: Its role in the treatment of anaplastic large cell and Hodgkin's lymphoma
-
Haddley, K. Brentuximab vedotin: Its role in the treatment of anaplastic large cell and Hodgkin's lymphoma. Drugs Today 2012, 48, 259-270.
-
(2012)
Drugs Today
, vol.48
, pp. 259-270
-
-
Haddley, K.1
-
45
-
-
84875467346
-
Brentuximab vedotin: A CD30-directed antibody-cytotoxic drug conjugate
-
Newland, A.M.; Li, J.X.; Wasco, L.E.; Aziz, M.T.; Lowe, D.K. Brentuximab vedotin: A CD30-directed antibody-cytotoxic drug conjugate. Pharmacother 2013, 33, 93-104.
-
(2013)
Pharmacother
, vol.33
, pp. 93-104
-
-
Newland, A.M.1
Li, J.X.2
Wasco, L.E.3
Aziz, M.T.4
Lowe, D.K.5
-
46
-
-
84875780947
-
Takeda's oncology discovery strategy
-
DeSchuytner, B.; Kuvalanka, K.; Hibner, B.; Bolen, J. Takeda's oncology discovery strategy. Jpn. J. Clin. Oncol. 2013, 43, 357-361.
-
(2013)
Jpn. J. Clin. Oncol.
, vol.43
, pp. 357-361
-
-
DeSchuytner, B.1
Kuvalanka, K.2
Hibner, B.3
Bolen, J.4
-
47
-
-
33644747384
-
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma
-
Tse, K.F.; Jeffers, M.; Pollack, V.A.; McCabe, D.A.; Shadish, M.L.; Khramtsov, N.V.; Hackett, C.S.; Shenoy, S.G.; Kuang, B.; Boldog, F.L.; et al. CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma. Clin. Cancer Res. 2006, 12, 1373-1382.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 1373-1382
-
-
Tse, K.F.1
Jeffers, M.2
Pollack, V.A.3
McCabe, D.A.4
Shadish, M.L.5
Khramtsov, N.V.6
Hackett, C.S.7
Shenoy, S.G.8
Kuang, B.9
Boldog, F.L.10
-
48
-
-
34250613133
-
Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB
-
Pollack, V.A.; Alvarez, E.; Tse, K.F.; Torgov, M.Y.; Xie, S.; Shenoy, S.G.; MacDougall, J.R.; Arrol, S.; Zhong, H.; Gerwien, R.W.; et al. Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB. Cancer Chemother. Pharmacol. 2007, 60, 423-435.
-
(2007)
Cancer Chemother. Pharmacol.
, vol.60
, pp. 423-435
-
-
Pollack, V.A.1
Alvarez, E.2
Tse, K.F.3
Torgov, M.Y.4
Xie, S.5
Shenoy, S.G.6
MacDougall, J.R.7
Arrol, S.8
Zhong, H.9
Gerwien, R.W.10
-
49
-
-
77950670628
-
Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer
-
Rose, A.A.; Grosset, A.A.; Dong, Z.; Russo, C.; Macdonald, P.A.; Bertos, N.R.; St-Pierre, Y.; Simantov, R.; Hallett, M.; Park, M.; et al. Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clin. Cancer Res. 2010, 16, 2147-2156.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2147-2156
-
-
Rose, A.A.1
Grosset, A.A.2
Dong, Z.3
Russo, C.4
Macdonald, P.A.5
Bertos, N.R.6
St-Pierre, Y.7
Simantov, R.8
Hallett, M.9
Park, M.10
-
50
-
-
84863745351
-
Gpnmb/osteoactivin, an attractive target in cancer immunotherapy
-
Zhou, L.T.; Liu, F.Y.; Li, Y.; Peng, Y.M.; Liu, Y.H.; Li, J. Gpnmb/osteoactivin, an attractive target in cancer immunotherapy. Neoplasma 2012, 59, 1-5.
-
(2012)
Neoplasma
, vol.59
, pp. 1-5
-
-
Zhou, L.T.1
Liu, F.Y.2
Li, Y.3
Peng, Y.M.4
Liu, Y.H.5
Li, J.6
-
51
-
-
84892858761
-
A Randomized Phase 2 Study of the Antibody-Drug Conjugate CDX-011 in Advanced GPNMB-Overexpressing Breast Cancer: The EMERGE Study
-
Yardley, D.A.; Weaver, R.; Melisko, M.E.; Saleh, M.N.; Arena, F.P.; Forero, A.; Cigler, T.; Stopeck, A.; Citron, D.; Oliff, I.; et al. A Randomized Phase 2 Study of the Antibody-Drug Conjugate CDX-011 in Advanced GPNMB-Overexpressing Breast Cancer: The EMERGE Study. In Proceedings of the CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, USA, 4-8 December 2012.
-
Proceedings of the CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, USA, 4-8 December 2012
-
-
Yardley, D.A.1
Weaver, R.2
Melisko, M.E.3
Saleh, M.N.4
Arena, F.P.5
Forero, A.6
Cigler, T.7
Stopeck, A.8
Citron, D.9
Oliff, I.10
-
52
-
-
84892877657
-
ABT-414: An Anti-EGFR Antibody-Drug Conjugate as a Potential Therapeutic for the Treatment of Patients with Squamous Cell Tumors
-
Phillips, A.C.; Boghaert, E.R.; Vaidya, K.S.; Ansell, P.J.; Shalinsky, D.R.; Zhang, Y.; Voorbach, M.J.; Mudd, S.; Holen, K.D.; Humerickhouse, R.A.; et al. ABT-414: An Anti-EGFR Antibody-Drug Conjugate as a Potential Therapeutic for the Treatment of Patients with Squamous Cell Tumors. In Proceedings of the 25th EORTC-NCI-AACR Symposium on Molecular Targets Cancer Therapeutics, Boston, MA, USA, 19-23 October 2013.
-
Proceedings of the 25th EORTC-NCI-AACR Symposium on Molecular Targets Cancer Therapeutics, Boston, MA, USA, 19-23 October 2013
-
-
Phillips, A.C.1
Boghaert, E.R.2
Vaidya, K.S.3
Ansell, P.J.4
Shalinsky, D.R.5
Zhang, Y.6
Voorbach, M.J.7
Mudd, S.8
Holen, K.D.9
Humerickhouse, R.A.10
-
53
-
-
33646385331
-
Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen
-
Ma, D.; Hopf, C.E.; Malewicz, A.D.; Donovan, G.P.; Senter, P.D.; Goeckeler, W.F.; Maddon, P.J.; Olson, W.C. Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen. Clin. Cancer Res. 2006, 12, 2591-2596.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 2591-2596
-
-
Ma, D.1
Hopf, C.E.2
Malewicz, A.D.3
Donovan, G.P.4
Senter, P.D.5
Goeckeler, W.F.6
Maddon, P.J.7
Olson, W.C.8
-
54
-
-
80052740269
-
In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen
-
Wang, X.; Ma, D.; Olson, W.C.; Heston, W.D. In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen. Mol. Cancer Ther. 2011, 10, 1728-1739.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1728-1739
-
-
Wang, X.1
Ma, D.2
Olson, W.C.3
Heston, W.D.4
-
55
-
-
84880072016
-
DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma
-
Li, D.; Poon, K.A.; Yu, S.F.; Dere, R.; Go, M.; Lau, J.; Zheng, B.; Elkins, K.; Danilenko, D.; Kozak, K.R.; et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma, Mol. Cancer Ther. 2013, 12, 1255-1265.
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 1255-1265
-
-
Li, D.1
Poon, K.A.2
Yu, S.F.3
Dere, R.4
Go, M.5
Lau, J.6
Zheng, B.7
Elkins, K.8
Danilenko, D.9
Kozak, K.R.10
-
56
-
-
84859224663
-
Astellas' drug discovery strategy: Focus on oncology
-
Yanagita, Y.; Takenaka, T. Astellas' drug discovery strategy: Focus on oncology. Jpn. J. Clin. Oncol. 2012, 42, 241-246.
-
(2012)
Jpn. J. Clin. Oncol.
, vol.42
, pp. 241-246
-
-
Yanagita, Y.1
Takenaka, T.2
-
57
-
-
84892875271
-
Development of AGS-22M6E, a Novel Antibody Drug Conjugate (ADC) Targeting Nectin-4 for the Treatment of Solid Tumors
-
Abstract 2832
-
Satpayev, D.; Torgov, M.; Yang, P.; Morrison, K.; Shostak, Y.; Raitano, A.; Liu, W.; Lortie, D.; An, Z.; Capo, L.; et al. Development of AGS-22M6E, a Novel Antibody Drug Conjugate (ADC) Targeting Nectin-4 for the Treatment of Solid Tumors. In Proceedings of the 102nd Annual Meeting American Association Cancer Research (AACR), Orlando, FL, 2-6 April 2011; Abstract 2832.
-
Proceedings of the 102nd Annual Meeting American Association Cancer Research (AACR), Orlando, FL, 2-6 April 2011
-
-
Satpayev, D.1
Torgov, M.2
Yang, P.3
Morrison, K.4
Shostak, Y.5
Raitano, A.6
Liu, W.7
Lortie, D.8
An, Z.9
Capo, L.10
-
58
-
-
81955160713
-
Antibody drug conjugates - Trojan horses in the war on cancer
-
Iyer, U.; Kadambi, V.J. Antibody drug conjugates - Trojan horses in the war on cancer. J. Pharmacol. Toxicol. Methods 2011, 64, 207-212.
-
(2011)
J. Pharmacol. Toxicol. Methods
, vol.64
, pp. 207-212
-
-
Iyer, U.1
Kadambi, V.J.2
-
59
-
-
84892836755
-
Phase 1, Open Label, Dose-Escalation Studies of SGN-CD19A in Patients with Relapsed or Refractory B-Lineage Acute Leukemia and Non-Hodgkin Lymphoma
-
Abstract 2412
-
Albertson, T.M.; Sandalic, L.; Law, C.-L.; Broglio, K.; Berry, S. Phase 1, Open Label, Dose-Escalation Studies of SGN-CD19A in Patients with Relapsed or Refractory B-Lineage Acute Leukemia and Non-Hodgkin Lymphoma. In Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013; Abstract 2412.
-
Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013
-
-
Albertson, T.M.1
Sandalic, L.2
Law, C.-L.3
Broglio, K.4
Berry, S.5
-
60
-
-
0042738861
-
cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity
-
Francisco, J.A.; Cerveny, C.G.; Meyer, D.L.; Mixan, B.J.; Klussman, K.; Chace, D.F.; Rejniak, S.X.; Gordon, K.A.; DeBlanc, R.; Toki, B.E.; et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 2003, 102, 1458-1465.
-
(2003)
Blood
, vol.102
, pp. 1458-1465
-
-
Francisco, J.A.1
Cerveny, C.G.2
Meyer, D.L.3
Mixan, B.J.4
Klussman, K.5
Chace, D.F.6
Rejniak, S.X.7
Gordon, K.A.8
DeBlanc, R.9
Toki, B.E.10
-
61
-
-
84892895945
-
AGS-16M8F: A Novel Antibody Drug Conjugate (ADC) for Treating Renal and Liver Cancers
-
Abstract 328
-
Gudas, J.M.; Torgov, M.; An, Z.; Jia, X.C.; Morrison, K.J.; Morrison, R.K.; Kanner, S.B.; Raitano, A.B.; Jakobovits, A. AGS-16M8F: A Novel Antibody Drug Conjugate (ADC) for Treating Renal and Liver Cancers. In Proceedings of the Genitourinary Cancers Symposium, San Francisco, CA, USA, 5-7 March 2010; Abstract 328.
-
Proceedings of the Genitourinary Cancers Symposium, San Francisco, CA, USA, 5-7 March 2010
-
-
Gudas, J.M.1
Torgov, M.2
An, Z.3
Jia, X.C.4
Morrison, K.J.5
Morrison, R.K.6
Kanner, S.B.7
Raitano, A.B.8
Jakobovits, A.9
-
62
-
-
84892883113
-
Targeting MUC16 with the Antibody-Drug Conjugate (ADC) DMUC5754A in Patients with Platinum-Resistant Ovarian Cancer: A Phase I Study of Safety and Pharmacokinetics
-
Abstract LB-290
-
Liu, J.; Moore, K.; Birrer, M.; Berlin, S.; Matulonis, U.; Infante, J.; Xi, J.; Kahn, R.; Wang, Y.; Wood, K.; et al. Targeting MUC16 with the Antibody-Drug Conjugate (ADC) DMUC5754A in Patients with Platinum-Resistant Ovarian Cancer: A Phase I Study of Safety and Pharmacokinetics. In Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013; Abstract LB-290.
-
Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013
-
-
Liu, J.1
Moore, K.2
Birrer, M.3
Berlin, S.4
Matulonis, U.5
Infante, J.6
Xi, J.7
Kahn, R.8
Wang, Y.9
Wood, K.10
-
63
-
-
84892873099
-
A Phase I Study of the Safety and Pharmacokinetics of DNIB0600A, an Anti-NaPi2b Antibody-Drug-Conjugate (ADC), in Patients (pts) with Non-Small Cell Lung Cancer (NSCLC) and Platinum-Resistant Ovarian Cancer (OC)
-
Abstract 2507
-
Gordon, M.S.; Gerber, D.E.; Infante, J.R.; Xu, J.; Shames, D.S.; Choi, Y.; Kahn, R.S. A Phase I Study of the Safety and Pharmacokinetics of DNIB0600A, an Anti-NaPi2b Antibody-Drug-Conjugate (ADC), in Patients (pts) with Non-Small Cell Lung Cancer (NSCLC) and Platinum-Resistant Ovarian Cancer (OC). In proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013; Abstract 2507.
-
Proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013
-
-
Gordon, M.S.1
Gerber, D.E.2
Infante, J.R.3
Xu, J.4
Shames, D.S.5
Choi, Y.6
Kahn, R.S.7
-
64
-
-
84872529363
-
Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
-
Sapra, P.; Damelin, M.; Dijoseph, J.; Marquette, K.; Geles, K.G.; Golas, J.; Dougher, M.; Narayanan, B.; Giannakou, A.; Khandke, K.; et al. Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells. Mol. Cancer Ther. 2013, 12, 38-47.
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 38-47
-
-
Sapra, P.1
Damelin, M.2
Dijoseph, J.3
Marquette, K.4
Geles, K.G.5
Golas, J.6
Dougher, M.7
Narayanan, B.8
Giannakou, A.9
Khandke, K.10
-
65
-
-
84892845663
-
-
Available online: accessed on 12 November 2013
-
Product Development Portfolio. Available online: http://www.roche.com/ research-and-development/ who-we-are-how-we-work/pipeline.htm (accessed on 12 November 2013).
-
Product Development Portfolio
-
-
-
66
-
-
84892843101
-
Cysteine Engineered Antibodies and Conjugates
-
US 2011/0301334 A1, 7 June
-
Bhakta, S.; Junutula, J.R. Cysteine Engineered Antibodies and Conjugates. US 2011/0301334 A1, 7 June 2011.
-
(2011)
-
-
Bhakta, S.1
Junutula, J.R.2
-
67
-
-
80054794058
-
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats
-
Boswell, C.A.; Mundo, E.E.; Zhang, C.; Bumbaca, D.; Valle, N.R.; Kozak, K.R.; Fourie, A.; Chuh, J.; Koppada, N.; Saad, O.; et al. Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats. Bioconjug. Chem. 2011, 22, 1994-2004.
-
(2011)
Bioconjug. Chem.
, vol.22
, pp. 1994-2004
-
-
Boswell, C.A.1
Mundo, E.E.2
Zhang, C.3
Bumbaca, D.4
Valle, N.R.5
Kozak, K.R.6
Fourie, A.7
Chuh, J.8
Koppada, N.9
Saad, O.10
-
68
-
-
84866735537
-
Pharmacokinetic considerations for antibody drug conjugates
-
Lin, K.; Tibbitts, J. Pharmacokinetic considerations for antibody drug conjugates. Pharm. Res. 2012, 29, 2354-2366.
-
(2012)
Pharm. Res.
, vol.29
, pp. 2354-2366
-
-
Lin, K.1
Tibbitts, J.2
-
69
-
-
84892838430
-
A Phase I Study of the Safety and Pharmacokinetics of DSTP3086S, an Anti-STEAP1 Antibody-Drug Conjugate (ADC), in Patients (pts) with Metastatic Castration-Resistant Prostate Cancer (CRPC)
-
Abstract 5020
-
Danila, D.C.; Szmulewitz, R.Z.; Higano, C.S.; Gilbert, H.; Kahn, R.S.; Wood, K.; Agarwal, P.; Lin, K.; Kabbarah, O.; Fine, B.M.; et al. A Phase I Study of the Safety and Pharmacokinetics of DSTP3086S, an Anti-STEAP1 Antibody-Drug Conjugate (ADC), in Patients (pts) with Metastatic Castration-Resistant Prostate Cancer (CRPC). In proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013; Abstract 5020.
-
Proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013
-
-
Danila, D.C.1
Szmulewitz, R.Z.2
Higano, C.S.3
Gilbert, H.4
Kahn, R.S.5
Wood, K.6
Agarwal, P.7
Lin, K.8
Kabbarah, O.9
Fine, B.M.10
-
70
-
-
84892845409
-
The Investigational Drug MLN0264 First-in-Human, First in Class ADC Targeting GCC: Phase I Dose-Escalation Study and Supportive Scientific Rationale
-
Abstract 329
-
Veiby, P.; Zhang, J.; Yang, J.; McDonald, A.; Fasanmade, A.; Wyant, T.; Almhanna, K.; Kalebic, T. The Investigational Drug MLN0264 First-in-Human, First in Class ADC Targeting GCC: Phase I Dose-Escalation Study and Supportive Scientific Rationale. In Proceedings of the 24th EORTC-NCI-AACR Symposium Molecular Targets Cancer Therapeutics, Dublin, Ireland, 6-9 November 2012; Abstract 329.
-
Proceedings of the 24th EORTC-NCI-AACR Symposium Molecular Targets Cancer Therapeutics, Dublin, Ireland, 6-9 November 2012
-
-
Veiby, P.1
Zhang, J.2
Yang, J.3
McDonald, A.4
Fasanmade, A.5
Wyant, T.6
Almhanna, K.7
Kalebic, T.8
-
71
-
-
84892888753
-
MLN0264, an Investigational, First-in-Class Antibody-Drug Conjugate (ADC) Targeting Guanylyl Cyclase C (GCC), Demonstrates Antitumor Activity Alone and in Combination with Gemcitabine in Human Pancreatic Cancer Xenograft Models Expressing GCC
-
Abstract B194
-
Zhang, J.; Gallery, M.; Wyant, T.; Stringer, B.; Manfredi, M.; DAnaee, H.; Veiby, P. MLN0264, an Investigational, First-in-Class Antibody-Drug Conjugate (ADC) Targeting Guanylyl Cyclase C (GCC), Demonstrates Antitumor Activity Alone and in Combination with Gemcitabine in Human Pancreatic Cancer Xenograft Models Expressing GCC. In Proceedings of the 25th EORTC-NCI-AACR Symposium Molecular Targets Cancer Therapeutics, Boston, MA, USA, 19-23 October 2013; Abstract B194.
-
Proceedings of the 25th EORTC-NCI-AACR Symposium Molecular Targets Cancer Therapeutics, Boston, MA, USA, 19-23 October 2013
-
-
Zhang, J.1
Gallery, M.2
Wyant, T.3
Stringer, B.4
Manfredi, M.5
DAnaee, H.6
Veiby, P.7
-
72
-
-
84892898297
-
SGN-LIV1A: A Development Stage Antibody Drug-Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer
-
Abstract 3962
-
Sussman, D.; Smith, L.M.; Anderson, M.E.; Duniho, S.; Hunter, J.H.; Kostner, H.; Miyamoto, J.B.; Nesterova, A.; Westendorf, L.; van Epps, H.A.; et al. SGN-LIV1A: A Development Stage Antibody Drug-Conjugate Targeting LIV-1 for the Treatment of Metastatic Breast Cancer. In Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013; Abstract 3962.
-
Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013
-
-
Sussman, D.1
Smith, L.M.2
Anderson, M.E.3
Duniho, S.4
Hunter, J.H.5
Kostner, H.6
Miyamoto, J.B.7
Nesterova, A.8
Westendorf, L.9
Van Epps, H.A.10
-
73
-
-
84892854954
-
SLITRK6, the Target of a Novel Antibody Drug Conjugate AGS15E, is Expressed in Bladder and Other Cancers
-
Abstract 1274
-
Yang, P.; Coleman, J.; Li, Y.; Zhang, Y.; Junge, C.; Morrison, K.; Donate, F.; Stover, D.; Morrison, K. SLITRK6, the Target of a Novel Antibody Drug Conjugate AGS15E, is Expressed in Bladder and Other Cancers. In Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013; Abstract 1274.
-
Proceedings of the 104th Annual Meeting American Association Cancer Research (AACR), Washington, DC, USA, 6-10 April 2013
-
-
Yang, P.1
Coleman, J.2
Li, Y.3
Zhang, Y.4
Junge, C.5
Morrison, K.6
Donate, F.7
Stover, D.8
Morrison, K.9
-
74
-
-
84892859190
-
Human Antibodies and Antibody-Drug Conjugates Against CD74
-
WO 2012/104344A1, 9 August
-
Verploegen, S.; Overdijk, M.; van Dijkhuizen, R.; Bleeker, W.K.; van Berkel, P.; Parren, P.; Lisby, S. Human Antibodies and Antibody-Drug Conjugates Against CD74. WO 2012/104344A1, 9 August 2012.
-
(2012)
-
-
Verploegen, S.1
Overdijk, M.2
Van Dijkhuizen, R.3
Bleeker, W.K.4
Van Berkel, P.5
Parren, P.6
Lisby, S.7
-
75
-
-
84892878422
-
Use of an Antibody-Drug Conjugate Targeting Tissue Factor to Induce Complete Tumor Regression in Xenograft Models with Heterogeneous Target Expression
-
Breij, E.C.W.; Satijn, D.; Verploegen, S.; de Goeij, B.E.; Schuurhuis, D.H.; Bleeker, W.K.; Houtkamp, M.; Parren, P.W. Use of an Antibody-Drug Conjugate Targeting Tissue Factor to Induce Complete Tumor Regression in Xenograft Models with Heterogeneous Target Expression. In Proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013.
-
Proceedings of the 2013 ASCO Annual Meeting, Chicago, IL, USA, 31 May-4 June 2013
-
-
Breij, E.C.W.1
Satijn, D.2
Verploegen, S.3
De Goeij, B.E.4
Schuurhuis, D.H.5
Bleeker, W.K.6
Houtkamp, M.7
Parren, P.W.8
-
76
-
-
8944251155
-
Novel Antiviral and Cytotoxic Agent
-
WO 9104985 A1, 19 April
-
Rinehart, K.L., Jr.; Lithgow-Bertelloni, A.M. Novel Antiviral and Cytotoxic Agent. WO 9104985 A1, 19 April 1991.
-
(1991)
-
-
Rinehart Jr., K.L.1
Lithgow-Bertelloni, A.M.2
-
77
-
-
84892844065
-
Semi-synthetic studies toward didemnin analogues
-
WO 98/17275, 24 October
-
Rinehart, K.L., Jr.; Katauskas, A.J. Semi-synthetic studies toward didemnin analogues. WO 98/17275, 24 October 1997.
-
(1997)
-
-
Rinehart Jr., K.L.1
Katauskas, A.J.2
-
79
-
-
0031045880
-
Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution
-
Jou, G.; González, I.; Albericio, F.; Lloyd-Williams, P.; Giralt, E. Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution. J. Org. Chem. 1997, 62, 354-366.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 354-366
-
-
Jou, G.1
González, I.2
Albericio, F.3
Lloyd-Williams, P.4
Giralt, E.5
-
80
-
-
84892862872
-
Procedimiento de Preparación de Didemnina A
-
ES 2102322, 16 July (in Spanish)
-
Giralt, E.; Albericio, F.; Lloyd-Williams, P.; González-Valcarcel, I.; Jou, G.; Gómez, A.; Manzanares, I. Procedimiento de Preparación de Didemnina A. ES 2102322, 16 July 1997 (in Spanish).
-
(1997)
-
-
Giralt, E.1
Albericio, F.2
Lloyd-Williams, P.3
González-Valcarcel, I.4
Jou, G.5
Gómez, A.6
Manzanares, I.7
-
81
-
-
84863230144
-
Didemnins, tamandarins and related natural products
-
Lee, J.; Currano, J.N.; Carroll, P.J.; Joullie, M.M. Didemnins, tamandarins and related natural products. Nat. Prod. Rep. 2012, 29, 404-424.
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 404-424
-
-
Lee, J.1
Currano, J.N.2
Carroll, P.J.3
Joullie, M.M.4
-
82
-
-
84876928396
-
Ecteinascidin-743 (Yondelis®). Aplidin® and Irvalec®
-
2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA
-
Cuevas, C.; Francesch, A.; Galmarini, C.M.; Aviles, P.; Munt, S. Ecteinascidin-743 (Yondelis®). Aplidin® and Irvalec®. In Anticancer Agents from Natural Products, 2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA, 2012; pp. 291-316.
-
(2012)
Anticancer Agents from Natural Products
, pp. 291-316
-
-
Cuevas, C.1
Francesch, A.2
Galmarini, C.M.3
Aviles, P.4
Munt, S.5
-
83
-
-
84856213732
-
A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An innovative therapies for children with cancer (ITCC) study
-
Geoerger, B.; Estlin, E.J.; Aerts, I.; Kearns, P.; Gibson, B.; Corradini, N.; Doz, F.; Lardelli, P.; Miguel, B.D.; Soto, A.; et al. A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An innovative therapies for children with cancer (ITCC) study. Eur. J. Cancer 2012, 48, 289-296.
-
(2012)
Eur. J. Cancer
, vol.48
, pp. 289-296
-
-
Geoerger, B.1
Estlin, E.J.2
Aerts, I.3
Kearns, P.4
Gibson, B.5
Corradini, N.6
Doz, F.7
Lardelli, P.8
Miguel, B.D.9
Soto, A.10
-
84
-
-
84861409243
-
Bacterial biosynthesis and maturation of the didemnin anti-cancer agents
-
Xu, Y.; Kersten, R.D.; Nam, S.-J.; Lu, L.; Al-Suwailem, A.M.; Zheng, H.; Fenical, W.; Dorrestein, P.C.; Moore, B.S.; Qian, P.-Y. Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J. Am. Chem. Soc. 2012, 134, 8625-8632.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 8625-8632
-
-
Xu, Y.1
Kersten, R.D.2
Nam, S.-J.3
Lu, L.4
Al-Suwailem, A.M.5
Zheng, H.6
Fenical, W.7
Dorrestein, P.C.8
Moore, B.S.9
Qian, P.-Y.10
-
85
-
-
33845945597
-
Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia
-
Ashour, M.; Edrada, R.; Ebel, R.; Wray, V.; Wätjen, W.; Padmakumar, K.; Müller, W.E.; Lin, W.H.; Proksch, P. Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. J. Nat. Prod. 2006, 69, 1547-1553.
-
(2006)
J. Nat. Prod.
, vol.69
, pp. 1547-1553
-
-
Ashour, M.1
Edrada, R.2
Ebel, R.3
Wray, V.4
Wätjen, W.5
Padmakumar, K.6
Müller, W.E.7
Lin, W.H.8
Proksch, P.9
-
86
-
-
84876074186
-
Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy
-
Von Schwarzenberg, K.; Vollmar, A.M. Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy. Cancer Lett. 2013, 332, 295-303.
-
(2013)
Cancer Lett.
, vol.332
, pp. 295-303
-
-
Von Schwarzenberg, K.1
Vollmar, A.M.2
-
87
-
-
80055016481
-
In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities
-
Shilabin, A.G.; Hamann, M.T. In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities. Bioorg. Med. Chem. 2011, 19, 6628-6632.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 6628-6632
-
-
Shilabin, A.G.1
Hamann, M.T.2
-
88
-
-
84884853147
-
Medicinal chemistry and chemical biology of diketopiperazine-type antimicrotubule and vascular-disrupting agents
-
Hayashi, Y.; Yamazaki-Nakamura, Y.; Yakushiji, F. Medicinal chemistry and chemical biology of diketopiperazine-type antimicrotubule and vascular-disrupting agents. Chem. Pharm. Bull. 2013, 61, 889-901.
-
(2013)
Chem. Pharm. Bull.
, vol.61
, pp. 889-901
-
-
Hayashi, Y.1
Yamazaki-Nakamura, Y.2
Yakushiji, F.3
-
89
-
-
84892891268
-
-
Scripps Institution of Oceanography, La Jolla, CA, USA. Personal Communication
-
Fenical, W. Scripps Institution of Oceanography, La Jolla, CA, USA. Personal Communication, 2013.
-
(2013)
-
-
Fenical, W.1
-
90
-
-
70349650687
-
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica
-
Nett, M.; Gulder, T.A.; Kale, A.J.; Hughes, C.C.; Moore, B.S. Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J. Med. Chem. 2009, 52, 6163-6167.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6163-6167
-
-
Nett, M.1
Gulder, T.A.2
Kale, A.J.3
Hughes, C.C.4
Moore, B.S.5
-
91
-
-
62149103377
-
Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
-
Fenical, W.; Jensen, P.R.; Palladino, M.A.; Lam, K.S.; Lloyd, G.K.; Potts, B.C. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorg. Med. Chem. 2009, 17, 2175-2180.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 2175-2180
-
-
Fenical, W.1
Jensen, P.R.2
Palladino, M.A.3
Lam, K.S.4
Lloyd, G.K.5
Potts, B.C.6
-
92
-
-
78650864040
-
Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations
-
Nguyen, H.; Ma, G.; Gladysheva, T.; Fremgen, T.; Romo, D. Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations. J. Org. Chem. 2011, 76, 2-12.
-
(2011)
J. Org. Chem.
, vol.76
, pp. 2-12
-
-
Nguyen, H.1
Ma, G.2
Gladysheva, T.3
Fremgen, T.4
Romo, D.5
-
93
-
-
84555190558
-
Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation
-
Lechner, A.; Eustáquio, A.S.; Gulder, T.A.; Hafner, M.; Moore, B.S. Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chem. Biol. 2011, 18, 1527-1536.
-
(2011)
Chem. Biol.
, vol.18
, pp. 1527-1536
-
-
Lechner, A.1
Eustáquio, A.S.2
Gulder, T.A.3
Hafner, M.4
Moore, B.S.5
-
94
-
-
78650691813
-
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution
-
Eustáquio, A.S.; Nam, S.J.; Penn, K.; Lechner, A.; Wilson, M.C.; Fenical, W.; Jensen, P.R.; Moore, B.S. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem 2011, 12, 61-64.
-
(2011)
Chembiochem
, vol.12
, pp. 61-64
-
-
Eustáquio, A.S.1
Nam, S.J.2
Penn, K.3
Lechner, A.4
Wilson, M.C.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
95
-
-
84880014851
-
Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds
-
Martin, M.J.; Coello, L.; Fernandez, R.; Reyes, F.; Rodriguez, A.; Murcia, C.; Garranzo, M.; Mateo, C.; Sanchez-Sancho, F.; Bueno, S.; et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J. Am. Chem. Soc. 2013, 135, 10164-10171.
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 10164-10171
-
-
Martin, M.J.1
Coello, L.2
Fernandez, R.3
Reyes, F.4
Rodriguez, A.5
Murcia, C.6
Garranzo, M.7
Mateo, C.8
Sanchez-Sancho, F.9
Bueno, S.10
-
96
-
-
84880000244
-
New interfacial microtubule inhibitors of marine origin with potent antitumor activity and a distinct mechanism
-
Pera, B.; Barasoain, I.; Canales, A.; Matesanz, R.; Rodríguez- Salarichs, J.; García-Fernández, L.F.; Moneo, V.; Jiménez-Barbero, J.; Galmarini, C.M.; Cuevas, C.; et al. New interfacial microtubule inhibitors of marine origin with potent antitumor activity and a distinct mechanism. ACS Chem. Biol. 2013, 8, 2084-2094.
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 2084-2094
-
-
Pera, B.1
Barasoain, I.2
Canales, A.3
Matesanz, R.4
Rodríguez-Salarichs, J.5
García-Fernández, L.F.6
Moneo, V.7
Jiménez-Barbero, J.8
Galmarini, C.M.9
Cuevas, C.10
-
97
-
-
78049428148
-
Marine antitumor drugs: Status, shortfalls and strategies
-
Bhatnagar, I.; Kim, S.K. Marine antitumor drugs: Status, shortfalls and strategies. Mar. Drugs 2010, 8, 2702-2720.
-
(2010)
Mar. Drugs
, vol.8
, pp. 2702-2720
-
-
Bhatnagar, I.1
Kim, S.K.2
-
98
-
-
84876739313
-
Marine natural products and related compounds as anticancer agents: An overview of their clinical status
-
Petit, K.; Biard, J.-F. Marine natural products and related compounds as anticancer agents: An overview of their clinical status. Anticaner Agents Med. Chem. 2013, 13, 603-631.
-
(2013)
Anticaner Agents Med. Chem.
, vol.13
, pp. 603-631
-
-
Petit, K.1
Biard, J.-F.2
-
99
-
-
84886275968
-
The dolastatins: Novel Antitumor Agents from Dolabella auricularia
-
2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA
-
Flahive, E.; Srirangam, J. The dolastatins: Novel Antitumor Agents from Dolabella auricularia. In Anticancer Agents from Natural Products, 2nd ed.; Cragg, G.M., Kingston, D.G.I., Newman, D.J., Eds.; Taylor and Francis: Boca Raton, FL, USA, 2012; pp. 263-289.
-
(2012)
Anticancer Agents from Natural Products
, pp. 263-289
-
-
Flahive, E.1
Srirangam, J.2
|