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Volumn 13, Issue 4, 2013, Pages 603-631

Marine natural products and related compounds as anticancer agents: An overview of their clinical status

Author keywords

Brentuximab vedotin; Clinical trials; Cytarabine; Elisidepsin; Eribulin; ILX 651; KLH; Marine natural products; MMAE; MMAF; Plinabulin; Plitidepsin; PM00104; PM01183; PM060184; Salinosporamide A; Trabectedin; TZT 1027

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1, 3, 4 OCTADECANETRIOL; 1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1,3,4 OCTADECANETRIOL; AE 941; BRENTUXIMAB VEDOTIN; BRYOSTATIN 1; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; DEHYDRODIDEMNIN B; DOLASTATIN 10; DOXORUBUCIN; ELISIDEPSIN; ERIBULIN; ERLOTINIB; GEMCITABINE; GLEMBATUMUMAB VEDOTIN; KEYHOLE LIMPET HEMOCYANIN; LURBINECTEDIN; PEMETREXED; PLINABULIN; SALINOSPORAMIDE A; SOBLIDOTIN; SQUALAMINE; TASIDOTIN; TRABECTEDIN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACMUNE; VORINOSTAT; VORSETUZUMAB MAFODOTIN; ZALYPSIS;

EID: 84876739313     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520611313040010     Document Type: Review
Times cited : (42)

References (280)
  • 1
    • 84858308226 scopus 로고    scopus 로고
    • Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. J. Nat. Prod., 2012, 75, 311-335.
    • (2012) J. Nat. Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 2
    • 84862522237 scopus 로고    scopus 로고
    • WHO, Accessed February 27
    • WHO. Fact Sheet N 297. http://www.who.int/mediacentre/factsheets/fs297/en/ (Accessed February 27, 2012).
    • (2012) Fact Sheet
  • 3
    • 84856406381 scopus 로고    scopus 로고
    • Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology
    • Gerwick, W.H.; Moore, B.S. Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology. Chem. Biol, 2012, 19, 85-98.
    • (2012) Chem. Biol , vol.19 , pp. 85-98
    • Gerwick, W.H.1    Moore, B.S.2
  • 4
    • 4344650390 scopus 로고    scopus 로고
    • Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
    • Newman, D.J.; Cragg, G.M. Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials. J. Nat. Prod., 2004, 67, 1216-1238.
    • (2004) J. Nat. Prod , vol.67 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 6
    • 78649378628 scopus 로고    scopus 로고
    • Marine Drugs: Implications and Future Studies
    • Vignesh, S; Raja, A.; James, R.A. Marine Drugs: Implications and Future Studies. Int. J. Pharmacol, 2011, 7(1), 22-30.
    • (2011) Int. J. Pharmacol , vol.7 , Issue.1 , pp. 22-30
    • Vignesh, S.1    Raja, A.2    James, R.A.3
  • 7
    • 67649491097 scopus 로고    scopus 로고
    • A renaissance in marine pharmacology: From preclinical curiosity to clinical reality
    • Glaser, K.B.; Mayer, A.M. A renaissance in marine pharmacology: from preclinical curiosity to clinical reality. Biochem. Pharmacol, 2009, 78(5), 440-448.
    • (2009) Biochem. Pharmacol , vol.78 , Issue.5 , pp. 440-448
    • Glaser, K.B.1    Mayer, A.M.2
  • 8
    • 78449275105 scopus 로고    scopus 로고
    • The pharmaceutical value of marine biodiversity for anti-cancer drug discovery
    • Erwin, P.M.; Lopez-Legentil, S.; Schuhmann, P.W. The pharmaceutical value of marine biodiversity for anti-cancer drug discovery. Ecol. Econ., 2010, 70, 445-451.
    • (2010) Ecol. Econ , vol.70 , pp. 445-451
    • Erwin, P.M.1    Lopez-Legentil, S.2    Schuhmann, P.W.3
  • 9
    • 42249104716 scopus 로고    scopus 로고
    • Efficacy of Selected Natural Products as Therapeutic Agents against Cancer
    • Banerjee, S.; Wang, Z.; Mohammad, M.; Sarkar, F.H.; Mohammad, R.M. Efficacy of Selected Natural Products as Therapeutic Agents against Cancer. J. Nat. Prod., 2008, 77(3), 492-496.
    • (2008) J. Nat. Prod , vol.7 , Issue.3 , pp. 492-496
    • Banerjee, S.1    Wang, Z.2    Mohammad, M.3    Sarkar, F.H.4    Mohammad, R.M.5
  • 10
    • 78049428148 scopus 로고    scopus 로고
    • Marine Antitumor Drugs: Status, Shortfalls and Strategies
    • Bhatnagar, I.; Kim, S.K. Marine Antitumor Drugs: Status, Shortfalls and Strategies. Mar. Drugs, 2010, 8, 2702-2720.
    • (2010) Mar. Drugs , vol.8 , pp. 2702-2720
    • Bhatnagar, I.1    Kim, S.K.2
  • 11
    • 1942467043 scopus 로고    scopus 로고
    • Les antitumoraux d'origine marine
    • Biard J.F. Les antitumoraux d'origine marine. Oceanis, 2001, 27(3-4), 449-497.
    • (2001) Oceanis , vol.27 , Issue.3-4 , pp. 449-497
    • Biard, J.F.1
  • 12
    • 33646067755 scopus 로고    scopus 로고
    • Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience
    • Cragg, G.M.; Newman, D.J.; Yang, S.S. Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience. J. Nat. Prod., 2006, 69, 488-498.
    • (2006) J. Nat. Prod , vol.69 , pp. 488-498
    • Cragg, G.M.1    Newman, D.J.2    Yang, S.S.3
  • 13
    • 62149117325 scopus 로고    scopus 로고
    • Discovery of natural product anticancer agents from biodiverse organisms
    • Kinghorn, A.D.; Chin, Y.W.; Swanson, S.M. Discovery of natural product anticancer agents from biodiverse organisms. Curr. Opin. Drug Disc, 2009, 7252, 189-196.
    • (2009) Curr. Opin. Drug Disc , vol.7 , Issue.252 , pp. 189-196
    • Kinghorn, A.D.1    Chin, Y.W.2    Swanson, S.M.3
  • 14
    • 79953240916 scopus 로고    scopus 로고
    • Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation
    • Kingston, D.G.I. Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation. J. Nat Prod., 2011, 74, 496-511.
    • (2011) J. Nat Prod , vol.74 , pp. 496-511
    • Kingston, D.G.I.1
  • 15
    • 33748125863 scopus 로고    scopus 로고
    • Marine pharmacology in 2003-2004: Anti-tumor and cytotoxic compounds
    • Mayer, A.M.S.; Gustafson, K.R. Marine pharmacology in 2003-2004: Anti-tumor and cytotoxic compounds. Eur. J. Cancer, 2006, 42(14), 2241-2270.
    • (2006) Eur. J. Cancer , vol.42 , Issue.14 , pp. 2241-2270
    • Mayer, A.M.S.1    Gustafson, K.R.2
  • 16
    • 54249139074 scopus 로고    scopus 로고
    • Marine pharmacology in 2005-2006: Antitumor and cytotoxic compounds
    • Mayer, A.M.S.; Gustafson, K.R. Marine pharmacology in 2005-2006: Antitumor and cytotoxic compounds. Eur. J. Cancer, 2008, 44(16), 2357-2387.
    • (2008) Eur. J. Cancer , vol.44 , Issue.16 , pp. 2357-2387
    • Mayer, A.M.S.1    Gustafson, K.R.2
  • 19
    • 52749092934 scopus 로고    scopus 로고
    • Clinical Status of Anti-Cancer Agents Derived from Marine Sources
    • Singh, R.; Sharma, M.; Joshi, P.; Rawat, D.S. Clinical Status of Anti-Cancer Agents Derived from Marine Sources. Anti-Cancer Agents-Med. Chem., 2008, 8, 603-617.
    • (2008) Anti-Cancer Agents-Med. Chem , vol.8 , pp. 603-617
    • Singh, R.1    Sharma, M.2    Joshi, P.3    Rawat, D.S.4
  • 20
    • 84876704336 scopus 로고    scopus 로고
    • Cochrane library, Accessed February 27
    • Cochrane library. http://www.mrw.interscience.wiley.com/cochrane/cochrane_clcentral_articles_fs.html (Accessed February 27, 2012).
    • (2012)
  • 21
    • 84876700208 scopus 로고    scopus 로고
    • Clinical trials, Accessed February 27
    • Clinical trials. http://clinicaltrials.gov/ct2/home (Accessed February 27, 2012).
    • (2012)
  • 22
    • 84876699714 scopus 로고    scopus 로고
    • WHO, Accessed February 27
    • WHO. http://apps.who.int/trialsearch/ (Accessed February 27, 2012).
    • (2012)
  • 23
    • 84876695910 scopus 로고    scopus 로고
    • nstitut National du Cancer, Accessed February 27
    • Institut National du Cancer. http://www.e-cancer.fr/recherche/recherche-clinique/registre-des-essais-cliniques/registre-des-essais-cliniques (Accessed February 27, 2012).
    • (2012)
  • 25
    • 84876703491 scopus 로고    scopus 로고
    • FPMA Clinical trials portal., Accessed February 27
    • IFPMA Clinical trials portal. http://clinicaltrials.ifpma.org/clinicaltrials/no_cache/fr/monportail/index.htm (Accessed February 27, 2012).
    • (2012)
  • 26
    • 84876723284 scopus 로고    scopus 로고
    • Accessed February 27
    • Canadian cancer trials. http://www.canadiancancertrials.ca/Default.aspx?lang=fr (Accessed February 27, 2012).
    • (2012) Canadian Cancer Trials
  • 27
    • 84876701743 scopus 로고    scopus 로고
    • National Cancer Institute, Accessed February 27
    • National Cancer Institute. http://www.cancer.gov/clinicaltrials (Accessed February 27, 2012).
    • (2012)
  • 28
    • 84868566361 scopus 로고    scopus 로고
    • Accessed February 27
    • Current controlled trials. http://www.controlled-trials.com/ (Accessed February 27, 2012).
    • (2012) Current Controlled Trials
  • 29
    • 84876706840 scopus 로고    scopus 로고
    • Accessed February 27
    • The marine pharmaceutical pipeline. http://marinepharmacology.midwestern.edu/clinPipeline.htm (Accessed February 27, 2012).
    • (2012) The Marine Pharmaceutical Pipeline
  • 30
    • 84876707541 scopus 로고    scopus 로고
    • Accessed February 27
    • Internet drug index. http://www.rxlist.com/(Accessed February 27, 2012).
    • (2012) Internet Drug Index
  • 31
  • 33
    • 84876730072 scopus 로고    scopus 로고
    • Aska Pharmaceutical, Accessed February 27
    • Aska Pharmaceutical. http://www.aska-pharma.co.jp/english/ (Accessed February 27, 2012).
    • (2012)
  • 34
    • 84876703060 scopus 로고    scopus 로고
    • Bedford laboratories, Accessed February 27
    • Bedford laboratories. http://www.bedfordlabs.com/ (Accessed February 27, 2012).
    • (2012)
  • 35
    • 84876741323 scopus 로고    scopus 로고
    • Biosyn, Accessed February 27
    • Biosyn. http://www.biosyncorp.com/bc_downloads/vacmune.pdf (Accessed February 27, 2012).
    • (2012)
  • 36
    • 84876721527 scopus 로고    scopus 로고
    • Eisai Inc, ccessed February 27
    • Eisai Inc. http://www.eisai.com/ (Accessed February 27, 2012).
    • (2012)
  • 37
    • 84876728113 scopus 로고    scopus 로고
    • Enzon Pharmaceuticals, Accessed February 27
    • Enzon Pharmaceuticals. http://enzon.com/(Accessed February 27, 2012).
    • (2012)
  • 38
    • 84876696605 scopus 로고    scopus 로고
    • Genzyme Corporation, Accessed February 27
    • Genzyme Corporation. http://www.genzyme.com/ (Accessed February 27, 2012).
    • (2012)
  • 39
    • 84876731087 scopus 로고    scopus 로고
    • Nereus Pharmaceuticals, Accessed February 27
    • Nereus Pharmaceuticals. http://www.nereuspharm.com/ (Accessed February 27, 2012).
    • (2012)
  • 40
    • 84876744805 scopus 로고    scopus 로고
    • PharmaMar, Accessed February 27
    • PharmaMar. http://www.pharmamar.com/ (Accessed February 27, 2012).
    • (2012)
  • 41
    • 84876710838 scopus 로고    scopus 로고
    • Accessed February 27
    • Seattle Genetics. http://www.seagen.com/(Accessed February 27, 2012).
    • (2012) Seattle Genetics
  • 42
    • 0000719402 scopus 로고
    • Contributions to the study of marine products. XXXII. The nucleosides of sponges I
    • Bergmann, W.; Feeney, R.J. Contributions to the study of marine products. XXXII. The nucleosides of sponges I. J. Org. Chem., 1951, 16(6), 981-987.
    • (1951) J. Org. Chem , vol.16 , Issue.6 , pp. 981-987
    • Bergmann, W.1    Feeney, R.J.2
  • 43
    • 9144248691 scopus 로고    scopus 로고
    • Antiviral Drugs - a short history of their discovery and development
    • Field, H. J.; De Clercq, E. Antiviral Drugs - a short history of their discovery and development. Microbiology Today, 2004, 31, 58-61.
    • (2004) Microbiology Today , vol.31 , pp. 58-61
    • Field, H.J.1    de Clercq, E.2
  • 44
    • 84858031069 scopus 로고    scopus 로고
    • National Cancer Institute, Accessed April 11
    • National Cancer Institute. Cancer Drug Information. http://www.cancer.gov/cancertopics/druginfo/cytarabine (Accessed April 11, 2012).
    • (2012) Cancer Drug Information
  • 48
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 trial
    • Burnett, A.K.; Hills, R.K.; Milligan, D.; Kjeldsen, L.; Kell, J.; Russell, N.H.; Yin, J.A.; Hunter, A.; Goldstone, A.H.; Wheatley, K. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J. Clin. Oncol., 2011, 29(4), 369-377.
    • (2011) J. Clin. Oncol , vol.29 , Issue.4 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6    Yin, J.A.7    Hunter, A.8    Goldstone, A.H.9    Wheatley, K.10
  • 51
    • 0033485264 scopus 로고    scopus 로고
    • Keyhole limpet hemocyanin (KLH): A biomedical review
    • Harris, J.R.; Markl, J. Keyhole limpet hemocyanin (KLH): a biomedical review. Micron., 1999, 30(6), 597-623.
    • (1999) Micron , vol.30 , Issue.6 , pp. 597-623
    • Harris, J.R.1    Markl, J.2
  • 52
    • 84876700273 scopus 로고    scopus 로고
    • Stellar Biotechnologieds, Accessed April 11, http://stellarbiotechnologies.com/
    • Stellar Biotechnologieds. Stellar KLH® Protein. http://stellarbiotechnologies.com/products/protein (Accessed April 11, 2012).http://stellarbiotechnologies.com/
    • (2012) Stellar KLH® Protein
  • 53
    • 84876724025 scopus 로고    scopus 로고
    • Products and solutions
    • Biosyn, Accessed April 11
    • Biosyn. Products and solutions. Keyhole Limpet Hemocyanin. http://www.biosyncorp.com/bc_seiten/bc_products.html (Accessed April 11, 2012).
    • (2012) Keyhole Limpet Hemocyanin
  • 54
    • 0015971044 scopus 로고
    • Immunologic reduction of bladder cancer recurrence rate
    • Olsson, C.A.; Chute, R.; Rao, C.N. Immunologic reduction of bladder cancer recurrence rate. J. Urol., 1974, 111(2), 173-176.
    • (1974) J. Urol , vol.111 , Issue.2 , pp. 173-176
    • Olsson, C.A.1    Chute, R.2    Rao, C.N.3
  • 55
    • 0038346717 scopus 로고    scopus 로고
    • Laboratory and Clinical Experience with Keyhole limpet hemocyanin (Immucothel) in Superficial Bladder Cancer
    • Lamm, D.L. Laboratory and Clinical Experience with Keyhole limpet hemocyanin (Immucothel) in Superficial Bladder Cancer. Journal für Urologie und Urogynäkologie, 2003, 10(2), 18-21.
    • (2003) Journal Für Urologie Und Urogynäkologie , vol.10 , Issue.2 , pp. 18-21
    • Lamm, D.L.1
  • 56
    • 0027453136 scopus 로고
    • Keyhole limpet hemocyanin immunotherapy of murine bladder cancer
    • Lamm, D.L; DeHaven, J.I.; Riggs, D.R.; Delgra, C.; Burrell, R. Keyhole limpet hemocyanin immunotherapy of murine bladder cancer. Urol. Res., 1993, 21(1), 33-37.
    • (1993) Urol. Res , vol.21 , Issue.1 , pp. 33-37
    • Lamm, D.L.1    Dehaven, J.I.2    Riggs, D.R.3    Delgra, C.4    Burrell, R.5
  • 57
    • 0034061940 scopus 로고    scopus 로고
    • Efficacy of prophylactic Immucothel in patients pretreated with conventional drugs to prevent recurrence of superficial bladder carcinoma
    • Echarti, C.; Jurincic-Winkler, C.D.; Klippel, K.F. Efficacy of prophylactic Immucothel in patients pretreated with conventional drugs to prevent recurrence of superficial bladder carcinoma. Eur. Urol., 2000, 37 Suppl 3, 50-53.
    • (2000) Eur. Urol , vol.37 , Issue.SUPPL. 3 , pp. 50-53
    • Echarti, C.1    Jurincic-Winkler, C.D.2    Klippel, K.F.3
  • 58
    • 0034102578 scopus 로고    scopus 로고
    • Keyhole limpet hemocyanin immunotherapy of bladder cancer: Laboratory and clinical studies
    • Lamm, D.L; DeHaven, J.I.; Riggs, D.R. Keyhole limpet hemocyanin immunotherapy of bladder cancer: laboratory and clinical studies. Eur Urol., 2000, 37 Suppl 3, 41-44.
    • (2000) Eur Urol , vol.37 , Issue.SUPPL. 3 , pp. 41-44
    • Lamm, D.L.1    Dehaven, J.I.2    Riggs, D.R.3
  • 59
    • 0029740038 scopus 로고    scopus 로고
    • Antibody response to keyhole limpet hemocyanin (KLH) treatment in patients with superficial bladder carcinoma
    • Jurincic-Winkler, C.D.; von der Kammer, H.; Beuth, J.; Scheit, K.H.; Klippel, K.F. Antibody response to keyhole limpet hemocyanin (KLH) treatment in patients with superficial bladder carcinoma. Anticancer Res., 1996, 16(4A), 2105-2110.
    • (1996) Anticancer Res , vol.16 , Issue.4 A , pp. 2105-2110
    • Jurincic-Winkler, C.D.1    von der Kammer, H.2    Beuth, J.3    Scheit, K.H.4    Klippel, K.F.5
  • 60
    • 0028024579 scopus 로고
    • Adjuvant immunotherapy with keyhole limpet hemocyanin in category PT 2 N+ and PT 3-4, No-N+, Mo renal cell carcinoma
    • Jurincic-Winkler, C.D.; Horlbeck, R.; von der Kammer, H.; Scheit, K.H.; Klippel, K.F. Adjuvant immunotherapy with keyhole limpet hemocyanin in category PT 2 N+ and PT 3-4, No-N+, Mo renal cell carcinoma. Wien Klin. Wochenschr., 1994, 106(14), 455-458.
    • (1994) Wien Klin. Wochenschr , vol.106 , Issue.14 , pp. 455-458
    • Jurincic-Winkler, C.D.1    Horlbeck, R.2    von der Kammer, H.3    Scheit, K.H.4    Klippel, K.F.5
  • 61
    • 0028349552 scopus 로고
    • Topical immunotherapy (KLH) vs. chemotherapy (Ethoglucid) in prevention of recurrence of superficial bladder cancer. A prospective randomized study
    • Flamm, J.; Donner, G.; Bucher, A.; Höltl, W.; Albrecht, W.; Havelec, L. Topical immunotherapy (KLH) vs. chemotherapy (Ethoglucid) in prevention of recurrence of superficial bladder cancer. A prospective randomized study. Urologe A., 1994, 33(2), 138-143.
    • (1994) Urologe A , vol.33 , Issue.2 , pp. 138-143
    • Flamm, J.1    Donner, G.2    Bucher, A.3    Höltl, W.4    Albrecht, W.5    Havelec, L.6
  • 62
    • 0026462675 scopus 로고
    • Postoperative long-term course of peripheral blood immune parameters and immunomodulating effects of keyhole limpet hemocyanin in patients with nonmetastatic renal cell carcinoma
    • Kleinknecht, S.; Bichler, K.H.; Strohmaier, W.L.; Postoperative long-term course of peripheral blood immune parameters and immunomodulating effects of keyhole limpet hemocyanin in patients with nonmetastatic renal cell carcinoma. Eur. Urol., 1992, 21(4), 315-322.
    • (1992) Eur. Urol , vol.21 , Issue.4 , pp. 315-322
    • Kleinknecht, S.1    Bichler, K.H.2    Strohmaier, W.L.3
  • 63
    • 0025976206 scopus 로고
    • Adjuvant topical chemotherapy versus immunotherapy in primary superficial transitional cell carcinoma of the bladder
    • Flamm, J.; Bucher, A. Adjuvant topical chemotherapy versus immunotherapy in primary superficial transitional cell carcinoma of the bladder. Br. J. Urol., 1991, 67(1), 70-73.
    • (1991) Br. J. Urol , vol.67 , Issue.1 , pp. 70-73
    • Flamm, J.1    Bucher, A.2
  • 64
    • 0026122298 scopus 로고
    • Intravesical prophylaxis of superficial bladder cancer with BCG and KLH-a prospective randomized trial
    • Kalble, T.; Mohring, K.; Ikinger, U.; Riedasch, G.; Staehler, G. Intravesical prophylaxis of superficial bladder cancer with BCG and KLH-a prospective randomized trial. Urologe A., 1991, 30(2), 118-121.
    • (1991) Urologe A , vol.30 , Issue.2 , pp. 118-121
    • Kalble, T.1    Mohring, K.2    Ikinger, U.3    Riedasch, G.4    Staehler, G.5
  • 65
    • 0025029747 scopus 로고
    • Recurrent superficial transitional cell carcinoma of the bladder: Adjuvant topical chemotherapy versus immunotherapy. A prospective randomized trial
    • Flamm, J.; Bucher, A.; Höltl, W.; Albrecht, W. Recurrent superficial transitional cell carcinoma of the bladder: adjuvant topical chemotherapy versus immunotherapy. A prospective randomized trial. J. Urol., 1990, 144(2 Pt 1), 260-263.
    • (1990) J. Urol , vol.144 , Issue.2 PART 1 , pp. 260-263
    • Flamm, J.1    Bucher, A.2    Höltl, W.3    Albrecht, W.4
  • 66
    • 0023934840 scopus 로고
    • Immunotherapy in bladder cancer with keyhole-limpet hemocyanin: A randomized study
    • Jurincic C.D., Engelmann U.; Gasch J.; Klippel K.F. Immunotherapy in bladder cancer with keyhole-limpet hemocyanin: a randomized study. J. Urol., 1988, 139(4), 723-726.
    • (1988) J. Urol , vol.139 , Issue.4 , pp. 723-726
    • Jurincic, C.D.1    Engelmann, U.2    Gasch, J.3    Klippel, K.F.4
  • 67
    • 0021719261 scopus 로고
    • Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide
    • Berd, D.; Maguire Jr., H.C.; Mastrangelo, M.J. Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide. Cancer Res., 1984, 44(11), 5439-5443.
    • (1984) Cancer Res , vol.44 , Issue.11 , pp. 5439-5443
    • Berd, D.1    Maguire, H.C.2    Mastrangelo, M.J.3
  • 68
    • 67649961713 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma
    • Freedman, A.; Neelapu, S.S.; Nichols, C.; Robertson, M.J.; Djulbegovic, B.; Winter, J.N.; Bender, J.F.; Gold, D.P.; Ghalie, R.G.; Stewart, M.E.; Esquibel, V.; Hamlin, P. Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma. J. Clin. Oncol, 2009, 27(18), 3036-3043.
    • (2009) J. Clin. Oncol , vol.27 , Issue.18 , pp. 3036-3043
    • Freedman, A.1    Neelapu, S.S.2    Nichols, C.3    Robertson, M.J.4    Djulbegovic, B.5    Winter, J.N.6    Bender, J.F.7    Gold, D.P.8    Ghalie, R.G.9    Stewart, M.E.10    Esquibel, V.11    Hamlin, P.12
  • 70
    • 0031007771 scopus 로고    scopus 로고
    • Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma-long-term results of a clinical trial
    • Hsu, F.J.; Caspar, C.B.; Czerwinski, D.; Kwak, L.W.; Liles, T.M.; Syrengelas, A.; Taidi-Laskowski, B.; Levy, R. Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma-long-term results of a clinical trial. Blood, 1997, 89(9), 3129-3135.
    • (1997) Blood , vol.89 , Issue.9 , pp. 3129-3135
    • Hsu, F.J.1    Caspar, C.B.2    Czerwinski, D.3    Kwak, L.W.4    Liles, T.M.5    Syrengelas, A.6    Taidi-Laskowski, B.7    Levy, R.8
  • 71
    • 0346994554 scopus 로고    scopus 로고
    • Clinical development of the STn-KLH vaccine (Theratope)
    • Ibrahim, N.K.; Murray, J.L. Clinical development of the STn-KLH vaccine (Theratope). Clin. Breast Cancer, 2003, 3 (Suppl 4), S139-143.
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4 , pp. 139-143
    • Ibrahim, N.K.1    Murray, J.L.2
  • 72
    • 0029804156 scopus 로고    scopus 로고
    • A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer
    • Miles, D.W.; Towlson, K.E.; Graham, R.; Reddish, M.; Longenecker, B.M.; Taylor-Papadimitriou, J.; Rubens, R.D. A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer. Brit. J. Cancer., 1996, 74(8), 1292-1296.
    • (1996) Brit. J. Cancer , vol.74 , Issue.8 , pp. 1292-1296
    • Miles, D.W.1    Towlson, K.E.2    Graham, R.3    Reddish, M.4    Longenecker, B.M.5    Taylor-Papadimitriou, J.6    Rubens, R.D.7
  • 73
    • 0029873154 scopus 로고    scopus 로고
    • Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine
    • MacLean, G.D.; Reddish, M.A.; Koganty; R.R.; Longenecker, B.M. Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine. J. Immunother. Emphasis Tumor Immunol, 1996, 19(1), 59-68.
    • (1996) J. Immunother. Emphasis Tumor Immunol , vol.19 , Issue.1 , pp. 59-68
    • Maclean, G.D.1    Reddish, M.A.2    Koganty, R.R.3    Longenecker, B.M.4
  • 74
    • 0034017617 scopus 로고    scopus 로고
    • Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: A dose-response study
    • Chapman, P.B.; Morrissey, D.M.; Panageas, K.S.; Hamilton, W.B.; Zhan, C; Destro, A.N.; Williams, L.; Israel, R.J.; Livingston, P.O. Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: a dose-response study. Clin. Cancer Res., 2000, 6(3), 874-879.
    • (2000) Clin. Cancer Res , vol.6 , Issue.3 , pp. 874-879
    • Chapman, P.B.1    Morrissey, D.M.2    Panageas, K.S.3    Hamilton, W.B.4    Zhan, C.5    Destro, A.N.6    Williams, L.7    Israel, R.J.8    Livingston, P.O.9
  • 75
    • 0034490177 scopus 로고    scopus 로고
    • Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: A trial comparing doses of G(D2)-keyhole limpet hemocyanin
    • Chapman, P.B.; Morrisey, D.; Panageas, K.S.; Williams, L.; Lewis, J.J.; Israel, R.J.; Hamilton, W.B.; Livingston, P.O. Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: a trial comparing doses of G(D2)-keyhole limpet hemocyanin. Clin. Cancer Res., 2000, 6(12), 4658-4662.
    • (2000) Clin. Cancer Res , vol.6 , Issue.12 , pp. 4658-4662
    • Chapman, P.B.1    Morrisey, D.2    Panageas, K.S.3    Williams, L.4    Lewis, J.J.5    Israel, R.J.6    Hamilton, W.B.7    Livingston, P.O.8
  • 76
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon a-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/ C509801
    • Kirkwood, J.M.; Ibrahim, J.G.; Sosman, J.A.; Sondak, V.K.; Agarwala, S.S.; Ernstoff, M.S.; Rao, U. High-dose interferon a-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/ C509801. J. Clin. Oncol, 2001, 19(9), 2370-2380.
    • (2001) J. Clin. Oncol , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3    Sondak, V.K.4    Agarwala, S.S.5    Ernstoff, M.S.6    Rao, U.7
  • 77
    • 0025070774 scopus 로고
    • Ecteinascidins 729, 743, 745, 759A, 759B, and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
    • erratum in: Rinehart, K.L. J. Org. Chem., 1991, 56(4), 1676
    • Rinehart, K.L.; Holt, T.G.; Fregeau, N.L.; Stroh, J.G.; Keifer, P.A.; Sun, F.; Li, L.H.; Martin, D.G. Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem., 1990, 55(15), 4512-4515 + erratum in: Rinehart, K.L. J. Org. Chem., 1991, 56(4), 1676.
    • (1990) J. Org. Chem , vol.55 , Issue.15 , pp. 4512-4515
    • Rinehart, K.L.1    Holt, T.G.2    Fregeau, N.L.3    Stroh, J.G.4    Keifer, P.A.5    Sun, F.6    Li, L.H.7    Martin, D.G.8
  • 78
    • 0024995421 scopus 로고
    • Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia Turbinata
    • Wright, A.E.; Forleo, D.A.; Gunawardana, G.P.; Gunasekera, S.P.; Koehn, F.E.; McConnell, O.J. Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata. J. Org. Chem., 1990, 55(15), 4508-4512.
    • (1990) J. Org. Chem , vol.55 , Issue.15 , pp. 4508-4512
    • Wright, A.E.1    Forleo, D.A.2    Gunawardana, G.P.3    Gunasekera, S.P.4    Koehn, F.E.5    McConnell, O.J.6
  • 80
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin-743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia Turbinata
    • Pommier, Y.; Kohlhagen, G.; Bailly, C; Waring, M.; Mazumder, A.; Kohn, K.W. DNA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin-743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry, 1996, 35, 13303-13309.
    • (1996) Biochemistry , vol.35 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 81
    • 0029944528 scopus 로고    scopus 로고
    • Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: Ecteinascidin 743, isohomohalichondrin-B and LL-15
    • Garcia-Rochal, M.; Garcia-Gravalos, M.D.; Avila, J. Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15. Brit. J. Cancer, 1996, 73, 875-883.
    • (1996) Brit. J. Cancer , vol.73 , pp. 875-883
    • Garcia-Rochal, M.1    Garcia-Gravalos, M.D.2    Avila, J.3
  • 82
    • 0031766324 scopus 로고    scopus 로고
    • In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients
    • Izbicka, E.; Lawrence, R.; Raymond, E.; Eckhardt, G.; Faircloth, G.; Jimeno, J.; Clark, G.; von Hoff; D.D. In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann. Oncol, 1998, 9, 981-987.
    • (1998) Ann. Oncol , vol.9 , pp. 981-987
    • Izbicka, E.1    Lawrence, R.2    Raymond, E.3    Eckhardt, G.4    Faircloth, G.5    Jimeno, J.6    Clark, G.7    von Hoff, D.D.8
  • 83
    • 84876700392 scopus 로고    scopus 로고
    • European Medicines Agency, Yondelis. Assessment history. Yondelis-H-C-773-II-08: EPAR-Assessment Report-Variation, ccessed April 11
    • European Medicines Agency. Human medicines. Yondelis. Assessment history. Yondelis-H-C-773-II-08: EPAR-Assessment Report-Variation. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/ 000773/WC500059175.pdf (Accessed April 11, 2012).
    • (2012) Human Medicines
  • 84
    • 84876700392 scopus 로고    scopus 로고
    • European Medicines Agency, Yondelis. Authorization details, ccessed April 11
    • European Medicines Agency. Human medicines. Yondelis. Authorization details. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000773/human_med_0 01165.jsp&jsenabled=true (Accessed April 11, 2012).
    • (2012) Human Medicines
  • 85
    • 84876700392 scopus 로고    scopus 로고
    • European Medicines Agency, Yondelis. Assessment history. Yondelis: EPAR-Product Information, Accessed April 11
    • European Medicines Agency. Human medicines. Yondelis. Assessment history. Yondelis: EPAR-Product Information. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000773/WC500045836.pdf (Accessed April 11, 2012).
    • (2012) Human Medicines
  • 86
    • 84876700392 scopus 로고    scopus 로고
    • European Medicines Agency, Yondelis. EMEA/CHMP/608550/2009, Accessed April 11
    • European Medicines Agency. Human medicines. Yondelis. EMEA/CHMP/608550/2009. http://www.ema.europa.eu/ema/pages/includes/document/open_document.jsp?webContentId=WC500059271 (Accessed April 11, 2012).
    • (2012) Human Medicines
  • 87
    • 84876700856 scopus 로고    scopus 로고
    • Johnson-Johnson website, News. All news. FDA Issues Complete Response Letter for Trabectedin Combined With DOXIL, Accessed April 11
    • Johnson-Johnson website. News. All news. FDA Issues Complete Response Letter for Trabectedin Combined With DOXIL. http://www.jnj.com/connect/news/all/20090910_130000 (Accessed April 11, 2012).
    • (2012)
  • 88
    • 84876730565 scopus 로고    scopus 로고
    • Pharmamar website. Products. Yondelis, Accessed April 11
    • Pharmamar website. Products. Yondelis. http://www.pharmamar. com/yondelis.aspx (Accessed April 11, 2012).
    • (2012)
  • 89
    • 77956884464 scopus 로고    scopus 로고
    • Correlation of CA-125 and RECIST evaluation in recurrent ovarian cancer (ROC): Results from a randomized phase III study of trabectedin (T) with pegylated liposomal doxorubicin (PLD) versus PLD alone
    • Herzog, T.J.; Vermorken, J.B.; Pujade-Lauraine, E.; Li, J.; Bayever, E.; Gomez, J.; Yovine, A.; Monk, B.J. Correlation of CA-125 and RECIST evaluation in recurrent ovarian cancer (ROC): results from a randomized phase III study of trabectedin (T) with pegylated liposomal doxorubicin (PLD) versus PLD alone. J. Clin. Oncol., 2009, 27(15s), 5550.
    • (2009) J. Clin. Oncol , vol.27 , Issue.15 S , pp. 5550
    • Herzog, T.J.1    Vermorken, J.B.2    Pujade-Lauraine, E.3    Li, J.4    Bayever, E.5    Gomez, J.6    Yovine, A.7    Monk, B.J.8
  • 90
    • 70350001556 scopus 로고    scopus 로고
    • Health-related quality of life/patient-reported outcomes in relapsed ovarian cancer: Results from a randomized phase III study of trabectedin with pegylated doxorubicin (PLD) versus PLD alone
    • Krasner, C.N.; Poveda, A.; Herzog, T.; Vermorken, J.; Monk, B.; Zintl, P.; Li, J.; Su, Y.; Dhawan, R.; Kaye, S. Health-related quality of life/patient-reported outcomes in relapsed ovarian cancer: results from a randomized phase III study of trabectedin with pegylated doxorubicin (PLD) versus PLD alone. J. Clin. Oncol., 2009, 27(15s), 5526.
    • (2009) J. Clin. Oncol , vol.27 , Issue.15 S , pp. 5526
    • Krasner, C.N.1    Poveda, A.2    Herzog, T.3    Vermorken, J.4    Monk, B.5    Zintl, P.6    Li, J.7    Su, Y.8    Dhawan, R.9    Kaye, S.10
  • 92
    • 78049445385 scopus 로고    scopus 로고
    • Extending platinum-free interval (PFI) in partially platinum-sensitive (PPS) patients (pts) with recurrent ovarian cancer (ROC) treated with trabectedin (Tr) plus pegylated liposomal doxorubicin (Tr+PLD) versus PLD alone: Results from a PPS cohort of a phase III study
    • Poveda, A.; Tjulandin, S.; Kong, B.; Roy, M.; Chan, S. Extending platinum-free interval (PFI) in partially platinum-sensitive (PPS) patients (pts) with recurrent ovarian cancer (ROC) treated with trabectedin (Tr) plus pegylated liposomal doxorubicin (Tr+PLD) versus PLD alone: results from a PPS cohort of a phase III study. J. Clin. Oncol., 2010, 28(7s), 5012.
    • (2010) J. Clin. Oncol , vol.28 , Issue.7 S , pp. 5012
    • Poveda, A.1    Tjulandin, S.2    Kong, B.3    Roy, M.4    Chan, S.5
  • 93
    • 84892785263 scopus 로고    scopus 로고
    • Influence of tumor control on tumor-related events (TRE) in relapsed ovarian cancer (ROC): Results from OVA-301, a randomized phase III study of trabectedin (Tr) with pegylated liposomal doxorubicin (PLD) versus PLD alone
    • Kong, B.; Biakhov, M.; Kelley, J.L.; Nunez, J.; Lebedinsky, C.; Parekh, T.V.; Vermorken, J.B. Influence of tumor control on tumor-related events (TRE) in relapsed ovarian cancer (ROC): results from OVA-301, a randomized phase III study of trabectedin (Tr) with pegylated liposomal doxorubicin (PLD) versus PLD alone. J. Clin. Oncol., 2010, 28(7s), e15529.
    • (2010) J. Clin. Oncol , vol.28 , Issue.7 S
    • Kong, B.1    Biakhov, M.2    Kelley, J.L.3    Nunez, J.4    Lebedinsky, C.5    Parekh, T.V.6    Vermorken, J.B.7
  • 96
    • 79960073564 scopus 로고    scopus 로고
    • Efficacy of trabectedin in platinum-sensitive-relapsed ovarian cancer: New data from the randomized OVA-301 study
    • Colombo, N. Efficacy of trabectedin in platinum-sensitive-relapsed ovarian cancer: new data from the randomized OVA-301 study. Int. J. Gynecol. Cancer, 2011, 21(10 Suppl 1), S12-6.
    • (2011) Int. J. Gynecol. Cancer , vol.21 , Issue.10 SUPPL. 1 , pp. 12-16
    • Colombo, N.1
  • 99
    • 84857594981 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: Current evidence and future perspectives
    • Sehouli, J.; Alfaro, V.; González-Martín, A. Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives. Ann. Oncol, 2012, 23(3), 556-562.
    • (2012) Ann. Oncol , vol.23 , Issue.3 , pp. 556-562
    • Sehouli, J.1    Alfaro, V.2    González-Martín, A.3
  • 100
    • 79951576840 scopus 로고    scopus 로고
    • Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: A phase II study of the Gynecologic Oncology Group
    • Monk, B.J.; Sill, M.W.; Hanjani, P.; Edwards, R.; Rotmensch, J.; De Geest, K.; Bonebrake, A.J.; Walker, J.L. Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol, 2011, 120(3), 459-463.
    • (2011) Gynecol Oncol , vol.120 , Issue.3 , pp. 459-463
    • Monk, B.J.1    Sill, M.W.2    Hanjani, P.3    Edwards, R.4    Rotmensch, J.5    de Geest, K.6    Bonebrake, A.J.7    Walker, J.L.8
  • 101
    • 84255167300 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma
    • Cioffi, A.; Italiano, A. Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma. Expert Opin. Drug Metab. Toxicol, 2012, 8(1), 113-122.
    • (2012) Expert Opin. Drug Metab. Toxicol , vol.8 , Issue.1 , pp. 113-122
    • Cioffi, A.1    Italiano, A.2
  • 102
    • 84886943184 scopus 로고    scopus 로고
    • Trabectedin for the treatment of advanced metastatic soft tissue sarcoma
    • Simpson, E.L.; Rafia, R.; Stevenson, M.D.; Papaioannou, D. Trabectedin for the treatment of advanced metastatic soft tissue sarcoma. Health Technol. Assess., 2010, 14(Suppl 1), 63-67.
    • (2010) Health Technol. Assess , vol.14 , Issue.SUPPL. 1 , pp. 63-67
    • Simpson, E.L.1    Rafia, R.2    Stevenson, M.D.3    Papaioannou, D.4
  • 103
    • 78049435500 scopus 로고    scopus 로고
    • Trabectedin for metastatic soft tissue sarcoma: A retrospective single center analysis
    • Schmitt, T.; Keller, E.; Dietrich, S.; Wuchter, P.; Ho, A.D.; Egerer, G. Trabectedin for metastatic soft tissue sarcoma: a retrospective single center analysis. Mar. Drugs., 2010, 8(10), 2647-2658.
    • (2010) Mar. Drugs , vol.8 , Issue.10 , pp. 2647-2658
    • Schmitt, T.1    Keller, E.2    Dietrich, S.3    Wuchter, P.4    Ho, A.D.5    Egerer, G.6
  • 104
    • 78650400907 scopus 로고    scopus 로고
    • Trabectedin in the treatment of metastatic soft tissue sarcoma: Cost-effectiveness, cost-utility and value of information
    • Soini, E.J.; García San Andrés, B.; Joensuu, T. Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information. Ann. Oncol, 2011, 22(1), 215-223.
    • (2011) Ann. Oncol , vol.22 , Issue.1 , pp. 215-223
    • Soini, E.J.1    García, S.A.B.2    Joensuu, T.3
  • 105
    • 79952220842 scopus 로고    scopus 로고
    • A Trabectedin: The evidence for its place in therapy in the treatment of soft tissue sarcoma
    • Thornton
    • Thornton, K.A Trabectedin: the evidence for its place in therapy in the treatment of soft tissue sarcoma. Core Evid., 2010, 15(4),191-198.
    • (2010) Core Evid , vol.15 , Issue.4 , pp. 191-198
    • Thornton, K.1
  • 108
    • 84857053120 scopus 로고    scopus 로고
    • A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group
    • Baruchel, S.; Pappo, A.; Krailo, M.; Baker, K.S.; Wu, B.; Villaluna, D.; Lee-Scott, M.; Adamson, P.C.; Blaney, S.M. A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group. Eur. J. Cancer, 2012, 48(4), 579-585.
    • (2012) Eur. J. Cancer , vol.48 , Issue.4 , pp. 579-585
    • Baruchel, S.1    Pappo, A.2    Krailo, M.3    Baker, K.S.4    Wu, B.5    Villaluna, D.6    Lee-Scott, M.7    Adamson, P.C.8    Blaney, S.M.9
  • 110
    • 83055194284 scopus 로고    scopus 로고
    • A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: A gynecologic oncology group study
    • Monk, B.J.; Blessing, J.A.; Street, D.G.; Muller, C.Y.; Burke, J.J.; Hensley, M.L. A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: A gynecologic oncology group study. Gynecol. Oncol, 2012, 124(1), 48-52.
    • (2012) Gynecol. Oncol , vol.124 , Issue.1 , pp. 48-52
    • Monk, B.J.1    Blessing, J.A.2    Street, D.G.3    Muller, C.Y.4    Burke, J.J.5    Hensley, M.L.6
  • 113
    • 72949093965 scopus 로고    scopus 로고
    • Long-term results of a randomized phase II study of trabectedin by two different dose and schedule regimens in patients with advanced liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide
    • Demetri, G.D.; Schuetze, S.; Blay, J.; Chawla, S.; von Mehren, M.; Casali, P.; Morris, D.; Bayever, E.; Alfaro, V.; LeCesne, A. Long-term results of a randomized phase II study of trabectedin by two different dose and schedule regimens in patients with advanced liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide. J. Clin. Oncol., 2009, 27(15S), 538.
    • (2009) J. Clin. Oncol , vol.27 , Issue.15 S , pp. 538
    • Demetri, G.D.1    Schuetze, S.2    Blay, J.3    Chawla, S.4    von Mehren, M.5    Casali, P.6    Morris, D.7    Bayever, E.8    Alfaro, V.9    Lecesne, A.10
  • 115
    • 80054120113 scopus 로고    scopus 로고
    • Final results of a phase II trial of trabectedin (T) in triple-negative, HER2-positive, and BRCA1/2 germ-line-mutated metastatic breast cancer (MBC) patients (pts)
    • Tedesco, K.L.; Blum, J.L.; Goncalves, A.; Lubinski, J.; Osborne, C.R.C.; Lardelli, P.; Tercero, J.C.; Flores, A.; Holmes, F.A.; Delaloge, S. Final results of a phase II trial of trabectedin (T) in triple-negative, HER2-positive, and BRCA1/2 germ-line-mutated metastatic breast cancer (MBC) patients (pts). J. Clin. Oncol., 2011, 29 (15, suppl), 1125.
    • (2011) J. Clin. Oncol , vol.29 , Issue.15 SUPPL. , pp. 1125
    • Tedesco, K.L.1    Blum, J.L.2    Goncalves, A.3    Lubinski, J.4    Osborne, C.R.C.5    Lardelli, P.6    Tercero, J.C.7    Flores, A.8    Holmes, F.A.9    Delaloge, S.10
  • 123
    • 84975897156 scopus 로고    scopus 로고
    • Newman, D.J.; Kingston, D.G.I.; Cragg, G.M., Eds.; Taylor & Francis: Washington, DC
    • Yu, M.J.; Kishi, Y.; Littlefield, B.A. In: Anticancer agents from natural products; Newman, D.J.; Kingston, D.G.I.; Cragg, G.M., Eds.; Taylor & Francis: Washington, DC, 2005: pp. 241-265.
    • (2005) Anticancer Agents From Natural Products , pp. 241-265
    • Yu, M.J.1    Kishi, Y.2    Littlefield, B.A.3
  • 124
    • 0022709534 scopus 로고
    • Halichondrins-antitumor polyether macrolides from a marine sponge
    • Hirata, Y.; Uemura, D. Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl. Chem., 1986, 58(5), 701-710.
    • (1986) Pure Appl. Chem , vol.58 , Issue.5 , pp. 701-710
    • Hirata, Y.1    Uemura, D.2
  • 125
    • 0026069885 scopus 로고
    • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
    • Bai, R.L.; Paull, K.D.; Herald, C.L.; Malspeis, L.; Pettit, G.R.; Hamel, E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J. Biol. Chem., 1991, 266(24), 15882-15889.
    • (1991) J. Biol. Chem , vol.266 , Issue.24 , pp. 15882-15889
    • Bai, R.L.1    Paull, K.D.2    Herald, C.L.3    Malspeis, L.4    Pettit, G.R.5    Hamel, E.H.B.6    Homohalichondrin, B.7
  • 126
    • 23144433687 scopus 로고    scopus 로고
    • The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    • Jordan, M.A.; Kamath, K.; Manna, T.; Okouneva, T.; Miller, H.P.; Davis, C.; Littlefield, B.A.; Wilson, L. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol. Cancer Ther., 2005, 4, 1086-1095.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1086-1095
    • Jordan, M.A.1    Kamath, K.2    Manna, T.3    Okouneva, T.4    Miller, H.P.5    Davis, C.6    Littlefield, B.A.7    Wilson, L.8
  • 127
    • 51049119664 scopus 로고    scopus 로고
    • Inhibition of Centromere Dynamics by Eribulin mesylate (E7389) during Mitotic Metaphase
    • Okouneva, T.; Azarenko, O.; Wilson, L.; Littlefield, B.A.; Jordan, M.A. Inhibition of Centromere Dynamics by Eribulin mesylate (E7389) during Mitotic Metaphase. Mol. Cancer Ther., 2008, 7(7), 2003-2011.
    • (2008) Mol. Cancer Ther , vol.7 , Issue.7 , pp. 2003-2011
    • Okouneva, T.1    Azarenko, O.2    Wilson, L.3    Littlefield, B.A.4    Jordan, M.A.5
  • 128
    • 76749127634 scopus 로고    scopus 로고
    • Eribulin mesylate Binds at Microtubule Ends to a Single Site on Tubulin to Suppress Dynamic Instability
    • Smith, J.A.; Wilson, L.; Azarenko, O.; Zhu, X.; Lewis, B.M.; Littlefield, B.A.; Jordan, M.A. Eribulin mesylate Binds at Microtubule Ends to a Single Site on Tubulin to Suppress Dynamic Instability. Biochemistry, 2010, 49(6), 1331-1337.
    • (2010) Biochemistry , vol.49 , Issue.6 , pp. 1331-1337
    • Smith, J.A.1    Wilson, L.2    Azarenko, O.3    Zhu, X.4    Lewis, B.M.5    Littlefield, B.A.6    Jordan, M.A.7
  • 129
    • 4143052665 scopus 로고    scopus 로고
    • Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analogue E7389
    • Kuznetsov, G.; Towle, M.J.; Cheng, H.; Kawamura, T.; TenDyke, K.; Liu, D.; Kishi, Y.; Yu, M.J.; Littlefield, B.A. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analogue E7389. Cancer Res., 2004, 64(16), 5760-5766.
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5760-5766
    • Kuznetsov, G.1    Towle, M.J.2    Cheng, H.3    Kawamura, T.4    Tendyke, K.5    Liu, D.6    Kishi, Y.7    Yu, M.J.8    Littlefield, B.A.9
  • 130
    • 78751525051 scopus 로고    scopus 로고
    • Eribulin mesylate induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions
    • Towle, M.J.; Salvato, K.A.; Wels, B.F.; Aalfs, K.K.; Zheng, W.; Seletsky, B.M.; Zhu, X.; Lewis, B.M.; Kishi, Y.; Yu, M.J.; Littlefield, B.A. Eribulin mesylate induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res., 2011, 71(2), 496-505.
    • (2011) Cancer Res , vol.71 , Issue.2 , pp. 496-505
    • Towle, M.J.1    Salvato, K.A.2    Wels, B.F.3    Aalfs, K.K.4    Zheng, W.5    Seletsky, B.M.6    Zhu, X.7    Lewis, B.M.8    Kishi, Y.9    Yu, M.J.10    Littlefield, B.A.11
  • 131
    • 84858031069 scopus 로고    scopus 로고
    • National Cancer Institute, Halaven, Accessed April 13
    • National Cancer Institute. Cancer Drug Information. Halaven. http://www.cancer.gov/cancertopics/druginfo/fda-eribulinmesylate (Accessed April 13, 2012).
    • (2012) Cancer Drug Information
  • 132
    • 79953152351 scopus 로고    scopus 로고
    • Eribulin mesylate: A promising new antineoplastic agent for locally advanced or metastatic breast cancer
    • Cortes, J.; Lorca, R. Eribulin mesylate: a promising new antineoplastic agent for locally advanced or metastatic breast cancer. Future Oncol., 2011, 7(3), 355-364.
    • (2011) Future Oncol , vol.7 , Issue.3 , pp. 355-364
    • Cortes, J.1    Lorca, R.2
  • 133
    • 84876741944 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence, Halaven, Accessed April 13
    • National Institute for Health and Clinical Excellence. Halaven. http://publications.nice.org.uk/eribulin-for-the-treatment-of-locally-advanced-or-metastatic-breast-cancer-ta250 (Accessed April 13, 2012).
    • (2012)
  • 134
    • 84876724893 scopus 로고    scopus 로고
    • Eisai Website. Research and Developmen, (Consolidated Financial Report For the Third quarter Fiscal 2011 Reference Data-Released: February 2, 2012), Accessed April 13
    • Eisai Website. Research and Development. Major R&D Pipeline. Major R&D Pipeline (Consolidated Financial Report For the Third quarter Fiscal 2011 Reference Data-Released: February 2, 2012). http://www.eisai.com/pdf/eir/erepo/epipeline.pdf (Accessed April 13, 2012).
    • (2012) Major R&D Pipeline
  • 136
    • 33745000162 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial
    • Synold, T.W.; Morgan, R.J.; Newman, E.M.; Lenz, H.J.; Gandara, D.R.; Colevas, A.D, Lewis, M.D.; Doroshow, J.H. A Phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer Consortium trial. J. Clin. Oncol., 2005, 23(16S), Part I of II (June 1 Supplement), 3036.
    • (2005) J. Clin. Oncol , vol.23 , Issue.16 S
    • Synold, T.W.1    Morgan, R.J.2    Newman, E.M.3    Lenz, H.J.4    Gandara, D.R.5    Colevas, A.D.6    Lewis, M.D.7    Doroshow, J.H.8
  • 138
    • 67449123315 scopus 로고    scopus 로고
    • Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors
    • Tan, A.R.; Rubin, E.H.; Walton, D.C.; Shuster, D.E.; Wong, Y.N.; Fang, F.; Ashworth, S.; Rosen, L.S. Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors. Clin. Cancer Res., 2009, 15(12), 4213-4219.
    • (2009) Clin. Cancer Res , vol.15 , Issue.12 , pp. 4213-4219
    • Tan, A.R.1    Rubin, E.H.2    Walton, D.C.3    Shuster, D.E.4    Wong, Y.N.5    Fang, F.6    Ashworth, S.7    Rosen, L.S.8
  • 139
    • 84867878727 scopus 로고    scopus 로고
    • Eribulin mesylate in patients with refractory cancers: A Phase I study
    • Mukohara, T.; Nagai, S.; Mukai, H.; Namiki, M.; Minami, H. Eribulin mesylate in patients with refractory cancers: a Phase I study. Invest. New Drugs, 2012, 30(5), 1926-1933.
    • (2012) Invest. New Drugs , vol.30 , Issue.5 , pp. 1926-1933
    • Mukohara, T.1    Nagai, S.2    Mukai, H.3    Namiki, M.4    Minami, H.5
  • 140
    • 84892798265 scopus 로고    scopus 로고
    • An Open-Label, Multicenter, Single Arm QT Interval Prolongation Study of Eribulin Mesylate in Patients With Advanced Solid Tumors
    • Edeline, J.; Lena, H.; Cvitkovic, E.C.; Penel, N.; Reyderman, L.; Edwards, G.; Law, K.; Delord, J.P.D.; Lesimple, T.L. An Open-Label, Multicenter, Single Arm QT Interval Prolongation Study of Eribulin Mesylate in Patients With Advanced Solid Tumors. Eur. J. Cancer, 2011, 47(Suppl. 1), S158.
    • (2011) Eur. J. Cancer , vol.47 , Issue.SUPPL. 1
    • Deline, J.1    Lena, H.2    Cvitkovic, E.C.3    Penel, N.4    Reyderman, L.5    Edwards, G.6    Law, K.7    Delord, J.P.D.8    Lesimple, T.L.9
  • 144
    • 81855172503 scopus 로고    scopus 로고
    • Eribulin mesylate for the treatment of late-stage breast cancer
    • Gourmelon, C.; Frenel, J.S.; Campone, M. Eribulin mesylate for the treatment of late-stage breast cancer. Expert Opin. Pharmacother., 2011, 12(18), 2883-2890.
    • (2011) Expert Opin. Pharmacother , vol.12 , Issue.18 , pp. 2883-2890
    • Gourmelon, C.1    Frenel, J.S.2    Campone, M.3
  • 145
    • 84856676007 scopus 로고    scopus 로고
    • Eribulin mesylate in the treatment of metastatic breast cancer
    • Jain, S.; Cigler, T. Eribulin mesylate in the treatment of metastatic breast cancer. Biologics, 2012, 6, 21-29.
    • (2012) Biologics , vol.6 , pp. 21-29
    • Jain, S.1    Cigler, T.2
  • 148
    • 59149099068 scopus 로고    scopus 로고
    • Phase II study of eribulin mesylate (E7389) in patients (pts) with locally advanced or metastatic breast cancer (MBC) previously treated with anthracycline, taxane, and capecitabine therapy
    • Vahdat, L.T.; Twelves, C.; Allison, M.K.; Cortes, J.A.; Campone, M.; Shuster, D.E.; Wanders, J.; Fang, F.; Gurnani, R.D.; Blum, J.L. Phase II study of eribulin mesylate (E7389) in patients (pts) with locally advanced or metastatic breast cancer (MBC) previously treated with anthracycline, taxane, and capecitabine therapy. J. Clin. Oncol., 2008, 26(15s), 1084.
    • (2008) J. Clin. Oncol , vol.26 , Issue.15 s , pp. 1084
    • Vahdat, L.T.1    Twelves, C.2    Allison, M.K.3    Cortes, J.A.4    Campone, M.5    Shuster, D.E.6    Wanders, J.7    Fang, F.8    Gurnani, R.D.9    Blum, J.L.10
  • 151
    • 84861733607 scopus 로고    scopus 로고
    • A phase II study of eribulin mesylate in Japanese patients with heavily pretreated metastatic breast cancer
    • Aogi, K.; Iwata, H.; Masuda, N.; Mukai, H.; Yoshida, M.; Rai, Y.; Taguchi, K.; Sasaki, Y.; Takashima, S. A phase II study of eribulin mesylate in Japanese patients with heavily pretreated metastatic breast cancer. Ann. Oncol., 2012, 23(6): 1441-1448.
    • (2012) Ann. Oncol , vol.23 , Issue.6 , pp. 1441-1448
    • Aogi, K.1    Iwata, H.2    Masuda, N.3    Mukai, H.4    Yoshida, M.5    Rai, Y.6    Taguchi, K.7    Sasaki, Y.8    Takashima, S.9
  • 152
    • 77950475001 scopus 로고    scopus 로고
    • Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer
    • Twelves, C.; Cortes, J.; Vahdat, L.T.; Wanders, J.; Akerele, C.; Kaufman, P.A. Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Clin. Breast Cancer, 2010, 10(2), 160-163.
    • (2010) Clin. Breast Cancer , vol.10 , Issue.2 , pp. 160-163
    • Twelves, C.1    Cortes, J.2    Vahdat, L.T.3    Wanders, J.4    Akerele, C.5    Kaufman, P.A.6
  • 153
    • 77955893812 scopus 로고    scopus 로고
    • A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane
    • Twelves, C.; Loesch, D.; Blum, J.L.; Vahdat, L.T.; Petrakova, K.; Chollet, P.J.; Akerele, C.E.; Seegobin, S.; Wanders, J.; Cortes, J. A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane. J. Clin. Oncol., 2010, 28(18s), 958.
    • (2010) J. Clin. Oncol , vol.28 , Issue.18 s , pp. 958
    • Twelves, C.1    Loesch, D.2    Blum, J.L.3    Vahdat, L.T.4    Petrakova, K.5    Chollet, P.J.6    Akerele, C.E.7    Seegobin, S.8    Wanders, J.9    Cortes, J.10
  • 155
    • 38649085581 scopus 로고    scopus 로고
    • A phase II study of a novel anti-tubulin, E7389, in patients with advanced non-small cell lung cancer (NSCLC)
    • Das, A.; Spira, A.; Iannotti, N.; Savin, M.; Zang, E.; Datta, K.; Shapiro, G.; Patturajan, M.; Silberman, S. A phase II study of a novel anti-tubulin, E7389, in patients with advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol., 2006, 24(18S), 7106.
    • (2006) J. Clin. Oncol , vol.24 , Issue.18 S , pp. 7106
    • Das, A.1    Spira, A.2    Iannotti, N.3    Savin, M.4    Zang, E.5    Datta, K.6    Shapiro, G.7    Patturajan, M.8    Silberman, S.9
  • 158
    • 84892810302 scopus 로고    scopus 로고
    • Eribulin mesylate (E7389) in patients with leiomyosarcoma (LMS) and other (OTH) subtypes of soft tissue sarcoma (STS): A Phase II study from the European Organisation for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC 62052)
    • Schöffski, P.; Hartmann, J.T.; Hohenberger, P.; Krarup-Hansen, A.; Wanders, J.; Hayward, C.; Druyts, D.; Van Glabbeke, M.; Sciot, R.; Blay, J.Y. Eribulin mesylate (E7389) in patients with leiomyosarcoma (LMS) and other (OTH) subtypes of soft tissue sarcoma (STS): a Phase II study from the European Organisation for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC 62052). Eur. J. Cancer Suppl., 2009, 7(2), 591.
    • (2009) Eur. J. Cancer Suppl , vol.7 , Issue.2 , pp. 591
    • Schöffski, P.1    Hartmann, J.T.2    Hohenberger, P.3    Krarup-Hansen, A.4    Wanders, J.5    Hayward, C.6    Druyts, D.7    van Glabbeke, M.8    Sciot, R.9    Blay, J.Y.10
  • 159
    • 80053383254 scopus 로고    scopus 로고
    • Activity of eribulin mesylate in patients with soft-tissue sarcoma: A phase 2 study in four independent histological subtypes
    • gov/pubmed?term=%22European Organisation for Research and Treatment of Cancer %28EORTC%29 Soft Tissue and Bone Sarcoma Group %28STBSG%29%22%5BCorporate Author%5D
    • Schöffski, P.; Ray-Coquard, I.L.; Cioffi, A.; Bui, N.B.; Bauer, S.; Hartmann, J.T.; Krarup-Hansen, A.; Grünwald, V.; Sciot, R.; Dumez, H.; Blay, J.Y.; Le Cesne, A.; Wanders, J.; Hayward, C.; Marreaud, S.; Ouali M.; Hohenberger, P. Activity of eribulin mesylate in patients with soft-tissue sarcoma: a phase 2 study in four independent histological subtypes. http://www.ncbi.nlm.nih. gov/pubmed?term=%22European Organisation for Research and Treatment of Cancer %28EORTC%29 Soft Tissue and Bone Sarcoma Group %28STBSG%29%22%5BCorporate Author%5D. Lancet Oncol., 2011, 12(11), 1045-1052.
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1045-1052
    • Chöffski, P.1    Ray-Coquard, I.L.2    Cioffi, A.3    Bui, N.B.4    Bauer, S.5    Hartmann, J.T.6    Krarup-Hansen, A.7    Grünwald, V.8    Sciot, R.9    Dumez, H.10    Blay, J.Y.11    Le Cesne, A.12    Wanders, J.13    Hayward, C.14    Marreaud, S.15    Ouali, M.16    Hohenberger, P.17
  • 161
    • 84860217796 scopus 로고    scopus 로고
    • Eribulin mesylate (halichondrin B analogue E7389) in platinum-resistant and platinum-sensitive ovarian cancer: A 2-cohort, phase 2 study
    • Hensley, M.L.; Kravetz, S.; Jia, X.; Iasonos, A.; Tew, W.; Pereira, L.; Sabbatini, P.; Whalen, C.; Aghajanian, C.A.; Zarwan, C.; Berlin, S. Eribulin mesylate (halichondrin B analogue E7389) in platinum-resistant and platinum-sensitive ovarian cancer: A 2-cohort, phase 2 study. Cancer, 2012, 118(9), 2403-2410.
    • (2012) Cancer , vol.118 , Issue.9 , pp. 2403-2410
    • Hensley, M.L.1    Kravetz, S.2    Jia, X.3    Iasonos, A.4    Tew, W.5    Pereira, L.6    Sabbatini, P.7    Whalen, C.8    Aghajanian, C.A.9    Zarwan, C.10    Berlin, S.11
  • 163
    • 79957508233 scopus 로고    scopus 로고
    • Phase II evaluation of eribulin mesylate (E7389, NSC 707389) in patients with metastatic or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group trial S0618
    • Arnold, S.M.; Moon, J.; Williamson, S.K.; Atkins, J.N.; Ou, S.H.; Le Blanc, M.; Urba, S.G. Phase II evaluation of eribulin mesylate (E7389, NSC 707389) in patients with metastatic or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group trial S0618. Invest. New Drugs, 2011, 29(2), 352-359.
    • (2011) Invest. New Drugs , vol.29 , Issue.2 , pp. 352-359
    • Arnold, S.M.1    Moon, J.2    Williamson, S.K.3    Atkins, J.N.4    Ou, S.H.5    Le Blanc, M.6    Urba, S.G.7
  • 165
    • 84876740259 scopus 로고    scopus 로고
    • Springer, Drugs in R & D (Open Access), Accessed April 16
    • Springer. Adis. Brentuximab Vedotin. Drugs in R & D (Open Access), 2011, 11(1), 85-95. http://adisonline.com/drugsrd/Fulltext/2011/11010/Brentuximab_Vedotin.8.aspx (Accessed April 16, 2012).
    • (2011) Adis. Brentuximab Vedotin , vol.11 , Issue.1 , pp. 85-95
  • 166
    • 70349645442 scopus 로고    scopus 로고
    • Complete remissions with weekly dosing of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in a phase I dose-escalation study in patients with relapsed or refractory Hodgkin lymphoma (HL) or systemic anaplastic large cell lymphoma (sALCL)
    • Bartlett, N.; Forero-Torres, A; Rosenblatt, J.; Fanale, M.; Horning, S.J.; Thompson, S.; Sievers, E.L.; Kennedy, D.A. Complete remissions with weekly dosing of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in a phase I dose-escalation study in patients with relapsed or refractory Hodgkin lymphoma (HL) or systemic anaplastic large cell lymphoma (sALCL). J. Clin. Oncol., 2009, 27(15s), 8500.
    • (2009) J. Clin. Oncol , vol.27 , Issue.15 s , pp. 8500
    • Bartlett, N.1    Forero-Torres, A.2    Rosenblatt, J.3    Fanale, M.4    Horning, S.J.5    Thompson, S.6    Sievers, E.L.7    Kennedy, D.A.8
  • 167
    • 84876726837 scopus 로고    scopus 로고
    • FDA, Accessed April 16
    • FDA. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm268781.htm (Accessed April 16, 2012)
    • (2012)
  • 168
    • 78650275149 scopus 로고    scopus 로고
    • Objective responses with brentuximab vedotin (SGN-35) retreatment in CD30-positive hematologic malignancies: A case series
    • Bartlett, N.; Grove, L.E.; Kennedy, D.A.; Sievers, E.L.; Forero-Torres, A. Objective responses with brentuximab vedotin (SGN-35) retreatment in CD30-positive hematologic malignancies: A case series. J. Clin. Oncol., 2010, 28(15s), 8062.
    • (2010) J. Clin. Oncol , vol.28 , Issue.15 s , pp. 8062
    • Bartlett, N.1    Grove, L.E.2    Kennedy, D.A.3    Sievers, E.L.4    Forero-Torres, A.5
  • 169
    • 53349093644 scopus 로고    scopus 로고
    • Objective responses in a phase I dose-escalation study of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in patients with relapsed or refractory Hodgkin lymphoma
    • May 20, abstr
    • Younes, A.; Forero-Torres, A; Bartlett, N.L.; Leonard, J.P.; Rege, B.; Kennedy, D.A; Lorenz, J.M.; Sievers, E.L. Objective responses in a phase I dose-escalation study of SGN-35, a novel antibody-drug conjugate (ADC) targeting CD30, in patients with relapsed or refractory Hodgkin lymphoma. J. Clin. Oncol., 2008, 26(May 20 suppl; abstr 8526).
    • (2008) J. Clin. Oncol , vol.26 , Issue.SUPPL. , pp. 8526
    • Ounes, A.1    Forero-Torres, A.2    Bartlett, N.L.3    Leonard, J.P.4    Rege, B.5    Kennedy, D.A.6    Lorenz, J.M.7    Sievers, E.L.8
  • 173
    • 84876703898 scopus 로고    scopus 로고
    • Effect of the phenyl ring modification on the antitumor activity of anti-microtubule agent dehydrophenylahistin
    • (41th Japanese Peptide Symposium)
    • Hayashi, Y.; Nicholson, B.; Tanaka, K.; Oda, A.; Lloyd, G.K.; Akamatsu, M.; Palladino, M.A.; Kiso, Y. Effect of the phenyl ring modification on the antitumor activity of anti-microtubule agent dehydrophenylahistin. Pept. Sci. 2004, (41th Japanese Peptide Symposium), 2005, 405-406.
    • (2005) Pept. Sci , vol.2004 , pp. 405-406
    • Hayashi, Y.1    Nicholson, B.2    Tanaka, K.3    Oda, A.4    Lloyd, G.K.5    Akamatsu, M.6    Palladino, M.A.7    Kiso, Y.8
  • 177
    • 33646118484 scopus 로고    scopus 로고
    • NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
    • Nicholson, B.; Lloyd G.K.; Miller, B.R.; Palladino, M.A.; Kiso, Y.; Hayashi, Y.; Neuteboom, S.T. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anti-cancer Drugs, 2006, 17(1), 25-31.
    • (2006) Anti-cancer Drugs , vol.17 , Issue.1 , pp. 25-31
    • Nicholson, B.1    Lloyd, G.K.2    Miller, B.R.3    Palladino, M.A.4    Kiso, Y.5    Hayashi, Y.6    Neuteboom, S.T.7
  • 178
  • 179
    • 78650751998 scopus 로고    scopus 로고
    • Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole
    • Yamazaki, Y.; Kido, Y.; Hidaka, K.; Yasui, H.; Kiso, Y.; Yakushiji, F.; Hayashi, Y. Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole. Bioorg. Med. Chem., 2011, 19(1), 595-602.
    • (2011) Bioorg. Med. Chem , vol.19 , Issue.1 , pp. 595-602
    • Yamazaki, Y.1    Kido, Y.2    Hidaka, K.3    Yasui, H.4    Kiso, Y.5    Yakushiji, F.6    Hayashi, Y.7
  • 180
    • 79957583553 scopus 로고    scopus 로고
    • A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells
    • Singh, A.V.; Bandi, M.; Raje, N.; Richardson, P.; Palladino M.A.; Chauhan, D.; Anderson, K.C. A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells. Blood, 2011, 117(21), 5692-700.
    • (2011) Blood , vol.117 , Issue.21 , pp. 5692-5700
    • Singh, A.V.1    Bandi, M.2    Raje, N.3    Richardson, P.4    Palladino, M.A.5    Chauhan, D.6    Anderson, K.C.7
  • 185
    • 84876740178 scopus 로고    scopus 로고
    • A Phase 1 Accelerated Titration Dose Escalation Study of Tiie Vascular Disrupting Agent NPI-2358 Utilizing DCE-MRI
    • Abstract 3987. 98th AACR Annual Meeting, Apr 14-18, 2007. In, Accessed April 17
    • LoRusso, P.; Papadopoulos, K.; Tolcher, A.; Lin, C.C.; Lloyd, K.; Morgan, E.; Ashton, E.; Cropp, G.; Spear, M. A Phase 1 accelerated titration dose escalation study of tiie vascular disrupting agent NPI-2358 utilizing DCE-MRI. Angiogenesis Inhibitors: Poster Presentations. Abstract 3987. 98th AACR Annual Meeting, Apr 14-18, 2007. In: http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/l_Annual_Meeting/3987?maxtoshow=&hits=10&RESULTFORMAT=&authorl=LoRusso%2C+P&fulltext=npi-2358&andorexactfulltext=and&searchid=l &FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT (Accessed April 17, 2012).
    • (2012) Angiogenesis Inhibitors: Poster Presentations
    • Lorusso, P.1    Papadopoulos, K.2    Tolcher, A.3    Lin, C.C.4    Lloyd, K.5    Morgan, E.6    Ashton, E.7    Cropp, G.8    Spear, M.9
  • 189
    • 84930540337 scopus 로고    scopus 로고
    • Plinabulin: Tubulin polymerization inhibitor vascular-disrupting agent oncolytic
    • Ferrer, E.; Bolos, J.; Castaner, R. Plinabulin: tubulin polymerization inhibitor vascular-disrupting agent oncolytic. Drugs Future, 2010, 35(1), 11-15.
    • (2010) Drugs Future , vol.35 , Issue.1 , pp. 11-15
    • Ferrer, E.1    Bolos, J.2    Castaner, R.3
  • 190
    • 84876700317 scopus 로고    scopus 로고
    • Nereus Pharmaceuticals Website, Clinical trials for Plinabulin (NPI-2358)(VDA), Accessed April 17
    • Nereus Pharmaceuticals Website. Products candidates. Clinical trials for Plinabulin (NPI-2358)(VDA). http://www.nereuspharm.com/ClinicalTrialsNPI-2358.shtml (Accessed April 17, 2012).
    • (2012) Products Candidates
  • 199
    • 0037265805 scopus 로고    scopus 로고
    • Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4
    • Broggini, M.; Marchini, S.V.; Galliera, E.; Borsotti, P.; Taraboletti, G.; Erba, E.; Sironi, M.; Jimeno, J.; Faircloth, G.T.; Giavazzi, R.; D'Incalci, M. Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4. Leukemia, 2003, 17(1), 52-59.
    • (2003) Leukemia , vol.17 , Issue.1 , pp. 52-59
    • Broggini, M.1    Marchini, S.V.2    Galliera, E.3    Borsotti, P.4    Taraboletti, G.5    Erba, E.6    Sironi, M.7    Jimeno, J.8    Faircloth, G.T.9    Giavazzi, R.10    D'Incalci, M.11
  • 206
    • 67650687006 scopus 로고    scopus 로고
    • Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma
    • Eisen, T.; Thomas, J.; Miller Jr., W.H.; Gore, M.; Wolter, P.; Kavan, P.; Martín, J.A.; Lardelli, P. Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma. Melanoma Res., 2009, 19(3), 185-192.
    • (2009) Melanoma Res , vol.19 , Issue.3 , pp. 185-192
    • Eisen, T.1    Thomas, J.2    Miller, W.H.3    Gore, M.4    Wolter, P.5    Kavan, P.6    Martín, J.A.7    Lardelli, P.8
  • 207
    • 76749105187 scopus 로고    scopus 로고
    • Phase II study of plitidepsin 3-hour infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma
    • Baudin, E.; Droz, J.P.; Paz-Ares, L.; van Oosterom, A.T.; Cullell-Young, M.; Schlumberger, M. Phase II study of plitidepsin 3-hour infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma. Am. J. Clin. Oncol., 2010, 33(1), 83-88.
    • (2010) Am. J. Clin. Oncol , vol.33 , Issue.1 , pp. 83-88
    • Baudin, E.1    Droz, J.P.2    Paz-Ares, L.3    van Oosterom, A.T.4    Cullell-Young, M.5    Schlumberger, M.6
  • 208
    • 77951089234 scopus 로고    scopus 로고
    • Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma
    • Le Tourneau, C.; Faivre, S.; Ciruelos, E.; Domínguez, M.J.; López-Martín, J.A.; Izquierdo, M.A.; Jimeno, J.; Raymond, E. Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma. Am. J. Clin. Oncol., 2010, 33(2), 132-136.
    • (2010) Am. J. Clin. Oncol , vol.33 , Issue.2 , pp. 132-136
    • Le Tourneau, C.1    Faivre, S.2    Ciruelos, E.3    Domínguez, M.J.4    López-Martín, J.A.5    Izquierdo, M.A.6    Jimeno, J.7    Raymond, E.8
  • 213
    • 84876741091 scopus 로고    scopus 로고
    • ClinicalTrials.Gov Website, NCT00229203 Study Results, Accessed May 05
    • ClinicalTrials.Gov Website. Plitidepsin. NCT00229203 Study Results. http://clinicaltrials.gov/ct2/show/results/NCT00229203? term=plitidepsin&rank=6 (Accessed May 05, 2012).
    • (2012) Plitidepsin
  • 216
    • 84856053807 scopus 로고    scopus 로고
    • Phase I study of weekly plitidepsin as 1-hour infusion combined with carboplatin in patients with advanced solid tumors or lymphomas
    • Salazar, R.; Plummer, R.; Oaknin, A.; Robinson, A.; Pardo, B.; Soto-Matos, A.; Yovine, A.; Szyldergemajn, S.; Calvert, A.H. Phase I study of weekly plitidepsin as 1-hour infusion combined with carboplatin in patients with advanced solid tumors or lymphomas. Invest. New Drugs, 2011, 29(6), 1406-1413.
    • (2011) Invest. New Drugs , vol.29 , Issue.6 , pp. 1406-1413
    • Salazar, R.1    Plummer, R.2    Oaknin, A.3    Robinson, A.4    Pardo, B.5    Soto-Matos, A.6    Yovine, A.7    Szyldergemajn, S.8    Calvert, A.H.9
  • 218
    • 0029842550 scopus 로고    scopus 로고
    • Kahalalides: Bioactive peptides from a marine mollusc Elysia rufescens and its diet algal Bryopsis sp
    • Hamann, M.T.; Otto, C.S.; Scheuer, P.J.; Dunbar, D.C. Kahalalides: bioactive peptides from a marine mollusc Elysia rufescens and its diet algal Bryopsis sp. J. Org. Chem., 1996, 67(19), 6594-6600.
    • (1996) J. Org. Chem , vol.6 , Issue.19 , pp. 6594-6600
    • Hamann, M.T.1    Otto, C.S.2    Scheuer, P.J.3    Dunbar, D.C.4
  • 221
    • 84876699622 scopus 로고    scopus 로고
    • Pharmamar Website. Products. Pipeline., Accessed April 17
    • Pharmamar Website. Products. Pipeline. http://www.pharmamar. com/pipeline.aspx (Accessed April 17, 2012).
    • (2012)
  • 222
    • 84876710019 scopus 로고    scopus 로고
    • Pharmamar Website. Products. Pipeline. Irvalec, Accessed April 17
    • Pharmamar Website. Products. Pipeline. Irvalec. http://www.pharmamar.com/irvalec.aspx (Accessed April 17, 2012).
    • (2012)
  • 223
    • 67149096306 scopus 로고    scopus 로고
    • Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models
    • Yi-He Ling, Y.H.; Aracil, M.; Jimeno, J.; Perez-Soler, R.; Zou, Y. Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models. Eur. J. Cancer, 2009, 45(10), 1855-1864.
    • (2009) Ur. J. Cancer , vol.45 , Issue.10 , pp. 1855-1864
    • Yi-He, L.Y.H.1    Aracil, M.2    Jimeno, J.3    Perez-Soler, R.4    Zou, Y.5
  • 226
    • 59149098944 scopus 로고    scopus 로고
    • Phase I study of PM02734: Association of dose-limiting hepatotoxicity with plasma concentrations
    • Bruce, J.Y.; Geary, D.; de las Heras, B. Phase I study of PM02734: association of dose-limiting hepatotoxicity with plasma concentrations. J. Clin. Oncol, 2008, 26(15s), 2513.
    • (2008) J. Clin. Oncol , vol.26 , Issue.15 s , pp. 2513
    • Bruce, J.Y.1    Geary, D.2    de las Heras, B.3
  • 228
    • 66749084494 scopus 로고    scopus 로고
    • Chemistry of renieramycins. Part 8: Synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues
    • Charupant, K.; Daikuhara, N.; Saito, E.; Amnuoypol, S.; Suwanborirux, K.; Owa, T.; Saito, N. Chemistry of renieramycins. Part 8: Synthesis and cytotoxicity evaluation of renieramycin M-jorunnamycin A analogues. Bioorg. Med. Chem., 2009, 17(13), 4548-4558.
    • (2009) Bioorg. Med. Chem , vol.1 , Issue.13 , pp. 4548-4558
    • Charupant, K.1    Daikuhara, N.2    Saito, E.3    Amnuoypol, S.4    Suwanborirux, K.5    Owa, T.6    Saito, N.7
  • 229
    • 67651158998 scopus 로고    scopus 로고
    • Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition
    • Guirouilh-Barbat, J.; Antony, S.; Pommier, Y. Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition. Mol. Cancer Ther., 2009, 8(7), 2007-2014.
    • (2009) Mol. Cancer Ther , vol.8 , Issue.7 , pp. 2007-2014
    • Guirouilh-Barbat, J.1    Antony, S.2    Pommier, Y.3
  • 233
    • 71649097915 scopus 로고    scopus 로고
    • Phase I study of the novel anti-cancer drug PM00104 as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors or lymphoma
    • Soria, J.C.; Plummer, R.; Soto, A.; Massard, C.; Calvert, H.; Prados, R.; Angevin, E.; Jones, C.; de las Heras, B. Phase I study of the novel anti-cancer drug PM00104 as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors or lymphoma. Eur. J. Cancer Suppl., 2008, 6(12), 57.
    • (2008) Eur. J. Cancer Suppl , vol.6 , Issue.12 , pp. 57
    • Soria, J.C.1    Plummer, R.2    Soto, A.3    Massard, C.4    Calvert, H.5    Prados, R.6    Angevin, E.7    Jones, C.8    de las Heras, B.9
  • 238
    • 84876710740 scopus 로고    scopus 로고
    • Pharmamar Website. Products. PM01183, Accessed April 17
    • Pharmamar Website. Products. PM01183. http://www.pharmamar. com/pm01183-en.aspx (Accessed April 17, 2012).
    • (2012)
  • 240
    • 34248592567 scopus 로고    scopus 로고
    • Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate
    • Ray, A.; Okouneva, T.; Manna, T.; Miller, H.P.; Schmid, S.; Arthaud, L.; Luduena, R.; Jordan, M.A.; Wilson, L. Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate. Cancer Res., 2007, 67(8), 3767-3776.
    • (2007) Cancer Res , vol.67 , Issue.8 , pp. 3767-3776
    • Ray, A.1    Okouneva, T.2    Manna, T.3    Miller, H.P.4    Schmid, S.5    Arthaud, L.6    Luduena, R.7    Jordan, M.A.8    Wilson, L.9
  • 241
    • 34848859978 scopus 로고    scopus 로고
    • Preclinical analysis of tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma
    • Garg, V.; Zhang, W.; Gidwani, P.; Kim, M.; Kolb, E.A. Preclinical analysis of tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma. Clin. Cancer Res., 2007, 13(18 Pt 1), 5446-5454.
    • (2007) Clin. Cancer Res , vol.13 , Issue.18 PART 1 , pp. 5446-5454
    • Garg, V.1    Zhang, W.2    Gidwani, P.3    Kim, M.4    Kolb, E.A.5
  • 242
    • 27744536541 scopus 로고    scopus 로고
    • A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors
    • Ebbinghaus, S.; Rubin, E.; Hersh, E.; Cranmer, L.D.; Bonate, P.L.; Fram, R.J.; Jekunen, A.; Weitman, S.; Hammond, L.A. A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors. Clin. Cancer Res., 2005, 11(21), 7807-7816.
    • (2005) Clin. Cancer Res , vol.11 , Issue.21 , pp. 7807-7816
    • Ebbinghaus, S.1    Rubin, E.2    Hersh, E.3    Cranmer, L.D.4    Bonate, P.L.5    Fram, R.J.6    Jekunen, A.7    Weitman, S.8    Hammond, L.A.9
  • 244
    • 33748991177 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors
    • Mita, A.C.; Hammond, L.A.; Bonate, P.L.; Weiss, G.; McCreery, H.; Syed, S.; Garrison, M.; Chu, Q.S.; DeBono, J.S.; Jones, C.B.; Weitman, S.; Rowinsky, E.K. Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors. Clin. Cancer Res., 2006, 12(17), 5207-5215.
    • (2006) Clin. Cancer Res , vol.12 , Issue.17 , pp. 5207-5215
    • Mita, A.C.1    Hammond, L.A.2    Bonate, P.L.3    Weiss, G.4    McCreery, H.5    Syed, S.6    Garrison, M.7    Chu, Q.S.8    Debono, J.S.9    Jones, C.B.10    Weitman, S.11    Rowinsky, E.K.12
  • 245
    • 84876732117 scopus 로고    scopus 로고
    • Genzyme Oncology Website, Accessed April 17
    • Genzyme Oncology Website. Our research. Tasidotin Hydrochloride. http://www.genzymeoncology.com/onc/research/onc_p_tasidotinHydrochloride.asp (Accessed April 17, 2012).
    • (2012) Our Research. Tasidotin Hydrochloride
  • 247
    • 84876732910 scopus 로고    scopus 로고
    • Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim, Germany
    • Kornprobst, J.M. In: Encyclopedia of marine natural products; Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim, Germany, 2010. Vol. 3, pp.1162-1166.
    • (2010) Encyclopedia of Marine Natural Products , vol.3 , pp. 1162-1166
    • Kornprobst, J.M.1
  • 249
    • 18844444472 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the dolastatin 10 analogue TZT-1027, given on days 1 and 8 of a 3-week cycle in patients with advanced solid tumors
    • de Jonge, M.J.; van der Gaast, A.; Planting, A.S.; van Doorn, L.; Lems, A.; Boot, I., Wanders, J.; Satomi, M.; Verweij, J. Phase I and pharmacokinetic study of the dolastatin 10 analogue TZT-1027, given on days 1 and 8 of a 3-week cycle in patients with advanced solid tumors. Clin. Cancer Res. 2005, 11(10), 3806-3813.
    • (2005) Clin. Cancer Res , vol.11 , Issue.10 , pp. 3806-3813
    • de Jonge, M.J.1    van der Gaast, A.2    Planting, A.S.3    van Doorn, L.4    Lems, A.5    Boot, I.6    Wanders, J.7    Satomi, M.8    Verweij, J.9
  • 250
    • 34248374465 scopus 로고    scopus 로고
    • Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses
    • Tamura, K.; Nakagawa, K.; Kurata, T.; Satoh, T.; Nogami, T.; Takeda, K.; Mitsuoka, S.; Yoshimura, N.; Kudoh, S.; Negoro, S.; Fukuoka, M. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses. Cancer Chemother. Pharmacol., 2007, 60(2), 285-293.
    • (2007) Cancer Chemother. Pharmacol , vol.60 , Issue.2 , pp. 285-293
    • Tamura, K.1    Nakagawa, K.2    Kurata, T.3    Satoh, T.4    Nogami, T.5    Takeda, K.6    Mitsuoka, S.7    Yoshimura, N.8    Kudoh, S.9    Negoro, S.10    Fukuoka, M.11
  • 251
    • 33845582571 scopus 로고    scopus 로고
    • Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy
    • Patel, S.; Keohan, M.L.; Saif, M.W.; Rushing, D.; Baez, L.; Feit, K.; De Jager, R.; Anderson, S. Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy. Cancer, 2006, 107(12), 2881-2887.
    • (2006) Cancer , vol.107 , Issue.12 , pp. 2881-2887
    • Patel, S.1    Keohan, M.L.2    Saif, M.W.3    Rushing, D.4    Baez, L.5    Feit, K.6    de Jager, R.7    Anderson, S.8
  • 252
    • 59349101632 scopus 로고    scopus 로고
    • A phase I/II study of CR011-vcMMAE, an antibody toxin conjugate drug, in patients with unresectable stage III/IV melanoma
    • May 20, abstr
    • Hwu, P.; Sznol, M.; Kluger, H.; Rink, L.; Kim, K.B.; Papadopoulos, N.E.; Sanders, D.; Boasberg, P.; Ooi, C.E.; Hamid, O. A phase I/II study of CR011-vcMMAE, an antibody toxin conjugate drug, in patients with unresectable stage III/IV melanoma. J. Clin. Oncol., 2008, 26(May 20 suppl; abstr 9029).
    • (2008) J. Clin. Oncol , vol.26 , Issue.SUPPL. , pp. 9029
    • Hwu, P.1    Sznol, M.2    Kluger, H.3    Rink, L.4    Kim, K.B.5    Papadopoulos, N.E.6    Sanders, D.7    Boasberg, P.8    Ooi, C.E.9    Hamid, O.10
  • 254
    • 79952674970 scopus 로고    scopus 로고
    • First-in-human phase I trail of prostate-specific membrane antigen antibody drug conjugate (PSMA ADC) in taxane-refractory prostate cancer
    • abstract, TPS245
    • Kantoff, P.; Petrylak, D.P.; Pomerantz, M, Israel R.J.; Olson, W.C.; Ramakrishna, T.; Morris, S. First-in-human phase I trail of prostate-specific membrane antigen antibody drug conjugate (PSMA ADC) in taxane-refractory prostate cancer. J. Clin. Oncol., 2010, 28(15s) (suppl. abstract TPS245).
    • (2010) J. Clin. Oncol , vol.28 , Issue.SUPPL.
    • Kantoff, P.1    Petrylak, D.P.2    Pomerantz, M.3    Israel, R.J.4    Olson, W.C.5    Ramakrishna, T.6    Morris, S.7
  • 255
    • 80052688423 scopus 로고    scopus 로고
    • Prostate-specific membrane antigen antibody-drug conjugate (PSMA ADC): A phase I trial in taxane-refractory prostate cancer
    • abstract
    • Petrylak, D.P.; Kantoff, P.W.; Franck, R.C.; Shore, N.D.; Rotshteyn, Y.; Israel, R.J.; Olson, W.C.; Ramakrishna, T.; Morris, S. Prostate-specific membrane antigen antibody-drug conjugate (PSMA ADC): a phase I trial in taxane-refractory prostate cancer. J. Clin. Oncol., 2011, 29(suppl. abstract 4650).
    • (2011) J. Clin. Oncol , vol.29 , Issue.SUPPL. , pp. 4650
    • Petrylak, D.P.1    Kantoff, P.W.2    Franck, R.C.3    Shore, N.D.4    Rotshteyn, Y.5    Israel, R.J.6    Olson, W.C.7    Ramakrishna, T.8    Morris, S.9
  • 256
    • 84872666009 scopus 로고    scopus 로고
    • The effect of SGN-75, a novel antibody-drug conjugate (ADC), in treatment of patients with renal cell carcinoma (RCC) or non-Hodgkin lymphoma (NHL): A phase I study
    • abstr
    • Thompson, J.A.; Forero-Torres, A.; Heath, E.I.; Ansell, S. M.; Pal, S. K.; Infante, J. R.; De Vos, S.; Hamlin, P. A.; Zhao, B.; Klussman, K.; Whiting, N. C. The effect of SGN-75, a novel antibody-drug conjugate (ADC), in treatment of patients with renal cell carcinoma (RCC) or non-Hodgkin lymphoma (NHL): A phase I study. J. Clin. Oncol., 2011, 29 (suppl; abstr 3071).
    • (2011) J. Clin. Oncol , vol.29 , Issue.SUPPL. , pp. 3071
    • Thompson, J.A.1    Forero-Torres, A.2    Heath, E.I.3    Ansell, S.M.4    Pal, S.K.5    Infante, J.R.6    de Vos, S.7    Hamlin, P.A.8    Zhao, B.9    Klussman, K.10    Whiting, N.C.11
  • 257
    • 0037455147 scopus 로고    scopus 로고
    • Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
    • Feling, R.H.; Buchanan, G.O.; Mincer, T.J.; Kauffman, C.A.; Jensen, P.R.; Fenical, W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew. Chem. Int. Ed. Engl., 2003, 42(3), 355-357.
    • (2003) Angew. Chem. Int. Ed. Engl , vol.42 , Issue.3 , pp. 355-357
    • Feling, R.H.1    Buchanan, G.O.2    Mincer, T.J.3    Kauffman, C.A.4    Jensen, P.R.5    Fenical, W.6
  • 258
  • 259
    • 2442720189 scopus 로고    scopus 로고
    • A simple stereocontrolled synthesis of salinosporamide A
    • Reddy, L.R.; Saravanan, P.; Corey, E.J. A simple stereocontrolled synthesis of salinosporamide A. J. Am. Chem. Soc., 2004, 126(20), 6230-6231.
    • (2004) J. Am. Chem. Soc , vol.126 , Issue.20 , pp. 6230-6231
    • Reddy, L.R.1    Saravanan, P.2    Corey, E.J.3
  • 260
    • 33750209537 scopus 로고    scopus 로고
    • A novel proteasome inhibitor NPI-0052 as an anticancer therapy
    • Chauhan, D.; Hideshima, T.; Anderson, K.C. A novel proteasome inhibitor NPI-0052 as an anticancer therapy. Brit. J. Cancer, 2006, 95(8), 961-965.
    • (2006) Brit. J. Cancer , vol.95 , Issue.8 , pp. 961-965
    • Chauhan, D.1    Hideshima, T.2    Anderson, K.C.3
  • 261
    • 70450227260 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • Shah, J.J.; Orlowski, R.Z. Proteasome inhibitors in the treatment of multiple myeloma. Leukemia, 2009, 23(11), 1964-1979.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 1964-1979
    • Shah, J.J.1    Orlowski, R.Z.2
  • 263
    • 84876700317 scopus 로고    scopus 로고
    • Nereus Pharmaceuticals Website. A novel proteasome inhibitor (NPI-0052), Accessed April 17
    • Nereus Pharmaceuticals Website. Products Candidates. A novel proteasome inhibitor (NPI-0052). http://www.nereuspharm.com/NPI-0052.shtml (Accessed April 17, 2012).
    • (2012) Products Candidates
  • 267
    • 70350773087 scopus 로고    scopus 로고
    • Clinical Trial of NPI-0052 (2nd generation proteasome inhibitor) in Patients Having Advanced Malignancies with Expanded RP2D Cohorts in Lymphoma and CLL
    • (ASH Annual Meeting Abstracts)
    • Price, T.; Padrik, P.; Townsend, A.; Mainwaring, P.; Catley, L.; Longenecker, A.; Cropp, G.; Palladino, M.; Lloyd, G.K.; Spear, M.; Millward, M. Clinical Trial of NPI-0052 (2nd generation proteasome inhibitor) in Patients Having Advanced Malignancies with Expanded RP2D Cohorts in Lymphoma and CLL. Blood (ASH Annual Meeting Abstracts), 2008, 112, 4934.
    • (2008) Blood , vol.112 , pp. 4934
    • Price, T.1    Padrik, P.2    Townsend, A.3    Mainwaring, P.4    Catley, L.5    Longenecker, A.6    Cropp, G.7    Palladino, M.8    Lloyd, G.K.9    Spear, M.10    Millward, M.11
  • 268
    • 70350779117 scopus 로고    scopus 로고
    • First-in-Human Phase 1 Dose Escalation Study of NPI-0052, a Novel Proteasome Inhibitor, in Patients with Lymphoma and Solid Tumor
    • (ASH Annual Meeting Abstracts)
    • Hamlin, P.; Aghajanian, C.; Hong, D.; Younes, A.; Palladino, M.; Longenecker, A.; Cropp, G.; Lloyd, G.K.; Hannah, A.; Spear, M.; Kurzrock, R. First-in-Human Phase 1 Dose Escalation Study of NPI-0052, a Novel Proteasome Inhibitor, in Patients with Lymphoma and Solid Tumor. Blood (ASH Annual Meeting Abstracts), 2008, 112, 4939.
    • (2008) Blood , vol.112 , pp. 4939
    • Hamlin, P.1    Aghajanian, C.2    Hong, D.3    Younes, A.4    Palladino, M.5    Longenecker, A.6    Cropp, G.7    Lloyd, G.K.8    Hannah, A.9    Spear, M.10    Kurzrock, R.11
  • 280
    • 84876742337 scopus 로고    scopus 로고
    • Pharmamar Website. Products. PM060184, Accessed April 17
    • Pharmamar Website. Products. PM060184. http://www.pharmamar.com/pm060184-en.aspx (Accessed April 17, 2012).
    • (2012)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.